DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and E01G6.1

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_510044.2 Gene:E01G6.1 / 181387 WormBaseID:WBGene00008449 Length:1467 Species:Caenorhabditis elegans


Alignment Length:1590 Identity:334/1590 - (21%)
Similarity:470/1590 - (29%) Gaps:636/1590 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly  1259 DGKSTPKGPFDEGCPIAKTCADTKYGCCLDGVSPAKGKNNKGCPKSQCAETLFGCCPDKFTAADG 1323
            |..|..|.| |.|.|      ::...|.|:| |.:|.|    |...:...:..|.|.....|.|.
 Worm    26 DPTSNVKKP-DPGSP------ESYLYCNLEG-SFSKRK----CASGKIFNSETGECDSLMQADDP 78

  Fly  1324 END---------------EGCPETTTVPPTTTTEETQPETTTEIEGSGQDSTTSEPDTKKSCSFS 1373
            .:|               ||.|.|....|.|.                ..|.:|.|| ..||.|.
 Worm    79 IDDIFSQPFFQAPDDLCGEGIPLTILSAPVTC----------------NPSISSCPD-GYSCQFY 126

  Fly  1374 E----FGCCPDAETSAK-GPDFEGCG--------LASPVAKGCAESENGCCPDGQTPASGPNGEG 1425
            |    ..||.:...:|| ..|...||        :|:...:.|..:.:..||.|           
 Worm   127 ERTGSSYCCQNPTPTAKSSTDKINCGEGRVTYIEMATGKPRSCVLTGDNSCPAG----------- 180

  Fly  1426 CSGCTRERFGCCPDSQTPAHGPNKEGCCLDTQFGCCPDNILAARGPNNEGCECHYTPYGCCPDNK 1490
                    |||     |...|.....|..|  .||..::....||.|         |..|.|.:.
 Worm   181 --------FGC-----TLVAGTTTRCCAKD--LGCATNSAPQLRGSN---------PVECSPTDG 221

  Fly  1491 SAATGYNQEGCACETTQY---------------GCCPDKITAAKGPKHEGCPCETTQ-----FGC 1535
            ||.    :.|..|..:||               |.||...|..     |...|..|:     |.|
 Worm   222 SAC----KNGYVCSKSQYLNKFICCSNPDGEIMGSCPGGETPL-----ENIQCSATKPCPNGFSC 277

  Fly  1536 -----------CPDGLTFAKGPHHHGCHCTQTEFKCCDDEKTPAKGPNGDGCTCVESKFG---CC 1586
                       ||.|.....||           .||.::...|      :|.:|| |..|   ||
 Worm   278 NDKKCCPYASACPAGAPLNNGP-----------MKCSENAPCP------EGHSCV-SNAGIQYCC 324

  Fly  1587 PDGVTKATDEKFGGCENVQEPPQKACGLPKETGTCNNYSVK----YYFDTSYGGCARFWYGGCDG 1647
            |                   ..:|.|.:|:.:|.....|:|    ||||.....|..|.:..|.|
 Worm   325 P-------------------AKEKVCNMPRNSGVQCASSMKSSNRYYFDIGTATCRSFKFTQCGG 370

  Fly  1648 NDNRFESEAECK----------------------------DTCQDYTGKHVCLLP---------- 1674
            |.|.|.|..||:                            |||.:   :|.|.||          
 Worm   371 NANNFGSLEECEGFCVDTQCPNGQAHRVGAVNANCALAQADTCPN---QHFCQLPLFGPSPICCP 432

  Fly  1675 ---------KSAG-PCTG---FTKKWYFDVDRNRCEEFQYGGCYGTNNRFDSLEQCQGTC----- 1721
                     .||| ||.|   ..:::||:....:|:.|.|.||.|..|.|::::|||..|     
 Worm   433 TPELTCNEMVSAGTPCFGRGLTIQRFYFNPSTQKCQPFHYYGCSGNGNNFETVDQCQNFCLHSAD 497

  Fly  1722 AASENLPTCEQP-------VESGPCAGNFERWYYDNETDICRPFTYGGCKGNKNNYPTEHACNYN 1779
            :|.:.|...:.|       .|..||...:|    .|::..|.|             .:|:|||.|
 Worm   498 SACDGLVPLKNPNSELQRCSEEDPCPAGYE----CNDSSYCCP-------------SSENACNAN 545

  Fly  1780 CRQPGVLKDRCALPKQTGDCSEKLAKWHFSESEKRCVPFYYSGCGGNKNNFPTLESCEDHCPRQV 1844
            ..:....|.           |.:.:.|.:.:|:|:|..|.|:||||..|.|.|..:|.:.|.:..
 Worm   546 MSRGNGCKG-----------STQRSMWFYDKSKKKCSQFVYNGCGGTPNRFTTKVACTESCVQSS 599

  Fly  1845 AKDICEIP------AEVGECANYVTSWYYDTQDQACRQFYYGGCGGNENRFPTEESCLARCDRKP 1903
            |..:|  |      .|.||..           .:.|.......|       |:..||:       
 Worm   600 AFGLC--PRGMNPFTEEGEIT-----------PKTCTLNVRSTC-------PSGASCV------- 637

  Fly  1904 EPTTTTPATRPQPSRQDVCDEEPAPGECSTWVLKWHFDRKIGAC--RQFYYGNCGGNG------N 1960
                      ...:.|.:|        |          :.:.||  .:..|...|.|.      .
 Worm   638 ----------KSSTNQSIC--------C----------KAVTACPDNRIPYNIPGTNSVVACSIE 674

  Fly  1961 RFETENDCQQRCL------------------SQEPPAPTPPRAPAPTR--QPDPAPTVAQCSQPA 2005
            |.:..:|.|  ||                  :|.|..|..|.||.|.|  :||....:.....|.
 Worm   675 RDDCPDDFQ--CLESATAPGFHMCCSGPLPSAQRPVRPIAPVAPMPRRPFEPDSFADLLSNISPC 737

  Fly  2006 DP--------------GQCDKWALHWNYNETEGRCQSFYYGGCGGNDNRFATEEECSAR------ 2050
            .|              |.|.|       |....|...|..|.|..     .|..:||.|      
 Worm   738 PPQLFSSGQSCTVNQVGDCPK-------NHICFRDIGFKQGSCCR-----TTPPKCSQRGYVPVF 790

  Fly  2051 --------CSVNIDIRIGADPVEHDTSKCFLA-----------FEPGNCYNNVTRWFYNSAEGLC 2096
                    |.|::|   |..    :.:||..:           ::|.:..||     ..:..|: 
 Worm   791 LDRTQVQVCQVDLD---GCP----EDAKCMTSSVAKLAICCQKYQPPSPNNN-----RPANRGV- 842

  Fly  2097 DEFVYTGCGGNANNYATEEECQNECNDAQTTCA--LPPVRGRCSDLSRRWYFDERSGECHEFEFT 2159
                  ..|..:||        |:.|:....||  ..|.||.          |.:..||      
 Worm   843 ------NQGSVSNN--------NQNNNKGAVCANGETPFRGP----------DNKFQEC------ 877

  Fly  2160 GCRGNRNNFVSQSDCLNFCIGEPVVEPSAPTYSVCAEPPEAGECDNRTTAWFYDSENMACTAFTY 2224
                   |||.     |.|......|.|:...:||........|.:.::.:.|....:||.|.:.
 Worm   878 -------NFVH-----NTCPSGYQCEFSSTGQAVCCTNTNVIRCPSGSSVFEYGGRPLACPAGSN 930

  Fly  2225 TGCGGNGNRFETRDQCERQCGEFKGVDVCNEPVTTGPCTDWQTKYYFNTAS---QACEPFTYGGC 2286
            ....|......|..|....|....|:.|.......|..       |.|.|:   |.|.|.. ..|
 Worm   931 KCPQGYSCMPSTNPQHHLCCSSGSGMGVSQPQCLRGVA-------YVNPATNQRQFCSPMK-ADC 987

  Fly  2287 DG----------------TGNRFSDLFE--------------------------CQT----VCLA 2305
            ..                |....||.|:                          |.|    ||:.
 Worm   988 PAGYTCFESDQSSQFICCTHGDLSDRFQGYCPPRQIPYISRDGFPPTCHMQLSPCPTTAPYVCIY 1052

  Fly  2306 GREPR---------------------VGSAKEICLL--------------------PVATG---- 2325
            ..|.:                     ...||.|.||                    |.|.|    
 Worm  1053 SPEKQDSYCCAPIDTAVHVVNPDRGYASPAKNIDLLETPDVPSSNVPGMTQTFPGGPPAPGMGPI 1117

  Fly  2326 ------------RCNGPSVHERRWYYDDEAGNCVSFIYAGCSGNQ--NNFRSFEACTNQCRPEPN 2376
                        |...|::.:.      |....:...:|..:.|:  |:|.:||..:.:.....|
 Worm  1118 GMPDPIPGIENARILPPALAQA------EMEKKIREQFANKNNNEHGNSFANFEGNSGESGNFGN 1176

  Fly  2377 KQDNEIGQNPCDTFDAECQELRCPYGVRRVAARSQPECTQCICENPC-EGYSCPEGQ-----QCA 2435
            ...| :|......|..:..:..||.|.|.:...:| :.|:| .:.|| :|:||...:     ||.
 Worm  1177 NNFN-MGGGAVPGFGNQASQSGCPLGSRPLIGFNQ-QITEC-SQQPCPDGFSCVFAEKDNRFQCC 1238

  Fly  2436 IDVA------SSDDRQFAPVCRDIYKPG---ECPALSANASG-C-------ARECYTDADC--RG 2481
            ..|:      ...::|..|      .|.   :||....|..| |       .:.|.:|..|  |.
 Worm  1239 SSVSIMLAVNKPTNKQSTP------SPNGQIDCPPGFFNMDGKCLKILFAGQKGCISDEQCSSRE 1297

  Fly  2482 DNKCCSDGCGQLCVHPARPTQPPRTQAPVV 2511
            .|..|.:|   .|:.|        |..|:|
 Worm  1298 ANSTCDNG---YCICP--------TDKPLV 1316

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559
ADAM_spacer1 214..329 CDD:283607
TSP1 468..521 CDD:214559
TSP_1 645..693 CDD:278517
Kunitz_BPTI 1611..1663 CDD:278443 21/83 (25%)
Kunitz_BPTI 1670..1721 CDD:278443 22/73 (30%)
Kunitz_BPTI 1729..1781 CDD:278443 13/58 (22%)
Kunitz_BPTI 1789..1840 CDD:278443 15/50 (30%)
Kunitz_BPTI 1848..1899 CDD:278443 10/56 (18%)
KU 1920..1973 CDD:238057 10/60 (17%)
Kunitz_BPTI 2001..2051 CDD:278443 14/77 (18%)
KU 2071..2121 CDD:238057 9/60 (15%)
Kunitz_BPTI 2127..2178 CDD:278443 12/52 (23%)
KU 2192..2245 CDD:238057 10/52 (19%)
KU 2251..2304 CDD:238057 16/101 (16%)
KU 2316..2372 CDD:238057 15/93 (16%)
WAP 2457..2497 CDD:278522 13/52 (25%)
Ig 2521..2610 CDD:299845
IG_like 2530..2610 CDD:214653
IG_like 2627..2703 CDD:214653
Ig 2636..2701 CDD:143165
IG_like 2766..2841 CDD:214653
Ig 2768..2830 CDD:299845
PLAC 2851..2883 CDD:285849
E01G6.1NP_510044.2 Lustrin_cystein 95..136 CDD:291299 15/57 (26%)
WR1 289..325 CDD:214601 14/53 (26%)
Kunitz_BPTI 330..386 CDD:278443 19/55 (35%)
Kunitz_BPTI 437..492 CDD:278443 19/54 (35%)
Kunitz_BPTI 541..596 CDD:278443 20/65 (31%)
Lustrin_cystein 860..902 CDD:291299 17/69 (25%)
Lustrin_cystein 909..951 CDD:291299 8/41 (20%)
Lustrin_cystein 963..1006 CDD:291299 8/50 (16%)
EB 1265..1321 CDD:279949 17/63 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4295
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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