DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ppn and Adamts2

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_783574.1 Gene:Adamts2 / 216725 MGIID:1347356 Length:1213 Species:Mus musculus


Alignment Length:577 Identity:182/577 - (31%)
Similarity:279/577 - (48%) Gaps:79/577 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 EGNDPDEWTPWSSPSDCSRTCGGGVSYQTRECLRRDD----RGEAVCSGGSRRYFSCNTQDCPEE 113
            :||    |..|:....||||||.||.::||:|   |:    .|...|||.:..:..||.||||..
Mouse   562 DGN----WGAWTPFGSCSRTCGTGVKFRTRQC---DNPHPANGGRTCSGLAYDFQLCNPQDCPNS 619

  Fly   114 ESDFRAQQCSRFDRQ-QFDGVFYEWVP--YTNAPNPCELNCMPKGERFYYRQREKVVDGTRCNDK 175
            .:|||.:||.::|.. :...|.:.|:|  :.:|...|.|.|..|........:..|.|||||:.|
Mouse   620 LADFREEQCQQWDLYFEHGDVQHHWLPHEHRDAKERCHLYCESKETGEVVSMKRMVHDGTRCSYK 684

  Fly   176 D-LDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLLLLPEGA 239
            | ..:||.|:|..||||.::||..:||||..||||.:.||.::.|.|.......|..:..:|.||
Mouse   685 DAFSLCVRGDCRKVGCDGVIGSRKQEDKCGVCGGDNTHCKVVKGTFTRSPRKQDYIKMFEIPAGA 749

  Fly   240 TNIRIEETVPSSNYLACRN-HSGHYYLNGDWRIDFPRPMFFA-NSWWNYQRKPMGFAAPDQLTCS 302
            .::.|:|...:|::|:.:| .:|.:.||.:..:|.....|.| ...|.|:.:.    ..:.|...
Mouse   750 RHLLIQEADTTSHHLSVKNLETGKFILNEENHLDPNSRSFIAMGVEWEYRNED----ERETLQTI 810

  Fly   303 GPISESLFIVMLVQ-EKNISLDYEYSIPE-SLSHSQQDT-------HTWTHHQFNACSASCGGGS 358
            ||:..::.::::.: :..|||.|:|.|.| ||:....:.       |.|...:::.||..|||||
Mouse   811 GPLHGTITVLVIPEGDTRISLTYKYMIHEDSLNVDDNNVLEDDAVRHEWALKKWSPCSKPCGGGS 875

  Fly   359 QSRKVTCNNRITLAEVNPSLCDQKSKP-VEEQACGTEPCA-PHWVEGEWSKCSKGCGSDGFQNRS 421
            |..|..|..|:....|:.:.|...:|| ...:||..:.|: |.||.|||..|::.||..|.|.||
Mouse   876 QFTKYGCRRRLDSKMVHRAFCSALAKPKAIRRACNPQECSQPVWVTGEWEPCTQSCGRTGMQVRS 940

  Fly   422 ITCERISSSGEHTVEEDAVCLKEVG-NKPATKQECNRDVKNCP-KYHLGPWTPCDKLCGDGKQTR 484
            :.|  |.....:|..  :|..|... ::|.:::.|||::  || ::..|.|:.|...||:|.|.|
Mouse   941 VRC--IQPLHNNTTR--SVHTKHCNDHRPESRRACNREL--CPGRWRAGSWSQCSVTCGNGTQER 999

  Fly   485 KVTCFIEENGHKRVLPEEDCVEEKPETEKSCLLTPC--EGVD-----WIISQW---SGCNACGQN 539
            .|.|...::..      ..|.||:|||.:.|.|.||  .|.|     ::: ||   ...::..|.
Mouse  1000 PVLCRTADDNF------GVCREERPETARICRLAPCPRNGSDPSKKSYVV-QWLSRPDPDSPIQK 1057

  Fly   540 TETRTAICGNKEGKVYPEEFCEPEVPTLSRPCKSPK-----CEAQWFSSEWSKCSAP 591
            ..::....|:|      ..||..||  |||.|..|.     |::         |:.|
Mouse  1058 ISSKDQCQGDK------SMFCRMEV--LSRYCSIPSYNKLCCKS---------CNPP 1097

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559 22/54 (41%)
ADAM_spacer1 214..329 CDD:283607 28/117 (24%)
TSP1 468..521 CDD:214559 20/54 (37%)
TSP_1 645..693 CDD:278517
Kunitz_BPTI 1611..1663 CDD:278443
Kunitz_BPTI 1670..1721 CDD:278443
Kunitz_BPTI 1729..1781 CDD:278443
Kunitz_BPTI 1789..1840 CDD:278443
Kunitz_BPTI 1848..1899 CDD:278443
KU 1920..1973 CDD:238057
Kunitz_BPTI 2001..2051 CDD:278443
KU 2071..2121 CDD:238057
Kunitz_BPTI 2127..2178 CDD:278443
KU 2192..2245 CDD:238057
KU 2251..2304 CDD:238057
KU 2316..2372 CDD:238057
WAP 2457..2497 CDD:278522
Ig 2521..2610 CDD:299845
IG_like 2530..2610 CDD:214653
IG_like 2627..2703 CDD:214653
Ig 2636..2701 CDD:143165
IG_like 2766..2841 CDD:214653
Ig 2768..2830 CDD:299845
PLAC 2851..2883 CDD:285849
Adamts2NP_783574.1 Pep_M12B_propep 99..210 CDD:279848
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..232
ZnMc_ADAMTS_like 267..468 CDD:239801
Reprolysin 269..471 CDD:279729
TSP1 565..617 CDD:214559 22/54 (41%)
Cell attachment site. /evidence=ECO:0000255 692..694 0/1 (0%)
Spacer 723..851 33/131 (25%)
ADAM_spacer1 724..838 CDD:283607 28/117 (24%)
TSP1 864..915 CDD:214559 17/50 (34%)
TSP1 918..977 CDD:214559 21/64 (33%)
TSP1 983..1030 CDD:214559 19/52 (37%)
PLAC 1064..1094 CDD:285849 12/46 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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