DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppn and appb

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_690842.1	Gene:	appb / 170846	ZFINID:	ZDB-GENE-020220-1	Length:	694	Species:	Danio rerio

Alignment Length:	282	Identity:	69/282 - (24%)
Similarity:	103/282 - (36%)	Gaps:	84/282 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   540 TETRTAICGNKEGKVYPEEFCEPEVPTLS----RPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRI 600
            |.|::.| ..|||.:   ::|:...|.|.    .....|.....|......:|.:.....|..|.
Zfish    59 TGTKSCI-STKEGIL---KYCQEVYPDLQITNVVEANQPVSIQNWCKMGRRQCRSHTHIVVPYRC 119

  Fly   601 VICGEFDGKTVTPADDDSKCNKETKPESEQDCEGEEKVCPGEWFTGPWGKCSK------------ 653
            :: |||....:...|   || |....|....||...     .|.|.....|..
Zfish   120 LV-GEFVSDALLVPD---KC-KFLHQERMDMCESHL-----HWHTVAKESCGDRSMNLHDYGMLL 174

  Fly   654 PCGGGERVREVLCLSNGTKSVNCDEEKVEPL----SEKCNSEA--------CTEDEILPLTSTDK 706
            || |.:|.|       |.:.|.|..|:.:.|    .|:.||:.        .|:..:|....|.|
Zfish   175 PC-GIDRFR-------GVEFVCCPMEEQKDLDSEEQEEANSDVWWGGAETEYTDASVLKEQVTAK 231

  Fly   707 P----IEDDEE---------DCDEDGIELISDGLSDDEK---SEDVIDLEGTAK----------- 744
            |    .||||:         |.||||     ||..|:::   .||:||.:.|::
Zfish   232 PDPAVTEDDEDLNNEEEEVWDNDEDG-----DGEDDEDEEDDDEDIIDEQDTSEQTSNIAMTTTT 291

  Fly   745 TETTPEAEDLMQ--SDSPTPYD 764
            |.||...|::::  :.:|:|.|
Zfish   292 TTTTESIEEVVRVPTMAPSPAD 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559
		ADAM_spacer1	214..329	CDD:283607
		TSP1	468..521	CDD:214559
		TSP_1	645..693	CDD:278517	15/71 (21%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
appb	NP_690842.1	A4_EXTRA	29..190	CDD:128326	34/152 (22%)
		APP_N	33..133	CDD:280358	17/78 (22%)
		APP_Cu_bd	135..190	CDD:289676	15/68 (22%)
		APP_E2	306..488	CDD:289677	3/8 (38%)
		Beta-APP	599..637	CDD:281491
		APP_amyloid	640..690	CDD:287486
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910