Protein Alignment Ppn and Adamts12

DIOPT Version :9

• Sequence 1: NP_788752.2
• Gene: Ppn / 43872
• FlyBaseID: FBgn0003137
• Length: 2898
• Species: Drosophila melanogaster
• Sequence 2: NP_001099890.2
• Gene: Adamts12 / 294809
• RGDID: 1307323
• Length: 1599
• Species: Rattus norvegicus
• Alignment Length: 928
• Identity: 237/928 - (25%)
• Similarity: 336/928 - (36%)
• Gaps: 304/928 - (32%)

  Fly    44 PESSVTPGGEGNDPDEWTPWSSPSDCSRTCGGGVSYQTRECLRRDDR-GEAVCSGGSRRYFSCNT 107
            |||  .|||.|    .|:||   |.||||||.|.....|.|...:.: |...|:|..:||..||.
  Rat   542 PES--IPGGWG----RWSPW---SHCSRTCGAGAQSAERLCNNPEPKFGGKYCTGERKRYRLCNV 597

  Fly   108 QDCPEEESDFRAQQCSRFDRQQFDGVFYEWVPYTNAPNPCELNCMPKGERFYYRQREKVVDGTRC 172
            ..|..:...||..|||.||...:...||.|.|..|..:||||.|.|..|:|..|..|.|:|||.|
  Rat   598 HPCRSDTPTFRQMQCSEFDTVPYKNQFYRWFPVFNPAHPCELYCRPIDEQFSERMLEAVIDGTPC 662

  Fly   173 --NDKDLDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLLLL 235
              .....:||:||.|..||||..:.|:|.||:|..|.||||.|:|::.....|: ..||.|:.|:
  Rat   663 FEGGNSRNVCINGICKRVGCDYEIDSNATEDRCGVCLGDGSACQTVKKVFRQKE-GSGYIDIGLI 726

  Fly   236 PEGATNIRIEETVPSSNYLACRNHSGH-YYLNGDWRIDFPRPMFFANSWWNYQRKPMGFAAPDQL 299
            |:||.:||:.|...:.|:||.|:.... |||||.:.|.:......|.:.:.|.||    ...::|
  Rat   727 PKGARDIRVMEIKAAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRK----GDLERL 787

  Fly   300 TCSGPISESLFIVMLVQEKNISLDYEYSI-PESLSHS-QQDTHTWTHHQFNACSASCGGGSQSRK 362
            ...||.:||:::.:|.|..|..:.|||:: .:.|.:. ::..:.|...::..||.:||.|.:.:.
  Rat   788 MAPGPTNESVWLQLLFQVTNPGIKYEYTVRKDGLDNDVEKLLYFWQFGRWTECSVTCGTGIRRQT 852

  Fly   363 VTCNNRITLAEVNPSLCDQKSKP-VEEQACGTEPCAPHWVEGEWSKCSKGCGSDGFQNRSITCER 426
            ..|..: ....|..:.|:.:::| |.::.|..:.|.|.|..|||..||..||..|.:.|::.|
  Rat   853 AHCVKK-GHGIVKTTFCNPETQPSVRQKKCYEKDCPPRWWAGEWEACSMTCGPYGEKKRTVLC-- 914

  Fly   427 ISSSGEHTVEEDAVCLKEVGN--KPATKQECNRDVKNCPK-YHLGPWTPCDKLCGDGKQTRKVTC 488
            |.:.|.   :|.|:...:..:  ||.|...||||:. ||. :.:|.|:.|...||.|.:.|.|||
  Rat   915 IQTMGS---DEQALPATDCQHLLKPKTLVSCNRDIL-CPSDWTVGNWSECSVSCGGGVRIRSVTC 975

  Fly   489 FIEENG---------------------HKRVL-PEEDCVE--EKPETEK--------------SC 515
            ....|.                     .:||| |.:|.|.  :.|.|.:              :.
  Rat   976 AKNLNEPCDKTRKPNSRALCGLQQCPFSRRVLKPNKDTVPSGKNPTTSEHDHFKPIPASTSRPTP 1040

  Fly   516 LLTPC-------------------------EGVDW-----------------------IISQWS- 531
            |.||.                         :|:.|                       .::.||
  Rat  1041 LSTPTVPESVSTSTPTINSLGSTITSQEEPDGIGWQNNSTQAEEDSHIPTSVGSTSQTPLTSWSW 1105

  Fly   532 ---------GCNACGQNTET----RTAICGNKEGKV--------YPEEFCEPEV----------- 564
                     ..:|.|..:|:    .|:..|......        |.....||||
  Rat  1106 SMQPDDENVSSSAIGPTSESDFWATTSDSGLSSSNAMTWQVTPFYSTATTEPEVEIHSGSGEDSD 1170

  Fly   565 -----------------------------------------------PTLSRPCKS--------- 573
                                                           |..|...||
  Rat  1171 QPLNKEENNSVLWNKIRVPERDAPMEMDAEIPLGPPPTSYVTEESSWPPFSTMMKSSLPAWSFKN 1235

  Fly   574 --PKCE----------------------------------------------------------- 577
              |:.|
  Rat  1236 ETPRDEGMITEKSGNIPLPLGGDHQTTSPEKLGNNDQLASANSTNPTQGSGPVLTEEDASTLIEE 1300

  Fly   578 ------------------AQWFSSEWSKCSAPCGKGVKSRIVICGEFDGKTVTPADDDSKCNKET 624
                              |.|....|||||..||.|...|.|.|     .|...||    |....
  Rat  1301 GFLLNASNYKHLMKDHSPAHWIVGNWSKCSTTCGLGAYWRSVEC-----STGMNAD----CAAIQ 1356

  Fly   625 KPESEQDCEGEEKVCPGEWFTGPWGKCSKPCGGGERVREVLCLS-----NGTKSVNCD--EEKVE 682
            :|:..:.|  ..:.|.| |..|.|.|||:.|.||.::|||.|:.     ...:..:|.  .....
  Rat  1357 RPDPAKKC--HLRPCAG-WRVGNWSKCSRNCSGGFKIREVQCMDGVDHHRSLRPFHCQFLAGVPP 1418

  Fly   683 PLSEKCNSEACTEDEILP 700
            |||..||.|.|.|.::.|
  Rat  1419 PLSMSCNLEPCEEWKVEP 1436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	20/51 (39%)
		ADAM_spacer1	214..329	CDD:283607	37/116 (32%)
		TSP1	468..521	CDD:214559	22/115 (19%)
		TSP_1	645..693	CDD:278517	19/54 (35%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
Adamts12	NP_001099890.2	Pep_M12B_propep	80..196	CDD:279848
		Reprolysin	250..460	CDD:279729
		ZnMc_ADAMTS_like	250..457	CDD:239801
		ADAM_CR	519..680	CDD:301627	60/146 (41%)
		TSP1	549..600	CDD:214559	21/57 (37%)
		ADAM_spacer1	706..816	CDD:283607	37/114 (32%)
		TSP1	832..887	CDD:214559	12/55 (22%)
		TSP1	950..1001	CDD:214559	11/50 (22%)
		PARM	1021..>1176	CDD:293666	18/154 (12%)
		TSP1	1429..1477	CDD:214559	3/8 (38%)
		TSP1	1479..1536	CDD:214559

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810