DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppn and Adamts16

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_742050.2	Gene:	Adamts16 / 271127	MGIID:	2429637	Length:	1222	Species:	Mus musculus

Alignment Length:	669	Identity:	218/669 - (32%)
Similarity:	319/669 - (47%)	Gaps:	92/669 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 GGEGNDP--DEWTPWSSPSDCSRTCGGGVSYQTRECLR-RDDRGEAVCSGGSRRYFSCNTQDCPE 112
            |.||..|  ..|:.||..|.||||||||:|::.|.|.. |...|...|.|.:|....||:|.||.
Mouse   576 GDEGPKPTHGHWSDWSPWSPCSRTCGGGISHRDRLCTNPRPSHGGKFCQGSTRTLKLCNSQRCPL 640

  Fly   113 EESDFRAQQCSRFDRQQFDGVFYEWVPYTNAPNP--CELNCMPKGERFYYRQREKVVDGTRCNDK 175
            :..||||.||:.::.::|.|..|:|.|||...:.  |:|.|:.:|..|::....||.|||.|::.
Mouse   641 DSVDFRAAQCAEYNSKRFRGWLYKWKPYTQLEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSED 705

  Fly   176 DLDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLLLLPEGAT 240
            ..:||::|.|..||||.:|||||.||.|..|.|:.|.|.|.|...:.......|..::.:|.||.
Mouse   706 SRNVCIDGMCERVGCDNVLGSDATEDSCGVCKGNNSDCVTHRGLYSKHHSTNQYYHMVTIPSGAR 770

  Fly   241 NIRIEETVPSSNYLACRNHSGHYYLNGDWRIDFPRPMFFANSWWNYQRKPMGFAAPDQLTCSGPI 305
            :|.|.||..|::|::.||....|||||.|.:|:|....|:.:.:||:|   .:..|:.||..||.
Mouse   771 SIHIYETNISTSYISVRNSLKRYYLNGHWSVDWPGRYKFSGATFNYKR---SYKEPENLTSPGPT 832

  Fly   306 SESLFIVMLVQEKNISLDYEYSIPES---LSHSQQDTHTWTHHQFNACSASCGGGSQSRKVTCNN 367
            :|:|.:.:|.|.:|..:.:|:|:|.|   .:.:.|.:::|...: :.||.|||||..:.|..|..
Mouse   833 NETLIVELLFQGRNPGVAWEFSLPRSGAKKTPAAQPSYSWAIVR-SECSVSCGGGKMNSKAGCYR 896

  Fly   368 RITLAEVNPSLCDQKSKPVEEQA-CGTEPCAPHWVEGEWSKCSKGCGSDGFQNRSITCERISSSG 431
            .:.: .||.|.|:.|::||.... |...||...|..|.||.||:.||. |.|:|.:.|.|.:...
Mouse   897 DLKV-PVNASFCNPKTRPVTGLVPCKVSPCPSSWSVGNWSVCSRTCGG-GTQSRPVRCTRRAHYR 959

  Fly   432 EHTVEEDAVCLKEVGNKPATKQECNRDVKNC-PKYHLGPWTPCDKLCGDGKQTRKVTC-FIEENG 494
            :.::.. ::|.:.   :|...|.||.  ::| |.:..|||..|.:.||.|.:.|.|.| ....:.
Mouse   960 DESIPA-SLCPQP---EPPIHQACNS--QSCPPAWSTGPWAECSRTCGKGWRKRTVACKSTNPSA 1018

  Fly   495 HKRVLPEEDCVEE-KPETEKSCLLTPCEGVDWIISQWSGCNACGQNTETRTAICGNKEGKVYPEE 558
            ..::|.:..|..| ||.|.:.|||..|                            :|..|:
Mouse  1019 RAQLLHDTACTSEPKPRTHEICLLKRC----------------------------HKHKKL---- 1051

  Fly   559 FCEPEVPTLSRPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRIVICGE--FDGKTVTPADDDSKCN 621
                                ||..|.||:||..|..|.:.|::.|.|  ..||....|  ..||.
Mouse  1052 --------------------QWLVSAWSQCSVTCQGGTQQRVLRCAEKYISGKYRELA--SKKCL 1094

  Fly   622 KETKPESEQDCEGEEKVCP------------GEWFTGPWGKCSKPCGGGERVREVLCLSNGTKSV 674
            ...||:.|.:.......||            |.||..||.:|:..||||.:.|.|.||..|..:.
Mouse  1095 HLPKPDLELERACGLIPCPKHPPFDASGSPRGSWFASPWSQCTASCGGGVQRRTVQCLLRGQPAS 1159

  Fly   675 NCDEEKVEPLSEKCNSEAC 693
            :|...:....|..||:..|
Mouse  1160 DCFLHEKPETSSACNTHFC 1178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	23/51 (45%)
		ADAM_spacer1	214..329	CDD:283607	38/114 (33%)
		TSP1	468..521	CDD:214559	19/54 (35%)
		TSP_1	645..693	CDD:278517	16/47 (34%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
Adamts16	NP_742050.2	Pep_M12B_propep	88..187	CDD:279848
		Cysteine switch. /evidence=ECO:0000250	245..253
		ZnMc_ADAMTS_like	288..489	CDD:239801
		Reprolysin	290..493	CDD:279729
		TSP1	587..639	CDD:214559	23/51 (45%)
		Spacer	745..871		41/128 (32%)
		ADAM_spacer1	745..856	CDD:283607	38/113 (34%)
		TSP1	927..985	CDD:214559	18/64 (28%)
		TSP1	988..>1017	CDD:214559	10/28 (36%)
		TSP1	1056..1113	CDD:214559	18/58 (31%)
		TSP1	1126..1179	CDD:214559	20/53 (38%)
		PLAC	1188..1218	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810