DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and Adamts17

DIOPT Version :10

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_001029049.2 Gene:Adamts17 / 233332 MGIID:3588195 Length:1122 Species:Mus musculus


Alignment Length:671 Identity:197/671 - (29%)
Similarity:278/671 - (41%) Gaps:169/671 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 SVTPGGEGNDPDEWTPWSSPSDCSRTCGGGVSYQTRECLRRDD----RGEAVCSGGSRRYFSCNT 107
            |.||..|..|.| |:.||:.|.||||||.|..::.|:|   |:    .|...|.|.|..:.:|..
Mouse   532 SKTPIPEHVDGD-WSLWSAWSMCSRTCGTGARFRQRKC---DNPPPGPGGTHCQGASVEHAACEK 592

  Fly   108 QDCPEEESDFRAQQCSRFDR--QQFDGVFYEWVPYTNAPNPCELNCMPKGERFYYRQREKVVDGT 170
            ..||:....||.|||...||  .:..|:....|.   ...||||.|.|.|:.......::|:|||
Mouse   593 LPCPKGVPSFRDQQCQAHDRLSSKKRGLLTAVVV---DDKPCELYCSPLGKESPLLVADRVLDGT 654

  Fly   171 RCNDKDLDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLLLL 235
            .|...:.|:||.|.|..:|||.::||.||||:|..|.|||.||:.::... :.....||.:.:::
Mouse   655 PCGPYEADLCVYGRCQKIGCDGIIGSAAKEDRCGVCSGDGKTCRVVKGDF-SHSRGTGYIEAVVI 718

  Fly   236 PEGATNIRIEETVPSSNYLACRNHSGHYYLNGDWRIDFPRPMFFANSWWNYQRKPMGFAAPDQLT 300
            |.||..||:.|..|:.::||.:: |....:|.||:|:.|.....|.:...|.|:.:.    ::.:
Mouse   719 PVGARRIRVVEDKPAHSFLALKD-SSKRSINSDWKIELPGEFQIAGTTVRYVRRGLW----EKFS 778

  Fly   301 CSGPISESL-FIVMLVQEKNISLDYEYSIPESLSHSQQD--------THTWTHHQFNACSASCGG 356
            ..||.:..| .:|:|..::|..:.|||:||.:.|...|.        ...|||..:..||..|||
Mouse   779 AKGPTTVPLHLMVLLFHDQNYGIHYEYTIPVNQSSENQSEPAKPQDALFLWTHSGWEGCSVQCGG 843

  Fly   357 GSQSRKVTC----NNRITLAEVNPSLCDQKSKPVEE-QACGTEPCAPHWVEGEWSKCSKGCGSDG 416
            |.:...|:|    |...||  ||.|.|.|.|:|..: :.|.:.||...||.|:||.||..| ..|
Mouse   844 GERRTIVSCTRIVNKTTTL--VNDSDCPQASRPEPQVRRCNSHPCQSRWVTGQWSPCSATC-EKG 905

  Fly   417 FQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVKNCPKYHLGPWTPCDKLCGDGK 481
            .|:|.:||.....:|.|                         |...|.|                
Mouse   906 VQHREVTCVYQLQNGTH-------------------------VTTRPIY---------------- 929

  Fly   482 QTRKVTCFIEENGHKRVLPEEDCVEEKPETEKSCLLTPCEGVDWIISQWSGCNACGQNTETRTAI 546
                                  |.|.:|...:|     |||.|                      
Mouse   930 ----------------------CSEPRPTPVQS-----CEGQD---------------------- 945

  Fly   547 CGNKEGKVYPEEFCEPEVPTLSRPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRIVICGEFDGKTV 611
                                         |.:.|.:||||:|||.||||::.|.|.|....|   
Mouse   946 -----------------------------CLSIWEASEWSECSANCGKGIQKRTVTCTNSQG--- 978

  Fly   612 TPADDDSKCNKETKPESEQDCEGEEKVCPGEWFTGPWGKCSKPCGGGERVREVLCLS--NGTKSV 674
                   ||:..|:|::|::|| :...| .||.||.|.|||..||.|.:.|.|.|:.  .|....
Mouse   979 -------KCDASTRPKAEEECE-DYSGC-YEWKTGDWSKCSSTCGKGLQSRVVQCMHKLTGRHGS 1034

  Fly   675 NCDEEKVEPLSEKCNSEACTE 695
            .|..........:|:.|.|.|
Mouse  1035 ECPTLSKPAAYRQCHQEVCNE 1055

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559 19/54 (35%)
ADAMTS_CR_3 116..213 CDD:437068 40/98 (41%)
ADAMTS_spacer1 222..329 CDD:461796 29/107 (27%)
TSP1_ADAMTS 347..396 CDD:465950 19/53 (36%)
TSP1_ADAMTS 400..457 CDD:465950 15/56 (27%)
TSP1_ADAMTS 465..520 CDD:465950 5/54 (9%)
TSP1_ADAMTS 580..632 CDD:465950 21/51 (41%)
TSP1_ADAMTS 643..693 CDD:465950 17/51 (33%)
MSCRAMM_ClfA <1049..1262 CDD:468110
Kunitz_papilin_lacunin-like 1612..1663 CDD:438681
Kunitz_BPTI 1670..1721 CDD:425421
Kunitz-type 1730..1780 CDD:438633
Kunitz_BPTI 1789..1840 CDD:425421
Kunitz_papilin_mig6-like 1849..1899 CDD:438679
Kunitz_papilin_mig6-like 1922..1972 CDD:438679
Kunitz_papilin_mig6-like 2001..2051 CDD:438679
Kunitz-type 2071..2121 CDD:438633
Kunitz_BPTI 2127..2178 CDD:425421
Kunitz_BPTI 2193..2245 CDD:425421
Kunitz_BPTI 2252..2303 CDD:425421
Kunitz_BPTI 2317..2372 CDD:425421
WAP 2455..2497 CDD:459672
Ig 2530..2610 CDD:472250
Ig strand B 2539..2543 CDD:409353
Ig strand C 2552..2556 CDD:409353
Ig strand E 2576..2579 CDD:409353
Ig strand F 2589..2594 CDD:409353
Ig strand G 2603..2606 CDD:409353
IG_like 2627..2703 CDD:214653
Ig strand B 2636..2640 CDD:409353
Ig strand C 2649..2653 CDD:409353
Ig strand E 2670..2674 CDD:409353
Ig strand F 2684..2689 CDD:409353
Ig strand G 2697..2700 CDD:409353
I-set 2766..2845 CDD:400151
Ig strand B 2771..2775 CDD:409353
Ig strand C 2784..2788 CDD:409353
Ig strand F 2821..2826 CDD:409353
PLAC 2851..2883 CDD:462560
Adamts17NP_001029049.2 Pep_M12B_propep 35..179 CDD:460254
ZnMc_ADAMTS_like 230..447 CDD:239801
ADAMTS_CR_2 464..531 CDD:465496
TSP1 544..596 CDD:214559 19/54 (35%)
ADAMTS_CR_3 <628..697 CDD:437068 31/68 (46%)
ADAMTS_spacer1 699..808 CDD:461796 29/114 (25%)
TSP1_ADAMTS 834..886 CDD:465950 19/53 (36%)
TSP1_ADAMTS 890..946 CDD:465950 26/175 (15%)
TSP1_ADAMTS 950..992 CDD:465950 21/51 (41%)
TSP1_ADAMTS 1001..1053 CDD:465950 17/51 (33%)
Blue background indicates that the domain is not in the aligned region.

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