DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppn and Adamts5

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_035912.2	Gene:	Adamts5 / 23794	MGIID:	1346321	Length:	930	Species:	Mus musculus

Alignment Length:	480	Identity:	130/480 - (27%)
Similarity:	191/480 - (39%)	Gaps:	119/480 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LRQKRQYGANMYLPESSVTPGGEG-------------------NDPDEWTPWSSPSDCSRTCGGG 76
            :||.:.......||....||.|:|                   :....|..|.....|||:||||
Mouse   522 VRQGQMVCLTKKLPAVEGTPCGKGRVCLQGKCVDKTKKKYYSTSSHGNWGSWGPWGQCSRSCGGG 586

  Fly    77 VSYQTRECLRRDDRGEA-VCSGGSRRYFSCNTQDCPEEESDFRAQQCSRFDRQQFD--GV--FYE 136
            |.:..|.|.....|... .|:|....|.||:...||.....||.:||...:..|.|  ||  |.|
Mouse   587 VQFAYRHCNNPAPRNSGRYCTGKRAIYRSCSVTPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVE 651

  Fly   137 WVPYTNAPNP---CELNCMPKGERFYYRQREKVVDGTRCNDKDLDVCVNGECMPVGCDMMLGSDA 198
            |||......|   |:|.|..||..:|.....||.|||.|......|||.|.|:..|||.::||..
Mouse   652 WVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRPYSNSVCVRGRCVRTGCDGIIGSKL 716

  Fly   199 KEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLLLLPEGATNIRI-----EETVPSSNYLACRN 258
            :.|||..||||.|:|..|..|...|  :.||.|::.:|||||:|::     ::....:.|||.:.
Mouse   717 QYDKCGVCGGDNSSCTKIIGTFNKK--SKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKK 779

  Fly   259 HSGHYYLNGDWRIDFPRPMFFAN------SWWNYQ---RKPMGFAAPDQLTCSGPISESLFIVML 314
            .:|.|.:||.:.|.....:...|      |.|:::   ...||::|         ..|.|.:.:|
Mouse   780 KTGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSA---------TKEILIVQIL 835

  Fly   315 VQEKNISLDYEYS--IPESLSHSQQDTHTWTHHQFNACSASCGGGSQSRKVTCNNRITLAEVNPS 377
            ..:...:||..||  :|:.                                      |..:||..
Mouse   836 ATDPTKALDVRYSFFVPKK--------------------------------------TTQKVNSV 862

  Fly   378 LCDQKSKPVEEQACGTEPCAPH-----WVEGEWSKCSKGCGSDGFQNRSITCERISSSGEHTVEE 437
            :           :.|:....||     ||.|.|..||:.|.: |:..|::.|:    .|...:.:
Mouse   863 I-----------SHGSNKVGPHSTQLQWVTGPWLACSRTCDT-GWHTRTVQCQ----DGNRKLAK 911

  Fly   438 DAVCLKEVGNKPATKQECNRDVKNC 462
            .  ||  :..:|:..::|.  :|.|
Mouse   912 G--CL--LSQRPSAFKQCL--LKKC 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	18/51 (35%)
		ADAM_spacer1	214..329	CDD:283607	33/130 (25%)
		TSP1	468..521	CDD:214559
		TSP_1	645..693	CDD:278517
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
Adamts5	NP_035912.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..68
		Pep_M12B_propep	68..174	CDD:279848
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..231
		Cysteine switch. /evidence=ECO:0000250	207..214
		Reprolysin	269..476	CDD:279729
		ZnMc_ADAMTS_like	269..473	CDD:239801
		ADAM_CR	486..556	CDD:301627	8/33 (24%)
		TSP1	570..622	CDD:214559	18/51 (35%)
		Spacer	732..874		39/201 (19%)
		ADAM_spacer1	732..852	CDD:283607	33/130 (25%)
		TSP1	879..930	CDD:214559	16/61 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810