DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppn and ADAMTS15

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_620686.1	Gene:	ADAMTS15 / 170689	HGNCID:	16305	Length:	950	Species:	Homo sapiens

Alignment Length:	490	Identity:	156/490 - (31%)
Similarity:	215/490 - (43%)	Gaps:	87/490 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 WTPWSSPSDCSRTCGGGVSYQTRECLR-RDDRGEAVCSGGSRRYFSCNTQDCPEEES--DFRAQQ 121
            |..|.....|||||||||....|:|.. ....|...|.|...:|.|||.:.||...|  .||.:|
Human   519 WAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQ 583

  Fly   122 CSRFDRQQFDGVFYE---------WVPYTNAPNP---CELNCMPKGERFYYRQREKVVDGTRCND 174
            |     :.|:|..:.         |||..:..:|   |:|.|...|..::|....||||||.|:.
Human   584 C-----EAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTLCSP 643

  Fly   175 KDLDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLLLLPEGA 239
            ....|||.|:|:..|||..|||..:.|||..||||..:||.:.. :.||.: .|||.::.:|.||
Human   644 DSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTG-LFTKPM-HGYNFVVAIPAGA 706

  Fly   240 TNIRIEE-----TVPSSNYLACRNHSGHYYLNGDWRID-FPRPMFFANSWWNYQRKPMGFAAPDQ 298
            ::|.|.:     .:...||||.:|..|.|.|||.:.:. ..|.:....|...|....   .|.:.
Human   707 SSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSLLRYSGTG---TAVES 768

  Fly   299 LTCSGPISESLFIVMLVQEKNI--SLDYEYSIP----ESLSHSQQDTHTWTHHQFNACSASCGGG 357
            |..|.||.|.|.:.:|...|..  .:.|.:.:|    |..|...:|..               |.
Human   769 LQASRPILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDKSSHPKDPR---------------GP 818

  Fly   358 SQSRKVTCNNRITLAEVNPSLCDQKSKPVEEQACGTEPCAPHWVEGEWSKCSKGCGSDGFQNRSI 422
            |     ..:|.:.      ||.:|..:|.:      .|.| .||.|.|..||..||| |.|.|::
Human   819 S-----VLHNSVL------SLSNQVEQPDD------RPPA-RWVAGSWGPCSASCGS-GLQKRAV 864

  Fly   423 TCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVKNCPKYHLGPWTPCDKLCGDGKQTRKVT 487
            .|.  .|:|:.||   ..|  :..::|...|.|.   :.||.:.|..|:||.|.||.|.|.|.:.
Human   865 DCR--GSAGQRTV---PAC--DAAHRPVETQACG---EPCPTWELSAWSPCSKSCGRGFQRRSLK 919

  Fly   488 CFIEENGH-KRVLPEEDC-VEEKPETEKSCLLTPC 520
            |.    || .|:|..:.| :..||:....|:|.||
Human   920 CV----GHGGRLLARDQCNLHRKPQELDFCVLRPC 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	20/51 (39%)
		ADAM_spacer1	214..329	CDD:283607	34/122 (28%)
		TSP1	468..521	CDD:214559	21/55 (38%)
		TSP_1	645..693	CDD:278517
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
ADAMTS15	NP_620686.1	Pep_M12B_propep	24..142	CDD:307618
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..172
		Cysteine switch. /evidence=ECO:0000250	172..179
		ZnMc_ADAMTS_like	218..424	CDD:239801
		ADAM_CR	437..506	CDD:326582
		TSP1	519..571	CDD:214559	20/51 (39%)
		ADAM_spacer1	683..801	CDD:310520	34/122 (28%)
		Spacer	701..838		39/171 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	798..822		6/43 (14%)
		TSP1	846..895	CDD:214559	19/59 (32%)
		TSP1	897..950	CDD:214559	20/56 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810