DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and HMCN2

DIOPT Version :10

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_001278744.1 Gene:HMCN2 / 256158 HGNCID:21293 Length:5079 Species:Homo sapiens


Alignment Length:892 Identity:190/892 - (21%)
Similarity:282/892 - (31%) Gaps:303/892 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  2108 ANNYATEEECQNECNDAQTTCALPPVRGRCSDLSRRWYFDERSGECHEFEFTGCRGNRNNFVSQS 2172
            |.|.|.|::     .|......:||:..:..|.|..:....|..|        .||....:    
Human  2721 ATNVAGEDD-----QDFNVLIQVPPMFQKVGDFSAAFEILSREEE--------ARGGVTEY---- 2768

  Fly  2173 DCLNFCIGEPVVEPSAPTYSVC---AEPPEAGECDNRTTAWFYDSENMACTAFTYTGCGG----- 2229
                    ..:|| :.|.|..|   |.||.       ...|:.:.:.::.........||     
Human  2769 --------REIVE-NNPAYLYCDTNAIPPP-------DLTWYREDQPLSAGDEVSVLQGGRVLQI 2817

  Fly  2230 ------NGNRFETRDQCERQCGEFKGVD-------VCNEPVTTGPCTDWQTKYYFNTASQACEPF 2281
                  |..|:..:  ...:.||    |       |...||..|...:...:...|.:|..... 
Human  2818 PLVRAENAGRYSCK--ASNEVGE----DWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQ- 2875

  Fly  2282 TYGGCDGTGN------------------RFSDLFECQT--------------VCLAGREPRVGSA 2314
                |...||                  |...|.:.|.              :|:|  |.:.|||
Human  2876 ----CPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVA--ENQAGSA 2934

  Fly  2315 KEICLLPV-------------ATGRCNGP-----SVH-----ERRWYYDDEA---GNCVSFIYAG 2353
            :::..|.|             .|...|..     .||     |..||.|.:|   |..| |:..|
Human  2935 EKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEV-FLLPG 2998

  Fly  2354 CSGNQNNFRSFEACTNQCRPEPNKQDNEIGQNPCDTFDAECQELRCPYGVRRVAARSQPECTQCI 2418
            ....|..               ..:.::.|...|:..:|              |.|.| :..|..
Human  2999 THTLQLG---------------RARLSDSGMYTCEALNA--------------AGRDQ-KLVQLS 3033

  Fly  2419 CENPCEGYSCPEGQQCAIDVASSDDRQFAPVCRDIYKPGECPALSANASGCARECYTDADCRGDN 2483
            ...|......|.|.|.|:                :.:.|:...||         |.|||......
Human  3034 VLVPPAFRQAPRGPQDAV----------------LVRVGDKAVLS---------CETDALPEPTV 3073

  Fly  2484 KCCSDGCGQLCVHPARPTQP----PRTQAPVVSYPGDARAALEPKEAHELD-------------- 2530
            ....||            ||    .||||    ..|..|  ||.:||...|              
Human  3074 TWYKDG------------QPLVLAQRTQA----LRGGQR--LEIQEAQVSDKGLYSCKVSNVAGE 3120

  Fly  2531 ----------------------VQTAIGGIAVLRCFATGNPAPNITWSLKNLVINTNKGRYVLTA 2573
                                  |....|...||.|..:|.|||.:||....:.:.::....|::.
Human  3121 AVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSR 3185

  Fly  2574 NGDLTIVQVRQTDDGTYVCVASNGLGEPVRREVALQVTEPVSQPAYIYGDKNVTQIVELNRPAVI 2638
            .|.|.:.:::....|||.|||.|...|..:..|...:..|..:.:.:..:.:|.:..|:.    :
Human  3186 GGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVR----L 3246

  Fly  2639 RCPAGGFPEPHVSWWRNGQMFGLKNNLMARDY----SLVFNSIQLSDLGLYTCEVYNQRRPVSLR 2699
            .|.|.|.|.|.|:|.::|...|.......|.|    |||...::.||.|.|||..:|        
Human  3247 DCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHN-------- 3303

  Fly  2700 VTLKAVGPVRPLSPEEEQYMQYVLNPATRPVTQRPSYPYRPTRPAYVPEPTVNVHAVLALEPKNS 2764
                         |..|....:.:|                   ..|| ||:...|      ..|
Human  3304 -------------PAGEDARLHTVN-------------------VLVP-PTIKQGA------DGS 3329

  Fly  2765 YT----PGSTIVMSCSVQGYPEPNVTWIKDDVPLYNNERVQITYQPHRLVLSDVTSADSGKYTCR 2825
            .|    ||..:.|.|.|:|.|..:|:|:||.:||..::|..:....|.|.:|.|..||:|.:||.
Human  3330 GTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCV 3394

  Fly  2826 ASNAYTYANGEANVSIQSVVPVSPECVDNPYFANCKLIVKGRYCSNP 2872
            |::....|  :.|.::|..||...|.|:   |.|..::|:|.....|
Human  3395 AASPAGVA--DRNFTLQVQVPPVLEPVE---FQNDVVVVRGSLVELP 3436

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559
ADAMTS_CR_3 116..213 CDD:437068
ADAMTS_spacer1 222..329 CDD:461796
TSP1_ADAMTS 347..396 CDD:465950
TSP1_ADAMTS 400..457 CDD:465950
TSP1_ADAMTS 465..520 CDD:465950
TSP1_ADAMTS 580..632 CDD:465950
TSP1_ADAMTS 643..693 CDD:465950
MSCRAMM_ClfA <1049..1262 CDD:468110
Kunitz_papilin_lacunin-like 1612..1663 CDD:438681
Kunitz_BPTI 1670..1721 CDD:425421
Kunitz-type 1730..1780 CDD:438633
Kunitz_BPTI 1789..1840 CDD:425421
Kunitz_papilin_mig6-like 1849..1899 CDD:438679
Kunitz_papilin_mig6-like 1922..1972 CDD:438679
Kunitz_papilin_mig6-like 2001..2051 CDD:438679
Kunitz-type 2071..2121 CDD:438633 4/12 (33%)
Kunitz_BPTI 2127..2178 CDD:425421 8/50 (16%)
Kunitz_BPTI 2193..2245 CDD:425421 9/65 (14%)
Kunitz_BPTI 2252..2303 CDD:425421 12/82 (15%)
Kunitz_BPTI 2317..2372 CDD:425421 16/80 (20%)
WAP 2455..2497 CDD:459672 9/41 (22%)
Ig 2530..2610 CDD:472250 24/115 (21%)
Ig strand B 2539..2543 CDD:409353 2/3 (67%)
Ig strand C 2552..2556 CDD:409353 1/3 (33%)
Ig strand E 2576..2579 CDD:409353 1/2 (50%)
Ig strand F 2589..2594 CDD:409353 3/4 (75%)
Ig strand G 2603..2606 CDD:409353 0/2 (0%)
IG_like 2627..2703 CDD:214653 22/79 (28%)
Ig strand B 2636..2640 CDD:409353 0/3 (0%)
Ig strand C 2649..2653 CDD:409353 1/3 (33%)
Ig strand E 2670..2674 CDD:409353 3/7 (43%)
Ig strand F 2684..2689 CDD:409353 3/4 (75%)
Ig strand G 2697..2700 CDD:409353 0/2 (0%)
I-set 2766..2845 CDD:400151 28/82 (34%)
Ig strand B 2771..2775 CDD:409353 1/3 (33%)
Ig strand C 2784..2788 CDD:409353 1/3 (33%)
Ig strand F 2821..2826 CDD:409353 2/4 (50%)
PLAC 2851..2883 CDD:462560 6/22 (27%)
HMCN2NP_001278744.1 ChlD <3..207 CDD:440853
IG_like 434..513 CDD:214653
IG_like 524..604 CDD:214653
Ig strand B 534..538 CDD:409353
Ig strand C 547..551 CDD:409353
Ig strand E 570..574 CDD:409353
Ig strand F 584..589 CDD:409353
Ig strand G 597..600 CDD:409353
I-set 608..692 CDD:400151
Ig strand B 625..629 CDD:409353
Ig strand C 638..642 CDD:409353
Ig strand E 660..664 CDD:409353
Ig strand F 674..679 CDD:409353
Ig strand G 687..690 CDD:409353
IG_like 712..782 CDD:214653
Ig strand B 715..719 CDD:409353
Ig strand C 728..732 CDD:409353
Ig strand E 748..752 CDD:409353
Ig strand F 762..767 CDD:409353
IG_like 792..879 CDD:214653
Ig strand B 803..807 CDD:409353
Ig strand C 816..820 CDD:409353
Ig strand E 845..849 CDD:409353
Ig strand F 859..864 CDD:409353
Ig strand G 872..875 CDD:409353
I-set 885..972 CDD:400151
Ig strand B 902..906 CDD:409353
Ig strand C 916..920 CDD:409353
Ig strand F 952..957 CDD:409353
Ig strand G 965..968 CDD:409353
Ig_3 975..1050 CDD:464046
Ig 1080..1161 CDD:472250
Ig strand B 1091..1095 CDD:409353
Ig strand C 1104..1108 CDD:409353
Ig strand E 1127..1131 CDD:409353
Ig strand F 1141..1146 CDD:409353
Ig strand G 1154..1157 CDD:409353
Ig 1165..1246 CDD:472250
Ig strand B 1182..1186 CDD:409353
Ig strand C 1195..1199 CDD:409353
Ig strand E 1212..1216 CDD:409353
Ig strand F 1226..1231 CDD:409353
Ig strand G 1239..1242 CDD:409353
IG_like 1258..1340 CDD:214653
Ig strand B 1269..1273 CDD:409353
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1271..1298
Ig strand C 1282..1286 CDD:409353
Ig strand E 1306..1310 CDD:409353
Ig strand F 1320..1325 CDD:409353
I-set 1354..1433 CDD:400151
Ig strand B 1363..1367 CDD:409353
Ig strand C 1376..1380 CDD:409353
Ig strand E 1399..1403 CDD:409353
Ig strand F 1413..1418 CDD:409353
Ig strand G 1426..1429 CDD:409353
IG_like 1446..1527 CDD:214653
Ig strand B 1456..1460 CDD:409353
Ig strand C 1469..1473 CDD:409353
Ig strand E 1492..1497 CDD:409353
Ig strand F 1507..1512 CDD:409353
I-set 1542..1620 CDD:400151
Ig strand B 1543..1554 CDD:409353
Ig strand C 1563..1567 CDD:409353
Ig strand E 1586..1590 CDD:409353
Ig strand F 1600..1605 CDD:409353
Ig 1632..1705 CDD:472250
Ig strand B 1644..1648 CDD:409353
Ig strand C 1657..1661 CDD:409353
Ig strand E 1680..1684 CDD:409353
Ig strand F 1694..1699 CDD:409353
I-set 1729..1807 CDD:400151
Ig strand B 1737..1741 CDD:409353
Ig strand C 1750..1754 CDD:409353
Ig strand E 1772..1777 CDD:409353
Ig strand F 1787..1792 CDD:409353
Ig strand G 1800..1803 CDD:409353
Ig 1820..1893 CDD:472250
Ig strand B 1829..1833 CDD:409353
Ig strand C 1842..1846 CDD:409353
Ig strand E 1857..1861 CDD:409353
Ig strand F 1871..1876 CDD:409353
Ig strand G 1884..1887 CDD:409353
I-set 1895..1975 CDD:400151
Ig strand B 1912..1916 CDD:409353
Ig strand C 1925..1929 CDD:409353
Ig strand E 1948..1952 CDD:409353
Ig strand F 1962..1967 CDD:409353
Ig strand G 1975..1978 CDD:409353
Ig_3 1985..2061 CDD:464046
Ig_3 2079..2154 CDD:464046
Ig 2171..2261 CDD:472250
Ig strand B 2189..2193 CDD:409353
Ig strand C 2202..2206 CDD:409353
Ig strand E 2227..2231 CDD:409353
Ig strand F 2241..2246 CDD:409353
Ig strand G 2254..2257 CDD:409353
I-set 2273..2355 CDD:400151
Ig strand B 2285..2289 CDD:409353
Ig strand C 2298..2302 CDD:409353
Ig strand E 2320..2325 CDD:409353
Ig strand F 2335..2340 CDD:409353
Ig 2367..2449 CDD:472250
Ig strand B 2379..2383 CDD:409353
Ig strand C 2392..2396 CDD:409353
Ig strand E 2415..2419 CDD:409353
Ig strand F 2429..2434 CDD:409353
Ig strand G 2442..2445 CDD:409353
I-set 2464..2542 CDD:400151
Ig strand B 2472..2476 CDD:409353
Ig strand C 2485..2489 CDD:409353
Ig strand E 2508..2512 CDD:409353
Ig strand F 2522..2527 CDD:409353
Ig strand G 2535..2538 CDD:409353
I-set 2560..2638 CDD:400151
Ig strand B 2568..2572 CDD:409353
Ig strand C 2581..2585 CDD:409353
Ig strand E 2604..2608 CDD:409353
Ig strand F 2618..2623 CDD:409353
I-set 2656..2728 CDD:400151 3/6 (50%)
Ig strand B 2666..2670 CDD:409353
Ig strand C 2679..2683 CDD:409353
Ig strand E 2702..2706 CDD:409353
Ig strand F 2716..2721 CDD:409353 190/892 (21%)
Ig 2770..2847 CDD:472250 16/90 (18%)
Ig strand B 2777..2781 CDD:409353 1/3 (33%)
Ig strand C 2790..2794 CDD:409353 0/3 (0%)
Ig strand E 2814..2817 CDD:409353 0/2 (0%)
Ig strand F 2827..2832 CDD:409353 1/6 (17%)
Ig strand G 2840..2843 CDD:409353 0/2 (0%)
I-set 2864..2942 CDD:400151 15/84 (18%)
Ig strand B 2872..2876 CDD:409353 0/8 (0%)
Ig strand C 2885..2889 CDD:409353 0/3 (0%)
Ig strand E 2907..2912 CDD:409353 1/4 (25%)
Ig strand F 2922..2927 CDD:409353 1/4 (25%)
IG_like 2954..3034 CDD:214653 21/110 (19%)
Ig strand B 2964..2968 CDD:409353 0/3 (0%)
Ig strand C 2977..2981 CDD:409353 1/3 (33%)
Ig strand E 3000..3004 CDD:409353 0/3 (0%)
Ig strand F 3014..3019 CDD:409353 1/4 (25%)
I-set 3038..3129 CDD:400151 26/133 (20%)
Ig strand B 3059..3063 CDD:409353 2/12 (17%)
Ig strand C 3072..3076 CDD:409353 0/3 (0%)
Ig strand E 3095..3099 CDD:409353 2/5 (40%)
Ig strand F 3109..3114 CDD:409353 0/4 (0%)
Ig_3 3132..3208 CDD:464046 20/75 (27%)
I-set 3238..3308 CDD:400151 24/94 (26%)
Ig strand B 3244..3248 CDD:409353 0/7 (0%)
Ig strand C 3257..3261 CDD:409353 1/3 (33%)
Ig strand E 3282..3286 CDD:409353 2/3 (67%)
Ig strand F 3296..3301 CDD:409353 3/4 (75%)
I-set 3335..3410 CDD:400151 26/76 (34%)
Ig strand B 3340..3344 CDD:409353 1/3 (33%)
Ig strand C 3353..3357 CDD:409353 1/3 (33%)
Ig strand E 3376..3380 CDD:409353 2/3 (67%)
Ig strand F 3390..3395 CDD:409353 2/4 (50%)
Ig 3424..3499 CDD:472250 3/13 (23%)
Ig strand B 3433..3437 CDD:409353 1/4 (25%)
Ig strand C 3446..3450 CDD:409353
Ig strand E 3464..3469 CDD:409353
Ig strand F 3479..3484 CDD:409353
Ig strand G 3492..3495 CDD:409353
Ig 3503..3590 CDD:472250
Ig strand B 3522..3526 CDD:409353
Ig strand C 3535..3539 CDD:409353
Ig strand E 3556..3560 CDD:409353
Ig strand F 3570..3575 CDD:409353
Ig strand G 3583..3586 CDD:409353
Ig 3602..3683 CDD:472250
Ig strand C 3626..3630 CDD:409353
Ig strand E 3648..3653 CDD:409353
Ig strand F 3663..3668 CDD:409353
Ig 3689..3765 CDD:472250
Ig strand B 3704..3708 CDD:409353
Ig strand C 3717..3721 CDD:409353
Ig strand E 3740..3744 CDD:409353
Ig strand F 3754..3759 CDD:409353
Ig_3 3777..3854 CDD:464046
Ig 3873..3958 CDD:472250
Ig strand B 3888..3892 CDD:409353
Ig strand C 3901..3905 CDD:409353
Ig strand E 3924..3928 CDD:409353
Ig strand F 3938..3943 CDD:409353
Ig strand G 3951..3954 CDD:409353
Ig_3 3962..4035 CDD:464046
I-set 4052..4139 CDD:400151
Ig strand B 4069..4073 CDD:409353
Ig strand C 4082..4086 CDD:409353
Ig strand E 4105..4109 CDD:409353
Ig strand F 4119..4124 CDD:409353
Ig strand G 4132..4135 CDD:409353
I-set 4143..4228 CDD:400151
Ig strand B 4160..4164 CDD:409353
Ig strand C 4173..4177 CDD:409353
Ig strand E 4194..4198 CDD:409353
Ig strand F 4208..4213 CDD:409353
Ig strand G 4223..4226 CDD:409353
I-set 4246..4317 CDD:400151
Ig strand B 4250..4254 CDD:409353
Ig strand C 4263..4267 CDD:409353
Ig strand E 4285..4289 CDD:409353
Ig strand F 4299..4304 CDD:409353
Ig 4324..4409 CDD:472250
Ig strand B 4340..4344 CDD:409353
Ig strand C 4353..4357 CDD:409353
Ig strand E 4375..4379 CDD:409353
Ig strand F 4389..4394 CDD:409353
Ig strand G 4402..4405 CDD:409353
nidG2 4411..4625 CDD:469646
FXa_inhibition 4652..4687 CDD:464251
EGF_CA 4689..4732 CDD:214542
EGF_CA 4733..4766 CDD:214542
EGF_CA 4776..4805 CDD:429571
EGF_CA 4883..4922 CDD:214542
EGF_CA 4923..4963 CDD:214542
Blue background indicates that the domain is not in the aligned region.

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