DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and nolo

DIOPT Version :10

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:XP_061512265.1 Gene:nolo / 1278170 VectorBaseID:AGAMI1_000955 Length:1305 Species:Anopheles gambiae


Alignment Length:1447 Identity:311/1447 - (21%)
Similarity:437/1447 - (30%) Gaps:602/1447 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDLSRRLCSTALVAFIVLASIHDSQSRFPGLRQKRQYGANMYLPESSVTPGG---EGNDPDE--- 59
            ||....:....|:..:..|:..|::.           |:|..|  |:.:|.|   |..|.:|   
Mosquito     1 MDYKEIILLLCLILTLAKATHKDNRG-----------GSNETL--STWSPSGVDLEDEDDEEVQK 52

  Fly    60 ------WTPWSSPSDCSRTCGGGVSYQTRECLRRDDRGEAVCSGGSRRYFSCNTQDCPEEESDFR 118
                  |:.|:..|.|||:|.|||:||.|.|     .....|.|.:.||..||.|.|||:: |||
Mosquito    53 RAKAQGWSSWTEWSTCSRSCDGGVAYQLRRC-----HAPHGCKGDAVRYKICNMQPCPEQQ-DFR 111

  Fly   119 AQQCSRFDRQQFDGVFYEWVPYTNAPNPCELNC----------MP----KGERFYYRQRE----- 164
            |.|||.:|...:||...:|.|:.:...||.|.|          ||    .|:.|.....|     
Mosquito   112 AHQCSAYDDVPYDGALLKWTPHYDYSEPCALTCRGRPQHLLEDMPDSAGAGDSFPISDDEPSVIV 176

  Fly   165 ----KVVDGTRCNDKDLDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDL 225
                :|.|||||....||:|:.|:|..||||:.:||..|.|.|..|||||::|            
Mosquito   177 QLSNRVQDGTRCRPGSLDMCIQGKCQRVGCDLKIGSTKKIDVCGVCGGDGTSC------------ 229

  Fly   226 APGYNDLLLLPEGATNIRIEETVPSSNYLACRNHSGHYYLNGDWRIDFPRPMFFANSWWNYQRKP 290
                                                                          .:|
Mosquito   230 --------------------------------------------------------------TQP 232

  Fly   291 MGFAAPDQLTCSGPISESLFIVMLVQEKNISLDYEYSI-PESLSHSQQDTHTWTHHQFNACSASC 354
            :                                |::.| |.||                 ||.:|
Mosquito   233 L--------------------------------YQWEIAPMSL-----------------CSVTC 248

  Fly   355 GGGSQSRKVTCNNRITLAEVNPSLCDQKSKPVEEQA-CGTEPCAPHWVEGEWSKCSKGCGSDGFQ 418
            |||.:....||.||:|..:|..|||:..|:|..... |.|..|.|.||..:|..|||.||. |.:
Mosquito   249 GGGYKMAMPTCRNRVTGVDVEESLCNASSRPEPTVVQCNTHLCPPKWVTDDWRSCSKPCGG-GIR 312

  Fly   419 NRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVKNCPKYHLGPWTPCDKLCGDGKQT 483
            .|.:.|...|:..::.|.::| |.   |.:|..::.||  |:.|||:.:|.|:.|...||.|.|.
Mosquito   313 ERVVVCAEESNGAKNKVPDEA-CR---GVRPKNQEPCN--VQECPKWVVGEWSGCSVSCGSGIQV 371

  Fly   484 RKVTCFIEENGHKRVLPEEDCVEEKPETEKSC--------------------------------- 515
            |.|.| ::.|||.....:...   ||.|.:.|                                 
Mosquito   372 RSVEC-MDTNGHYSAQCDPGA---KPVTGQPCTTGIICNAGSVSSGLSGGANTGTTVSGSSNAGI 432

  Fly   516 -LLTPCEGVDW------------------------------------------------------ 525
             .:.|....|:                                                      
Mosquito   433 IAVPPSSASDFDGLTMGVESEAERASISAMMKEKAAMHHERDPTLMTYNDQPYYAQPLRQDRLPK 497

  Fly   526 ---IISQ-------------WSGCN-ACGQNTETRTAIC-------------------------- 547
               |:||             ||.|: .||:....:...|                          
Mosquito   498 AEKIVSQRVPSEATFIQDTEWSPCSVTCGEGIRRKPFRCKIFLEFSKRVAVLNDSLCHAYKPLDE 562

  Fly   548 ----------------------GNKE------------GKVYP-----------------EE--- 558
                                  ||::            ||.|.                 ||   
Mosquito   563 VERCVMEPCSYSHNFEDTYLKDGNRQSLENIKVHVSVPGKTYSWREEGYTSCSASCLGGVEELII 627

  Fly   559 --------------FCEPEVPTLS--RPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRIVIC---- 603
                          .|.||....:  |.|....|..:|..||::.||..||.|:::|.|.|    
Mosquito   628 NCVRDDTNKIVSPFLCSPETKPEARIRTCNDIPCPPRWNYSEFTPCSKSCGFGIQTREVTCIHEV 692

  Fly   604 ---GEFDGKTVTPADDDSKCNKETKPESE-QDCEGEEKVCPGEWFTGPWGKCSKPCGGGERVREV 664
               ||  ...:.|   :|.|.  |||:.: |.|...:  ||..|....|.||||.||||.:.|.|
Mosquito   693 TRGGE--NTMIVP---NSMCT--TKPQPDRQYCNIID--CPVRWEVSEWSKCSKSCGGGFKERRV 748

  Fly   665 LCLSNGTKSVNCDEEKVE-----------PLSEKCNSEACT-EDEILPLTSTDKPIEDDEEDCDE 717
            .|     |.:...|.|||           |..:.||::||. ||:..|:..|:.....       
Mosquito   749 EC-----KQIMAQEHKVERPASMCPSSKPPDKKPCNTKACAPEDQRPPIAGTNSTFIQ------- 801

  Fly   718 DGIELISDGLSDDEKSEDVIDLEGTA--------------------KTETTPEAEDLMQSDSPTP 762
                      .|.:|::..:.:.|.|                    |...|.:.:.|::    |.
Mosquito   802 ----------HDPKKNKITLKIGGAATVFYGTQVKIKCPVKRFNRTKIRWTKDQQPLLK----TK 852

  Fly   763 YDEFESTG------TTFEGSGYDSESTTDSGISTEGSGDDEETSEASTDLSSSTDSGSTSSDSTS 821
            ..:....|      .||.          ::||.|..:|    .|.|...|:.....|..:..:..
Mosquito   853 KIKMSKKGALRILDVTFR----------EAGIYTCHAG----LSHADLKLAVKAKPGGENQPNED 903

  Fly   822 SDSSSSISSD---ATSEAPASSVSDSSD---STDAS--------------TETTGVSDDSTDVSS 866
            .|.......:   |.|.|.|:...:...   :.|.:              ||....|||...:.|
Mosquito   904 HDRHRGADPNALLANSYAMANGNEEEKSGRKNRDRNRGRNRQRQQQDTLLTEHGDGSDDEEPLRS 968

  Fly   867 STEASASESTDVSGASDSTGSTNASDSTPESSTEASSSTDD-----------------STDSSDN 914
            .::.:.|            |||.|||    :|..|||.|..                 ...:..|
Mosquito   969 HSQMTVS------------GSTVASD----ASAAASSGTRTLPLPHFQHLLAGLQLLWPFQTFSN 1017

  Fly   915 SSNVSESSTEASSSSVSDSNDSSDGSTD-GVSSTTENSSDSTSDATSDSTASSDSTDST---SDQ 975
            |.|..:...      .....|..|||.. |.....|............|..:|:|.|..   ..|
Mosquito  1018 SKNYGQQYL------AERGYDPFDGSIGRGDVEDEEPPRPMNVYQLLKSRHTSESVDEPMIHDGQ 1076

  Fly   976 TTE-------TTPESSTDST---------------------ESSTLDAS----------STTDAS 1002
            .||       |||.|....|                     .|.|:|.|          .|.|..
Mosquito  1077 ATEGYEFEWMTTPWSECSQTCGANGGGYKLRSAHCMLRMSNSSRTVDNSFCEDAGLPVPETVDKC 1141

  Fly  1003 STSESSSESSTDGSSTTSNSASSETTGLSS-------DGSTTDATTAASDNTDITTDGSTDESTD 1060
            ...:.....:.|.|....:...|..|.|..       ||..:|..........:|.....:|...
Mosquito  1142 GNIDCPRWVTADWSGCQQSKCFSWHTALQRRDVYCQFDGERSDEKVCEDQEKPVTKQECYNELCK 1206

  Fly  1061 G--------SSNASTEG 1069
            |        ..||:.||
Mosquito  1207 GVWRVEPWSDCNAACEG 1223

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559 21/50 (42%)
ADAMTS_CR_3 116..213 CDD:437068 46/119 (39%)
ADAMTS_spacer1 222..329 CDD:461796 3/107 (3%)
TSP1_ADAMTS 347..396 CDD:465950 19/49 (39%)
TSP1_ADAMTS 400..457 CDD:465950 18/56 (32%)
TSP1_ADAMTS 465..520 CDD:465950 17/88 (19%)
TSP1_ADAMTS 580..632 CDD:465950 20/59 (34%)
TSP1_ADAMTS 643..693 CDD:465950 21/60 (35%)
MSCRAMM_ClfA <1049..1262 CDD:468110 7/29 (24%)
Kunitz_papilin_lacunin-like 1612..1663 CDD:438681
Kunitz_BPTI 1670..1721 CDD:425421
Kunitz-type 1730..1780 CDD:438633
Kunitz_BPTI 1789..1840 CDD:425421
Kunitz_papilin_mig6-like 1849..1899 CDD:438679
Kunitz_papilin_mig6-like 1922..1972 CDD:438679
Kunitz_papilin_mig6-like 2001..2051 CDD:438679
Kunitz-type 2071..2121 CDD:438633
Kunitz_BPTI 2127..2178 CDD:425421
Kunitz_BPTI 2193..2245 CDD:425421
Kunitz_BPTI 2252..2303 CDD:425421
Kunitz_BPTI 2317..2372 CDD:425421
WAP 2455..2497 CDD:459672
Ig 2530..2610 CDD:472250
Ig strand B 2539..2543 CDD:409353
Ig strand C 2552..2556 CDD:409353
Ig strand E 2576..2579 CDD:409353
Ig strand F 2589..2594 CDD:409353
Ig strand G 2603..2606 CDD:409353
IG_like 2627..2703 CDD:214653
Ig strand B 2636..2640 CDD:409353
Ig strand C 2649..2653 CDD:409353
Ig strand E 2670..2674 CDD:409353
Ig strand F 2684..2689 CDD:409353
Ig strand G 2697..2700 CDD:409353
I-set 2766..2845 CDD:400151
Ig strand B 2771..2775 CDD:409353
Ig strand C 2784..2788 CDD:409353
Ig strand F 2821..2826 CDD:409353
PLAC 2851..2883 CDD:462560
noloXP_061512265.1 None
Blue background indicates that the domain is not in the aligned region.

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