DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and Adamts2

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_001382353.1 Gene:Adamts2 / 287899 RGDID:1565950 Length:1212 Species:Rattus norvegicus


Alignment Length:598 Identity:185/598 - (30%)
Similarity:276/598 - (46%) Gaps:103/598 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 EGNDPDEWTPWSSPSDCSRTCGGGVSYQTRECLRRDD----RGEAVCSGGSRRYFSCNTQDCPEE 113
            :||    |..|:....||||||.||.::||:|   |.    .|...|||.:..:..||.||||..
  Rat   563 DGN----WGAWTPFGSCSRTCGTGVKFRTRQC---DSPHPANGGRTCSGLAYDFQLCNPQDCPNS 620

  Fly   114 ESDFRAQQCSRFDRQQFDGVFYE-------WVP--YTNAPNPCELNCMPKGERFYYRQREKVVDG 169
            .:|||.:||.::|      :::|       |:|  :.:|...|.|.|..|........:..|.||
  Rat   621 LADFREEQCRQWD------LYFEHGDAQHHWLPHEHRDAKERCHLYCESKETGEVVSMKRMVHDG 679

  Fly   170 TRCNDKD-LDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLL 233
            |||:.|| ..:||.|:|..||||.::||..:||||..||||.:.||.::.|.|.......|..:.
  Rat   680 TRCSYKDAFSLCVRGDCRKVGCDGVIGSRKQEDKCGVCGGDNTHCKVVKGTFTRSPRKQDYIKMF 744

  Fly   234 LLPEGATNIRIEETVPSSNYLACRN-HSGHYYLNGDWRIDFPRPMFFA-NSWWNYQRKPMGFAAP 296
            .:|.||.::.|:||..:|::|:.:| .:|.:.||.:..:|.....|.| ...|.|:.:.    ..
  Rat   745 EIPAGARHLLIQETDTTSHHLSVKNLETGKFILNEENHLDPNSRSFIAMGVEWEYRNED----ER 805

  Fly   297 DQLTCSGPISESLFIVMLVQ-EKNISLDYEYSIPE-SLSHSQQDT-------HTWTHHQFNACSA 352
            :.|...||:..::.::::.: :..|||.|:|.|.| ||:....:.       |.|...:::.||.
  Rat   806 ETLQTIGPLHGTITVLVIPEGDARISLTYKYMIHEDSLNVDDNNVLEDDSVRHEWALKKWSPCSK 870

  Fly   353 SCGGGSQSRKVTCNNRITLAEVNPSLCDQKSKP-VEEQACGTEPCA-PHWVEGEWSKCSKGCGSD 415
            .||||||..|..|..|:....|:.:.|...:|| ...:||..:.|: |.||.|||..|::.||..
  Rat   871 PCGGGSQFTKYGCRRRLDSKMVHRAFCSALAKPKAIRRACNPQECSQPVWVTGEWEPCTQSCGRT 935

  Fly   416 GFQNRSITCERISSSGEHTVEEDAVCLKEVG-NKPATKQECNRDVKNCP-KYHLGPWTPCDKLCG 478
            |.|.||:.|  |.....:|..  :|..|... ::|.:::.|||::  || ::..|.|:.|...||
  Rat   936 GMQVRSVRC--IQPLHNNTTR--SVHTKHCNDHRPESRRACNREL--CPGRWRAGSWSQCSVTCG 994

  Fly   479 DGKQTRKVTCFIEENGHKRVLPEEDCVEEKPETEKSCLLTPCEG-----------VDWI------ 526
            :|.|.|.|.|...::..      ..|.||:|||.:.|.|.||..           |.|:      
  Rat   995 NGTQERPVLCRTADDNF------GVCQEERPETARICRLAPCPRNSSDPSKKSYVVQWLSRPDPD 1053

  Fly   527 --ISQWSGCNACGQNTETRTAICGNKEGKVYPEEFCEPEVPTLSRPCKSP--------KCEAQWF 581
              |.:.|..:.|.          |:|      ..||..||  |||.|..|        .|.....
  Rat  1054 SPIQKISSKDQCQ----------GDK------SMFCRMEV--LSRYCSIPSYNKLCCKSCSPNLG 1100

  Fly   582 SSEWSKCSAPCGK 594
            .:|......|.||
  Rat  1101 HAEDRGSEPPPGK 1113

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559 22/54 (41%)
ADAM_spacer1 214..329 CDD:283607 29/117 (25%)
TSP1 468..521 CDD:214559 19/52 (37%)
TSP_1 645..693 CDD:278517
Kunitz_BPTI 1611..1663 CDD:278443
Kunitz_BPTI 1670..1721 CDD:278443
Kunitz_BPTI 1729..1781 CDD:278443
Kunitz_BPTI 1789..1840 CDD:278443
Kunitz_BPTI 1848..1899 CDD:278443
KU 1920..1973 CDD:238057
Kunitz_BPTI 2001..2051 CDD:278443
KU 2071..2121 CDD:238057
Kunitz_BPTI 2127..2178 CDD:278443
KU 2192..2245 CDD:238057
KU 2251..2304 CDD:238057
KU 2316..2372 CDD:238057
WAP 2457..2497 CDD:278522
Ig 2521..2610 CDD:299845
IG_like 2530..2610 CDD:214653
IG_like 2627..2703 CDD:214653
Ig 2636..2701 CDD:143165
IG_like 2766..2841 CDD:214653
Ig 2768..2830 CDD:299845
PLAC 2851..2883 CDD:285849
Adamts2NP_001382353.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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