DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ppn and Adamtsl3

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_001177303.1 Gene:Adamtsl3 / 269959 MGIID:3028499 Length:1706 Species:Mus musculus


Alignment Length:1902 Identity:408/1902 - (21%)
Similarity:622/1902 - (32%) Gaps:584/1902 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 FIVLASIHDSQSRFPGLRQKRQYGANMYLPESSVTPGG--------------------------E 53
            |.|...:..:..:.||.         .:|||.:::|.|                          |
Mouse    28 FTVSGLLQATAEKSPGA---------YFLPEFALSPQGSFLEDTTGEQFLTYRYDDQTSRNAHSE 83

  Fly    54 GNDPDEWTPWSSPSDCSRTCGGGVSYQTRECLRRDDRGEAVCSGGSRRYFSCNTQDCPEEESDFR 118
            .:....|..|...||||||||||.||..|.||...:     |.|.:.||.:|:..|||.:..|||
Mouse    84 EDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRN-----CEGQNIRYKTCSNHDCPADAEDFR 143

  Fly   119 AQQCSRFDRQQFDGVFYEWVPYTNAP-NPCELNCMPKGERFYYRQREKVVDGTRCNDKDLDVCVN 182
            |||||.::..|:.|.:|||:|..|.| .||.|.|..:|:........||:||||||...||:|::
Mouse   144 AQQCSAYNDVQYQGHYYEWIPLYNDPAAPCALKCHARGQSLVVELAPKVLDGTRCNADSLDMCIS 208

  Fly   183 GECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYND--LLLLPEGATNIRIE 245
            |.|..||||..|||:||||.|..|.||||||:.:|.. |...|:|...:  ::.:|.|:.::||.
Mouse   209 GICQIVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQ-TKMHLSPEKKEENVIAVPLGSRSVRIT 272

  Fly   246 ETVPSSNYL---ACRNHSGHYYLNG-------DWRIDFPR-----------PM------------ 277
            ...|:..::   ..:...|.:..|.       :..|:|.:           |:            
Mouse   273 VKGPALIFIESKTLQGSRGEHSFNSPGVFTVENTTIEFQKGADRQTFKIAGPLMADFIFKTRYTV 337

  Fly   278 -------FFANSWWNYQRKPMGFAAPDQLTCSGPISESLFIVMLVQEKNISLD-YEYSIPESLSH 334
                   ||.....::|.:...| .|..:||.|....:....|.::.|.:..| |.:..||::..
Mouse   338 AKGSVVQFFFYQPISHQWRQTDF-FPCTVTCGGGYQLNSAECMDIRLKRVVPDHYCHYYPENVKP 401

  Fly   335 SQ-------------------------QDTHTWTHHQFNACSASCGGGSQSRKVTC---NNRITL 371
            ..                         |....|.|:.:.|||.|||||.|.|...|   :....:
Mouse   402 KPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHAEI 466

  Fly   372 AEVNPSLCDQKSKPVEEQACGTEPCAPHWVEGEWSKCSKGCGSDGFQNRSITCERISSSGEHT-- 434
            .:|....|....||...|||....| |.||..|||:|:..||. |.:.|.:.|  |:..|:|.  
Mouse   467 LQVEEWKCMYAPKPTVMQACNLFDC-PKWVAMEWSQCTVTCGR-GLRYRVVLC--INHRGQHVGG 527

  Fly   435 --------VEEDAV----CLKEVGNKP----------ATKQECNRDVKNCPKYHLGPWTPCDKLC 477
                    ::|:.|    |.|.....|          |.:.|..|.....||:...||:.|...|
Mouse   528 CNPQMKLHIKEECVIPIPCYKPREKSPVEAKLPWLKQAQELEETRIATEEPKFIPEPWSACSTTC 592

  Fly   478 GDGKQTRKVTC-----FIEENGHKRVLPEEDCVEEKPETEKSCL--------------------- 516
            |.|.|.|:|.|     |.:....   ||||:|...||.|::.||                     
Mouse   593 GPGIQVREVRCRVLLTFTQTEAE---LPEEECEGPKPPTDRPCLRQACDQSPVSRELGGRLQEKD 654

  Fly   517 -----------LTPCEGV----------------------------------------------D 524
                       .|||...                                              .
Mouse   655 SEMTYDWEYAGFTPCTATCLGGHQEAIAVCLHTQTHQTVNDSLCDTVHRPPPMSQACNMEPCPPR 719

  Fly   525 WIISQWSGCNA-CGQNTETRTAICGNKEGKVYPEEF------CEPEVPTLSRPCKSPKCEAQWFS 582
            |.:..|..|:| ||...:||...|      ::||||      |..|.|...|.|....|...|..
Mouse   720 WHMGSWGACSATCGVGIQTRDVYC------LHPEEFPAPPEECREEKPHALRACNQFDCPPSWHI 778

  Fly   583 SEWSKCSAPCGKGVKSRIVICGEF--DGKTVTPADDDSKCNKETKPESEQDCEGEEKVCPGEWFT 645
            .||.:||..||.|.::|.|.|.:.  ||..:..:|:  .| :..|..|.:.|...:  ||.:...
Mouse   779 EEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDE--LC-QGPKASSHKSCARTD--CPPQLAA 838

  Fly   646 GPWGKCSKPCGGGERVREVLC--LSNGTKSVN-----CDEEKVEPLSEKCNSEACTEDEILPLTS 703
            |.|.|||..||.|.:.|:.:|  |:...:.|:     |.:....||...|....|::.::...|.
Mouse   839 GDWSKCSVTCGVGFQRRKQVCQKLTAKGRRVSVAETLCRDLPGLPLVRPCQMPICSKAKLGTKTK 903

  Fly   704 TDKPIEDDEEDCDEDGIELISDGLSD---DEKSEDVIDLEGTAKTETTPEAEDLMQSDS---PTP 762
                       ..|.|.:::  |:..   ..:.|..|:|       |......|:.:.|   ..|
Mouse   904 -----------LGERGPQIL--GVRRVYIQTREEKRINL-------TVGSRAYLLLNTSVIIKCP 948

  Fly   763 YDEFESTGTTFEGSGYDSESTTDSGISTEGS------------------GDDEET---------- 799
            ...|:.:...:|..|:..:::...||:..||                  |..:||          
Mouse   949 VRRFQKSLIQWEKDGHCLKNSKQLGITKSGSLKIHSLAAPDIGVYRCIAGSAQETVVLKLIGTDN 1013

  Fly   800 -------------SEASTDLSSSTDSGSTSSDSTSSDSSSS------------------ISSDAT 833
                         .....|.:.:...|:|........::.:                  .....|
Mouse  1014 RLIAHPSLREHVRGHPGVDHNEANSLGATWHKMRQMWNNKNDLYLHGGEMNKQPFLRALFGPCRT 1078

  Fly   834 SEAPASSVSDSSDSTDASTETTGVSDDSTDVSSSTEASASESTDVSGASDSTGSTN--------- 889
            ||...:|....:...:|:.:....|.|:........ :.|:..::..|||...|..         
Mouse  1079 SEGNDNSWEFKNKQFEAAMKQGAYSMDTAQFDELIR-NMSQLMEMGEASDDLASQMIYQLVAELA 1142

  Fly   890 ------------ASDSTPESSTEASSSTDDSTDSSDNSSN--------VSESSTEASSSSVSDSN 934
                        ..:..||:.....:.......:..||..        |........|.|.:.:.
Mouse  1143 KAQPTPVQWRGIREEVAPEAQLRGKTERVPKNPTVKNSGKLTFKPKGPVLMRQILPPSVSFNKTI 1207

  Fly   935 DSSDGSTDGVSSTTE----------NSSDSTSDATSDSTASSDSTDSTSDQTTETTPESSTDSTE 989
            ::..|:|..::.:||          .|.::|...|.|......|.....|:|.:....:.| ..|
Mouse  1208 NARIGNTVYITKSTEIINILCSLITPSKEATYTWTKDGALLQPSVKIILDETGKMQIRNPT-RKE 1271

  Fly   990 SSTLDASSTTDASSTSESSSESSTDGS---STTSNSASSETTGLS-SDGSTTDATTAASDNTDIT 1050
            ....:.|..:...|..|||.....:..   |...|....|...|| ..|.|.:|...|       
Mouse  1272 QGIYECSVASHLGSDVESSLVLYAEAPVILSIERNVTKPEHNHLSVVVGGTVEAALQA------- 1329

  Fly  1051 TDGSTDESTDGSSNASTEGSTEGASEDTTISTESSGSTESTDAIASDGSTTEGSTVEDLSSSTSS 1115
                         |.:.....:|..:......::.||.....::..:||...      .|:|..:
Mouse  1330 -------------NVTIHCPVKGVPQPNVTWLKTGGSLSDNVSLLFNGSLLL------QSASLEN 1375

  Fly  1116 DVTSDSTITDS-SPSTEVSGSTDSSSSTDGSSTDASSTEASSTDVTESTDSTVSGGTSDTTESGP 1179
            :.|...|.|:: ..:...||.........|..  |:..:...|.|.::..|.::.... |.:|.|
Mouse  1376 EGTYICTATNALGKAVATSGLRLLERREPGGK--AAFPKVQKTRVLQAPRSRINSNNL-TGKSLP 1437

  Fly  1180 TEESTTEGSTESTTEGSTDSTQSTDLDSTTSDIWSTSDKDDESESSTPYSFDSEVTKSKPRKCKP 1244
            .|.                             .|...:....|.:..|..|..:    :||    
Mouse  1438 QEH-----------------------------FWEPGNWTHCSATCGPLGFRLQ----RPR---- 1465

  Fly  1245 KKSTCAK------SEYGCCPDGKSTPKGPFDEGCPIA--KTCADTKYGCCLDGVSPAKGKNNKGC 1301
                |..      ||..|.|..|           |:|  ::|                  |.:.|
Mouse  1466 ----CVMASGQEVSEALCGPHRK-----------PLAGFQSC------------------NIRDC 1497

  Fly  1302 PK-------SQCAETLFGCCPDKFTAADGENDEGCPETTTVPPTTTTEETQPETTTEIEGSGQDS 1359
            |.       |:|:.:    |.:.|.:..                .|.::|:...|.::......:
Mouse  1498 PARWFTSMWSECSAS----CGEGFHSRQ----------------VTCKQTKANGTVQVVSPRACA 1542

  Fly  1360 TTSEPDTKKSCSFSEFGCCPDAETSAKGPDFEGCGLASPVA---KGCA-ESENGCCPDGQTPASG 1420
            ....|..:|.||...  |...|............|.|:.:.   ..|: .|.:..|.||:.||.|
Mouse  1543 PKDRPLGRKPCSIRP--CVQQAIDPGNQCPGRCMGHATRMQHHHTACSHNSSSSDCEDGRRPAFG 1605

  Fly  1421 PN---GEGCSGCTRERFGCCPDSQTPAHGPNKEGCCLDTQFGCCPDNILAARGPNNEGCECHYTP 1482
            .|   |. |..|.|.             ||.|            |...:..||..:...:|.:| 
Mouse  1606 RNCTLGP-CEACWRV-------------GPWK------------PCTAVCGRGFQSRKVDCIHT- 1643

  Fly  1483 YGCCPDNKSAATGYNQEGCACETTQYGCCPDKITAAK---GPKHEGCPCETTQFGCCPDGLTFAK 1544
             |.|   |..|..|             |...|..|.:   ||..:....:||.:  |    .|.|
Mouse  1644 -GSC---KIVADRY-------------CVQVKPAAWRHCLGPSCDRNCTDTTHY--C----MFVK 1685

  Fly  1545 GPHHHGCHCTQTEFKCC 1561
              |.:.|.......:||
Mouse  1686 --HLNLCSLAVYRQRCC 1700

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559 23/50 (46%)
ADAM_spacer1 214..329 CDD:283607 26/157 (17%)
TSP1 468..521 CDD:214559 23/89 (26%)
TSP_1 645..693 CDD:278517 16/54 (30%)
Kunitz_BPTI 1611..1663 CDD:278443
Kunitz_BPTI 1670..1721 CDD:278443
Kunitz_BPTI 1729..1781 CDD:278443
Kunitz_BPTI 1789..1840 CDD:278443
Kunitz_BPTI 1848..1899 CDD:278443
KU 1920..1973 CDD:238057
Kunitz_BPTI 2001..2051 CDD:278443
KU 2071..2121 CDD:238057
Kunitz_BPTI 2127..2178 CDD:278443
KU 2192..2245 CDD:238057
KU 2251..2304 CDD:238057
KU 2316..2372 CDD:238057
WAP 2457..2497 CDD:278522
Ig 2521..2610 CDD:299845
IG_like 2530..2610 CDD:214653
IG_like 2627..2703 CDD:214653
Ig 2636..2701 CDD:143165
IG_like 2766..2841 CDD:214653
Ig 2768..2830 CDD:299845
PLAC 2851..2883 CDD:285849
Adamtsl3NP_001177303.1 TSP1 90..136 CDD:214559 23/50 (46%)
TSP1 438..492 CDD:214559 19/54 (35%)
TSP1 498..>527 CDD:214559 12/31 (39%)
TSP1 583..>603 CDD:214559 9/19 (47%)
TSP1 720..773 CDD:214559 18/58 (31%)
TSP1 776..833 CDD:214559 18/61 (30%)
TSP1 839..894 CDD:214559 16/54 (30%)
Ig 942..1006 CDD:299845 12/63 (19%)
Ig 1234..1293 CDD:299845 14/59 (24%)
IG_like 1321..1393 CDD:214653 14/97 (14%)
IGc2 1330..1388 CDD:197706 11/63 (17%)
TSP_1 1503..1558 CDD:301595 11/76 (14%)
PLAC 1674..1704 CDD:285849 9/35 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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