DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppn and ADAMTS18

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_955387.1	Gene:	ADAMTS18 / 170692	HGNCID:	17110	Length:	1221	Species:	Homo sapiens

Alignment Length:	724	Identity:	243/724 - (33%)
Similarity:	346/724 - (47%)	Gaps:	104/724 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RLCSTALVAFIVLASI------HDSQSRFPGLRQKRQYGANMYLPESSVTPGGE-GNDP--DEWT 61
            :|||...|..| ..|:      |..:::|....:....|.:|:..:......|| |..|  .:|:
Human   530 KLCSLGFVKDI-CKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWS 593

  Fly    62 PWSSPSDCSRTCGGGVSYQTRECLR-RDDRGEAVCSGGSRRYFSCNTQDCPEEESDFRAQQCSRF 125
            .||..|:|||||||||.:|.|.|.. :...|...|.|.||.|..||...|.|...|||||||:.:
Human   594 AWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEY 658

  Fly   126 DRQQFDGVFYEWVPYTNA--PNPCELNCMPKGERFYYRQREKVVDGTRCNDKDLDVCVNGECMPV 188
            :.:.|.|.||:|.|||..  .:.|:|.|..:...|::....||.|||.|:....|||::|.|..|
Human   659 NSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELV 723

  Fly   189 GCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLLLLPEGATNIRIEETVPSSNY 253
            |||..|||.|..|.|..|.||.||||..:.....:..|..|..::|:|.||.:|.|:|...||:|
Human   724 GCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSY 788

  Fly   254 LACRNHSGHYYLNGDWRIDFPRPMFFANSWWNYQRKPMGFAAPDQLTCSGPISESLFIVMLVQEK 318
            ||.|:.|..|||.|.|.||:|....||.:.:.|||   .|..|::|...||.:|:|...:|:|.|
Human   789 LAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQR---SFNRPERLYAPGPTNETLVFEILMQGK 850

  Fly   319 NISLDYEYSIPESLS----HSQQDTHTWTHHQFNACSASCGGGSQSRKVTCNNRITLAEVNPSLC 379
            |..:.::|::|:.::    .:::..:||:..| :.||.|||||..:.|..| .|....:||.|.|
Human   851 NPGIAWKYALPKVMNGTPPATKRPAYTWSIVQ-SECSVSCGGGYINVKAIC-LRDQNTQVNSSFC 913

  Fly   380 DQKSKPV-EEQACGTEPCAPHWVEGEWSKCSKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLK 443
            ..|:||| |.:.|....|..:|:.||||.|||.| :.|.|:|.|.|.:.....:......::|
Human   914 SAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKAC-AGGQQSRKIQCVQKKPFQKEEAVLHSLC-- 975

  Fly   444 EVGNKPATKQECNRDVKNC-PKYHLGPWTPCDKLCGDGKQTRKVTCFIEENGHKRVLPEEDCVE- 506
             ..:.|...|.||...  | |::.||||:.|.|.||.|.:.|::.|   :......|||..|..
Human   976 -PVSTPTQVQACNSHA--CPPQWSLGPWSQCSKTCGRGVRKRELLC---KGSAAETLPESQCTSL 1034

  Fly   507 EKPETEKSCLLTPCEGVDWIISQWSGCNACGQNTETRTAICGNKEGKVYPEEFCEPEVPTLSRPC 571
            .:||.::.|:|..|                                            |..||
Human  1035 PRPELQEGCVLGRC--------------------------------------------PKNSR-- 1053

  Fly   572 KSPKCEAQWFSSEWSKCSAPCGKGVKSRIVICGE--FDGKTVT-PADDDSKCNKETKP--ESEQD 631
                  .||.:|.||:|||.||.||:.|.:.|.|  |.||.:| |   :.:|....||  :.|:.
Human  1054 ------LQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFP---ERRCRNIKKPNLDLEET 1109

  Fly   632 CEGEEKVCPGE--------WFTGPWGKCSKPCGGGERVREVLCLSNGTKSVNCDEEKVEPLSEKC 688
            |  ..:.||..        |::.||.:|:..||||.:.|.|.|:..|..|.:|...:..|:...|
Human  1110 C--NRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRAC 1172

  Fly   689 NSEACTEDE 697
            |:..|...|
Human  1173 NTNFCPAPE 1181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	24/51 (47%)
		ADAM_spacer1	214..329	CDD:283607	42/114 (37%)
		TSP1	468..521	CDD:214559	18/53 (34%)
		TSP_1	645..693	CDD:278517	16/47 (34%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
ADAMTS18	NP_955387.1	Pep_M12B_propep	86..202	CDD:279848
		Cysteine switch. /evidence=ECO:0000250	252..259
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..291
		ZnMc_ADAMTS_like	293..494	CDD:239801
		Reprolysin	295..498	CDD:279729
		TSP1	592..643	CDD:214559	24/50 (48%)
		ADAM_spacer1	749..861	CDD:283607	42/114 (37%)
		Spacer	750..876		42/128 (33%)
		TSP1	938..992	CDD:214559	18/59 (31%)
		TSP1	995..1049	CDD:214559	20/100 (20%)
		TSP1	1059..1116	CDD:214559	23/61 (38%)
		TSP1	1131..1178	CDD:214559	16/46 (35%)
		PLAC	1188..1218	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810