DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and mec-1

DIOPT Version :10

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_741559.3 Gene:mec-1 / 188259 WormBaseID:WBGene00003165 Length:2007 Species:Caenorhabditis elegans


Alignment Length:2314 Identity:497/2314 - (21%)
Similarity:760/2314 - (32%) Gaps:707/2314 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   335 SQQDTHTWTHHQFNACS----ASCGGGSQ--SRKVTCNNRITLAEVNPSLCDQKSKPVEEQACGT 393
            |||....:.....:.|.    :.|||.|.  .|:..|.||                      |..
 Worm    56 SQQLVRYYYDAAVDECKRFTFSGCGGNSNRFMRRAHCRNR----------------------CVK 98

  Fly   394 EPCAPHWVEGEWSKCSKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQEC--- 455
            :|..|...|.:..:......|..||         :.:.|.|||..|.....| ..|..|.|.   
 Worm    99 QPNKPEVQELKHRRTVTSTTSTPFQ---------TVNEESTVEPSATKRLPV-TLPVKKLELVQV 153

  Fly   456 ---NRDVKNCPKYH-LGPWTPCDKL---CGDGKQTRKVTCFIEENGHKRVLPEEDCVEEKPETEK 513
               |:...:....| .|....||.|   |.|||      |              .|::......|
 Worm   154 RIFNKTESSFQSGHGNGLCQDCDPLYGTCLDGK------C--------------GCMKGFRSLGK 198

  Fly   514 SCL-LTPCEGVDWIISQWSGCNACGQNTETRTAICGNKEGKVYPEEFCEPEVPTLSRPCKSPKCE 577
            .|: |..|:                     ..|:||       |...|..|:.:....|.:    
 Worm   199 VCIDLNECD---------------------NGAVCG-------PNARCVNEIGSFQCVCDA---- 231

  Fly   578 AQWFSSEWSKCSAPCGKGVKSRIVIC-GEFDGKTVTPADDDSKCNKETKPESEQDCEGEEKVCPG 641
              .||::     ..|..|.::    | .|||   |...::|  || ..|.|.:...:.:...|. 
 Worm   232 --GFSTD-----GDCKIGQEA----CMDEFD---VNLTEED--CN-NGKQEIKYYYDADSVQCK- 278

  Fly   642 EWFTGPWGKCSKPCGGGERVREVLCLSN-----GTKSVNCDEEKVEPLSEKCN------------ 689
            ::|.|.....|:......:..:|:|:||     .:|..:.....|..:|...|            
 Worm   279 QFFYGGCKTTSRNFFADLQTCDVICVSNQRDYLKSKGQSLSHHPVLEISSDLNNGNDLKSNHYKI 343

  Fly   690 ------SEACTEDEILPLTSTDKPIE-------------------DDEEDCDEDGIELISDGLSD 729
                  |...|.:.  ||::.|.|::                   ..|:..:.|..|::...|:.
 Worm   344 DLFSSPSSPVTPNR--PLSADDWPLKPITLKPALNLDFSQGKTKSTAEKHKEADDAEILVHQLTP 406

  Fly   730 DEKSEDVIDLEGTAKTETTPEAEDLMQSDSPTPY---DEFESTGTTFEGSGYDSESTTDSGISTE 791
            :..|.|:       |.|.... |:.:.:|....:   .||:..    |...|||     |....:
 Worm   407 EHNSCDL-------KFEPVLR-EECISADWAEKFFWNSEFKDC----EPFWYDS-----SCDPRD 454

  Fly   792 GSGDD-EETSEASTDLSSSTDSGSTSSDSTSSDSSSSISSDATSEAPASSVSDSSDSTDASTETT 855
            .:|.: .||.|...:......|......:|..|..|.|....|||.|                  
 Worm   455 RAGKNFFETFEDCKNKCDGVQSQYVVPITTVPDEQSKIEEVETSETP------------------ 501

  Fly   856 GVSDDSTDVSSSTEASASESTDVSG--------------ASDSTGSTNASDSTPESSTEASSSTD 906
            |:.|::|     |.|:..|.::.:|              .|..|..|......|....:.:|...
 Worm   502 GIVDETT-----TTAAPEEESEENGFFFKVKPQNYLEDVLSSETEETQHYGFNPNEFLKQNSQNQ 561

  Fly   907 DSTDSSDNSSNVSESSTEASSSSVSDSNDSSDGS----------TDGVSSTTENSSDSTSDATSD 961
            ..|:.:: ...:..:.||...:|.....|..:..          |:.|.||.........||..:
 Worm   562 KPTEITE-ILRILPAQTEHDEASELKKEDKIEHDILEHLKNKEPTEKVLSTPSTCDLEYDDALRN 625

  Fly   962 STASSDSTD------------------STSDQ-------------------------TTETTPES 983
            ...|:|.|:                  |..||                         ..:..||:
 Worm   626 ECTSADWTELYYWNAQFKECEAFWYDSSCGDQDFSKKNLFKNFDDCNNQCVKKIGEALKKMDPET 690

  Fly   984 STDSTESSTLDASSTTDASSTSESSSESSTDGSSTTSNSASSETTGLSSDGSTTDATTAASDNTD 1048
            :|.::.::|...:.||......:.|:...:|..:...|.|      |:.|.|:            
 Worm   691 TTTTSTTTTTTTAPTTTKMEEPKRSNYKQSDPLNLILNKA------LNPDESS------------ 737

  Fly  1049 ITTDGSTDESTDGSSNASTEGSTEGASEDTTISTESSGST------------ESTDAIASDGSTT 1101
                    |..:....|..:|....|     |.:|.:.:|            :...|:..:.|||
 Worm   738 --------ELPEKFPPAHEQGFVNFA-----IKSEVTATTKFDRLKYMAEFRKKLLALPDNFSTT 789

  Fly  1102 EGSTVEDLSSSTSSDVTSDSTITDSSPSTE---VSGSTDSSSSTDGSSTDASSTEASSTDVTEST 1163
                     ...||..:|.:|....||||.   ||.:|.::|||..|    .||..|..|..|..
 Worm   790 ---------PKQSSPTSSPTTTRMRSPSTHKSTVSQATKTASSTPQS----PSTTTSFDDFVEKE 841

  Fly  1164 DSTVSGGTSDTTESGPTEESTTEGSTESTTEGSTDSTQSTDLDSTTSDIWSTSDKDDESESSTPY 1228
            ..||    .:|.:.....|...:.......|           :...:|.|...           :
 Worm   842 KKTV----LETIKILDRPEDLCDEPLHPKLE-----------EDCKNDQWEIQ-----------W 880

  Fly  1229 SFDSEVTKSKPRKCKPKKSTCAKSEYGCC--------PDGKSTPKGPFDEGCPIAKTCADTKYGC 1285
            .|:|:            :..|....||.|        ||.                  |:.::.|
 Worm   881 FFNSD------------RGACKSFWYGGCEIESRNFFPDH------------------ANCRHSC 915

  Fly  1286 CLDGVSPAKGKNNKGCPKSQCAETLFGCCPDKFTAADGENDEGCPETTTVPP-----TTTTEETQ 1345
            .....:||...:....|..:.                         :|.|||     ||:.:.|.
 Worm   916 AHKYATPASFSSKVYIPPGEL-------------------------STPVPPRKDRLTTSLKLTY 955

  Fly  1346 P-----------ETTTEIEGSGQDSTTSE----------------PDTKKSCSFSEFGCCPDAET 1383
            |           .|..|::|:.|.:...|                |......:.||      .|.
 Worm   956 PHSEDLFPSEEHSTVVELDGNFQRTEKQERIRLFPTKTFRPRAPTPTASNIVNVSE------GEK 1014

  Fly  1384 SAKGPDF--------------EGCGLASP---VAKGCAESENGCCPDGQTP-------ASGPNGE 1424
            :...|.|              |..|...|   |.:..:.|.:....|.|.|       .|.|.  
 Worm  1015 TETAPAFYSHIDRVVHDMKTGEHPGYTKPEEFVRRIESASNDYIKYDLQKPDVVTIIDKSPPT-- 1077

  Fly  1425 GCSGCTRERFGCCPDSQTPAHGPNKEGCCLDTQFGCCPDNILAARGPNNEGCECHYTP---YGCC 1486
                             .|:.....|...:.|:        |.:....|:.|:..|.|   ..|.
 Worm  1078 -----------------VPSRKERTERTEVTTK--------LPSTRSINDPCDDEYDPKWDEDCL 1117

  Fly  1487 PDNKSAATGYNQEGCACETTQYGCCPDKITAAKGPKHEGCPCETTQFGCCPDGLTFAKGPHHHGC 1551
            .|.....:.|:.:...|:...||.|.   |:::....:...|.|:.....|..:     |.:.|.
 Worm  1118 GDTWVVRSYYDSKAEKCKAFWYGGCH---TSSRNIWFDKETCRTSCAHKFPTDM-----PMYGGA 1174

  Fly  1552 HCTQ--TEFKCCDDEKTPAKGPNGDGCTCVESKFG-CCPDGVTKA-TDEKFG-------GCEN-- 1603
            ..::  .|......|:..:|..:....:...|... ..|:...|. .|:||.       |.|:  
 Worm  1175 QSSEVSAEILPSPQEENSSKETSSSSSSSSSSNTAHISPEHRFKVDLDQKFADVKREHEGREDLA 1239

  Fly  1604 ----VQEPPQKA--------CGLPKETGTCNNYSVKYYFDTSYGGCARFWYGGC-DGNDNRFESE 1655
                ||.|...:        ..|.|..|...::|.:|::|.....|..||..|| ..:.|.|:..
 Worm  1240 YSQMVQHPVTVSADCLEVYNASLSKPCGDGKSWSNRYFYDKDTRSCRMFWSNGCFSSSKNNFDDL 1304

  Fly  1656 AECKDTCQDYTGKHVCLLPKSAG-PCTG--------------FTKKWYFDVDRNRCEEFQYGGCY 1705
            ..|:..|:   |:|    |:.|| .|..              ||.::|||.||.:|..|.:|||.
 Worm  1305 ETCQWKCE---GRH----PQPAGKSCLDKFDERYLEDCRHGEFTNRFYFDHDRKKCVAFHWGGCQ 1362

  Fly  1706 G-TNNRFDSLEQCQGTCAA--SENLPTCEQPVES---GPCAGN--FERWYYDNETDICRPFTYGG 1762
            . :.|.|..:..||..|.:  .|....|.||.::   ..|:..  .:.:|:|..:.||:.|.:|.
 Worm  1363 SKSQNFFADMTVCQDLCESPPRELTQACLQPFDTTYETSCSAEKPQQYYYFDMSSGICKMFWFGN 1427

  Fly  1763 CKG-NKNNYPTEHACNYNC------RQPGVLKDRCALPKQTGDC--SEKLAKWHFSESEKRCVPF 1818
            ||| |:|.:.|..||.:.|      |:|.:..|:.. .|.|..|  |:...||:|.:|...|..|
 Worm  1428 CKGENQNIFSTLEACQWICERKRDERKPAICADKFD-TKYTESCGDSQWTEKWYFDQSSGDCSSF 1491

  Fly  1819 YYSGC-GGNKNNFPTLESCEDHCPR-----------QVAKDICEIPAEVGECANYVTSWYYDTQD 1871
            ::..| ..::|.||..:||..:|..           :.:|..|..|.|:|.|.....::|||...
 Worm  1492 WWDECTSSSQNIFPDEKSCTSNCKHPGFEISSKLATEESKFRCLEPVEIGSCQETYPAFYYDRAS 1556

  Fly  1872 QACRQFYYGGCGGNENRFPTEESCLARC-----DRKPEPTTTTPATRPQPSRQDVCDEEPAPGEC 1931
            :.||.|.|.|||||.|||.|...|...|     ..:.|.....|........:|.|  .|..|  
 Worm  1557 RTCRPFAYSGCGGNSNRFMTVSQCENLCFAFNSMNEAEVDCHLPMHIGYGKNEDSC--LPQAG-- 1617

  Fly  1932 STWVLKWHFDRKIGACRQFYYGNCGGNGNRFETENDCQQRCLSQEPPAPTPPRAPAPTRQPDPAP 1996
                .::::||..|.|.|.:|..||||.|.|.:...||:.|...:.|.....:..|.:.      
 Worm  1618 ----FRFYYDRNYGKCSQMWYLGCGGNANNFYSYEICQRTCSQSDVPRELERKTRASSE------ 1672

  Fly  1997 TVAQCSQ-PADPGQCDKWA-----LHWNYNETEGRCQSFYYGGCGGNDNRFATEEECSARCSVNI 2055
               .|.: |.|.|.|.|.:     ..|.|...  :|.||.|.|||||.|||||::.|...|:..:
 Worm  1673 ---VCFEPPGDRGICGKNSSTNPLKRWTYGNQ--KCTSFTYSGCGGNRNRFATQDICENTCNGLM 1732

  Fly  2056 DIRIGADPVEHDTSKCFLAFEPGNCYNNVTRWFYNSAEGLCDEFVYTGCGGNANNYATEEECQNE 2120
            :        .:|...|..:.:.|:|......||||...|.||:|:|.|||||.|.:.|.|.||..
 Worm  1733 N--------SNDPRICSFSPDWGSCNQLRYVWFYNLTRGTCDQFLYGGCGGNPNRFDTFEICQKA 1789

  Fly  2121 CNDAQT-TCALPPVRGR-CSDLSRRWYFDERSGECHEFEFTGCRGNRNNFVSQSDCLNFCIGEPV 2183
            |....| .|.....||. |..:|.|:||::|:.:|..|.:|||..:.|||:::.:|...|  |..
 Worm  1790 CEVTGTDPCMESLDRGSWCEAMSNRYYFNKRARQCKGFHYTGCGKSGNNFLTKEECQTKC--EKR 1852

  Fly  2184 VEPSAPT-----------YSVCAEPPEAGEC--------DNRTTAWFYDSENM-----ACTAFTY 2224
            ...:||:           || .|:|.:....        :|:|   ::.||..     :|..:.|
 Worm  1853 FPRAAPSKKKAKVKLPVGYS-GAKPKDKTPMLRHINLNGNNQT---YFKSEPQWMDYSSCYGYRY 1913

  Fly  2225 --TG---------CGGNGNRFETRDQCERQCGEFKGVDVCN--EPVTTGPCTDWQTKYYFNTASQ 2276
              ||         |...|    :.|.........:|.:.||  .|...|     |..|.|.....
 Worm  1914 NVTGRDTILNVHYCAIRG----SADCISESYRSTEGEEYCNILRPFLRG-----QNLYSFYFGLD 1969

  Fly  2277 ACEPFTYGGCDGTGNRFSDLFE------------CQTVC 2303
            :..|. |...||...|.....|            |..:|
 Worm  1970 SVNPM-YRPKDGLSGRIQRKNETIAAVLVLKANQCHEIC 2007

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559
ADAMTS_CR_3 116..213 CDD:437068
ADAMTS_spacer1 222..329 CDD:461796
TSP1_ADAMTS 347..396 CDD:465950 10/54 (19%)
TSP1_ADAMTS 400..457 CDD:465950 13/62 (21%)
TSP1_ADAMTS 465..520 CDD:465950 14/59 (24%)
TSP1_ADAMTS 580..632 CDD:465950 14/52 (27%)
TSP1_ADAMTS 643..693 CDD:465950 12/72 (17%)
MSCRAMM_ClfA <1049..1262 CDD:468110 46/235 (20%)
Kunitz_papilin_lacunin-like 1612..1663 CDD:438681 14/51 (27%)
Kunitz_BPTI 1670..1721 CDD:425421 20/66 (30%)
Kunitz-type 1730..1780 CDD:438633 18/55 (33%)
Kunitz_BPTI 1789..1840 CDD:425421 16/53 (30%)
Kunitz_papilin_mig6-like 1849..1899 CDD:438679 22/49 (45%)
Kunitz_papilin_mig6-like 1922..1972 CDD:438679 17/49 (35%)
Kunitz_papilin_mig6-like 2001..2051 CDD:438679 23/55 (42%)
Kunitz-type 2071..2121 CDD:438633 22/49 (45%)
Kunitz_BPTI 2127..2178 CDD:425421 18/51 (35%)
Kunitz_BPTI 2193..2245 CDD:425421 13/75 (17%)
Kunitz_BPTI 2252..2303 CDD:425421 14/64 (22%)
Kunitz_BPTI 2317..2372 CDD:425421
WAP 2455..2497 CDD:459672
Ig 2530..2610 CDD:472250
Ig strand B 2539..2543 CDD:409353
Ig strand C 2552..2556 CDD:409353
Ig strand E 2576..2579 CDD:409353
Ig strand F 2589..2594 CDD:409353
Ig strand G 2603..2606 CDD:409353
IG_like 2627..2703 CDD:214653
Ig strand B 2636..2640 CDD:409353
Ig strand C 2649..2653 CDD:409353
Ig strand E 2670..2674 CDD:409353
Ig strand F 2684..2689 CDD:409353
Ig strand G 2697..2700 CDD:409353
I-set 2766..2845 CDD:400151
Ig strand B 2771..2775 CDD:409353
Ig strand C 2784..2788 CDD:409353
Ig strand F 2821..2826 CDD:409353
PLAC 2851..2883 CDD:462560
mec-1NP_741559.3 Kunitz_BPTI 45..97 CDD:425421 12/62 (19%)
EGF_CA 202..240 CDD:214542 11/76 (14%)
Kunitz-type <265..304 CDD:444694 6/39 (15%)
Kunitz_TAP-like 408..472 CDD:438634 17/80 (21%)
Kunitz_TAP-like 615..675 CDD:438634 8/59 (14%)
Kunitz_TAP-like 857..915 CDD:438634 12/109 (11%)
Kunitz-type <1121..1160 CDD:444694 8/41 (20%)
KU 1261..1311 CDD:197529 14/49 (29%)
Kunitz-type <1338..1379 CDD:444694 16/40 (40%)
Kunitz-type 1390..1446 CDD:438633 18/55 (33%)
Kunitz-type 1458..1514 CDD:444694 17/56 (30%)
Kunitz-type 1534..1584 CDD:438633 22/49 (45%)
Kunitz-type 1597..1654 CDD:438633 19/64 (30%)
Kunitz_BPTI 1673..1728 CDD:425421 23/56 (41%)
Kunitz-type 1740..1790 CDD:438633 22/49 (45%)
Kunitz-type 1798..1849 CDD:438633 18/50 (36%)
Blue background indicates that the domain is not in the aligned region.

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