DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and Siglec1

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:XP_036015809.1 Gene:Siglec1 / 20612 MGIID:99668 Length:1719 Species:Mus musculus


Alignment Length:1293 Identity:239/1293 - (18%)
Similarity:379/1293 - (29%) Gaps:458/1293 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1848 ICEIPAEVGECANYVTS-WYYDTQDQACRQFYYGGCGGNENRFPTEESCLARCDRKPEPTTTTPA 1911
            |...||:| ..:|.:|: ||||...:.....:.|.....:.||......:...|.|         
Mouse    48 IFSYPADV-PVSNGITAIWYYDYSGKRQVVIHSGDPKLVDKRFRGRAELMGNMDHK--------- 102

  Fly  1912 TRPQPSRQDVCD---EEPAPGECSTWVLKWHFDRKIGACRQFYYGNCGGNGNRFETENDCQQRCL 1973
                     ||:   ::..|.:..|    ::|                    |||..:  ..|.|
Mouse   103 ---------VCNLLLKDLKPEDSGT----YNF--------------------RFEISD--SNRWL 132

  Fly  1974 SQEPPAPTPPRAPAPTRQPDPAPTVAQCSQPADPGQCDKWALHWNYNETEGRCQSFYYGGCGGND 2038
            ..:....|....|:|       ||:....:..:       .:..|:|     |.:.|.       
Mouse   133 DVKGTTVTVTTDPSP-------PTITIPEELRE-------GMERNFN-----CSTPYL------- 171

  Fly  2039 NRFATEEECSARCSVNIDIRIGADPVEHDTSKCFLAFEPGNCYNNVT-----RWFYNSAEGLCD- 2097
                    |.....|::..| |.||. |..:..|.:.||...|:..|     .|..:....||. 
Mouse   172 --------CLQEKQVSLQWR-GQDPT-HSVTSSFQSLEPTGVYHQTTLHMALSWQDHGRTLLCQF 226

  Fly  2098 ----------------------EFVYTGCGGNANNYATEEECQNECNDAQTTCALPPVR------ 2134
                                  |.:.:..|   .|....:.....|....:..|:..|:      
Mouse   227 SLGAHSSRKEVYLQVPHAPKGVEILLSSSG---RNILPGDPVTLTCRVNSSYPAVSAVQWARDGV 288

  Fly  2135 -----GRCSDLSRRWYFDERSGECHEFEFTGCRGNRNNFVSQSDCLNFCIGEPVVEPSAPTYS-- 2192
                 |....|....:.|..:..|.      ...:..:.||....|:..:.|..:.|:.|...  
Mouse   289 NLGVTGHVLRLFSAAWNDSGAYTCQ------ATNDMGSLVSSPLSLHVFMAEVKMNPAGPVLENE 347

  Fly  2193 ----VCAEPPEAGECDNRTTAWFYDSENMACTAFTYTGCGGNGNRFETRDQCERQCGEFKGVDVC 2253
                :|:.|.||.:  ....:|:                   .|.....|         ......
Mouse   348 TVTLLCSTPKEAPQ--ELRYSWY-------------------KNHILLED---------AHASTL 382

  Fly  2254 NEPVTTGPCTDWQTKYYFNTASQACEPFTYGGCDGTGN-----RFSDLFECQTVCLAGREPRVGS 2313
            :.|..|..    .|.:||      ||.....|.:.:..     |:..|....|..|..:...||.
Mouse   383 HLPAVTRA----DTGFYF------CEVQNAQGSERSSPLSVVVRYPPLTPDLTTFLETQAGLVGI 437

  Fly  2314 AK-EICLLPVATGRCNGPSVHERRWYYDDEAGNCVSFIYAG----CSGNQNNFR---SFEACTNQ 2370
            .. .:...|:||                      |...:.|    .:..:|:|.   ...:..|.
Mouse   438 LHCSVVSEPLAT----------------------VVLSHGGLTLASNSGENDFNPRFRISSAPNS 480

  Fly  2371 CRPE-PNKQDNEIGQNPC---DTFDAECQELRCPYGVRRVAARSQPECTQCICENPCEGYSCPEG 2431
            .|.| .:.|..:.|:..|   ::.......|.....|.|:......|    :.|......||..|
Mouse   481 LRLEIRDLQPADSGEYTCLAVNSLGNSTSSLDFYANVARLLINPSAE----VVEGQAVTLSCRSG 541

  Fly  2432 QQCAIDVASSDDRQFAPVCRDIYKPGE-----------CPALSANASGCARECYTDADCRGDNKC 2485
                  ::.:.|.:|:     .|..|.           .||.|:..:| :..|.|.|   |.|  
Mouse   542 ------LSPAPDTRFS-----WYLNGALLLEGSSSSLLLPAASSTDAG-SYYCRTQA---GPN-- 589

  Fly  2486 CSDGCGQLCVHPARPT-----QPPRTQAPVVSYPGDARAALEPKEAHELDVQTA---IGGIAVLR 2542
             :.|       |:.||     .|||                :|.....||:.|:   .|...:|.
Mouse   590 -TSG-------PSLPTVLTVFYPPR----------------KPTFTARLDLDTSGVGDGRRGILL 630

  Fly  2543 CFATGNPAPNITWSLKNLVINTN--------KGRYVLTANGDLTIVQVRQ---TDDGTYVCVASN 2596
            |....:|...:....|..|:.|:        ..|..::...:...|::::   .|:|.|:|.|||
Mouse   631 CHVDSDPPAQLRLLHKGHVVATSLPSRCGSCSQRTKVSRTSNSLHVEIQKPVLEDEGVYLCEASN 695

  Fly  2597 GLGEP--------------------------------VRREVALQVT------------------ 2611
            .||..                                |.:|||:...                  
Mouse   696 TLGNSSAAASFNAKATVLVITPSNTLREGTEANLTCNVNQEVAVSPANFSWFRNGVLWTQGSLET 760

  Fly  2612 ---EPVSQ-PAYIYGDKNVTQI-VELNRP-------------------------AVIRCPAGGFP 2646
               :||:: .|.:|..:.:|:. .:|:.|                         ||..|....:|
Mouse   761 VRLQPVARTDAAVYACRLLTEDGAQLSAPVVLSVLYAPDPPKLSALLDVGQGHMAVFICTVDSYP 825

  Fly  2647 EPHVSWWRNGQMFGLKNNLMARDYS-------LVFNSIQLS-------DLGLYTCEVYNQRRPVS 2697
            ..|:|.:|...:  |..||..:..|       ...||:||.       |.|.|.||..|.....:
Mouse   826 LAHLSLFRGDHL--LATNLEPQRPSHGRIQAKATANSLQLEVRELGLVDSGNYHCEATNILGSAN 888

  Fly  2698 LRVTLKAVG---PVRPLSPEEEQYMQYVLN-PATRPVTQRPSYP-YRPTRPAYVPEPTVNVHAVL 2757
            ..:..:..|   .|.| |||..:....||: .....|::..||. |:..||  :.|.|.:...:.
Mouse   889 SSLFFQVRGAWVQVSP-SPELREGQAVVLSCQVPTGVSEGTSYSWYQDGRP--LQESTSSTLRIA 950

  Fly  2758 ALEPKN--------------------------SYTPGSTIV-------------MSCSVQGYPEP 2783
            |:..:.                          ||||....:             :.||||..|..
Mouse   951 AISLRQAGAYHCQAQAPDTAIASLAAPVSLHVSYTPRHVTLSALLSTDPERLGHLVCSVQSDPPA 1015

  Fly  2784 NV-----------TWIKDDVPLYNNERVQITYQPH--RLVLSDVTSADSGKYTCRASNAYTYANG 2835
            .:           |....|....:|.|:.:|..|:  ||.:......|.|.|||.|||....|:.
Mouse  1016 QLQLFHRNRLVASTLQGADELAGSNPRLHVTVLPNELRLQIHFPELEDDGTYTCEASNTLGQASA 1080

  Fly  2836 EANVSIQSV-VPVSPEC-VDNPYFANCKLIVKGRYCSNPYYTQF-------CCRSCTL 2884
            .|:...|:| |.|.|.. |......|...:|...:..:..||.:       ..||.||
Mouse  1081 AADFDAQAVRVTVWPNATVQEGQQVNLTCLVWSTHQDSLSYTWYKGGQQLLGARSITL 1138

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559
ADAM_spacer1 214..329 CDD:283607
TSP1 468..521 CDD:214559
TSP_1 645..693 CDD:278517
Kunitz_BPTI 1611..1663 CDD:278443
Kunitz_BPTI 1670..1721 CDD:278443
Kunitz_BPTI 1729..1781 CDD:278443
Kunitz_BPTI 1789..1840 CDD:278443
Kunitz_BPTI 1848..1899 CDD:278443 13/51 (25%)
KU 1920..1973 CDD:238057 9/55 (16%)
Kunitz_BPTI 2001..2051 CDD:278443 5/49 (10%)
KU 2071..2121 CDD:238057 11/77 (14%)
Kunitz_BPTI 2127..2178 CDD:278443 9/61 (15%)
KU 2192..2245 CDD:238057 7/58 (12%)
KU 2251..2304 CDD:238057 11/57 (19%)
KU 2316..2372 CDD:238057 8/62 (13%)
WAP 2457..2497 CDD:278522 11/50 (22%)
Ig 2521..2610 CDD:299845 26/134 (19%)
IG_like 2530..2610 CDD:214653 24/125 (19%)
IG_like 2627..2703 CDD:214653 24/115 (21%)
Ig 2636..2701 CDD:143165 21/78 (27%)
IG_like 2766..2841 CDD:214653 25/100 (25%)
Ig 2768..2830 CDD:299845 21/87 (24%)
PLAC 2851..2883 CDD:285849 7/39 (18%)
Siglec1XP_036015809.1 IgV_CD33 27..134 CDD:409377 25/130 (19%)
Ig strand B 43..47 CDD:409377
Ig strand C 62..66 CDD:409377 1/3 (33%)
Ig strand E 104..108 CDD:409377 1/3 (33%)
Ig strand F 118..123 CDD:409377 2/28 (7%)
C2-set_2 148..235 CDD:400489 21/115 (18%)
Ig strand A 148..153 CDD:409353 2/4 (50%)
Ig strand B 161..169 CDD:409353 3/12 (25%)
Ig strand C 178..184 CDD:409353 2/6 (33%)
Ig strand D 193..199 CDD:409353 1/5 (20%)
Ig strand E 203..212 CDD:409353 2/8 (25%)
Ig strand G 231..239 CDD:409353 0/7 (0%)
Ig strand A 245..253 CDD:409353 1/7 (14%)
Ig strand A' 257..261 CDD:409353 1/3 (33%)
IGc2 261..319 CDD:197706 7/63 (11%)
Ig strand B 262..272 CDD:409353 1/9 (11%)
Ig strand C 279..285 CDD:409353 1/5 (20%)
Ig strand C' 287..290 CDD:409353 0/2 (0%)
Ig strand E 296..301 CDD:409353 1/4 (25%)
Ig strand F 308..316 CDD:409353 1/13 (8%)
Ig strand G 319..330 CDD:409353 3/10 (30%)
Ig 334..417 CDD:416386 18/122 (15%)
Ig strand A' 342..345 CDD:409353 1/2 (50%)
Ig strand B 346..356 CDD:409353 1/9 (11%)
Ig strand C 363..369 CDD:409353 1/24 (4%)
Ig strand C' 371..374 CDD:409353 0/2 (0%)
Ig strand E 380..386 CDD:409353 0/5 (0%)
Ig strand F 393..401 CDD:409353 4/13 (31%)
Ig strand G 404..417 CDD:409353 1/12 (8%)
Ig strand A' 412..415 CDD:409353 0/2 (0%)
Ig 428..511 CDD:416386 16/104 (15%)
Ig strand B 436..443 CDD:409353 1/6 (17%)
Ig strand C 449..454 CDD:409353 2/26 (8%)
Ig strand C' 456..458 CDD:409353 1/1 (100%)
Ig strand D 471..477 CDD:409353 0/5 (0%)
Ig strand E 480..486 CDD:409353 2/5 (40%)
Ig strand F 494..502 CDD:409353 2/7 (29%)
Ig_3 523..583 CDD:404760 13/75 (17%)
IG 624..702 CDD:214652 18/77 (23%)
Ig_3 712..777 CDD:404760 8/64 (13%)
Ig strand A' 720..723 CDD:409353 0/2 (0%)
Ig strand B 724..734 CDD:409353 0/9 (0%)
Ig strand C 742..748 CDD:409353 0/5 (0%)
Ig strand C' 750..753 CDD:409353 0/2 (0%)
Ig strand E 759..765 CDD:409353 0/5 (0%)
Ig strand F 772..780 CDD:409353 1/7 (14%)
Ig strand G 783..796 CDD:409353 2/12 (17%)
Ig 815..895 CDD:416386 21/81 (26%)
Ig strand B 815..819 CDD:409353 2/3 (67%)
Ig strand C 828..832 CDD:409353 2/3 (67%)
Ig strand E 861..865 CDD:409353 2/3 (67%)
Ig strand F 875..880 CDD:409353 2/4 (50%)
Ig 900..975 CDD:416386 16/77 (21%)
Ig strand A' 907..910 CDD:409353 1/2 (50%)
Ig strand B 911..921 CDD:409353 2/9 (22%)
Ig strand C 928..934 CDD:409353 2/5 (40%)
Ig strand C' 936..939 CDD:409353 2/4 (50%)
Ig strand E 945..951 CDD:409353 0/5 (0%)
Ig strand F 958..968 CDD:409353 0/9 (0%)
Ig strand G 971..984 CDD:409353 0/12 (0%)
IG_like 1005..1093 CDD:214653 26/87 (30%)
Ig strand C 1026..1031 CDD:409353 1/4 (25%)
Ig strand C' 1033..1035 CDD:409353 0/1 (0%)
Ig strand D 1042..1048 CDD:409353 2/5 (40%)
Ig strand E 1051..1057 CDD:409353 2/5 (40%)
Ig strand F 1065..1073 CDD:409353 5/7 (71%)
Ig_2 1095..1167 CDD:404734 10/44 (23%)
Ig strand A' 1095..1100 CDD:409353 1/4 (25%)
Ig strand B 1105..1114 CDD:409353 2/8 (25%)
Ig strand C 1121..1126 CDD:409353 2/4 (50%)
Ig strand C' 1128..1131 CDD:409353 0/2 (0%)
Ig strand E 1133..1138 CDD:409353 2/4 (50%)
Ig strand F 1148..1156 CDD:409353
Ig strand G 1160..1170 CDD:409353
IG_like 1195..1258 CDD:214653
Ig strand C 1204..1208 CDD:409353
Ig strand E 1226..1230 CDD:409353
Ig strand F 1240..1245 CDD:409353
Ig 1265..1344 CDD:416386
Ig strand A' 1271..1274 CDD:409353
Ig strand B 1278..1284 CDD:409353
Ig strand C 1294..1299 CDD:409353
Ig strand C' 1301..1303 CDD:409353
Ig strand E 1309..1314 CDD:409353
Ig strand F 1322..1327 CDD:409353
Ig strand G 1338..1344 CDD:409353
Ig <1365..1440 CDD:416386
Ig strand B 1365..1372 CDD:409353
Ig strand C 1378..1383 CDD:409353
Ig strand C' 1386..1388 CDD:409353
Ig strand D 1394..1407 CDD:409353
Ig strand E 1409..1415 CDD:409353
Ig strand F 1424..1432 CDD:409353
Ig_3 1450..1517 CDD:404760
Ig strand B 1555..1561 CDD:409353
Ig <1556..1630 CDD:416386
Ig strand C 1566..1571 CDD:409353
Ig strand C' 1573..1575 CDD:409353
Ig strand D 1592..1596 CDD:409353
Ig strand E 1599..1603 CDD:409353
Ig strand F 1613..1621 CDD:409353
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4475
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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