Protein Alignment Ppn and AMBP

DIOPT Version :10

• Sequence 1: NP_788752.2
• Gene: Ppn / 43872
• FlyBaseID: FBgn0003137
• Length: 2898
• Species: Drosophila melanogaster
• Sequence 2: NP_001624.1
• Gene: AMBP / 259
• HGNCID: 453
• Length: 352
• Species: Homo sapiens
• Alignment Length: 142
• Identity: 54/142 - (38%)
• Similarity: 67/142 - (47%)
• Gaps: 15/142 - (10%)

  Fly  2044 EEECSARCSVNIDIRIGADPVEHDTSK---CFLAFEPGNCYNNVTRWFYNSAEGLCDEFVYTGCG 2105
            |||.|.          |...|...|.|   |.|.:..|.|....:|:|||.....|:.|.|.||.
Human   211 EEEGSG----------GGQLVTEVTKKEDSCQLGYSAGPCMGMTSRYFYNGTSMACETFQYGGCM 265

  Fly  2106 GNANNYATEEECQNECNDAQTTCALPPVRGRCSDLSRRWYFDERSGECHEFEFTGCRGNRNNFVS 2170
            ||.||:.||:||...|... ..|.||.|||.|....:.|.||...|:|..|.:.||:||.|.|.|
Human   266 GNGNNFVTEKECLQTCRTV-AACNLPIVRGPCRAFIQLWAFDAVKGKCVLFPYGGCQGNGNKFYS 329

  Fly  2171 QSDCLNFCIGEP 2182
            :.:|..:| |.|
Human   330 EKECREYC-GVP 340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559
		ADAMTS_CR_3	116..213	CDD:437068
		ADAMTS_spacer1	222..329	CDD:461796
		TSP1_ADAMTS	347..396	CDD:465950
		TSP1_ADAMTS	400..457	CDD:465950
		TSP1_ADAMTS	465..520	CDD:465950
		TSP1_ADAMTS	580..632	CDD:465950
		TSP1_ADAMTS	643..693	CDD:465950
		MSCRAMM_ClfA	<1049..1262	CDD:468110
		Kunitz_papilin_lacunin-like	1612..1663	CDD:438681
		Kunitz_BPTI	1670..1721	CDD:425421
		Kunitz-type	1730..1780	CDD:438633
		Kunitz_BPTI	1789..1840	CDD:425421
		Kunitz_papilin_mig6-like	1849..1899	CDD:438679
		Kunitz_papilin_mig6-like	1922..1972	CDD:438679
		Kunitz_papilin_mig6-like	2001..2051	CDD:438679	4/6 (67%)
		Kunitz-type	2071..2121	CDD:438633	21/49 (43%)
		Kunitz_BPTI	2127..2178	CDD:425421	21/50 (42%)
		Kunitz_BPTI	2193..2245	CDD:425421
		Kunitz_BPTI	2252..2303	CDD:425421
		Kunitz_BPTI	2317..2372	CDD:425421
		WAP	2455..2497	CDD:459672
		Ig	2530..2610	CDD:472250
		Ig strand B	2539..2543	CDD:409353
		Ig strand C	2552..2556	CDD:409353
		Ig strand E	2576..2579	CDD:409353
		Ig strand F	2589..2594	CDD:409353
		Ig strand G	2603..2606	CDD:409353
		IG_like	2627..2703	CDD:214653
		Ig strand B	2636..2640	CDD:409353
		Ig strand C	2649..2653	CDD:409353
		Ig strand E	2670..2674	CDD:409353
		Ig strand F	2684..2689	CDD:409353
		Ig strand G	2697..2700	CDD:409353
		I-set	2766..2845	CDD:400151
		Ig strand B	2771..2775	CDD:409353
		Ig strand C	2784..2788	CDD:409353
		Ig strand F	2821..2826	CDD:409353
		PLAC	2851..2883	CDD:462560
AMBP	NP_001624.1	lipocalin_A1M-like	28..190	CDD:381193
		Glycopeptide (secretory piece)	206..226		6/24 (25%)
		Kunitz_bikunin_1-like	229..282	CDD:438639	21/52 (40%)
		Kunitz_bikunin_2-like	284..338	CDD:438640	22/55 (40%)