DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppn and mig-6

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_505017.1	Gene:	mig-6 / 179162	WormBaseID:	WBGene00003242	Length:	2167	Species:	Caenorhabditis elegans

Alignment Length:	2785	Identity:	770/2785 - (27%)
Similarity:	1062/2785 - (38%)	Gaps:	934/2785 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LCSTALVAFIVLASIHDSQSRFPGL-------------RQKRQYGANMYLP-ESSVTPGGEG-ND 56
            |||....||.:.:......::.|.|             |.||| ...:|:. :.|||....| .:
Worm    12 LCSVPTWAFSLSSFFGSDVAQKPYLHPNSPPERDPASSRMKRQ-AYQVYVDGDVSVTVDKSGQKE 75

  Fly    57 PDEWTPWSSPSDCSRTCGGGVSYQTRECLRRDDRGEAVCSGGSRRYFSCNTQDCPEEESDFRAQQ 121
            ...|.||...::|||:|||||..:.|:|     .|:  |:|.|.||.|||...| |..:||||:|
Worm    76 TGNWGPWVPENECSRSCGGGVQLEKRQC-----SGD--CTGASVRYISCNLNAC-ESGTDFRAEQ 132

  Fly   122 CSRFDRQQFDGVFYEWVPYTNAPNPCELNCMPKGERFYYRQREKVVDGTRCNDKDLDVCVNGECM 186
            ||:|:.:..||.:::|.|| ...|.|||.|.|:...|||:..:||||||:|:.|..|:||:|||:
Worm   133 CSKFNDEALDGNYHKWTPY-KGKNKCELVCKPESGNFYYKWADKVVDGTKCDSKSNDICVDGECL 196

  Fly   187 PVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLLLLPEGATNIRIEETVPSS 251
            |||||..|||..|.|||.||.|||||||||......::|:|||:|::.||||||||:|:|...|:
Worm   197 PVGCDGKLGSSLKFDKCGKCDGDGSTCKTIEGRFDERNLSPGYHDIIKLPEGATNIKIQEARKST 261

  Fly   252 NYLACRNHSGHYYLNGDWRIDFPRPMFFANSWWNYQRKPMGFAAPDQLTCSGPISESLFIVMLVQ 316
            |.||.:|.|.|:||||:..|...:.:....:.:.|..     |.|:.|:..||:||.|.:.:|.:
Worm   262 NNLALKNGSDHFYLNGNGLIQVEKEVEVGGTIFVYDD-----AEPETLSAQGPLSEELTVALLFR 321

  Fly   317 E--KNISLDYEYSIP--ESLSHSQQDTHTWTHHQFNACSASCGGGSQSRKVTCNNRITLAEVNPS 377
            :  ::.::.||:|||  |.:.:..: ...||     .||.|||.|.|:|.:.|.:......|...
Worm   322 KGSRDTAIKYEFSIPLEEEVDYMYK-FDNWT-----PCSVSCGKGVQTRNLYCIDGKNKGRVEDD 380

  Fly   378 LCDQK--SKPVEEQACGTEPCAPHWVEGEWSKCSKGCGSDGFQNRSITCERISSSGEHTVEEDAV 440
            ||::.  :||..|::|.|..|...|..|:|..||..||..|.|.|.:.|.::.::|.....||..
Worm   381 LCEENNATKPEFEKSCETVDCEAEWFTGDWESCSSTCGDQGQQYRVVYCHQVFANGRRVTVEDGN 445

  Fly   441 CLKEVGNKPATKQECNRDVKNCPKYHLGPWTPCDKLCGDGKQTRKVTCFIEENGHK-RVLPEEDC 504
            |..|   :|..||.|||..  ||::..|||:.|.:.|||..|.|.|||..|:.|.: ::|..:.|
Worm   446 CTVE---RPPVKQTCNRFA--CPEWQAGPWSACSEKCGDAFQYRSVTCRSEKEGEEGKLLAADAC 505

  Fly   505 ---VEEKPETEKSCLLTPCEGVDWIISQWSGCNACGQNTETRTAICGNKEGKVYPEEFC----EP 562
               .:||.:||::|.|.||||:.::..:|:.|..|....|||...|.:.:|:.||.|.|    ..
Worm   506 PADEQEKFDTERTCNLGPCEGLTFVTGEWNLCTRCNDTEETREVTCKDSQGRAYPLEKCLVDNST 570

  Fly   563 EVPTLSRPCKS-PKCEAQWFSSEWSKCSAPCGKGVKSRIVICG--EFDGKTVTPADDDSKCNKET 624
            |:||.:|.|.: |.||.:|..||||||:..||.|.|:|.|||.  :..|..|.   |:..|..|
Worm   571 EIPTDTRSCATQPPCEYEWTVSEWSKCTTECGHGHKTRRVICAIHQNGGLEVV---DEGHCQAE- 631

  Fly   625 KPESEQDCEGEEKVCPGEWFTGPWGKCSKPCGGGERVREVLCLSNGTKSVNCDEEKVEPLSEKCN 689
            |||.:.:|..||| |.|.|:|..|.:|:..||||.:.|..:||       |.|:   :|:.|.|
Worm   632 KPEGKTNCTNEEK-CTGTWYTSSWSECTAECGGGSQDRVAVCL-------NYDK---KPVPEWC- 684

  Fly   690 SEACTEDEILPLTSTDKPIEDDEEDCDEDGIELISDGLSDDEKSEDVIDLEGTAKTETTPEAEDL 754
                  ||.:      ||.|  ::||:.|
Worm   685 ------DEAV------KPSE--KQDCNVD------------------------------------ 699

  Fly   755 MQSDSPTPYDEFESTGTTFEGSGYDSESTTDSGISTEGSGDDEETSEASTDLSSSTDSGSTSSDS 819
               |.||..|
Worm   700 ---DCPTCVD------------------------------------------------------- 706

  Fly   820 TSSDSSSSISSDATSEAPASSVSDSSDSTDASTETTGVSDDSTDVSSSTEASASESTDVSGASDS 884
                                  |:.....|.||..||                         ..:
Worm   707 ----------------------SEFGCCPDNSTFATG-------------------------EFN 724

  Fly   885 TGSTNASDSTPESSTEASSSTDDSTDSSDNSSNVSESSTEASSSSVSDSNDSSDGSTDGVSSTTE 949
            .|.:|.|:      ||.....|:.|.::..:|...|...|:..:..:|.
Worm   725 FGCSNCSE------TEFGCCADNVTVATGPNSKGCEEFVESPLNLEADV---------------- 767

  Fly   950 NSSDSTSDATSDSTASSDSTDSTSDQTTETTPE-SSTDSTESSTLDASSTTDASSTSESSSESST 1013
                    |.:|:.||.|:            || .|..:.....:|....|.|..|
Worm   768 --------ANADAEASGDA------------PELCSVTNENGEAVDVECATIAPIT--------- 803

  Fly  1014 DGSSTTSNSASSETTGLSSDGSTTDATTAASDNTDITTDGSTDESTDGSSNASTEGSTEGASEDT 1078

Worm   804 ----------------------------------------------------------------- 803

  Fly  1079 TISTESSGSTESTDAIASDGSTTEGSTVEDLSSSTSSDVTSDSTITDSSPSTEVSGSTDSSSSTD 1143
                          |:..||...
Worm   804 --------------ALLGDGELI------------------------------------------ 812

  Fly  1144 GSSTDASSTEASSTDVTESTDSTVSGGTSDTTESGPTEESTTEGSTESTTEGSTDSTQSTDLDST 1208
            |:.||||             :.|:.
Worm   813 GNDTDAS-------------NETIH---------------------------------------- 824

  Fly  1209 TSDIWSTSDKDDESESSTPYSFDSEVTKSKPRKCKPKKSTCAKSEYGCCPDGKSTPKGPFDEGCP 1273
                                                    |:|:|:||||
Worm   825 ----------------------------------------CSKTEFGCCP--------------- 834

  Fly  1274 IAKTCADTKYGCCLDGVSPAKGKNNKGCPK---SQCAETLFGCCPDKFTAADGENDEGCPETTTV 1335
                          |..:.|.||.|:|||.   ..|.||.||||.|..|.|.|.|.|||
Worm   835 --------------DWYTAASGKGNEGCPSFTLGGCNETQFGCCHDDVTLARGANLEGC------ 879

  Fly  1336 PPTTTTEETQPETTTEIEGSGQDSTTSEPDTKKSCSFSEFGCCPDAETSAKGPDFEGCGLAS-PV 1399
                                      .||    ||:.|.:|||.|.:|.|.||.:.||..:| |
Worm   880 --------------------------GEP----SCAASLYGCCKDRKTIAFGPHYSGCERSSFP- 913

  Fly  1400 AKGCAESENGCCPDGQTPASGPNGEGCSGCTRERFGCCPDSQTPAHGPNKEGCCLDTQFGCCPDN 1464
               |..|:.||||||:|.|.|.||.||                   |.|    ||.|:||||||.
Worm   914 ---CELSDFGCCPDGETAALGKNGTGC-------------------GEN----CLTTKFGCCPDG 952

  Fly  1465 ILAARGPNNEGCECHYTPYGCCPDNKSAATGYNQEGC--ACETTQYGCCPDKITAAKGPKHEGCP 1527
            ...|:|.:||||.|.:..||||||.||.|.|....||  :|..:|:|||||..|.|:|...||||
Worm   953 KTTAKGSHNEGCGCEFAQYGCCPDGKSVAKGAGFYGCPESCAQSQFGCCPDGKTRARGENKEGCP 1017

  Fly  1528 CETTQFGCCPDGLTFAKGPHHHGCHCTQTEFKCCDDEKTPAKGPNGDGC-TCVESKFGCCPDGVT 1591
            |:.|::||||||                         :|.|.||..||| .|..:|.||||||.|
Worm  1018 CQYTRYGCCPDG-------------------------ETTALGPRNDGCDNCRYAKHGCCPDGET 1057

  Fly  1592 KATDEKFGGCENVQEPP-----------QKACGLPKETGT-CN-NYSVKYYFDTSYGGCARFWYG 1643
            ||......||.....||           ..||...:|:|| |. .|.:.:::||:.|.|.:||||
Worm  1058 KALGPDGAGCPPTTTPPFLMGGTVAPHKIAACNQTQESGTVCGAGYKLAWHYDTTEGRCNQFWYG 1122

  Fly  1644 GCDGNDNRFESEAECKDTCQDYTGKHVCLLPKSAGP--CTGFTKKWYFDVDRNRCEEFQYGGCYG 1706
            ||.||||.|.|:..|:..|.:..||..|.||:..||  |.....::|:|..:..|..|.:.||.|
Worm  1123 GCGGNDNNFASQDMCETICVEPPGKGRCYLPRVDGPLRCDQLQPRYYYDHSKKHCVAFWWRGCLG 1187

  Fly  1707 TNNRFDSLEQCQGTCA--------------------ASENLPT----------CEQP-------- 1733
            ..|.|:|.|:|...|.                    |.:.|||          .|||
Worm  1188 NANNFNSFEECSMFCKDVGPYDAPTTAAPPPPPQQNAQQYLPTPEVQQIEIQSAEQPQPQQPQQQ 1252

  Fly  1734 ----------------------VESGPCAGNFERWYYDNETDICRPFTYGGCKGNKNNYPTEHAC 1776
                                  .::|||....::|:|:..:..|..||||||.||.|.:.::..|
Worm  1253 QQQQQQQPQQPRQSMEDICRSRQDAGPCETYSDQWFYNAFSQECETFTYGGCGGNLNRFRSKDEC 1317

  Fly  1777 NYNC-------------------------RQPGVL-------------------KDRCALPKQTG 1797
            ...|                         .||..:                   :|.|.|....|
Worm  1318 EQRCFFVHGAQPSAARQEQAQPAAQPAQPAQPSNIVSPPQQSASPVVVPSNSKQRDACHLNVDQG 1382

  Fly  1798 DCSEKLAKWHFSESEKRCVPFYYSGCGGNKNNFPTLESCEDHCPRQVAK-------------DIC 1849
            .|......|::..:...||.|.|:|||||.|.|.:.:.||..|.:..::             .:|
Worm  1383 RCKGAFDSWYYEVATGSCVTFKYTGCGGNANRFASKDQCESLCVKPASEAASAGIDGAAGINSVC 1447

  Fly  1850 EIPAEVGECANYVTSWYYDTQDQACRQFYYGGCGGNENRFPTEESCLARCDRKPEPTTTTPATRP 1914
            :...:.|.|.|:||.|||:..|..|.:|:||||.|..|||..|:.|.|.|.
Worm  1448 DEAKDTGPCTNFVTKWYYNKADGTCNRFHYGGCQGTNNRFDNEQQCKAACQ-------------- 1498

  Fly  1915 QPSRQDVCDEEPAPGECSTWVLKWHFDRKIGACRQFYYGNCGGNGNRFETENDCQQRC------- 1972
              :.:|.|......|.||.....::::.....|..|.||.|.||.|||.|..:||.||
Worm  1499 --NHKDACQLPKVQGPCSGKHSYYYYNTASHQCETFTYGGCLGNTNRFATIEECQARCPKDDQTT 1561

  Fly  1973 ------------LSQEPPAPTPP-----------RAPAPTRQ--------PDPAPTVAQCSQPAD 2006
                        |.||.|.|.|.           |..||..:        ||.......|....|
Worm  1562 TTSQPEELPSLPLVQEDPQPRPAFSLKQSFAHSRRRDAPFARSVSARHHTPDSEEERVDCYAVPD 1626

  Fly  2007 PGQCDKWALHWNYNETEGRCQSFYYGGCGGNDNRFATEEECSARCSVNIDIRIGA---------- 2061
            ||.|..:.|.|:|:.|...|:.||||||.||.|||.|.::|...|...|:.|:.:
Worm  1627 PGSCGDYRLVWHYSATSNSCRQFYYGGCAGNTNRFETRDKCETSCVAKIEERVESVSEASKSLEE 1691

  Fly  2062 -------------------DPVEH-------DTSK----CFLAFEPGNCYNNVTRWFYNSAEGLC 2096
                               |.:|.       ||..    |.|..:.|:||:|:.||.::|.:..|
Worm  1692 VRLTDPRMDSHFGYHDPEVDQIEEEAEYVIVDTGALPELCMLPEQRGSCYDNILRWRFDSEKSQC 1756

  Fly  2097 DEFVYTGCGGNANNYATEEECQNECNDAQ--TTCALPPVRGRCSDLSRRWYFDERSGECHEFEFT 2159
            ..|:|:||..|||::.::|.|:..|...:  ..|.||...|.|.....|||.|.::.:|....:|
Worm  1757 VTFMYSGCNPNANHFTSQETCERACGKWRNVAVCELPAEHGDCQLAIPRWYHDPKTSQCQMMMWT 1821

  Fly  2160 GCRGNRNNFVSQSDCLNFCIGEPVVEPSAPTYSVCAEPPEAGECDNRTTAWFYDSENMACTAFTY 2224
            ||.||.|.|.|::||.:.|..|.:...:.   ..|.....||.|.:..:.|::||.::.|..|||
Worm  1822 GCGGNGNAFSSKADCESLCRVETLWSNNT---DFCTLERSAGPCTDSISMWYFDSTHLDCKPFTY 1883

  Fly  2225 TGCGGNGNRFETRDQCERQC--GEFKGVDVCNEPVTTGPCTDWQTKYYFNTASQACEPFTYGGCD 2287
            .||.||.|||.:::||::.|  |:.|..|:|......|||.....||:::...|:|..|.||||:
Worm  1884 GGCRGNQNRFVSKEQCQQSCRPGDTKSEDICTLRPEPGPCRLGLEKYFYDPVIQSCHMFHYGGCE 1948

  Fly  2288 GTGNRFSDLFECQTVCL-----AGREPRVG-----SAKEICLL---PVATG-----RCNGPSVHE 2334
            |..|||....:|...|.     |....|||     |...|.::   .:..|     |||...|..
Worm  1949 GNANRFDSELDCFRRCSSVKVEASESERVGQLTSASTPVIYIVNKTAIFVGNTFRIRCNSYGVLP 2013

  Fly  2335 RRWYYDDEAGNCVSFIYAGCSGNQNNFRSFEACTNQCRPEPNKQDNEIGQNPCDTFDAECQELRC 2399
            ..||   :.|..:.|.......|.:.....:|.|           .:.|...|    ...|:...
Worm  2014 ITWY---KNGGLLQFGSRITEENDDTLEIVDALT-----------ADAGVYTC----IAGQDSTM 2060

  Fly  2400 PYGVRRVAAR-------SQPECTQCICENPCEGYSC---PEGQQCAIDV----------ASSDDR 2444
            ..||..|..|       |:|..|      |.:.:|.   |......:..          |.||.|
Worm  2061 SEGVEVVIKRLPGHRTTSRPMLT------PSKNFSLGTPPTPSPSTVSTTPFRIYTPGSAPSDAR 2119

  Fly  2445 QFAPV---CRDIYKPGECPALSANASGCARECYTDADCRGDNKCCSDGCGQLCVH 2496
            ...|.   |.|:.....|..:..|.. |.::.|                |..|.|
Worm  2120 VSRPTSNSCMDVGNASTCDLIVKNGL-CGKKRY----------------GTFCCH 2157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	22/50 (44%)
		ADAM_spacer1	214..329	CDD:283607	43/116 (37%)
		TSP1	468..521	CDD:214559	23/56 (41%)
		TSP_1	645..693	CDD:278517	15/47 (32%)
		Kunitz_BPTI	1611..1663	CDD:278443	24/53 (45%)
		Kunitz_BPTI	1670..1721	CDD:278443	18/52 (35%)
		Kunitz_BPTI	1729..1781	CDD:278443	21/116 (18%)
		Kunitz_BPTI	1789..1840	CDD:278443	18/50 (36%)
		Kunitz_BPTI	1848..1899	CDD:278443	23/50 (46%)
		KU	1920..1973	CDD:238057	20/71 (28%)
		Kunitz_BPTI	2001..2051	CDD:278443	23/49 (47%)
		KU	2071..2121	CDD:238057	19/49 (39%)
		Kunitz_BPTI	2127..2178	CDD:278443	20/50 (40%)
		KU	2192..2245	CDD:238057	21/54 (39%)
		KU	2251..2304	CDD:238057	19/52 (37%)
		KU	2316..2372	CDD:238057	13/63 (21%)
		WAP	2457..2497	CDD:278522	7/40 (18%)
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
mig-6	NP_505017.1	TSP1	79..123	CDD:214559	23/51 (45%)
		ADAM_spacer1	224..336	CDD:283607	43/116 (37%)
		TSP1	350..402	CDD:214559	19/56 (34%)
		TSP1	468..525	CDD:214559	23/56 (41%)
		TSP1	651..702	CDD:214559	24/114 (21%)
		Kunitz_BPTI	1088..1142	CDD:278443	24/53 (45%)
		KU	1149..1203	CDD:238057	18/53 (34%)
		KU	1269..1321	CDD:238057	16/51 (31%)
		Kunitz_BPTI	1374..1426	CDD:278443	18/51 (35%)
		Kunitz_BPTI	1446..1498	CDD:278443	23/51 (45%)
		KU	1502..1555	CDD:238057	19/52 (37%)
		Kunitz_BPTI	1621..1672	CDD:278443	23/50 (46%)
		Kunitz_BPTI	1731..1782	CDD:278443	19/50 (38%)
		Kunitz_BPTI	1789..1841	CDD:278443	20/51 (39%)
		Kunitz_BPTI	1852..1904	CDD:278443	20/51 (39%)
		KU	1912..1964	CDD:238057	19/51 (37%)
		IG_like	1998..2068	CDD:214653	17/87 (20%)
		IGc2	1999..2054	CDD:197706	14/72 (19%)
		PLAC	2128..2160	CDD:285849	9/47 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166662
Domainoid	1	1.000	133	1.000	Domainoid score	I3144
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	733	1.000	Inparanoid score	I312
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28783
OrthoDB	1	1.010	-	-		D36783at33208
OrthoFinder	1	1.000	-	-		FOG0005760
OrthoInspector	1	1.000	-	-		oto20441
orthoMCL	1	0.900	-	-		OOG6_106772
Panther	1	1.100	-	-	LDO	PTHR13723
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2734
SonicParanoid	1	1.000	-	-		X4788
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.940