DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppn and W05B2.2

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_499406.2	Gene:	W05B2.2 / 189208	WormBaseID:	WBGene00012271	Length:	1278	Species:	Caenorhabditis elegans

Alignment Length:	1147	Identity:	267/1147 - (23%)
Similarity:	374/1147 - (32%)	Gaps:	378/1147 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1541 TFAKGPHHHGCHCTQTEFKCCDDEKTPAKGPNGDGCT----CVESK--FGCCPDGVTKATDEKFG 1599
            ||...|...|.|  |...:...|.|     ..|:.||    ||...  .|.|
Worm    21 TFGTIPLSEGLH--QIYARNAADLK-----KFGENCTRNTECVSEAICLGTC------------- 65

  Fly  1600 GCENVQEPPQKACGLPKETGTCNNYSVKYYFDTSYGGCARFW-YGGCDGNDNRFESEAEC--KDT 1661
            .|::...|.::.|....|.|     :|...||..   |...| ...|.      ..:.||  ::|
Worm    66 RCKSTHVPVEEQCWKKIEPG-----NVGCTFDEQ---CEGVWPMTRCQ------NGQCECSEEET 116

  Fly  1662 CQDYTGKHVCLLPKS-----------------AGPCTGFTKKWYFDVDRNRCEEFQYGGCYGTNN 1709
            ..:....:||:|..:                 ...|..||.|    .|:|   ..|:.||    :
Worm   117 LIETPEGNVCVLEGNCPTNNVNGALYDRATHRVSTCLTFTSK----KDKN---TQQFIGC----D 170

  Fly  1710 RFDSLEQC-QGTCAASENLPTCEQPVESGPC--AGNF----ERWYYDNETDICRPFTYGGCKGNK 1767
            .:..:..| .|||..:..: ||.||:.:|..  ||..    |||:|.:.|..|.||.|.|..||.
Worm   171 EYPEVYDCIGGTCCPTRGM-TCIQPLNTGDTKDAGAVVVADERWWYSSVTGKCIPFKYTGQGGNS 234

  Fly  1768 NNYPTEHACNYNCRQPGVLKDRCA----------LPKQTGDCSEKLAKWHFSESEKRCVP---FY 1819
            ||:.|:..|...|      ..||.          :|..|   ...:.|.|.| ..:.|.|   |.
Worm   235 NNFLTQWQCESYC------GGRCTRGDPLPFDDPIPTTT---DNHICKTHES-GRQLCCPTPTFI 289

  Fly  1820 YSGCGGNKNNFPTLESCEDHCPRQVAKDICEIPAEVGECANYVTSWYYDTQDQACRQFYYGGCGG 1884
            .|..||...:..|:.......||:              .|:.:..||:||.|..||.|.|.|.||
Worm   290 CSSLGGVNVDKTTMRPFSSGSPRR--------------GADTIQRWYWDTNDLTCRTFKYHGQGG 340

  Fly  1885 NENRFPTEESCLARCDRKPEPTTTTPATRPQPSRQDVCDEEPAPGECSTWVLKWHFDRKIGACRQ 1949
            |.|.|..::.||                       |.|.|:    .||
Worm   341 NFNNFGDKQGCL-----------------------DFCTEK----LCS----------------- 361

  Fly  1950 FYYGNCGGNGNRFETENDCQQRCLSQEPPAPTPPRAPAPTRQPDPAPTVAQCSQPADPGQCDKWA 2014
                    :|:.....:|..|||..:| ..|...........|.||.|..|..:..|..:..:..
Worm   362 --------HGSPLNDPSDNVQRCSGKE-HCPETHDCKNTVCCPKPAATCLQQLRTRDNCEQGETV 417

  Fly  2015 LHWNYNETEGRCQSFYYGGCGGNDNRFATEEECSARCSVNIDIRIGADPVEHDTSKCFLAFEPGN 2079
            ..|.|:.....|:|.....|...||:|.:.|||.:.||     .:.|.|      ||.:    |.
Worm   418 TKWTYSTEHNMCKSVLASRCLKGDNQFDSIEECQSVCS-----SVQAQP------KCPI----GR 467

  Fly  2080 CYNNVTRWFYN-SAEGLCD---EFVYTGCGGNANNYATEEEC----QNECN---DAQTTCALPPV 2133
            .|....:.... |:...|.   |.||||         |...|    :..||   ...|||.|..:
Worm   468 AYKGSNQVVLRCSSAKRCPSNYECVYTG---------TMHACCPSRELTCNQGLQVGTTCGLSTL 523

  Fly  2134 RGRCSDLSRRWYFDERSGECHEFEFTGCRGNRNNFVSQSDCLNFCI-------GEPVVE------ 2185
                    :|||:|.....|::||:.||.||.||||::.||:..|.       |:.:::
Worm   524 --------QRWYYDPLHNRCNQFEYQGCNGNDNNFVTRVDCIETCHRSDCPDGGDALIDSSNGRI 580

  Fly  2186 ---------PSAPT-----YS-----------VCAEPPEAG-ECDNRTTAWFYDSENMACTAFTY 2224
                     ||..|     ||           :|:.....| .|...:..:::|:....|..|||
Worm   581 IACERNDDCPSTHTCTRQLYSNRTSCCPSRKWICSHDANEGISCGTPSKRFYFDANTETCHQFTY 645

  Fly  2225 TGCGGNGNRFETRDQCERQC---------------------------------------GEFKGV 2250
            .||.||.|.|..|..|.:.|                                       .|.|.|
Worm   646 LGCAGNANSFSNRVACYQFCQSASCSSSEVIYQPSNLDEPFDCSLKTCPRHFSCVKSVWDETKNV 710

  Fly  2251 DVCNEPVTTGPCTDWQTKYYFNTASQ--ACEPFTYGGCD-GTGNRFSDL----FECQTV-----C 2303
             .|..| ..|.|:..|......:..|  .|.|.:...|. |....:|.:    |.|:.:     |
Worm   711 -CCGSP-NFGVCSSTQHPMLLFSTQQPMTCTPNSQNSCPLGFQCTYSSIRMLYFCCRDIVRIDKC 773

  Fly  2304 LAG---------REPRVGSAKEICLLPVATGRCNGPSVHERRWYYDDEAGNCVSFIYAGC----- 2354
            |.|         .|||..|....|   .:|..|..|:..        .:|.|.:.|...|
Worm   774 LQGSRPEIWQSTAEPRACSRDAQC---PSTTSCYAPTPF--------SSGLCCASIDEVCPATFI 827

  Fly  2355 -----SGNQNNFRSFEACTNQCRPEPNKQDNEIGQNPCDTFDAECQELRCPYGVRRVAARSQ--- 2411
                 |||:           ||.|.......:.||:.|...|.:.:.:.|....|::.|.::
Worm   828 YEEEKSGNE-----------QCSPLEKNTCGQDGQSVCLYSDVKARFVCCRREARQIQALAKCPP 881

  Fly  2412 ---PECTQCIC--ENPCE-------------GYSC--PEGQQCAIDVASSDDRQFAPVCRDIYKP 2456
               .|.|:..|  ||||:             |..|  |..::    |.....|:...|.|.....
Worm   882 GSIVELTKTYCDPENPCQKTHFCMKKSTDRKGICCRHPSLKR----VMPLRTRKLGVVSRKQTPR 942

  Fly  2457 GECP----ALSANASGCARECYTDADCRGDNKCCSDGCGQLC 2494
            ..||    .|..|  |...:|.|..||...:||.:.|...:|
Worm   943 YRCPKGDKVLKLN--GDVFQCTTTDDCPEFHKCTAQGSVSIC 982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559
		ADAM_spacer1	214..329	CDD:283607
		TSP1	468..521	CDD:214559
		TSP_1	645..693	CDD:278517
		Kunitz_BPTI	1611..1663	CDD:278443	12/54 (22%)
		Kunitz_BPTI	1670..1721	CDD:278443	14/68 (21%)
		Kunitz_BPTI	1729..1781	CDD:278443	23/57 (40%)
		Kunitz_BPTI	1789..1840	CDD:278443	14/63 (22%)
		Kunitz_BPTI	1848..1899	CDD:278443	18/50 (36%)
		KU	1920..1973	CDD:238057	9/52 (17%)
		Kunitz_BPTI	2001..2051	CDD:278443	12/49 (24%)
		KU	2071..2121	CDD:238057	12/57 (21%)
		Kunitz_BPTI	2127..2178	CDD:278443	20/50 (40%)
		KU	2192..2245	CDD:238057	18/103 (17%)
		KU	2251..2304	CDD:238057	13/64 (20%)
		KU	2316..2372	CDD:238057	12/65 (18%)
		WAP	2457..2497	CDD:278522	13/42 (31%)
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
W05B2.2	NP_499406.2	EB	67..118	CDD:279949	14/64 (22%)
		Kunitz_BPTI	190..248	CDD:278443	24/63 (38%)
		KU	305..355	CDD:197529	21/86 (24%)
		Kunitz_BPTI	507..560	CDD:278443	23/60 (38%)
		KU	613..665	CDD:197529	16/51 (31%)
		EB	1210..1262	CDD:279949
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810