DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and T22F7.3

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_497207.4 Gene:T22F7.3 / 188757 WormBaseID:WBGene00020702 Length:1517 Species:Caenorhabditis elegans


Alignment Length:1763 Identity:361/1763 - (20%)
Similarity:547/1763 - (31%) Gaps:617/1763 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1423 GEGCSGCTR-ERFGCCPDSQTPAHGPNKEGCCLD---TQFGCCPDNI------------------ 1465
            |:.|:...| ..:.|..|::...:.|:|...|:|   .||.|...|:                  
 Worm    41 GQPCNNFDRLPVYTCNNDTKKVNYTPSKYFMCIDGEVIQFDCSHRNMPPAVFNQITRECVQEETT 105

  Fly  1466 -------LAARGPNNEGCECHYTPYGCCPDNKSAATGYNQEGCACETTQYGCCPDKITAAK---- 1519
                   .|..|.:..|..|::.. .|            |.|..|......|..|.::.::    
 Worm   106 DNHIRRRRATTGSSRVGDVCNFNT-DC------------QRGMFCGGGVCSCLSDFVSISQHCWP 157

  Fly  1520 --GPKHEGC----PCETTQFG--CCPDGLTFAKGPHHHGCHCTQTEFKCCDDEKTPAKGPNGDGC 1576
              .|...||    .||....|  |...||          |.|.:        |..|::  ..||.
 Worm   158 KVNPGESGCVENRQCEAVWPGTICTSAGL----------CECPK--------ETVPSR--TRDGT 202

  Fly  1577 TCVESKF-GCCPDGVTKATDEKFGGCENVQEPPQKACGLPKETGT-----CNNYSVKYYFDTSYG 1635
            .|:.|.. ..||      ..|...|..|...........|...|.     ||:.|.:  ..||.|
 Worm   203 VCISSAIPPACP------LPEAHNGNPNPATVLANPSTHPLNPGNYMPVLCNSLSSE--VRTSNG 259

  Fly  1636 GCARFWYGGCDGNDNRFESEA-EC-------KDTCQDYTGK----------HVCLLPKSAG--PC 1680
            |....|....||..:.|.::. .|       .|...:|:.|          .||:.|..:|  |.
 Worm   260 GDGSTWCVYPDGEQDVFIADTYNCISHPQVNNDLFNEYSEKVDGICCHNRAFVCIQPLESGDEPS 324

  Fly  1681 TGFTKKWYFDVDRNRCEEFQYGGCYGTN---NRFDSLEQCQGTCAASENLPTCEQPVESGPCAGN 1742
               ..:|:::.....|.:|.:.....||   |.|.:.|.|:..|.     .||.:....      
 Worm   325 ---VPRWWYNSATGTCVQFMWDPDTITNASPNNFRTAEHCESYCR-----DTCRRGAPE------ 375

  Fly  1743 FERWYYDNETDICRPFTYGGCKGNKNNYPTEHAC-------------NYNCRQPGVLKDRCAL-- 1792
                :..::..|........|..:.:....||.|             ::.|...|   .|..|  
 Worm   376 ----FASSKFSILDEVPRTNCLASTSRCDQEHQCTLIGSQQTCCPTASHICSANG---GRMLLTK 433

  Fly  1793 PKQTGDCSEKLA------KWHFSESEKRCVPFYYSGCGGNKNNFPTLESCEDHCPRQVAKDICE- 1850
            |.:..|...::|      ::::...:.|||.|.|.|. ||.|||.|.:.||..|    :|.:|| 
 Worm   434 PPENYDRGLQIAGHKAVTRYYYDIDQGRCVNFLYHGL-GNYNNFLTKQDCESFC----SKLVCEN 493

  Fly  1851 -IPAEVGECANYVTSWYYDTQDQACRQFYYGGCGGNENRFPTEESCLAR----CDRKPEPTTTTP 1910
             .|..:||      .|      |.|..  ...|       |:..||...    |           
 Worm   494 GNPLRIGE------EW------QRCET--NADC-------PSSHSCQGSHKVCC----------- 526

  Fly  1911 ATRPQPSRQDVCDEEPAPGECSTWVLKWHFDRKIGACRQFYYGNCGGNGNRFETENDCQQRCLSQ 1975
                 |:.|.:|.:....|:|::.|.::.::....:|..|.|..|.||.|.|.|...|||:|.. 
 Worm   527 -----PTAQSLCTQPKRLGDCTSAVRRYWYNAATRSCEMFQYTGCQGNDNNFNTLMACQQKCRG- 585

  Fly  1976 EPPAPTPPRAPAPTRQPDPAPTVAQCSQPADPGQCDKWALHWNY-----NETEGRCQSFYYGGCG 2035
               ....|:........|......|||...:..:|..     ||     ..|.|.|.:..:    
 Worm   586 ---IHVEPKCQHGRAFRDRNGNFQQCSDKQNGPKCPV-----NYVCSFDGTTHGCCPTKAF---- 638

  Fly  2036 GNDNRFATEEECSARCSVNID--IRIGADPVEHDTSKCFLAFEPGNCYNNVTRWFYNSAEGLCDE 2098
                          .||:|.|  ::.|:                |..|    |:::||.:..|:.
 Worm   639 --------------TCSLNPDKGVQCGS----------------GRSY----RYYFNSNKQSCES 669

  Fly  2099 FVYTGCGGNANNYATEEECQNECN----------------------------------------- 2122
            |.|.||.|||||:.|.|:||:.|.                                         
 Worm   670 FQYEGCDGNANNFLTSEDCQHYCGVGGCPNGGMPLRDEATNKPMSCSEQKSCPSTHECLTIPVNG 734

  Fly  2123 --------DAQTTCALPPVRG-RCSDLS-RRWYFDERSGECHEFEFTGCRGNRNNFVSQSDCLNF 2177
                    ..|..|:.||.:| .||.:| .|:||:..:.||..|::.||.||.|||.:||:|.||
 Worm   735 HVGSRCCPTKQHICSQPPQQGNHCSKISVGRFYFNIVTRECATFQYNGCNGNLNNFATQSECNNF 799

  Fly  2178 C------IGEPVVEPSAPTYSVCAEPPEAGECD----NRTTAWFYDSENMACTAFTYTG------ 2226
            |      :||...:.        ....:|.:|:    |...|.|....|...:|:...|      
 Worm   800 CSSAGCAVGEVAYKD--------VNTKKAFDCNNVLINSCPANFQCRFNSLTSAYVCCGSTSMDV 856

  Fly  2227 CGGNGNRF-ETRDQCERQCGEFKGVDVCNEPVTTGPC-TDW-------QTKYYFNTASQACEPFT 2282
            |......| .:.|:..|:|       ..|.|   |.| :|:       :.:||      .|.|.|
 Worm   857 CPSEERAFINSLDETVREC-------AINVP---GSCPSDFLCRFNAQRNRYY------CCAPTT 905

  Fly  2283 YGGC-DG------------------TGNRFSDLFECQT---------------VCLAGRE----- 2308
            ...| ||                  ..|..||.:.||:               ||....|     
 Worm   906 ENVCPDGRALFRAKKTLLPVRCTLNNANTCSDGYSCQSRSKNVLQGFCCSARNVCKGDSEFLMDE 970

  Fly  2309 ----PRVGSAKEICLLPVATGRCN--GPSVHERRWYYDDEAGNCVSFIYAGCSGNQNNFRSFEAC 2367
                ||:.:.......||.. ||:  .||.         .:|.|       |.|..|      |.
 Worm   971 KSKMPRICTPGAFISCPVGY-RCHKQTPSA---------MSGFC-------CRGEIN------AI 1012

  Fly  2368 TNQCRP--------------EPNKQDNE-------------------IGQNPCDTFDAECQELRC 2399
            :..|.|              :|...:|:                   .|::|.:..:.|.:||.|
 Worm  1013 SEGCPPGEYAYAKKNEVVACDPFNPENKGCPATFSCQFAVAFQRYQCCGKDPIEEDEIEQEELGC 1077

  Fly  2400 PYGVRRVAARSQP-ECTQCICENPCEGYSCPEGQQCAIDVASSDDRQFAPVCRDIYKPGECPA-- 2461
            |:....:.....| .||       ..|.|||.|..|..   |..::|| ..|.  :|.| ||.  
 Worm  1078 PHSQVALVNNDHPVVCT-------ASGASCPTGYFCQF---SDRNKQF-QCCG--HKAG-CPGDS 1128

  Fly  2462 -----LSANASGCA---RECYTDADCR----GDNKCCS------------DGCGQLCVHPARP-- 2500
                 |:..|..|:   |.|.....|:    |...||:            :|...:.:.|..|  
 Worm  1129 VAYLDLTGGAQECSVKLRNCPEGYSCQNSKGGKTICCTARIGGRDRPMIGEGSSNITIAPGAPET 1193

  Fly  2501 ---TQPPRTQAPVVSYPGDARAALEPKEA----HELDVQTAIGGIAVLRCFATGNPAPNITWSLK 2558
               |.||.|.:|.|:..|:...:|.|.:.    .|..|:.|:|.:.:|....|            
 Worm  1194 PGATVPPPTMSPSVTSGGNPGKSLCPPDTALINGECKVRGAVGSVCLLSSQCT------------ 1246

  Fly  2559 NLVINTNKGRYVLTANGDLTIVQVRQTDDGTYVCVASNGLGEPVRREVALQVTEPVSQPAYIYGD 2623
                           :|...:.|         :|.......|...|.:.:...|.|         
 Worm  1247 ---------------SGAECVGQ---------MCACGKKFREQDGRCIQVDTDEVV--------- 1278

  Fly  2624 KNVTQIVELNRPAVIRCPAGGFPEPHVSWWRNGQMFGLKNNLMARDYSLVFNSIQLSDLGLYTCE 2688
            |.|....|:.||.:..|                     |.|.:.:      ||..|....:....
 Worm  1279 KEVVVAKEVIRPVLAGC---------------------KENQVEK------NSACLDKSAIGAAC 1316

  Fly  2689 VYNQRRPVSLRVTLKAVGPVRPLSPEEEQYMQYV-LNPATRPVTQRPSYPYRPTRPAYVPEPTVN 2752
            ..:::.|.....||.........||.:::.:..: :..|.|.......|..........|:|:..
 Worm  1317 TADEQCPNGTVCTLMMCKCAHGSSPYKDRCLNNINICEAPRQPVISSDYTLIQCAKQKCPKPSAC 1381

  Fly  2753 VHAVLALEPKNSYTPGST----------------IVMSCSVQGYP-EPNVTWIKDDVPLYN--NE 2798
            |::.:.    .||...|:                ||....:.|.| ......:|..:..|.  :.
 Worm  1382 VYSKMI----QSYVCCSSAPVTLSKPIAPPVVGRIVKGGRIVGAPATTGAVIVKPHLAKYTCPDG 1442

  Fly  2799 RVQITYQPHR--LVLSDVTSADSGKYTC---------RASNAYTYANGEANVSIQSVVPVSPECV 2852
            ||.:.:..:.  ||.:.|.....| :||         |...:.:...|...|.........|:| 
 Worm  1443 RVPMLFPQNNMPLVCNPVKGCPQG-HTCINKMCCPNGRVKRSESCPRGYLMVERGGEAQCEPQC- 1505

  Fly  2853 DNPYFANC 2860
              |::|.|
 Worm  1506 --PWYAPC 1511

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559
ADAM_spacer1 214..329 CDD:283607
TSP1 468..521 CDD:214559
TSP_1 645..693 CDD:278517
Kunitz_BPTI 1611..1663 CDD:278443 15/64 (23%)
Kunitz_BPTI 1670..1721 CDD:278443 14/55 (25%)
Kunitz_BPTI 1729..1781 CDD:278443 7/64 (11%)
Kunitz_BPTI 1789..1840 CDD:278443 19/58 (33%)
Kunitz_BPTI 1848..1899 CDD:278443 12/56 (21%)
KU 1920..1973 CDD:238057 16/52 (31%)
Kunitz_BPTI 2001..2051 CDD:278443 8/54 (15%)
KU 2071..2121 CDD:238057 19/49 (39%)
Kunitz_BPTI 2127..2178 CDD:278443 24/52 (46%)
KU 2192..2245 CDD:238057 12/63 (19%)
KU 2251..2304 CDD:238057 19/94 (20%)
KU 2316..2372 CDD:238057 12/57 (21%)
WAP 2457..2497 CDD:278522 13/65 (20%)
Ig 2521..2610 CDD:299845 13/92 (14%)
IG_like 2530..2610 CDD:214653 10/79 (13%)
IG_like 2627..2703 CDD:214653 11/75 (15%)
Ig 2636..2701 CDD:143165 7/64 (11%)
IG_like 2766..2841 CDD:214653 18/104 (17%)
Ig 2768..2830 CDD:299845 16/91 (18%)
PLAC 2851..2883 CDD:285849 4/10 (40%)
T22F7.3NP_497207.4 EB 144..199 CDD:396311 15/74 (20%)
KU 311..365 CDD:197529 14/56 (25%)
KU <450..486 CDD:197529 14/36 (39%)
Kunitz_BPTI 533..584 CDD:394972 16/50 (32%)
Kunitz_BPTI 639..693 CDD:394972 24/73 (33%)
Kunitz_BPTI 747..800 CDD:394972 24/52 (46%)
Lustrin_cystein 1077..1118 CDD:405330 14/51 (27%)
EB 1218..1269 CDD:396311 11/86 (13%)
EB 1295..1346 CDD:396311 11/77 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4295
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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