DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppn and ADAMTS14

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_631894.2	Gene:	ADAMTS14 / 140766	HGNCID:	14899	Length:	1226	Species:	Homo sapiens

Alignment Length:	740	Identity:	218/740 - (29%)
Similarity:	296/740 - (40%)	Gaps:	141/740 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 PESSVTPGGEGNDPDEWTPWSSPSDCSRTCGGGVSYQTRECLRRDDR-GEAVCSGGSRRYFSCNT 107
            ||.  |.|.:|.    |:.|:....|||:|||||..::|.|...... |..:|.|....|..||:
Human   548 PEQ--TYGQDGG----WSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNS 606

  Fly   108 QDCPEEESDFRAQQCSRFDRQQF---DGVFYEWVPY--TNAPNPCELNCMPKGERFYYRQREKVV 167
            ::||....|||||||::  |..:   ....:.||||  .:....|||.|............:.|.
Human   607 EECPGTYEDFRAQQCAK--RNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVH 669

  Fly   168 DGTRCNDKD-LDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYND 231
            |||||:.:| ..||..|||:|||||..:||...:|||..||||.|.|:|::.|:.......|...
Human   670 DGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALK 734

  Fly   232 LLLLPEGATNIRIEETVPSSNYLACRNH-SGHYYLNGDWRIDFPRPMFFANSWWNYQRKPMGFAA 295
            |:.:|.||.:|:||....|.:.:..:|. :|.:.||...:....|........|....:.    |
Human   735 LVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVED----A 795

  Fly   296 PDQLTCSGPISESLFIVMLVQEK---NISLDYEYSIPESL-----SHS----QQDTHTWTHHQFN 348
            .:.|..|||:.|::.|:.|...:   ..||.|:|.|.|.|     |::    :.||:.|....:.
Human   796 KESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDTYEWALKSWA 860

  Fly   349 ACSASCGGGSQSRKVTCNNRITLAEVNPSLCDQKSKPVE-EQACGTEPCA-PHWVEGEWSKCSKG 411
            .||.:||||.|..|..|..|.....|...|||.|.:|.. .:.|...||: |.||..||..||:.
Human   861 PCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRS 925

  Fly   412 CGSDGFQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVKNCP-KYHLGPWTPCDK 475
            ||..|.|.|.|.|....|:|.|.|.....|   .|::|..::.|.|  ..|| ::.||.|:.|..
Human   926 CGKLGVQTRGIQCLLPLSNGTHKVMPAKAC---AGDRPEARRPCLR--VPCPAQWRLGAWSQCSA 985

  Fly   476 LCGDGKQTRKVTCFIEEN--GHKRVLPEEDCVEEKPETEKSCLLTPCEGVDWIISQWSGCNACGQ 538
            .||:|.|.|:|.|....|  ||        |..::|:|.:.|.|..|.|..             |
Human   986 TCGEGIQQRQVVCRTNANSLGH--------CEGDRPDTVQVCSLPACGGNH-------------Q 1029

  Fly   539 NTETRTAI--CGNKEGKVYPEE---------------------FCEPEVPTLSRPCKSPKCEAQW 580
            |:..|..:  .|..||:..|:.                     ||:.||  |.|.|..|......
Human  1030 NSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEV--LDRYCSIPGYHRLC 1092

  Fly   581 FSSEWSKCSAPCGKGVKSRIVICGEFDGKT---------------VTPADDDSKCNKETKPESEQ 630
            ..|...|.|.|..          |...|.|               ..|||......|.|..|..|
Human  1093 CVSCIKKASGPNP----------GPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQ 1147

  Fly   631 DCEGEEKVCPGEWFTGPWGKCSKPCGGGERVREVLCLSNGTKSVNCDEEKVEPLSEKCNSEACTE 695
              .|.....||...|.                     |.||:.....|   .|:.....|.:.|.
Human  1148 --HGRATQLPGALDTS---------------------SPGTQHPFAPE---TPIPGASWSISPTT 1186

  Fly   696 DEILP--LTSTDKPIEDDEEDCDED 718
            ...||  .|.|..|:.:|:....||
Human  1187 PGGLPWGWTQTPTPVPEDKGQPGED 1211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	18/51 (35%)
		ADAM_spacer1	214..329	CDD:283607	29/118 (25%)
		TSP1	468..521	CDD:214559	18/54 (33%)
		TSP_1	645..693	CDD:278517	7/47 (15%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
ADAMTS14	NP_631894.2	Pep_M12B_propep	104..206	CDD:279848
		ZnMc_ADAMTS_like	273..460	CDD:239801
		TSP1	558..610	CDD:214559	18/51 (35%)
		ADAM_spacer1	717..832	CDD:283607	29/118 (25%)
		Spacer	733..849		30/119 (25%)
		TSP1	913..972	CDD:214559	22/63 (35%)
		TSP1	978..1024	CDD:214559	18/53 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1103..1226		30/145 (21%)
		DUF1180	1114..>1188	CDD:284165	18/99 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810