DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppn and Adamts8

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_038934.2	Gene:	Adamts8 / 30806	MGIID:	1353468	Length:	905	Species:	Mus musculus

Alignment Length:	376	Identity:	115/376 - (30%)
Similarity:	177/376 - (47%)	Gaps:	54/376 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 EWTPWSSPSDCSRTCGGGVSYQTRECLRRDD----RGEAVCSGGSRRYFSCNTQDCPEEESDFRA 119
            :|.||.....||||||||:.:..|||   |:    .|...|.|...:|.||||::||.....||.
Mouse   544 DWGPWRPWGQCSRTCGGGIQFSNREC---DNPMPQNGGRFCLGERVKYQSCNTEECPPNGKSFRE 605

  Fly   120 QQCSR---FDRQQFDGVFYEWVPYTNAPNP---CELNCMPKGERFYYRQREKVVDGTRCNDKDLD 178
            |||.:   ::....||.|.:|||..:..:|   |:|.|..:|...:.....||:|||.|....|.
Mouse   606 QQCEKYNAYNHTDLDGNFLQWVPKYSGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPDTLS 670

  Fly   179 VCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLLLLPEGATNIR 243
            :||.|:|:..|||.::.|..|.|||..|||.|:.|:.|..:.|  ..:.||||::.:|.|||||.
Mouse   671 ICVRGQCVKAGCDHVVNSPKKLDKCGVCGGKGTACRKISGSFT--PFSYGYNDIVTIPAGATNID 733

  Fly   244 IEE-TVP----SSNYLACRNHSGHYYLNGDWRID-FPRPMFFANSWWNYQRKPMGFAAPDQLTCS 302
            ::: :.|    ..:|||.:..:|.|.|||:..|. ..:.:....:...|..   ..|..::|...
Mouse   734 VKQRSHPGVRNDGSYLALKTANGQYLLNGNLAISAIEQDILVKGTILKYSG---SMATLERLQSF 795

  Fly   303 GPISESLFIVMLVQEKNI---SLDYEYSIPESLSHSQQDTH--------------TWTHHQFNAC 350
            ..:.|.|.:.:|.....:   .:.|.:.:|..:..|.|::.              .|....::.|
Mouse   796 QALPEPLTVQLLTVSGEVFPPKVRYTFFVPNDMDFSVQNSKERATTNIIQSLPSAEWVLGDWSEC 860

  Fly   351 SASCGGGSQSRKVTCNNRITLAEVNPS-----LCDQKSKPVEEQACGTEPC 396
            .::|.|..|.|.|.|.        :||     .||:..||.:.:.||::||
Mouse   861 PSTCRGSWQRRTVECR--------DPSGQASDTCDEALKPEDAKPCGSQPC 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	23/54 (43%)
		ADAM_spacer1	214..329	CDD:283607	29/123 (24%)
		TSP1	468..521	CDD:214559
		TSP_1	645..693	CDD:278517
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
Adamts8	NP_038934.2	Pep_M12B_propep	52..152	CDD:279848
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..163
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..225
		Reprolysin	234..444	CDD:279729
		ZnMc_ADAMTS_like	234..441	CDD:239801
		ADAM_CR	463..529	CDD:301627
		TSP1	545..597	CDD:214559	23/54 (43%)
		Spacer	706..847		32/145 (22%)
		ADAM_spacer1	706..825	CDD:283607	29/123 (24%)
		TSP1	852..904	CDD:214559	18/60 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	877..905		10/27 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I11845
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810