DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppn and Thsd4

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_001035516.2	Gene:	Thsd4 / 207596	MGIID:	2672033	Length:	1018	Species:	Mus musculus

Alignment Length:	719	Identity:	231/719 - (32%)
Similarity:	324/719 - (45%)	Gaps:	112/719 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 RGEAV-CSGGSRRYFSCNTQDCPEEESDFRAQQCSRFDRQQFDGVFYEWVPYTNAP--NPCELNC 151
            |..|: |.|..|:|..|||..|||.....|..||:.::.:.|.|.||||.|:....  ..|||||
Mouse   285 RSTAISCIGAYRQYKLCNTNACPESGRSIREVQCASYNNKPFMGRFYEWEPFAEVKGNRKCELNC 349

  Fly   152 MPKGERFYYRQREKVVDGTRCNDKDLDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTI 216
            ...|.|||.||.|||:|||.|:.....:||:|:|..:|||..||||...|||..||||.:.|:.:
Mouse   350 QATGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDFLGSDKVLDKCGVCGGDNTGCQVV 414

  Fly   217 RNTITTKDLAPGYNDLLLLPEGATNIRIEETVPSSNYLACRNHSGHYYLNGDWRIDFPRPMFFAN 281
            .........:.||:.::.:|:|||.|.|.|...|:||||.|:.||...:||:|.||.|.......
Mouse   415 SGVFKHALTSLGYHRVVEIPQGATKINITEMHKSNNYLALRSRSGRSIINGNWAIDRPGKYEGGG 479

  Fly   282 SWWNYQR-KPMGFAAPDQLTCSGPISESLFIVMLVQEKNISLDYEYSI----------------- 328
            :.:.|:| ..:...|.:.....||.:|.|.:.|:.|:.|..:.|||.|
Mouse   480 TMFTYKRPNEVSSTAGESFLAEGPTNEILDVYMIHQQPNPGVHYEYVIMRNNAISPQVPPHRRPG 544

  Fly   329 -------------------------------------------------PESLSHSQQDT----- 339
                                                             ||.....:.|.
Mouse   545 EPFNGQLEEEDRGQEDREEREKNQEKEDSQVEAPEVFTSESTQTFPVRHPERFPSHRPDNLVPPA 609

  Fly   340 ---------HTWTHHQFNACSASCGGGSQSRKVTCNNRITLAEVNPSLCDQKSKPV-EEQACGTE 394
                     |.|.......||.:||.|||.....|.:|.|..||..|.||...||. ||:.|...
Mouse   610 PQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRNTHEEVPESYCDSSMKPTPEEEPCNLF 674

  Fly   395 PCAPHWVEGEWSKCSKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDV 459
            ||...|..||||:|||.||. |.|:|.:.|.::.::...||:.......|   ||.|...|  .:
Mouse   675 PCPAFWDIGEWSECSKTCGL-GMQHRQVLCRQVYANRSLTVQPYRCQHLE---KPETTSTC--QL 733

  Fly   460 KNCPKYHL-GPWTPCDKLCGDGKQTRKVTCFIEENGHKRVLPEEDC-VEEKPETEKSCLLTPCEG 522
            |.|.::.: ..||.|...||.|::||.|.| :...|.  ::.:|:| ::.:|...::|.:.|| .
Mouse   734 KICSEWQIRTDWTSCSVPCGVGQRTRDVKC-VSNIGD--MVHDEECNMKLRPNDIENCDMGPC-A 794

  Fly   523 VDWIISQWS-GCNA-CGQNTETRTAICGNKEGKVYPEEFCEPEVPTLSRPCKSPKC--EAQWFSS 583
            ..|.:::|| .|:| ||....||:.:|........|.|.|....|..:.||.:..|  :.:||:.
Mouse   795 KSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPVEATPCDNGPCTGKVEWFTG 859

  Fly   584 EWSKCSAPCGKGVKSRIVICGEFDGKTVTPADDDSKCNKETKPESEQDCEGEEKVCPGEWFTGPW 648
            .||:||..||.|.:.|.|||...:..|.... |..:|:...||.|:|.|  ..|.|..:||:..|
Mouse   860 SWSQCSIECGSGTQQREVICVRKNADTFEVL-DPYECSFLEKPPSQQAC--HLKPCGAKWFSTEW 921

  Fly   649 GKCSKPCGGGERVREVLCLSNG-TKSVNCDEEKVEPLSEKCNSEACTEDEILPLTSTDKPIEDDE 712
            ..|||.|.||.|||||.|||:. |.|..||.:......|.||::.|..:       .|:..:|..
Mouse   922 SMCSKSCQGGFRVREVRCLSDDMTPSSLCDPQLKPEERESCNTQDCVPE-------VDENCKDKY 979

  Fly   713 EDCD 716
            .:|:
Mouse   980 YNCN 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	9/21 (43%)
		ADAM_spacer1	214..329	CDD:283607	37/181 (20%)
		TSP1	468..521	CDD:214559	16/53 (30%)
		TSP_1	645..693	CDD:278517	22/48 (46%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
Thsd4	NP_001035516.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..56
		TSP1	57..>81	CDD:214559
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..240
		ADAM_spacer1	412..528	CDD:368694	36/115 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	534..623		5/88 (6%)
		TSP1_ADAMTS	627..676	CDD:408800	20/48 (42%)
		TSP1_ADAMTS	680..736	CDD:408800	22/61 (36%)
		TSP1_ADAMTS	739..793	CDD:408800	15/56 (27%)
		TSP1_ADAMTS	797..850	CDD:408800	16/52 (31%)
		TSP1_ADAMTS	856..912	CDD:408800	22/58 (38%)
		TSP1_ADAMTS	916..967	CDD:408800	24/50 (48%)
		PLAC	975..1005	CDD:400844	2/9 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810