DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppn and Adamts13

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_001001322.1	Gene:	Adamts13 / 279028	MGIID:	2685556	Length:	1426	Species:	Mus musculus

Alignment Length:	705	Identity:	197/705 - (27%)
Similarity:	282/705 - (40%)	Gaps:	147/705 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 WTPWSSPSDCSRTCGGGVSYQTRECLR-RDDRGEAVCSGGSRRYFSCNTQDCPEEESDFRAQQCS 123
            |:.|...|.|||:|||||..:.|.|.. |...|...|.|...:...||||.|.:.:.:|.::||:
Mouse   392 WSSWGPHSPCSRSCGGGVITRRRWCNNPRPAFGGRACVGEDLQAKMCNTQACEKTQLEFMSEQCA 456

  Fly   124 RFDRQ-----QFDGVFYEW---VPYTNAPNPCELNCMPKGERFYYRQREKVVDGTRC------ND 174
            :.|||     |....||.|   |.|:.....|...|...||.|...:.::.:|||||      :|
Mouse   457 QTDRQPLQLSQGTASFYHWDAAVQYSQGDTLCRHMCWAVGESFIVSRGDRFLDGTRCVPSGPQDD 521

  Fly   175 KDLDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLLLLPEGA 239
            ..|.:|:.|.|...|||..:.|....|.|:.||||.|||.: ||...|...|..|...|::....
Mouse   522 GTLSLCLLGSCRTFGCDGRMDSQKVWDACQVCGGDNSTCSS-RNGSFTAGRAREYVTFLIVTPNM 585

  Fly   240 TNIRIEETVPSSNYLACRNHSGHYYLNG---------------DWRIDFPRPMFFANSWWNYQRK 289
            ||..|....|...:||.| ..|||.:.|               |:|:::...:
Mouse   586 TNAHIVNRRPLFTHLAVR-IQGHYIVAGKTSISPNTTYPSLLEDYRVEYRVTL------------ 637

  Fly   290 PMGFAAPDQLT------CSGPISESLFIVMLVQEKNISLDY--EYSIPESLSH----------SQ 336
                 ..|||.      ..||:.:.:       |..:...|  ||.   .|:|          .|
Mouse   638 -----TEDQLPHLEEIHIRGPVRDDI-------EIQVYRRYGGEYG---DLTHPDITFSYFQLKQ 687

  Fly   337 QDTHTWTHHQFNACSASCGGGSQSRKVTCNNRITLAEVNPSLCD-QKSKPVEEQACGTEPCAPHW 400
            |....||..: ..||.|||.|.:....:|.::.....|..:.|. ....|..::.|.:.||:|:|
Mouse   688 QAAWVWTAKR-GPCSVSCGAGLRWVTYSCQDQAQDKWVKNAQCQGSPQPPAWQEPCVSAPCSPYW 751

  Fly   401 VEGEWSKCSKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQE-CNRDVKNCP- 463
            |.|::|.||..||. |.:.||:.|.........|: ..|.| :.|..:||.:.| ||.  :.||
Mouse   752 VAGDFSPCSVSCGG-GLRERSLRCVETQDGFLKTL-PPARC-RAVAQQPAAEVENCNS--QPCPT 811

  Fly   464 KYHLGPWTPC-DKLCGDGKQTRKVTCFIEENGHKRVLPEEDCVEEKPET-------EKSCLLTPC 520
            ::.:....|| ...|..|..:|.||| :...|.          .|||||       |.|.:|.||
Mouse   812 RWEVSDPGPCMSSACEAGLDSRNVTC-VSRAGD----------PEKPETAGPCRTDEMSAMLEPC 865

  Fly   521 E---------GVDWIIS--------------------QWSG----CN-ACGQNTETRTAICGNKE 551
            .         .||..:|                    .|:.    |: :||:..:....:|.:..
Mouse   866 SRSLCSPGLGQVDNTMSLGEEAPSPVGSDKPGAQAEHVWTPLVGLCSISCGRGLKELYFLCMDSV 930

  Fly   552 GKV-YPEEFC--EPEVPTLSRPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRIVICGEFD-GKTVT 612
            .|: ..||.|  ..:.|:....|::..|.|:|.:...:.|...||.|.....|.|.:.| |..::
Mouse   931 LKMPVQEELCGLASKPPSRWEVCRARPCPARWETQVLAPCPVTCGGGRVPLSVRCVQLDRGHPIS 995

  Fly   613 PADDDSKCNKETKPESEQDCEGEEKVCPGEWFTGPWGKCSKPCGGGERVREVLCL 667
            .  ..|||:...||.|.:||..|.  ||..|.....|.||..||.|...:.|.|:
Mouse   996 V--PHSKCSPVPKPGSFEDCSPEP--CPARWKVLSLGPCSASCGLGTATQMVACM 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	21/51 (41%)
		ADAM_spacer1	214..329	CDD:283607	28/137 (20%)
		TSP1	468..521	CDD:214559	18/60 (30%)
		TSP_1	645..693	CDD:278517	8/23 (35%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
Adamts13	NP_001001322.1	ZnMc_ADAMTS_like	82..286	CDD:239801
		TSP1	392..444	CDD:214559	21/51 (41%)
		Cysteine-rich	445..561		39/115 (34%)
		Cell attachment site. /evidence=ECO:0000255	503..505		0/1 (0%)
		Spacer	556..685		34/157 (22%)
		ADAM_spacer1	565..683	CDD:283607	28/145 (19%)
		TSP1	754..810	CDD:214559	19/60 (32%)
		TSP1	1082..>1113	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810