DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppn and Mag

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_058886.1	Gene:	Mag / 29409	RGDID:	3035	Length:	626	Species:	Rattus norvegicus

Alignment Length:	377	Identity:	82/377 - (21%)
Similarity:	129/377 - (34%)	Gaps:	132/377 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  2575 GDLTIVQVRQTDDGTYVCVA---------SNGLGEPVRREVALQVTEP-------------VSQP 2617
            |:.|::...:.|:||:|.|:         :||      ..:..|...|             |..|
  Rat   181 GEPTVLGRLREDEGTWVQVSLLHFVPTREANG------HRLGCQAAFPNTTLQFEGYASLDVKYP 239

  Fly  2618 AYIYGDKNVTQIVELNRPAVIRCPAGGFPEPHVSWWRNGQMFGLKNNLMARDYSLVFNSIQLSDL 2682
            ..|....:..:.:|.:..::: |.|...|.|.::|.|:|.:.   ...:|....|....:..::.
  Rat   240 PVIVEMNSSVEAIEGSHVSLL-CGADSNPPPLLTWMRDGMVL---REAVAESLYLDLEEVTPAED 300

  Fly  2683 GLYTC---EVYNQ-RRPVSLRVTLKAVGPVRPLSPEEEQYMQYVLNPATRPVTQRPSYPYRPTRP 2743
            |:|.|   ..|.| .|.|.|.|
  Rat   301 GIYACLAENAYGQDNRTVELSV------------------------------------------- 322

  Fly  2744 AYVP-EPTVNVHAVLALEPKNSYTPGSTIVMSCSVQGYPEPNVTWIKDDVPLYNNERVQITYQPH 2807
            .|.| :|||| ..|:|:|       |.|:.:.||.|..|:|.:|..|:...|     ..:.|:..
  Rat   323 MYAPWKPTVN-GTVVAVE-------GETVSILCSTQSNPDPILTIFKEKQIL-----ATVIYESQ 374

  Fly  2808 -RLVLSDVTSADSGKYTCRASNAYTYANGEANVSIQ--SVVPVSPECVDNPYFANCKLIVKGRYC 2869
             :|.|..||..|.|:|.|.|.|.|.......|:|::  .::.:...|........|..:||
  Rat   375 LQLELPAVTPEDDGEYWCVAENQYGQRATAFNLSVEFAPIILLESHCAAARDTVQCLCVVK---- 435

  Fly  2870 SNP----------------------YYTQFCCRS-------CTLAGQVASPP 2892
            |||                      .|::   ||       .||.||..:||
  Rat   436 SNPEPSVAFELPSRNVTVNETEREFVYSE---RSGLLLTSILTLRGQAQAPP 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559
		ADAM_spacer1	214..329	CDD:283607
		TSP1	468..521	CDD:214559
		TSP_1	645..693	CDD:278517
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845	9/43 (21%)
		IG_like	2530..2610	CDD:214653	9/43 (21%)
		IG_like	2627..2703	CDD:214653	19/79 (24%)
		Ig	2636..2701	CDD:143165	17/68 (25%)
		IG_like	2766..2841	CDD:214653	23/75 (31%)
		Ig	2768..2830	CDD:299845	21/62 (34%)
		PLAC	2851..2883	CDD:285849	10/60 (17%)
Mag	NP_058886.1	Interaction with RTN4R and RTN4RL2. /evidence=ECO:0000269\|PubMed:19420245	20..325		33/196 (17%)
		IgV_CD33	22..138	CDD:409377
		Ig strand B	38..42	CDD:409377
		Ig strand C	56..60	CDD:409377
		Ganglioside GT1b binding. /evidence=ECO:0000250\|UniProtKB:P20917	65..67
		Ig strand E	100..104	CDD:409377
		Ig strand F	114..119	CDD:409377
		Ganglioside GT1b binding. /evidence=ECO:0000250\|UniProtKB:P20917	124..128
		Ig strand G	128..133	CDD:409377
		IgC2_CD33_d2_like	141..235	CDD:409579	11/59 (19%)
		Ig strand B	155..159	CDD:409579
		Ig strand C	171..175	CDD:409579
		Ig strand E	200..204	CDD:409579	0/3 (0%)
		Ig strand F	214..219	CDD:409579	0/4 (0%)
		Ig strand G	229..232	CDD:409579	0/2 (0%)
		Ig_3	239..309	CDD:404760	15/73 (21%)
		Ig strand A	239..242	CDD:409353	1/2 (50%)
		Ig strand A'	248..251	CDD:409353	0/2 (0%)
		Ig strand B	256..264	CDD:409353	1/8 (13%)
		Ig strand C	270..274	CDD:409353	0/3 (0%)
		Ig strand C'	277..280	CDD:409353	1/2 (50%)
		Ig strand E	289..293	CDD:409353	1/3 (33%)
		Ig strand F	301..309	CDD:409353	3/7 (43%)
		Ig strand G	312..322	CDD:409353	4/9 (44%)
		IG	333..409	CDD:214652	26/87 (30%)
		Required for normal axon myelination in the central nervous system. /evidence=ECO:0000250\|UniProtKB:P20917	577..626
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..608
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900