DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ppn and Hhip

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_064655.4 Gene:Hhip / 15245 MGIID:1341847 Length:700 Species:Mus musculus


Alignment Length:726 Identity:138/726 - (19%)
Similarity:218/726 - (30%) Gaps:255/726 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1959 GNRFETENDCQQRCLSQEPPAPTPPRAPAPTRQPDPA-----------PTVAQCSQPADPGQCDK 2012
            |.|.|.....::|||:..||.....|......|.:..           |.|:.|.|...||.   
Mouse    26 GERNEGSGARRRRCLNGNPPKRLKRRDRRVMSQLELLSGGEILCGGFYPRVSCCLQSDSPGL--- 87

  Fly  2013 WALHWNYNETEGRCQSFYYGGCGGND-NRFATEEECSARCSVNIDIRIGADPVEHDTSKCFLAFE 2076
                       ||.::..:.....:: :|...|.:| |.||.:.. .:...| |.|.....||. 
Mouse    88 -----------GRLENKIFSATNNSECSRLLEEIQC-APCSPHSQ-SLFYTP-ERDVLDGDLAL- 137

  Fly  2077 PGNCYNNVTRWFY-----------NSAEGLCDEFVYTGCG------------GNANNYATEEE-- 2116
            |..|.:....:||           .:|:..|..:.....|            |.|:||..:.|  
Mouse   138 PLLCKDYCKEFFYTCRGHIPGLLQTTADEFCFYYARKDAGLCFPDFPRKQVRGPASNYLGQMEDY 202

  Fly  2117 ---------CQNEC---NDAQTTCALPPVRGRCSDLSRRWYFDERSG-----------------E 2152
                     .::.|   .:..:....|.......|.|.|.:..|:.|                 :
Mouse   203 EKVGGISRKHKHNCLCVQEVMSGLRQPVSAVHSGDGSHRLFILEKEGYVKILTPEGELFKEPYLD 267

  Fly  2153 CHEFEFTGCRG-----------------NRNNFVS-QSDCLNFCIGE-----PVVEPSAPTYSVC 2194
            .|:...:|.:|                 |...:|| .::...:.||.     .|||     |:|.
Mouse   268 IHKLVQSGIKGGDERGLLSLAFHPNYKKNGKLYVSYTTNQERWAIGPHDHILRVVE-----YTVS 327

  Fly  2195 AEPPEAGECDNRTTAWFYDSENM-----------ACTAFTYTGCGGNGNRFETRDQCERQCG--E 2246
            .:.|.  :.|.||...|.:...:           ....|.|...   |:...|.|..|...|  :
Mouse   328 RKNPH--QVDVRTARVFLEVAELHRKHLGGQLLFGPDGFLYIIL---GDGMITLDDMEEMDGLSD 387

  Fly  2247 FKG--------VDVCNEPVTTGPCTDWQTKYYFNTASQACEPFTYG----GCDGTGNRFSDL-FE 2298
            |.|        .|:||.|.:..     ::..:||:.:|..|.|.:|    |........:|: ..
Mouse   388 FTGSVLRLDVDTDMCNVPYSIP-----RSNPHFNSTNQPPEVFAHGLHDPGRCAVDRHPTDININ 447

  Fly  2299 CQTVCLAGREPRVGSAKEICLLPVATGR--------------CNGPSVHERRWYYDDEAGNCVSF 2349
            ...:|.........||:   :|.:..||              .|||.|.              .|
Mouse   448 LTILCSDSNGKNRSSAR---ILQIIKGRDYESEPSLLEFKPFSNGPLVG--------------GF 495

  Fly  2350 IYAGCS----------GNQN-NFRSFE--ACTNQCRPEP------------------NKQDNEIG 2383
            :|.||.          |::| ||.:.:  ..|.|.:.:|                  ...::|:|
Mouse   496 VYRGCQSERLYGSYVFGDRNGNFLTLQQSPVTKQWQEKPLCLGASSSCRGYFSGHILGFGEDELG 560

  Fly  2384 Q--------NPCDTFDAECQEL------RCPYGVRRVAARSQPECTQC--ICENPCEGYSCPEGQ 2432
            :        :...|.:.:..::      ..|...|.....:||..:.|  :|.|   ||..|.|:
Mouse   561 EVYILSSSKSMTQTHNGKLYKIVDPKRPLMPEECRVTVQPAQPLTSDCSRLCRN---GYYTPTGK 622

  Fly  2433 QCAIDVASSDDRQFAPVCRDIYKPGECPALSANASGCARECYTDADCRGDNKC-CSDG-----CG 2491
            .|.......|      .||              .:.|...|.....|...||| |..|     |.
Mouse   623 CCCSPGWEGD------FCR--------------IAKCEPACRHGGVCVRPNKCLCKKGYLGPQCE 667

  Fly  2492 QLCVHPARPTQ 2502
            |:..:..|.|:
Mouse   668 QVDRNVRRVTR 678

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559
ADAM_spacer1 214..329 CDD:283607
TSP1 468..521 CDD:214559
TSP_1 645..693 CDD:278517
Kunitz_BPTI 1611..1663 CDD:278443
Kunitz_BPTI 1670..1721 CDD:278443
Kunitz_BPTI 1729..1781 CDD:278443
Kunitz_BPTI 1789..1840 CDD:278443
Kunitz_BPTI 1848..1899 CDD:278443
KU 1920..1973 CDD:238057 4/13 (31%)
Kunitz_BPTI 2001..2051 CDD:278443 10/50 (20%)
KU 2071..2121 CDD:238057 14/83 (17%)
Kunitz_BPTI 2127..2178 CDD:278443 12/85 (14%)
KU 2192..2245 CDD:238057 12/63 (19%)
KU 2251..2304 CDD:238057 12/57 (21%)
KU 2316..2372 CDD:238057 17/82 (21%)
WAP 2457..2497 CDD:278522 10/45 (22%)
Ig 2521..2610 CDD:299845
IG_like 2530..2610 CDD:214653
IG_like 2627..2703 CDD:214653
Ig 2636..2701 CDD:143165
IG_like 2766..2841 CDD:214653
Ig 2768..2830 CDD:299845
PLAC 2851..2883 CDD:285849
HhipNP_064655.4 Folate_rec 38..220 CDD:281076 39/199 (20%)
GSDH 226..>428 CDD:285269 42/216 (19%)
Interaction with SHH zinc binding site. /evidence=ECO:0000250 376..388 3/11 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4295
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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