DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and Papln

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_001192272.1 Gene:Papln / 170721 MGIID:2386139 Length:1302 Species:Mus musculus


Alignment Length:2915 Identity:499/2915 - (17%)
Similarity:699/2915 - (23%) Gaps:1700/2915 - (58%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 TPGGEGND----PDEWTPWSSPSDCSRTCGGGVSYQTRECL--RRDDRGEAVCSGGSRRYFSCNT 107
            |||....:    .|.|..|...|.||||||||:|::.|.|.  |||  |...|.|.:|.:.:|:|
Mouse    15 TPGSWARNVRRQSDTWGTWGEWSPCSRTCGGGISFRERPCYSQRRD--GGTSCVGPARSHRTCHT 77

  Fly   108 QDCPEEESDFRAQQCSRFDRQQFDGVFYEWVPYTNAPNPCELNCMPKGERFYYRQREKVVDGTRC 172
            :.||:...||||:||:.||...|.|..|.|:||..|||.|||||:|||:.|||:.::.|||||.|
Mouse    78 ESCPDGVRDFRAEQCAEFDGTDFQGRRYRWLPYYAAPNKCELNCIPKGQNFYYKHKDAVVDGTPC 142

  Fly   173 NDKDLDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLLLLPE 237
            .....|:||:|.|..||||..|.|..:||||.:||||||:|..:..|....||:.|||.:.::|.
Mouse   143 EPGQRDICVDGVCRVVGCDHKLDSIKQEDKCLQCGGDGSSCYPVTGTFDGNDLSRGYNQIFIIPA 207

  Fly   238 GATNIRIEETVPSSNYLACRNHSGHYYLNGDWRIDFPRPMFFANSWWNYQRKPMGFAAPDQLTCS 302
            |||:|||||...|.|:||.::..|.|||||.|.|:..:.:..|::...|:|...|..||::|...
Mouse   208 GATSIRIEEAAASRNFLAVKSIRGEYYLNGHWTIEAAQALPVASTVLQYERGVEGDLAPERLQAR 272

  Fly   303 GPISESLFIVMLVQEKNISLDYEYSIPESLSHSQQDTHTWTHHQFNACSASCGGGSQSRKVTC-- 365
            ||.||.|.|.:|.||.|..:.|||.:|   ::......:|:|..:..|||.||||.|||.|.|  
Mouse   273 GPTSEPLVIELLSQESNPGVHYEYYLP---ANDPGRGFSWSHGSWGDCSAECGGGHQSRLVFCTI 334

  Fly   366 NNRITLAEVNPS-LCDQKSKPVEEQACGTEPC-------------------APH-----WVEGEW 405
            :|     |..|. :|..:.:|...::|.|:||                   ..|     |..|.|
Mouse   335 DN-----EAYPDHMCQHQPRPTHRRSCNTQPCPKTKRISFLHRPGAWRYAGVQHMCGNSWKVGPW 394

  Fly   406 SKCSKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVKNCPKYHLGPW 470
            :.||..||. |.|:||:.|.....:|.....|:..|...|| ||.|.|.||  :::|..:.:.||
Mouse   395 TPCSVSCGG-GVQSRSVYCISSDGTGGQEAAEETQCAGLVG-KPPTTQACN--LQHCAVWSVEPW 455

  Fly   471 TPCDKLCGDGKQTRKVTCFIEENGHKRVLPEEDCVEEKPETEKSCLLTPCEGVDWIISQWSGCNA 535
            ..|...||.|.:.|.|||..:|.              .|....:|||                  
Mouse   456 GECSVTCGTGIRKRSVTCRGDEG--------------SPVHAAACLL------------------ 488

  Fly   536 CGQNTETRTAICGNKEGKVYPEEFCEPEVPTLSRPCKSPKCEA----QWFSSEWSKCSAPCGKGV 596
                                      .:.|||:.||....|..    .|....||.||..||.|:
Mouse   489 --------------------------KDQPTLTEPCVQEACPVFRGQAWHVGSWSLCSKSCGSGI 527

  Fly   597 KSRIVICGEFDGKTVTPADDDSKCNKETKPESEQDCEGEEKVCPGEWFTGPWGKC-----SKPCG 656
            :.|.|:|      |:                                  ||.|:|     |||..
Mouse   528 RRRQVVC------TI----------------------------------GPPGRCVDLQSSKPAE 552

  Fly   657 GGERVREVLCLSNGTKSVNCDEEKVEPLSEKCNSEACTEDEILPLTSTDKPIEDDEEDCDEDGIE 721
                                        .|.||.:.|.    ||                     
Mouse   553 ----------------------------MEACNRQPCH----LP--------------------- 564

  Fly   722 LISDGLSDDEKSEDVIDLEGTAKTETTPEAEDLMQSDSPTPYDEFESTGTTFEGSGYDSESTTDS 786
                                                                             
Mouse   565 ----------------------------------------------------------------- 564

  Fly   787 GISTEGSGDDEETSEASTDLSSSTDSGSTSSDSTSSDSSSSISSDATSEAPASSVSDSSDSTDAS 851
                                                           .|.|              
Mouse   565 -----------------------------------------------QEVP-------------- 568

  Fly   852 TETTGVSDDSTDVSSSTEASASESTDVSGASDSTGSTNASDSTPESSTEASSSTDDSTDSSDNSS 916
                                                                             
Mouse   569 ----------------------------------------------------------------- 568

  Fly   917 NVSESSTEASSSSVSDSNDSSDGSTDGVSSTTENSSDSTSDATSDSTASSDSTDSTSDQTTETTP 981
                                                                             
Mouse   569 ----------------------------------------------------------------- 568

  Fly   982 ESSTDSTESSTLDASSTTDASSTSESSSESSTDGSSTTSNSASSETTGLSSDGSTTDATTAASDN 1046
                                                                 |..|..|.:||.
Mouse   569 -----------------------------------------------------SIQDPRTRSSDP 580

  Fly  1047 TDITTDGSTDESTDGSSNASTEGSTEGASEDTTISTESSGSTESTDAIASDGSTTEGSTVEDLSS 1111
            ..:                                                              
Mouse   581 RML-------------------------------------------------------------- 583

  Fly  1112 STSSDVTSDSTITDSSPSTEVSGSTDSSSSTDGSSTDASSTEASSTDVTESTDSTVSGGTSDTTE 1176
                                                                             
Mouse   584 ----------------------------------------------------------------- 583

  Fly  1177 SGPTEESTTEGSTESTTEGSTDSTQSTDLDSTTSDIWSTSDKDDESESSTPYSFDSEVTKSKPRK 1241
            |||.....::|..:.                     |:..::                       
Mouse   584 SGPRVSPVSDGREQQ---------------------WAPLER----------------------- 604

  Fly  1242 CKPKKSTCAKSEYGCCPDGKSTPKGPFDEGCPIAKTCADTKYGCCLDGVSPAKGKNNKGCPKSQC 1306
                            |..:|.|:                      :|..|              
Mouse   605 ----------------PRAQSNPR----------------------EGQDP-------------- 617

  Fly  1307 AETLFGCCPDKFTAADGENDEGCPETTTVPPTTTTEETQPETTTEIEGSGQDSTTSEPDTKKSCS 1371
                                                        .:..:|:..|...|..:    
Mouse   618 --------------------------------------------NLSSAGRAPTLQRPPHQ---- 634

  Fly  1372 FSEFGCCPDAETSAKGPDFEGCGLASPVAKGCAESENGCCPDGQTPASGPNGEGCSGCTRERFGC 1436
                   |....|: ||            :.|..|.:||||||.||:.||..:||          
Mouse   635 -------PPLRPSS-GP------------RDCRHSPHGCCPDGHTPSLGPQWQGC---------- 669

  Fly  1437 CPDSQTPAHGPNKEGCCLDTQFGCCPDNILAARGPNNEGCECHYTPYGCCPDNKSAATGYNQEGC 1501
                  |..|.:    ||.:::|||||.:.||.||...||.   ..:|  .||    || |:.| 
Mouse   670 ------PLAGAS----CLQSRYGCCPDGVSAAEGPQQAGCT---RSHG--SDN----TG-NRPG- 713

  Fly  1502 ACETTQYGCCPDKITAAKGPK------HEGCPCETTQFGCCPDGLTFAKGPHHHGCHCTQTEFKC 1560
                       .:..|:|.||      |||.|.|                       |..:.|.|
Mouse   714 -----------SRAVASKNPKIHQPQAHEGEPSE-----------------------CRSSRFGC 744

  Fly  1561 CDDEKTPAKGPNGDGCTCVESKFGCCPDGVTKATDEKFGGCENVQEPPQKACGLPKETGTCNNYS 1625
            |.|....|.||.|:||.                      |..:...|.:  |.||...|:|.:::
Mouse   745 CYDNVASAAGPLGEGCV----------------------GQPSYAYPVR--CLLPSAQGSCGDWA 785

  Fly  1626 VKYYFDTSYGGCARFWYGGCDGNDNRFESEAECKDTCQDYTGKHVCLLPKSAGPCTGFTKKWYFD 1690
            .::||..|.|.|.|||||||.||.|.|.||.||.:||:   |:|        ||           
Mouse   786 ARWYFVASVGRCNRFWYGGCHGNANNFASEQECMNTCR---GQH--------GP----------- 828

  Fly  1691 VDRNRCEEFQYGGCYGTNNRFDSLEQCQGTCAASENLPTCEQPVESGPCAGNFERWYYDNETDIC 1755
                                                    .:| |:| .||:             
Mouse   829 ----------------------------------------RRP-EAG-AAGH------------- 838

  Fly  1756 RPFTYGGCKGNKNNYPTEHACNYNCRQPGVLKDRCALPKQTGDCSEKLAKWHFSESEKRCVPFYY 1820
            |....||.:|                 ||               .::...||             
Mouse   839 RAHVDGGQRG-----------------PG---------------GQQEPDWH------------- 858

  Fly  1821 SGCGGNKNNFPTLESCEDHCPRQVAKDICEIPAEVGECANYVTSWYYDTQDQACRQFYYGGCGGN 1885
                                             ..|                             
Mouse   859 ---------------------------------RAG----------------------------- 861

  Fly  1886 ENRFPTEESCLARCDRKPEPTTTTPATRPQPSRQDVCDEEPAPGECSTWVLKWHFDRKIGACRQF 1950
                       |...|.|.|:.:       |.|:   ::||||||                    
Mouse   862 -----------ATIPRLPSPSGS-------PWRR---EQEPAPGE-------------------- 885

  Fly  1951 YYGNCGGNGNRFETENDCQQRCLSQEPPAPTPPRAPAPTRQPDPAPTVAQCSQPADPGQCDKWAL 2015
                                           ||..||...:|.     .|..:|..||.      
Mouse   886 -------------------------------PPHIPAYGNRPG-----GQEIRPRVPGL------ 908

  Fly  2016 HWNYNETEGRCQSFYYGGCGGNDNRFATEEECSARCSVNIDIRIGADPVEHDTSKCFLAFEPGNC 2080
                                                                             
Mouse   909 ----------------------------------------------------------------- 908

  Fly  2081 YNNVTRWFYNSAEGLCDEFVYTGCGGNANNYATEEECQNECNDAQTTCALPPVRGRCSDLSRRWY 2145
                                                      |.:...|:||..           
Mouse   909 ------------------------------------------DREARPAVPPTH----------- 920

  Fly  2146 FDERSGECHEFEFTGCRGNRNNFVSQSDCLNFCIGEPVVEPSAPTYSVCAEPPEAGECDNRTTAW 2210
                                    |.|..:.....||.:..:||                     
Mouse   921 ------------------------SPSYRIRLAGSEPSLVQAAP--------------------- 940

  Fly  2211 FYDSENMACTAFTYTGCGGNGNRFETRDQCERQCGEFKGVDVCNEPVTTGPCTDWQTKYYFNTAS 2275
                 ..|...|    |.||       ...|.|.|                   ||.:       
Mouse   941 -----GQAVQLF----CPGN-------IPSEFQAG-------------------WQKE------- 963

  Fly  2276 QACEPFTYGGCDGTGNRFSDLFECQTVCLAGREPRVGSAKEICLLPVATGRCNGPSVHERRWYYD 2340
                                          ||             |:::.|           |..
Mouse   964 ------------------------------GR-------------PISSNR-----------YQL 974

  Fly  2341 DEAGNCVSFIYAGCSGNQNNFRSFEACTNQCRPEPNKQDNEIGQNPCDTFDAECQELRCPYGVRR 2405
            ...|:.:                    .::.|||                ||         |:  
Mouse   975 QADGSLI--------------------ISRLRPE----------------DA---------GI-- 992

  Fly  2406 VAARSQPECTQCICENPCEGYSCPEGQQCAIDVASSDDRQFAPVCRDIYKPGECP-ALSANASGC 2469
                                |||..                       ::||..| .:....:| 
Mouse   993 --------------------YSCGS-----------------------HRPGHEPQEIQLRVTG- 1013

  Fly  2470 ARECYTDADCRGDNKCCSDGCGQLCVHP-ARPTQPPRTQAPVVSYPGDARAALEPKEAHELDVQT 2533
                                 |.:.|.| .:|...|..:.|.:.:....|........|      
Mouse  1014 ---------------------GDMAVFPEGQPRHFPEPRNPDLGHGPPHRGTGAEAGGH------ 1051

  Fly  2534 AIGGIAVLRCFATGNPAPNITWSLKNLVINTNKGRYVLTANGDLTIVQVRQTDDGTYVCVASNGL 2598
                    |..:..:|.|                         .|.:::.:|..|    |.....
Mouse  1052 --------RVLSPSHPRP-------------------------ATRLRLDRTQPG----VVDASP 1079

  Fly  2599 GEPVRREVALQVTEPVSQPAYIYGDKNVTQIVELNRPAVIRCPAGGFPEPHVSWWRNGQMFGLKN 2663
            |:.:|                                  :.|.|.|||.|.:.|.|:||:.....
Mouse  1080 GQRIR----------------------------------LTCRAEGFPVPTIEWQRDGQLVSSPR 1110

  Fly  2664 NLMARDYSLVFNSIQLSDLGLYTCEVYN----QRRPVSLRVTLKAVGPVRPLSPEEEQYMQYVLN 2724
            :.:..|.|||.:.:.:.|.|.|:|..:|    .:|.|.|||       :|.|:            
Mouse  1111 HQVQPDGSLVISRVDVEDGGYYSCVAFNGQDRDQRWVQLRV-------LRELT------------ 1156

  Fly  2725 PATRPVTQRPSYPYRPTRPAYVPEPTVNVHAVLALEPKNSYTPGSTIVMSCSVQGYPEPNVTWIK 2789
                                           :..|.|..:...|.|..:.|.|.| ...|:.|.:
Mouse  1157 -------------------------------ITGLPPAVTVAEGDTARLLCVVAG-ESVNIRWSR 1189

  Fly  2790 DDVPLY-NNERVQITYQPHR-----LVLSDVTSADSGKYTCRASNAYTYANGEANVSIQSVVP-- 2846
            :.:|:. :..||      |:     |::.::...|.|.|||.|.......:....|.:....|  
Mouse  1190 NGLPIQADGHRV------HQSPDGTLLIHNLRPRDEGSYTCSAFRGSQAVSRSTEVKVALPAPAA 1248

  Fly  2847 ----VSPECVDNPYFANCKLIVKGRYCSNPYYTQFCCRSCTLAGQVASPPLHPNA 2897
                :..:|:|.|..|||.||::.:.|.|.||:.|||.||:        ...|||
Mouse  1249 QSRDLGKDCIDQPELANCALILQAQLCGNEYYSSFCCASCS--------RFQPNA 1295

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559 23/52 (44%)
ADAM_spacer1 214..329 CDD:283607 47/114 (41%)
TSP1 468..521 CDD:214559 15/52 (29%)
TSP_1 645..693 CDD:278517 10/52 (19%)
Kunitz_BPTI 1611..1663 CDD:278443 26/51 (51%)
Kunitz_BPTI 1670..1721 CDD:278443 2/50 (4%)
Kunitz_BPTI 1729..1781 CDD:278443 9/51 (18%)
Kunitz_BPTI 1789..1840 CDD:278443 2/50 (4%)
Kunitz_BPTI 1848..1899 CDD:278443 2/50 (4%)
KU 1920..1973 CDD:238057 6/52 (12%)
Kunitz_BPTI 2001..2051 CDD:278443 3/49 (6%)
KU 2071..2121 CDD:238057 0/49 (0%)
Kunitz_BPTI 2127..2178 CDD:278443 5/50 (10%)
KU 2192..2245 CDD:238057 7/52 (13%)
KU 2251..2304 CDD:238057 2/52 (4%)
KU 2316..2372 CDD:238057 4/55 (7%)
WAP 2457..2497 CDD:278522 5/40 (13%)
Ig 2521..2610 CDD:299845 10/88 (11%)
IG_like 2530..2610 CDD:214653 9/79 (11%)
IG_like 2627..2703 CDD:214653 24/79 (30%)
Ig 2636..2701 CDD:143165 23/68 (34%)
IG_like 2766..2841 CDD:214653 19/80 (24%)
Ig 2768..2830 CDD:299845 18/67 (27%)
PLAC 2851..2883 CDD:285849 16/31 (52%)
PaplnNP_001192272.1 TSP1 30..81 CDD:214559 23/52 (44%)
ADAM_spacer1 184..299 CDD:368694 47/114 (41%)
TSP1 309..362 CDD:214559 22/57 (39%)
TSP1 389..447 CDD:214559 23/61 (38%)
TSP1 447..504 CDD:214559 21/114 (18%)
TSP1 511..562 CDD:214559 22/118 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 563..648 27/705 (4%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 694..737 19/87 (22%)
Kunitz_BPTI 771..822 CDD:333766 25/52 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 822..924 45/510 (9%)
Papilin_u7 831..922 CDD:374683 39/437 (9%)
Ig 932..>995 CDD:386229 27/246 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1024..1064 8/78 (10%)
I-set 1070..1141 CDD:369462 24/108 (22%)
Ig 1157..1241 CDD:386229 21/90 (23%)
PLAC 1257..1289 CDD:370061 16/31 (52%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 135 1.000 Domainoid score I4974
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H71541
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S7316
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0005760
OrthoInspector 1 1.000 - - oto94832
orthoMCL 1 0.900 - - OOG6_106772
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2734
SonicParanoid 1 1.000 - - X4788
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1211.650

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