DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ppn and Adamtsl3

DIOPT Version :10

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_001177303.1 Gene:Adamtsl3 / 269959 MGIID:3028499 Length:1706 Species:Mus musculus


Alignment Length:1902 Identity:408/1902 - (21%)
Similarity:622/1902 - (32%) Gaps:584/1902 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 FIVLASIHDSQSRFPGLRQKRQYGANMYLPESSVTPGG--------------------------E 53
            |.|...:..:..:.||.         .:|||.:::|.|                          |
Mouse    28 FTVSGLLQATAEKSPGA---------YFLPEFALSPQGSFLEDTTGEQFLTYRYDDQTSRNAHSE 83

  Fly    54 GNDPDEWTPWSSPSDCSRTCGGGVSYQTRECLRRDDRGEAVCSGGSRRYFSCNTQDCPEEESDFR 118
            .:....|..|...||||||||||.||..|.||...:     |.|.:.||.:|:..|||.:..|||
Mouse    84 EDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRN-----CEGQNIRYKTCSNHDCPADAEDFR 143

  Fly   119 AQQCSRFDRQQFDGVFYEWVPYTNAP-NPCELNCMPKGERFYYRQREKVVDGTRCNDKDLDVCVN 182
            |||||.::..|:.|.:|||:|..|.| .||.|.|..:|:........||:||||||...||:|::
Mouse   144 AQQCSAYNDVQYQGHYYEWIPLYNDPAAPCALKCHARGQSLVVELAPKVLDGTRCNADSLDMCIS 208

  Fly   183 GECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYND--LLLLPEGATNIRIE 245
            |.|..||||..|||:||||.|..|.||||||:.:|.. |...|:|...:  ::.:|.|:.::||.
Mouse   209 GICQIVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQ-TKMHLSPEKKEENVIAVPLGSRSVRIT 272

  Fly   246 ETVPSSNYL---ACRNHSGHYYLNG-------DWRIDFPR-----------PM------------ 277
            ...|:..::   ..:...|.:..|.       :..|:|.:           |:            
Mouse   273 VKGPALIFIESKTLQGSRGEHSFNSPGVFTVENTTIEFQKGADRQTFKIAGPLMADFIFKTRYTV 337

  Fly   278 -------FFANSWWNYQRKPMGFAAPDQLTCSGPISESLFIVMLVQEKNISLD-YEYSIPESLSH 334
                   ||.....::|.:...| .|..:||.|....:....|.::.|.:..| |.:..||::..
Mouse   338 AKGSVVQFFFYQPISHQWRQTDF-FPCTVTCGGGYQLNSAECMDIRLKRVVPDHYCHYYPENVKP 401

  Fly   335 SQ-------------------------QDTHTWTHHQFNACSASCGGGSQSRKVTC---NNRITL 371
            ..                         |....|.|:.:.|||.|||||.|.|...|   :....:
Mouse   402 KPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHAEI 466

  Fly   372 AEVNPSLCDQKSKPVEEQACGTEPCAPHWVEGEWSKCSKGCGSDGFQNRSITCERISSSGEHT-- 434
            .:|....|....||...|||....| |.||..|||:|:..||. |.:.|.:.|  |:..|:|.  
Mouse   467 LQVEEWKCMYAPKPTVMQACNLFDC-PKWVAMEWSQCTVTCGR-GLRYRVVLC--INHRGQHVGG 527

  Fly   435 --------VEEDAV----CLKEVGNKP----------ATKQECNRDVKNCPKYHLGPWTPCDKLC 477
                    ::|:.|    |.|.....|          |.:.|..|.....||:...||:.|...|
Mouse   528 CNPQMKLHIKEECVIPIPCYKPREKSPVEAKLPWLKQAQELEETRIATEEPKFIPEPWSACSTTC 592

  Fly   478 GDGKQTRKVTC-----FIEENGHKRVLPEEDCVEEKPETEKSCL--------------------- 516
            |.|.|.|:|.|     |.:....   ||||:|...||.|::.||                     
Mouse   593 GPGIQVREVRCRVLLTFTQTEAE---LPEEECEGPKPPTDRPCLRQACDQSPVSRELGGRLQEKD 654

  Fly   517 -----------LTPCEGV----------------------------------------------D 524
                       .|||...                                              .
Mouse   655 SEMTYDWEYAGFTPCTATCLGGHQEAIAVCLHTQTHQTVNDSLCDTVHRPPPMSQACNMEPCPPR 719

  Fly   525 WIISQWSGCNA-CGQNTETRTAICGNKEGKVYPEEF------CEPEVPTLSRPCKSPKCEAQWFS 582
            |.:..|..|:| ||...:||...|      ::||||      |..|.|...|.|....|...|..
Mouse   720 WHMGSWGACSATCGVGIQTRDVYC------LHPEEFPAPPEECREEKPHALRACNQFDCPPSWHI 778

  Fly   583 SEWSKCSAPCGKGVKSRIVICGEF--DGKTVTPADDDSKCNKETKPESEQDCEGEEKVCPGEWFT 645
            .||.:||..||.|.::|.|.|.:.  ||..:..:|:  .| :..|..|.:.|...:  ||.:...
Mouse   779 EEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDE--LC-QGPKASSHKSCARTD--CPPQLAA 838

  Fly   646 GPWGKCSKPCGGGERVREVLC--LSNGTKSVN-----CDEEKVEPLSEKCNSEACTEDEILPLTS 703
            |.|.|||..||.|.:.|:.:|  |:...:.|:     |.:....||...|....|::.::...|.
Mouse   839 GDWSKCSVTCGVGFQRRKQVCQKLTAKGRRVSVAETLCRDLPGLPLVRPCQMPICSKAKLGTKTK 903

  Fly   704 TDKPIEDDEEDCDEDGIELISDGLSD---DEKSEDVIDLEGTAKTETTPEAEDLMQSDS---PTP 762
                       ..|.|.:::  |:..   ..:.|..|:|       |......|:.:.|   ..|
Mouse   904 -----------LGERGPQIL--GVRRVYIQTREEKRINL-------TVGSRAYLLLNTSVIIKCP 948

  Fly   763 YDEFESTGTTFEGSGYDSESTTDSGISTEGS------------------GDDEET---------- 799
            ...|:.:...:|..|:..:::...||:..||                  |..:||          
Mouse   949 VRRFQKSLIQWEKDGHCLKNSKQLGITKSGSLKIHSLAAPDIGVYRCIAGSAQETVVLKLIGTDN 1013

  Fly   800 -------------SEASTDLSSSTDSGSTSSDSTSSDSSSS------------------ISSDAT 833
                         .....|.:.:...|:|........::.:                  .....|
Mouse  1014 RLIAHPSLREHVRGHPGVDHNEANSLGATWHKMRQMWNNKNDLYLHGGEMNKQPFLRALFGPCRT 1078

  Fly   834 SEAPASSVSDSSDSTDASTETTGVSDDSTDVSSSTEASASESTDVSGASDSTGSTN--------- 889
            ||...:|....:...:|:.:....|.|:........ :.|:..::..|||...|..         
Mouse  1079 SEGNDNSWEFKNKQFEAAMKQGAYSMDTAQFDELIR-NMSQLMEMGEASDDLASQMIYQLVAELA 1142

  Fly   890 ------------ASDSTPESSTEASSSTDDSTDSSDNSSN--------VSESSTEASSSSVSDSN 934
                        ..:..||:.....:.......:..||..        |........|.|.:.:.
Mouse  1143 KAQPTPVQWRGIREEVAPEAQLRGKTERVPKNPTVKNSGKLTFKPKGPVLMRQILPPSVSFNKTI 1207

  Fly   935 DSSDGSTDGVSSTTE----------NSSDSTSDATSDSTASSDSTDSTSDQTTETTPESSTDSTE 989
            ::..|:|..::.:||          .|.::|...|.|......|.....|:|.:....:.| ..|
Mouse  1208 NARIGNTVYITKSTEIINILCSLITPSKEATYTWTKDGALLQPSVKIILDETGKMQIRNPT-RKE 1271

  Fly   990 SSTLDASSTTDASSTSESSSESSTDGS---STTSNSASSETTGLS-SDGSTTDATTAASDNTDIT 1050
            ....:.|..:...|..|||.....:..   |...|....|...|| ..|.|.:|...|       
Mouse  1272 QGIYECSVASHLGSDVESSLVLYAEAPVILSIERNVTKPEHNHLSVVVGGTVEAALQA------- 1329

  Fly  1051 TDGSTDESTDGSSNASTEGSTEGASEDTTISTESSGSTESTDAIASDGSTTEGSTVEDLSSSTSS 1115
                         |.:.....:|..:......::.||.....::..:||...      .|:|..:
Mouse  1330 -------------NVTIHCPVKGVPQPNVTWLKTGGSLSDNVSLLFNGSLLL------QSASLEN 1375

  Fly  1116 DVTSDSTITDS-SPSTEVSGSTDSSSSTDGSSTDASSTEASSTDVTESTDSTVSGGTSDTTESGP 1179
            :.|...|.|:: ..:...||.........|..  |:..:...|.|.::..|.::.... |.:|.|
Mouse  1376 EGTYICTATNALGKAVATSGLRLLERREPGGK--AAFPKVQKTRVLQAPRSRINSNNL-TGKSLP 1437

  Fly  1180 TEESTTEGSTESTTEGSTDSTQSTDLDSTTSDIWSTSDKDDESESSTPYSFDSEVTKSKPRKCKP 1244
            .|.                             .|...:....|.:..|..|..:    :||    
Mouse  1438 QEH-----------------------------FWEPGNWTHCSATCGPLGFRLQ----RPR---- 1465

  Fly  1245 KKSTCAK------SEYGCCPDGKSTPKGPFDEGCPIA--KTCADTKYGCCLDGVSPAKGKNNKGC 1301
                |..      ||..|.|..|           |:|  ::|                  |.:.|
Mouse  1466 ----CVMASGQEVSEALCGPHRK-----------PLAGFQSC------------------NIRDC 1497

  Fly  1302 PK-------SQCAETLFGCCPDKFTAADGENDEGCPETTTVPPTTTTEETQPETTTEIEGSGQDS 1359
            |.       |:|:.:    |.:.|.:..                .|.::|:...|.::......:
Mouse  1498 PARWFTSMWSECSAS----CGEGFHSRQ----------------VTCKQTKANGTVQVVSPRACA 1542

  Fly  1360 TTSEPDTKKSCSFSEFGCCPDAETSAKGPDFEGCGLASPVA---KGCA-ESENGCCPDGQTPASG 1420
            ....|..:|.||...  |...|............|.|:.:.   ..|: .|.:..|.||:.||.|
Mouse  1543 PKDRPLGRKPCSIRP--CVQQAIDPGNQCPGRCMGHATRMQHHHTACSHNSSSSDCEDGRRPAFG 1605

  Fly  1421 PN---GEGCSGCTRERFGCCPDSQTPAHGPNKEGCCLDTQFGCCPDNILAARGPNNEGCECHYTP 1482
            .|   |. |..|.|.             ||.|            |...:..||..:...:|.:| 
Mouse  1606 RNCTLGP-CEACWRV-------------GPWK------------PCTAVCGRGFQSRKVDCIHT- 1643

  Fly  1483 YGCCPDNKSAATGYNQEGCACETTQYGCCPDKITAAK---GPKHEGCPCETTQFGCCPDGLTFAK 1544
             |.|   |..|..|             |...|..|.:   ||..:....:||.:  |    .|.|
Mouse  1644 -GSC---KIVADRY-------------CVQVKPAAWRHCLGPSCDRNCTDTTHY--C----MFVK 1685

  Fly  1545 GPHHHGCHCTQTEFKCC 1561
              |.:.|.......:||
Mouse  1686 --HLNLCSLAVYRQRCC 1700

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559 23/50 (46%)
ADAMTS_CR_3 116..213 CDD:437068 51/97 (53%)
ADAMTS_spacer1 222..329 CDD:461796 24/149 (16%)
TSP1_ADAMTS 347..396 CDD:465950 18/51 (35%)
TSP1_ADAMTS 400..457 CDD:465950 21/80 (26%)
TSP1_ADAMTS 465..520 CDD:465950 22/91 (24%)
TSP1_ADAMTS 580..632 CDD:465950 17/53 (32%)
TSP1_ADAMTS 643..693 CDD:465950 16/56 (29%)
MSCRAMM_ClfA <1049..1262 CDD:468110 33/219 (15%)
Kunitz_papilin_lacunin-like 1612..1663 CDD:438681
Kunitz_BPTI 1670..1721 CDD:425421
Kunitz-type 1730..1780 CDD:438633
Kunitz_BPTI 1789..1840 CDD:425421
Kunitz_papilin_mig6-like 1849..1899 CDD:438679
Kunitz_papilin_mig6-like 1922..1972 CDD:438679
Kunitz_papilin_mig6-like 2001..2051 CDD:438679
Kunitz-type 2071..2121 CDD:438633
Kunitz_BPTI 2127..2178 CDD:425421
Kunitz_BPTI 2193..2245 CDD:425421
Kunitz_BPTI 2252..2303 CDD:425421
Kunitz_BPTI 2317..2372 CDD:425421
WAP 2455..2497 CDD:459672
Ig 2530..2610 CDD:472250
Ig strand B 2539..2543 CDD:409353
Ig strand C 2552..2556 CDD:409353
Ig strand E 2576..2579 CDD:409353
Ig strand F 2589..2594 CDD:409353
Ig strand G 2603..2606 CDD:409353
IG_like 2627..2703 CDD:214653
Ig strand B 2636..2640 CDD:409353
Ig strand C 2649..2653 CDD:409353
Ig strand E 2670..2674 CDD:409353
Ig strand F 2684..2689 CDD:409353
Ig strand G 2697..2700 CDD:409353
I-set 2766..2845 CDD:400151
Ig strand B 2771..2775 CDD:409353
Ig strand C 2784..2788 CDD:409353
Ig strand F 2821..2826 CDD:409353
PLAC 2851..2883 CDD:462560
Adamtsl3NP_001177303.1 TSP1 90..136 CDD:214559 23/50 (46%)
ADAMTS_CR_3 141..239 CDD:437068 51/97 (53%)
TSP1_ADAMTS 355..413 CDD:465950 11/58 (19%)
TSP1_ADAMTS 434..491 CDD:465950 20/56 (36%)
TSP1_ADAMTS 494..546 CDD:465950 16/54 (30%)
TSP1_ADAMTS 582..637 CDD:465950 21/57 (37%)
TSP1_ADAMTS 661..716 CDD:465950 3/54 (6%)
TSP1_ADAMTS 720..772 CDD:465950 18/57 (32%)
TSP1_ADAMTS 776..832 CDD:465950 18/60 (30%)
TSP1_ADAMTS 838..893 CDD:465950 16/54 (30%)
Ig <942..1006 CDD:472250 12/63 (19%)
Ig strand B 943..947 CDD:409353 0/3 (0%)
Ig strand C 956..960 CDD:409353 0/3 (0%)
Ig strand E 978..982 CDD:409353 2/3 (67%)
Ig strand F 992..997 CDD:409353 0/4 (0%)
Ig strand G 1001..1004 CDD:409353 1/2 (50%)
Ig 1224..1291 CDD:409353 13/67 (19%)
Ig strand B 1224..1228 CDD:409353 0/3 (0%)
Ig strand C 1238..1242 CDD:409353 1/3 (33%)
Ig strand E 1260..1264 CDD:409353 0/3 (0%)
Ig strand F 1274..1279 CDD:409353 0/4 (0%)
Ig strand G 1288..1291 CDD:409353 2/2 (100%)
Ig 1331..1394 CDD:409353 10/68 (15%)
Ig strand B 1331..1335 CDD:409353 0/3 (0%)
Ig strand C 1344..1348 CDD:409353 0/3 (0%)
Ig strand E 1364..1368 CDD:409353 2/3 (67%)
Ig strand F 1378..1383 CDD:409353 1/4 (25%)
TSP1_ADAMTS 1442..1497 CDD:465950 16/95 (17%)
TSP1_ADAMTS 1501..1558 CDD:465950 11/78 (14%)
TSP1_ADAMTS 1617..1670 CDD:465950 19/95 (20%)
PLAC 1674..1704 CDD:462560 9/35 (26%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.