DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and Thsd7b

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:XP_011246266.1 Gene:Thsd7b / 210417 MGIID:2443925 Length:1609 Species:Mus musculus


Alignment Length:897 Identity:192/897 - (21%)
Similarity:302/897 - (33%) Gaps:301/897 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 PGLRQKRQYGANMYLPESSVTPGGEGNDPDEWTPWSSPSDCSRTCGGGVSYQTRECLRRDDRGEA 93
            |..|.|.|..::..|...|:..|..|.              |..||.|:..:...|:..|::   
Mouse   796 PSYRWKPQKWSSCILVPESIRQGRTGT--------------SEACGKGLQTRAVSCISDDNQ--- 843

  Fly    94 VCSGGSRRYFSCNTQDCPEEESDF--RAQQCSRFDRQQFDGVFYEWVPYTNAPNPCELNCMPKGE 156
                      |....:|.::.:..  ..|:|:...|.  |..|..|..:|    ||..||    |
Mouse   844 ----------SAEMTECLKQMNGMPPLVQECTIPCRD--DCTFTPWSKFT----PCSKNC----E 888

  Fly   157 RFYYRQRE---KVVDGTRCNDKDLDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRN 218
            ....|:|:   |.....:|.|..|...|  |..|..||..:....         |:.|.|     
Mouse   889 ATQIRRRQLTGKSRKKEKCQDASLYPLV--EMEPCPCDTFMSHPY---------GNWSAC----- 937

  Fly   219 TITTKDLAPGYNDLLLLPEG------------------ATNIRIEETVPSSNYLACRNHSGHYYL 265
                           :||||                  ...:|...       :||.|      :
Mouse   938 ---------------ILPEGKRDAQQGGLWVQGDDKECGEGVRFRA-------IACSN------I 974

  Fly   266 NGDWRIDFPRPM--FFANSWWNYQRKPMGFAAPDQLTCS-------GPISESLFIVMLVQEK--- 318
            ||       ||:  .|.||....|.   ....|....|.       |..|.|..|.:.::.|   
Mouse   975 NG-------RPVDPSFCNSSGYIQE---ACVIPCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLK 1029

  Fly   319 -----------NISLDYEYSIPESL-SHSQQDTHTWTHHQFNAC-------SASCGGGSQSRKVT 364
                       .:.|..:..:.|:: .:|:.|.::|....::.|       |..||.|:|||::.
Mouse  1030 EKPYSGGRPCPKLDLKNQAQVHEAVPCYSECDQYSWVVEHWSPCKINNELRSPRCGRGTQSRRIR 1094

  Fly   365 CNNRITLAE-----VNPSLCDQKSKPVEEQACG----TEPCAPHWVEGEWSKCSKGCGSDGFQNR 420
            |   ::.|:     ||.|||:|...|.|.|||.    :|.....|  |.||:|.:.|.....|.|
Mouse  1095 C---VSTADREGGAVNRSLCNQDDAPQETQACSLLCPSECVMSEW--GTWSRCPQSCDPHAMQRR 1154

  Fly   421 SITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVKNC--PKYHLGPWTPC----DKLCGD 479
            :....|.|.:.....|:..|       :|....|      ||  .:|:|..|:.|    :..||.
Mouse  1155 TRHLLRPSLNSRTCGEDSQV-------RPCLLNE------NCFQFQYNLTEWSTCQLSENVSCGQ 1206

  Fly   480 GKQTRKVTCFIEENGHKRVLPEEDCVE---EKPETEK-SCL---LTPCEGVDWIISQWSGCN-AC 536
            |.:||.::| :..:|  :.:..:.|.:   |||:... .||   :..|:...|  :.|:.|: .|
Mouse  1207 GVRTRLLSC-VRSDG--KSVSMDHCEQRNLEKPQRMSIPCLVECVVNCQLSGW--TTWTECSQTC 1266

  Fly   537 GQN---TETRTAICGNK-EGKVYPEEFCEPEVPTLSRPCKSPKCEAQWFSSEWSKC---SAPCGK 594
            ||.   :.||..|...: ||:..|.|.      |..:||....|.: |....||.|   ...||:
Mouse  1267 GQGGRMSRTRFIIMPTQGEGRQCPTEL------TQQKPCPVTPCYS-WVLGNWSACKLEGGDCGE 1324

  Fly   595 GVKSRIVICGEFDGK---TVTPADDDSKCNKETKPES--EQDCEGEEKVCPGEWFTGPWGKCSK- 653
            ||:.|...|...:|.   |..|. :::.|.:....|.  :|.|   ...|||:....||.:.|| 
Mouse  1325 GVQVRSFSCVVHNGSISHTAVPV-EEALCGEVPFQEGILKQLC---SVPCPGDCHITPWSEWSKC 1385

  Fly   654 -----------------------------------------PCGGGE---RVREVLCLSNGTKSV 674
                                                     ||.||:   .:.:....:|..::|
Mouse  1386 ELTCIDGRSFETTGRQSRSRTFIIQSFENQDSCPQQVLETRPCTGGKCYHYIWKASLWNNNERTV 1450

  Fly   675 NCDEEKVEPLSEKCNSEA------------------CTEDEILPLTSTDKPIEDDEEDCDEDGIE 721
            .|.......::..|:.:|                  ||:..:.              .|::...|
Mouse  1451 WCQRSDGLNVTGGCSPQARPAAIRQCIPACKKPFSYCTQGGVC--------------GCEKGYTE 1501

  Fly   722 LI-SDGLSD--------DEKSEDVIDLEGTAKTETTPEAEDLMQSDSPTPYD 764
            :: |.|..|        ::|..||.:|.|..: ....:..|:.:..|..|.|
Mouse  1502 IMRSSGFLDYCMKVPGSEDKKADVKNLSGKNR-PVNSKIHDIFKGWSLQPLD 1552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559 7/50 (14%)
ADAM_spacer1 214..329 CDD:283607 24/155 (15%)
TSP1 468..521 CDD:214559 15/63 (24%)
TSP_1 645..693 CDD:278517 13/110 (12%)
Kunitz_BPTI 1611..1663 CDD:278443
Kunitz_BPTI 1670..1721 CDD:278443
Kunitz_BPTI 1729..1781 CDD:278443
Kunitz_BPTI 1789..1840 CDD:278443
Kunitz_BPTI 1848..1899 CDD:278443
KU 1920..1973 CDD:238057
Kunitz_BPTI 2001..2051 CDD:278443
KU 2071..2121 CDD:238057
Kunitz_BPTI 2127..2178 CDD:278443
KU 2192..2245 CDD:238057
KU 2251..2304 CDD:238057
KU 2316..2372 CDD:238057
WAP 2457..2497 CDD:278522
Ig 2521..2610 CDD:299845
IG_like 2530..2610 CDD:214653
IG_like 2627..2703 CDD:214653
Ig 2636..2701 CDD:143165
IG_like 2766..2841 CDD:214653
Ig 2768..2830 CDD:299845
PLAC 2851..2883 CDD:285849
Thsd7bXP_011246266.1 TSP1_ADAMTS 44..95 CDD:408800
TSP1_ADAMTS <137..176 CDD:408800
TSP1_spondin 180..229 CDD:408798
TSP1_spondin 337..398 CDD:408798
TSP1_spondin 602..660 CDD:408798
TSP1_ADAMTS 665..734 CDD:408800
TSP1_spondin 738..789 CDD:408798
TSP1_ADAMTS 1065..1125 CDD:408800 22/62 (35%)
TSP1_spondin 1131..1177 CDD:408798 12/54 (22%)
TSP1_spondin 1251..1304 CDD:408798 17/60 (28%)
TSP1_spondin 1374..1433 CDD:408798 8/58 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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