DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and THSD7A

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_056019.1 Gene:THSD7A / 221981 HGNCID:22207 Length:1657 Species:Homo sapiens


Alignment Length:2264 Identity:405/2264 - (17%)
Similarity:584/2264 - (25%) Gaps:985/2264 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly   400 WVEGEWSKC-SKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVKNCP 463
            |..|.|.:| ...||..|.|.|::.|..:  .|..|:..:.    :...:|..:|.|   .|.|.
Human    61 WKTGPWGRCMGDECGPGGIQTRAVWCAHV--EGWTTLHTNC----KQAERPNNQQNC---FKVCD 116

  Fly   464 ------KYHLGPWTPCDKLCG-------------DGKQTRKVTCFIEENGHKRVLPEEDCV---- 505
                  .:.||||..|..:..             :|.|.|::.|..::    :.:|.||.:    
Human   117 WHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKD----KDIPAEDIICEYF 177

  Fly   506 EEKPETEKSCLLTPCEGVDWIISQ---WSGCN-ACGQNTETRTAICGNKEGKVYPEEFCEPEVPT 566
            |.||..|::||: ||: .|.|:|:   ||.|: .||...:.||      ...|.|.:|.....|.
Human   178 EPKPLLEQACLI-PCQ-QDCIVSEFSAWSECSKTCGSGLQHRT------RHVVAPPQFGGSGCPN 234

  Fly   567 LS--RPCKSPKCEAQWFS-----SEWSKCSAP--------------------CGKGVK------- 597
            |:  :.|:|..|||:...     ..||.||.|                    ..||||       
Human   235 LTEFQVCQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEAREL 299

  Fly   598 -------------------------SRIVICGEFDGKTVTPADDDSKCNKETKPESEQDCEGEEK 637
                                     :|.|:|....||    |.|.|.|.:|..|.:.|.|...::
Human   300 IKKKRNRNRQNRQENKYWDIQIGYQTREVMCINKTGK----AADLSFCQQEKLPMTFQSCVITKE 360

  Fly   638 VCPGEWFTGPWGKCSKPC-----GGGERVREVLCLSNGTKSVNCDEEKVEPL-SEKCNSEACTED 696
            ....||  ..|..|||.|     ..|.|||        |:::     :..|: |||    .|.|.
Human   361 CQVSEW--SEWSPCSKTCHDMVSPAGTRVR--------TRTI-----RQFPIGSEK----ECPEF 406

  Fly   697 EILPLTSTDKPIEDDEEDCDEDGIELISDGLSDDEKSEDVIDLEGTAKTETTPEAEDLMQSDSPT 761
            |             ::|.|                                      |.|.|...
Human   407 E-------------EKEPC--------------------------------------LSQGDGVV 420

  Fly   762 PYDEFESTGTTFEGSGYDSESTTDSGISTEGSGDDEETSEASTDLSSSTDSGSTSSDSTSSDSSS 826
            |...:          |:.:...|:..:....|..|:.....:........:........:.:..|
Human   421 PCATY----------GWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLS 475

  Fly   827 SISSDATSEAPASSVSDSSDSTDASTETTGVSDDSTDVSSSTEASASESTDVSGASDSTGSTNAS 891
            .:|:....|  ||...|....|.....||.:    ..:...||...|                  
Human   476 QLSTHKNKE--ASKPMDLKLCTGPIPNTTQL----CHIPCPTECEVS------------------ 516

  Fly   892 DSTPESSTEASSSTDDSTDSSDNSSNVSESSTEASSSSVSDSNDSSDGSTDGVSSTTENSSDSTS 956
               |.|:..                                            ..|.||.:|...
Human   517 ---PWSAWG--------------------------------------------PCTYENCNDQQG 534

  Fly   957 D---------ATSDSTASSDSTDSTSDQTTETTPESSTDSTESSTLDASSTTDASSTSESSSESS 1012
            .         .|::.|..|..| .......|..|     ..|.:..|..:....:...::..|. 
Human   535 KKGFKLRKRRITNEPTGGSGVT-GNCPHLLEAIP-----CEEPACYDWKAVRLGNCEPDNGKEC- 592

  Fly  1013 TDGSSTTSNSASSETTGLSSDGSTTDATTAASDNTDITTDGSTDESTDGSSNASTEGSTEGASED 1077
              |..|    ...|...::|||...|....                                   
Human   593 --GPGT----QVQEVVCINSDGEEVDRQLC----------------------------------- 616

  Fly  1078 TTISTESSGSTESTDAIASDGSTTEGSTVEDLSSSTSSDVTSDSTITDSSPSTEVSGSTDSSSST 1142
                         .|||.......:....:|...||.|        |.||.|...||.|     |
Human   617 -------------RDAIFPIPVACDAPCPKDCVLSTWS--------TWSSCSHTCSGKT-----T 655

  Fly  1143 DGSSTDASSTEASSTDVTESTDSTVSGGTSDTTESGPTEESTTEGSTESTTEGSTDSTQSTDLDS 1207
            :|....|.|..|.:.:                           ||........:....:|.:...
Human   656 EGKQIRARSILAYAGE---------------------------EGGIRCPNSSALQEVRSCNEHP 693

  Fly  1208 TTSDIWSTSDKDDESESSTPYSFDSEVTKSKPRKC----KPKKSTCAKSEYGCCPDGKSTPKGPF 1268
            .|...|.|.......|.::..||::..|.:....|    :.:|..|.:...|        ..|| 
Human   694 CTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVG--------QVGP- 749

  Fly  1269 DEGCPIAKTCADTKYGCCLDGVSPAKGKNNKGCPKSQCAETLFGCCPDKFTAADGENDEGCPETT 1333
                                          |.||:|...||:..|                    
Human   750 ------------------------------KKCPESLRPETVRPC-------------------- 764

  Fly  1334 TVPPTTTTEETQPETTTEIEGSGQDSTTSEPDTKKSC---SFSEFGCCPDAETSAKGPDFEGCGL 1395
            .:|                             .||.|   .:|::..||.:              
Human   765 LLP-----------------------------CKKDCIVTPYSDWTSCPSS-------------- 786

  Fly  1396 ASPVAKGCAESENGCCPDG------QTPASGPNGEGCSGCTRERFGCCPDSQTPAHGPNKEGCCL 1454
                   |.|.::......      |.||:|  |..|:....|...|    :.|      :.|  
Human   787 -------CKEGDSSIRKQSRHRVIIQLPANG--GRDCTDPLYEEKAC----EAP------QAC-- 830

  Fly  1455 DTQFGCCPDNILAARGPNNEGCECHYTPYGCCPDNKSAATGYNQEGCACETTQYGCCPDK----I 1515
                       .:.|...::...|...|:....|:..|     ||||.         |.:    |
Human   831 -----------QSYRWKTHKWRRCQLVPWSVQQDSPGA-----QEGCG---------PGRQARAI 870

  Fly  1516 TAAKGPKHEGCPCETTQFGCCPDGLTFAKGPHHHGCHCTQTEFKCCDDEKTPAKGPNGDGCTCVE 1580
            |..|....:....|..|:......||.|         |   :..|.||            |....
Human   871 TCRKQDGGQAGIHECLQYAGPVPALTQA---------C---QIPCQDD------------CQLTS 911

  Fly  1581 -SKFGCCPDGVTKATDEKFGGCENVQEPPQKACGLPKETGTCNNYSVKYYFDTSYGGCARFWYGG 1644
             |||..|.           |.|..|:...:...|..|:...|.|..:....:|.|          
Human   912 WSKFSSCN-----------GDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQY---------- 955

  Fly  1645 CDGNDNRFESEAECKDTCQDYTGKHV-----CLLP----------KSAGPCTGFTKKWYFDVDRN 1694
                         |  .|..|..:.|     |:||          |..|             |..
Human   956 -------------C--PCDKYNAQPVGNWSDCILPEGKVEVLLGMKVQG-------------DIK 992

  Fly  1695 RCEE---FQYGGCYGTNNRFDSLEQCQGTCAASENLPTCEQPVESGPCAGNFERWYYDNETDICR 1756
            .|.:   :|...||..|.|.                      ||:..|                 
Human   993 ECGQGYRYQAMACYDQNGRL----------------------VETSRC----------------- 1018

  Fly  1757 PFTYGGCKGNKNNYPTEHACNYNCRQPGVLKDRCALPKQTGDCSEKLAKW-HFSESEKRC----- 1815
                     |.:.| .|.||...|               ..||  ||::| ::|...|.|     
Human  1019 ---------NSHGY-IEEACIIPC---------------PSDC--KLSEWSNWSRCSKSCGSGVK 1056

  Fly  1816 --------VPFYYSG---CGGNKNNFPTLESCEDHCPRQVAKDICEIPAEVGECANYVTSWYYDT 1869
                    .|  |:|   |       |.|    ||..:....::  :|.. .:|..|:  |..:.
Human  1057 VRSKWLREKP--YNGGRPC-------PKL----DHVNQAQVYEV--VPCH-SDCNQYL--WVTEP 1103

  Fly  1870 QDQACRQFYYG---GCG-GNENRFPTEESCLARCDRKP----EPTTTTPATRPQPSRQDVCDEEP 1926
            . ..|:..:..   .|| |.:.|   :..|:......|    |.....|...|..||  || :.|
Human  1104 W-SICKVTFVNMRENCGEGVQTR---KVRCMQNTADGPSEHVEDYLCDPEEMPLGSR--VC-KLP 1161

  Fly  1927 APGEC--STWVLKWHFDRKIGACRQFYYGNCGGNGNRFETENDCQQRCLSQEPPAPTPPRAPAPT 1989
            .|.:|  |.|                        |...:....|.|....|        |:..|.
Human  1162 CPEDCVISEW------------------------GPWTQCVLPCNQSSFRQ--------RSADPI 1194

  Fly  1990 RQPDPAPTVAQCSQPADPGQC--DKWALHWNYNETE-GRCQSFYYGGCG---------------- 2035
            ||  ||.....|....:...|  :|...|::||.|: ..||......||                
Human  1195 RQ--PADEGRSCPNAVEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGK 1257

  Fly  2036 ----------GNDNRFATEEECSARCSVNIDI----------------------RIGADPVEHDT 2068
                      |.:..:.....|...|.||..:                      |....|.:.|.
Human  1258 SVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDG 1322

  Fly  2069 SKCFLAFEPGN------CYNNVTRWFYNSAEGLCDEFVYTGCGGNANNYATEEECQNECNDAQTT 2127
            ..|....:...      ||    ||.|..         ::.|      ...|.:|.........:
Human  1323 RPCPSLMDQSKPCPVKPCY----RWQYGQ---------WSPC------QVQEAQCGEGTRTRNIS 1368

  Fly  2128 CALPPVRGRCSDLSRRWYFDERSGECHEFEFTGCRGNRNNFVSQSDCLNFCIGEPVVEPSAPTYS 2192
            |.:..  |...|.|:  ..||..  |.:.|.. ..||: |.|.:..|...|.|:..::..: ::|
Human  1369 CVVSD--GSADDFSK--VVDEEF--CADIELI-IDGNK-NMVLEESCSQPCPGDCYLKDWS-SWS 1424

  Fly  2193 VCAEPPEAGECDNRTTAWFYDSENMACTAFTYTGCGGNGNR-------------------FETRD 2238
            :|                     .:.|......|.||...|                   .||:.
Human  1425 LC---------------------QLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQMLETKS 1468

  Fly  2239 QCERQCGEFK-------------------GVDV---------------CNEPVTTGPCTDWQTKY 2269
            ..:.||.|:|                   |::|               ||.     ||:. ...|
Human  1469 CYDGQCYEYKWMASAWKGSSRTVWCQRSDGINVTGGCLVMSQPDADRSCNP-----PCSQ-PHSY 1527

  Fly  2270 YFNTASQACEPFTYGGCDGTGNRFSDLFEC---QTVCLAGREPRVGSAKEICLL--------PVA 2323
            ...|.:..||.    |.....:..|.|.:|   ..|.|...|.:.|..|....:        |..
Human  1528 CSETKTCHCEE----GYTEVMSSNSTLEQCTLIPVVVLPTMEDKRGDVKTSRAVHPTQPSSNPAG 1588

  Fly  2324 TGRC-----NGPSVHERRWYYDDEAGN------CVSFIYAGC------SGNQNN 2360
            .||.     .||....:.|.|...||.      .||.||..|      ...|||
Human  1589 RGRTWFLQPFGPDGRLKTWVYGVAAGAFVLLIFIVSMIYLACKKPKKPQRRQNN 1642

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559
ADAM_spacer1 214..329 CDD:283607
TSP1 468..521 CDD:214559 18/69 (26%)
TSP_1 645..693 CDD:278517 14/53 (26%)
Kunitz_BPTI 1611..1663 CDD:278443 7/51 (14%)
Kunitz_BPTI 1670..1721 CDD:278443 13/68 (19%)
Kunitz_BPTI 1729..1781 CDD:278443 8/51 (16%)
Kunitz_BPTI 1789..1840 CDD:278443 15/67 (22%)
Kunitz_BPTI 1848..1899 CDD:278443 10/54 (19%)
KU 1920..1973 CDD:238057 10/54 (19%)
Kunitz_BPTI 2001..2051 CDD:278443 13/78 (17%)
KU 2071..2121 CDD:238057 9/55 (16%)
Kunitz_BPTI 2127..2178 CDD:278443 13/50 (26%)
KU 2192..2245 CDD:238057 10/71 (14%)
KU 2251..2304 CDD:238057 14/70 (20%)
KU 2316..2372 CDD:238057 17/70 (24%)
WAP 2457..2497 CDD:278522
Ig 2521..2610 CDD:299845
IG_like 2530..2610 CDD:214653
IG_like 2627..2703 CDD:214653
Ig 2636..2701 CDD:143165
IG_like 2766..2841 CDD:214653
Ig 2768..2830 CDD:299845
PLAC 2851..2883 CDD:285849
THSD7ANP_056019.1 TSP1 197..247 CDD:214559 15/55 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 265..311 5/45 (11%)
TSP_1 364..412 CDD:301595 20/79 (25%)
TSP1 1039..>1077 CDD:214559 10/50 (20%)
TSP1 1290..1340 CDD:214559 4/49 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1570..1591 2/20 (10%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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