DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and Hmcn1

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_001258221.1 Gene:Hmcn1 / 289094 RGDID:1564772 Length:5635 Species:Rattus norvegicus


Alignment Length:1370 Identity:281/1370 - (20%)
Similarity:425/1370 - (31%) Gaps:464/1370 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   274 PRPMFFANSWWNYQRKPMGFAAPDQLTCSGPISESLFIVMLVQEKNISLDYEYSIPESLSHS--- 335
            |:|..    .|:.|.:|:.:  .::||...  :.||:|.  ...|..:.:|| .:..:|..|   
  Rat  4467 PQPTI----TWSRQGRPIPW--DNRLTMLP--NSSLYIA--AARKEDTSEYE-CVARNLMGSVLV 4520

  Fly   336 QQDTHTWTHHQFN------ACSASCGGGSQSRKVTCNNRITLAEVNPSLC---DQKSKPVEEQAC 391
            :.......|..|:      :||.:||.|.|.|...|||........|  |   :.:::..:.:.|
  Rat  4521 RVPVIVQVHGGFSLWSAWRSCSVTCGKGIQKRSRLCNNPPPANGGRP--CQGSESEARQCQNKLC 4583

  Fly   392 GTEPCAPHWVEGE-WSKCSKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQE- 454
               |...||.|.. |.:||:.|| .|.|.|:.||.  :...:|            |.:|..... 
  Rat  4584 ---PVDGHWSEWSFWEECSRSCG-HGNQTRTRTCS--NPPAQH------------GGRPCEGYAV 4630

  Fly   455 ----CNRDVKNCPKYHL----GPWTPCDKLCGDGKQTRKVTCFIEE--------NGHKRVLPEED 503
                ||  ::.||.:.:    .||..|.|.||.|.|||...|....        ||.:..:  :.
  Rat  4631 ETIMCN--IRPCPVHGVWNAWQPWGSCSKSCGKGSQTRTRLCNSPPPSFGGAYCNGAETQM--QV 4691

  Fly   504 CVEEKPETEKSCLLTPCEG--VDWIISQWSGCN-ACGQNTETRTAIC--------GNK-EGKVYP 556
            |      .|:.|   |.:|  ..|  :.||.|. :||..|..||..|        ||| ||....
  Rat  4692 C------NERHC---PVDGKWAAW--TSWSTCTVSCGGGTRKRTRDCSDPVPQYGGNKCEGTGVQ 4745

  Fly   557 EEFCEPEVPTLSRPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRIVICGEFDGKTVTPADDDSKCN 621
            .:||.      |.||.:....:.|  |.|..||..|..|...|...|     ....|::....|.
  Rat  4746 SDFCN------SDPCPTHGNWSPW--SGWGMCSRTCNGGQMRRYRTC-----DNPRPSNGGRACG 4797

  Fly   622 KETKPESE-QDCEGEEKVCP--GEWFT-GPWGKCSKPCGGGERVREVLC----LSNGTKSVNCDE 678
               .|::: |.|..:  :||  |.|.| ..|..||..||||||.|:.||    .|...:|...|.
  Rat  4798 ---GPDTQIQRCNTD--MCPVDGSWGTWHSWSHCSVSCGGGERTRKRLCDNPVPSKSGRSCPGDA 4857

  Fly   679 EKVEPLSEKCNSEACTEDEILPLTSTDKPIEDDEEDCDEDGIELISDGLSDDEKSEDVIDLEGTA 743
            .:|    .:||.:||                                                  
  Rat  4858 TQV----SRCNMQAC-------------------------------------------------- 4868

  Fly   744 KTETTPEAEDLMQSDSPTPYDEFESTGTTFEGSGYDSESTTDSGISTEGSGDDEETSEASTDLSS 808
                              |.....:.|                  |..|:.:|.|...|..:   
  Rat  4869 ------------------PGGPQRARG------------------SVIGNINDIEFGIAFLN--- 4894

  Fly   809 STDSGSTSSDSTSSDS---SSSISSDATSEAPA-------------SSVSDSSDSTDASTETTGV 857
                 :|.:||.:||:   .::|::...|..||             ::..:..::.:..|.|..|
  Rat  4895 -----ATITDSPNSDTRIIQATITNVPRSLGPAMRKIISILNPIYWTTAKEIGEAVNGFTLTNAV 4954

  Fly   858 SDDSTDVSSSTEASASESTDVSGASDSTGS----TNASDSTPESSTEASSSTDDSTDSSDNSSNV 918
            ....|.|..:| ......|.|:...||.|:    ...|....:..:.|..|..|.|   ::....
  Rat  4955 FKRETQVEFAT-GEVLRMTHVARGLDSDGALLLDVIVSGHVLQLHSPAEVSVKDYT---EDYIQT 5015

  Fly   919 SESSTEASSSSVSDSNDSSDGSTDGVS-STTENSSDSTSDATSD-----STASSDSTDSTSDQTT 977
            ......|.|:.:.        :.||:| ..|.|.:.....|...     .|..:.|.:|..:|..
  Rat  5016 GPGQLYAYSTRLF--------TIDGISVPYTWNHTIFYDQAWGKMPFLVETLHASSVESDYNQLE 5072

  Fly   978 ETTPESSTDSTESSTLDASSTTDASSTSESSSESSTDGSSTTSNSASSET-------------TG 1029
            ||.......|....  |.|:...:....:|:.....|....|:.:..|.|             .|
  Rat  5073 ETLGFKIHASISKG--DRSNQCPSGFILDSAGPFCADEDECTAGNPCSHTCHNAIGAYYCSCPKG 5135

  Fly  1030 LSSDGSTTDATTAASDNTDITTDGSTDESTDGSSNASTEGST--EGASEDTTISTESSGSTESTD 1092
            |:                 |..||.|.:..|   ..:..|.|  .|...|.||.        |..
  Rat  5136 LT-----------------IAADGRTCQDID---ECALGGHTCHAGQDCDNTIG--------SYR 5172

  Fly  1093 AIASDGS----TTEGSTVEDLSSSTSSDVTSDSTITDSSPSTE----VSGSTDSSSSTDGSSTDA 1149
            .:...|:    |::|.:.:|::.           ..:|||..:    |.||...     |.....
  Rat  5173 CVVHCGTGFRRTSDGLSCQDINE-----------CQESSPCHQRCFNVIGSFHC-----GCEAGY 5221

  Fly  1150 SSTEASSTDVTESTDS---------TVSGGTS--DTTESGPTEESTTEGSTESTTEGSTDSTQST 1203
            ........||.|...|         ...||..  |...||.|:..                    
  Rat  5222 QLKGRKCIDVNECRQSVCRPDQHCKNTRGGYKCIDLCPSGMTKAE-------------------- 5266

  Fly  1204 DLDSTTSDIWSTSDKDDESESSTPYSFDSEVTKSKPRKCKPKKSTCAKSEYGC-CP-----DGKS 1262
              :.|..||       ||.:..|.....:::.::            .:..|.| ||     .|..
  Rat  5267 --NGTCIDI-------DECKDGTHQCRYNQICEN------------TRGSYRCACPRGYRSQGVG 5310

  Fly  1263 TPKGPFDEGCPIAKTCADTKYGCCLDGVSPAKGKNNKGCPKSQCAETLFGCCPDKFTAADGENDE 1327
            .|....:|...:.|.||   :.|          .|:.|..|  |.     |.|.:....||::..
  Rat  5311 RPCVDINECDQVPKPCA---HQC----------SNSPGSFK--CI-----CLPGQHLLGDGKSCA 5355

  Fly  1328 GCPETTTV--------------------PPTTTTEETQPETT-TEIEGSGQDSTTSEPDTKKSC- 1370
            |....::.                    |...|.:::|..:: :|...|....:.|....:|:| 
  Rat  5356 GLERLSSYGTQYSSYDLERFSPVRSGYQPRQHTRQQSQLYSSYSEYRNSRASFSRSRRTIRKTCP 5420

  Fly  1371 --SFSEFGCCPDAETSAKGPDFEGCGLASPVAKGCAESENGCCPDGQTPASGPNGEGCSG---CT 1430
              |.:....|.|.:      :.:.........|....|....||.|.....  ||:.|..   |.
  Rat  5421 EGSEANHETCVDID------ECQNRDTCQHECKNTIGSYQCVCPPGYRLML--NGKTCQDVDECL 5477

  Fly  1431 RERFGCCPDSQTPAHGPNKEGC--------CLDTQFGCCPDN---------ILAARGPNNEGCEC 1478
            .:...|         |||:. |        |:||.   ||.|         .|....||:  .||
  Rat  5478 EQNVRC---------GPNRM-CFNMRGSYQCIDTP---CPPNYQRDPVLGFCLKNCPPND--LEC 5527

  Fly  1479 HYTPY 1483
            ..:||
  Rat  5528 TLSPY 5532

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559
ADAM_spacer1 214..329 CDD:283607 13/54 (24%)
TSP1 468..521 CDD:214559 17/60 (28%)
TSP_1 645..693 CDD:278517 19/52 (37%)
Kunitz_BPTI 1611..1663 CDD:278443
Kunitz_BPTI 1670..1721 CDD:278443
Kunitz_BPTI 1729..1781 CDD:278443
Kunitz_BPTI 1789..1840 CDD:278443
Kunitz_BPTI 1848..1899 CDD:278443
KU 1920..1973 CDD:238057
Kunitz_BPTI 2001..2051 CDD:278443
KU 2071..2121 CDD:238057
Kunitz_BPTI 2127..2178 CDD:278443
KU 2192..2245 CDD:238057
KU 2251..2304 CDD:238057
KU 2316..2372 CDD:238057
WAP 2457..2497 CDD:278522
Ig 2521..2610 CDD:299845
IG_like 2530..2610 CDD:214653
IG_like 2627..2703 CDD:214653
Ig 2636..2701 CDD:143165
IG_like 2766..2841 CDD:214653
Ig 2768..2830 CDD:299845
PLAC 2851..2883 CDD:285849
Hmcn1NP_001258221.1 VWA_2 42..212 CDD:290253
I-set 520..608 CDD:254352
ig 524..606 CDD:278476
I-set 612..696 CDD:254352
Ig 626..696 CDD:299845
I-set 702..789 CDD:254352
Ig 716..789 CDD:299845
Ig 792..884 CDD:299845
IG_like 799..884 CDD:214653
I-set 890..977 CDD:254352
IGc2 903..967 CDD:197706
Ig 980..1071 CDD:299845
IG 994..1068 CDD:214652
I-set 1085..1167 CDD:254352
Ig 1086..1167 CDD:299845
I-set 1171..1258 CDD:254352
Ig 1188..1255 CDD:143165
Ig 1261..1357 CDD:299845
I-set 1267..1355 CDD:254352
I-set 1368..1448 CDD:254352
Ig 1380..1448 CDD:299845
IG 1460..1541 CDD:214652
IGc2 1470..1532 CDD:197706
IG_like 1557..1633 CDD:214653
Ig 1565..1632 CDD:143165
I-set 1645..1729 CDD:254352
Ig 1648..1725 CDD:299845
I-set 1752..1822 CDD:254352
Ig 1754..1815 CDD:299845
IG 1834..1915 CDD:214652
IGc2 1843..1905 CDD:197706
IG_like 1929..2008 CDD:214653
IGc2 1935..1998 CDD:197706
I-set 2012..2100 CDD:254352
Ig 2021..2092 CDD:299845
I-set 2111..2191 CDD:254352
IGc2 2119..2181 CDD:197706
I-set 2203..2286 CDD:254352
IGc2 2210..2276 CDD:197706
Ig 2299..2380 CDD:299845
IG_like 2300..2380 CDD:214653
I-set 2392..2474 CDD:254352
IGc2 2400..2464 CDD:197706
I-set 2478..2567 CDD:254352
IGc2 2493..2557 CDD:197706
I-set 2582..2663 CDD:254352
IGc2 2594..2653 CDD:197706
I-set 2681..2762 CDD:254352
Ig 2688..2762 CDD:299845
IG_like 2789..2865 CDD:214653
IGc2 2791..2855 CDD:197706
I-set 2879..2960 CDD:254352
Ig 2879..2950 CDD:299845
IG 2972..3052 CDD:214652
IGc2 2982..3042 CDD:197706
IG 3069..3147 CDD:214652
IGc2 3073..3137 CDD:197706
IG 3150..3241 CDD:214652
Ig 3150..3241 CDD:299845
Ig 3244..3338 CDD:299845
I-set 3252..3336 CDD:254352
I-set 3354..3430 CDD:254352
IGc2 3357..3420 CDD:197706
Ig 3433..3523 CDD:299845
IG_like 3443..3523 CDD:214653
IG_like 3535..3616 CDD:214653
IGc2 3543..3606 CDD:197706
I-set 3629..3709 CDD:254352
IGc2 3636..3699 CDD:197706
I-set 3713..3800 CDD:254352
Ig 3719..3795 CDD:299845
Ig 3823..3889 CDD:143165
I-set 3897..3984 CDD:254352
IGc2 3913..3974 CDD:197706
Ig 3993..4066 CDD:299845
IG_like 3994..4075 CDD:214653
IG_like 4085..4165 CDD:214653
IGc2 4092..4155 CDD:197706
Ig 4168..4258 CDD:299845
IG 4177..4256 CDD:214652
I-set 4260..4345 CDD:254352
IGc2 4274..4335 CDD:197706
IG_like 4356..4435 CDD:214653
IGc2 4364..4426 CDD:197706
I-set 4440..4526 CDD:254352 15/69 (22%)
Ig 4440..4521 CDD:299845 15/64 (23%)
TSP1 4533..4584 CDD:214559 13/55 (24%)
TSP1 4589..4641 CDD:214559 17/68 (25%)
TSP1 4646..4698 CDD:214559 16/62 (26%)
TSP1 4703..4755 CDD:214559 19/59 (32%)
TSP1 4760..4812 CDD:214559 14/63 (22%)
TSP1 4817..4869 CDD:214559 22/123 (18%)
G2F 4868..5092 CDD:214774 50/331 (15%)
EGF_CA 5107..5146 CDD:214542 10/55 (18%)
EGF_CA 5147..5190 CDD:284955 11/53 (21%)
EGF_CA 5192..5229 CDD:214542 8/52 (15%)
EGF_CA 5230..5263 CDD:238011 9/32 (28%)
EGF_CA 5272..5313 CDD:284955 10/59 (17%)
EGF_CA 5315..5354 CDD:214542 13/58 (22%)
EGF_CA 5432..5471 CDD:214542 8/46 (17%)
EGF_CA 5472..5508 CDD:214542 12/48 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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