Protein Alignment Ppn and AdamTS-A

DIOPT Version :10

• Sequence 1: NP_788752.2
• Gene: Ppn / 43872
• FlyBaseID: FBgn0003137
• Length: 2898
• Species: Drosophila melanogaster
• Sequence 2: XP_061498656.1
• Gene: AdamTS-A / 1274038
• VectorBaseID: AGAMI1_000621
• Length: 1780
• Species: Anopheles gambiae
• Alignment Length: 1099
• Identity: 247/1099 - (22%)
• Similarity: 394/1099 - (35%)
• Gaps: 343/1099 - (31%)

  Fly    36 QYGANMYLPESSVTPGGEGNDPDEWTPWSSPSDCSRTCGGGVSYQTREC-LRRDDRGEAVCSGGS 99
            |.|..:.:..:::.|...|     |:.|||.::||||||||:..:|||| ..:...|...|:|..
Mosquito   668 QKGQCVPIDRTALKPQNGG-----WSAWSSFNECSRTCGGGIQARTRECDSPKPKNGGKFCTGLR 727

  Fly   100 RRYFSCNTQDCPEEESDFRAQQCSRFDRQQFDGVFYE----WVPYTNAP--NPCELNCMPKGERF 158
            ..|..||||.||....:||.:||...|.|.||....|    |.|....|  :.|:|.|..:.:..
Mosquito   728 IEYRPCNTQPCPSWRYNFREEQCHEMDGQNFDVPSLEPNVRWTPKYGTPVADQCKLLCRVQDKSL 792

  Fly   159 YYRQREKVVDGTRCN--DKDLDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTIT 221
            |:..:|||:|||.|.  :...|:|:||:|...|||.:|.||||.|:|..|.||.|||:.:...:
Mosquito   793 YFMLKEKVIDGTPCTFPEDSFDMCINGQCRKAGCDYVLNSDAKLDQCGVCRGDNSTCRPVTGRL- 856

  Fly   222 TKDLAPGY-----ND---LLLLPEGATNIRIEET--VPSSNYLACRNHSGHYYLNGDWRIDFP-- 274
              :|..|.     :|   ...:|||||:|.|..|  :..:.||:..  ||:..:..|.:...|
Mosquito   857 --NLGKGVVRRVSSDGPMEFRIPEGATSINIINTGYMKDACYLSVM--SGNEIIFNDPKHLTPHT 917

  Fly   275 -RPMFFANSWWNYQRKPMGFAAPDQLTCS--GPISESLFIVMLVQEKNISL-----DYEYSIP-- 329
             |...||.....|...    ::.:::|.:  .|:.|.| .|.::.:|::.|     ||.|.:|
Mosquito   918 SRHRLFAGVRLEYTVT----SSEERITSTFGRPLKEKL-TVRVIHKKHVELHKGFVDYSYMVPVH 977

  Fly   330 ---ESLSHS-----QQDTHTWTHHQFNA-------------------------------CSASCG 355
               .:||::     :.|.:...||..::                               |...|
Mosquito   978 PFGNTLSNAIYSKVEPDPYDHPHHTHHSHYSGNSVHRLQPTVAPTPESPYRWELAPWTECDQQC- 1041

  Fly   356 GGSQSRKVTCNNRITLAEVNPSLCDQKSKPVEE-QACGTE------------------------- 394
            .|.:.|...|.:.....:|:|..|:|..||.:| ::|.||
Mosquito  1042 TGKKRRTAICVDAEAQQQVSPDYCNQSVKPQDEFESCNTECHFYWEPGRTECSSACGEGTKKIEY 1106

  Fly   395 -----------------------------------PCA-PHWVEGEWSKCSKGCGSDGFQNRSIT 423
                                               ||. ..|:..:|:|||  | ||..|||:..
Mosquito  1107 KCVRSYSQTQRKEHVDDAMCYGSTKPVNIRETCMGPCMNATWLYSQWNKCS--C-SDRTQNRTAK 1168

  Fly   424 CERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVKNCPKYHLGPWTPCDKLCGDGKQTRKVTC 488
            |  :|......: :||.|  |...:..|.:.|:.|..:|.::..|..|||...||:|::...:.|
Mosquito  1169 C--LSEPNGFPI-QDAYC--EFREQKITVRSCDADQADCARWVKGELTPCSVTCGEGQRAYALQC 1228

  Fly   489 FIEENGHKRVLPEEDCVEEKPETEKSCLLTPCEGV------------------------------ 523
            .::.......|    |.........:|.:.||:..
Mosquito  1229 MLKNVSVNAAL----CGARPAPDVMTCTMPPCDQKPMPNTQYSSFRNDVQPNQSMKNVNYQPTPE 1289

  Fly   524 -------DWIISQWSGCNA-CGQNTETRTAICGNKEGKVYPEEFCEPEVPTLSRPCKSPKCEAQW 580
                   .|....:|.|:| |....:.|...|.::.|:...|.:|....|.....|.:.:|.: |
Mosquito  1290 PSPVPRGQWRAYSYSNCSAECDGGFKKRLVRCLSETGQTLDERYCPHPKPVTQINCANVRCPS-W 1353

  Fly   581 FSSEWSKCSAPCGKGVKSRIVICGEFDGKTVTPADDDSKCNKETKPESEQDC------------- 632
            ....||||:..|   ::||.|:|.:..||      :..:|:.|.||.:.:.|
Mosquito  1354 NFGTWSKCNDEC---IRSRQVLCQDHRGK------ESDQCSTELKPPAVESCCSFKWRVTCAGSC 1409

  Fly   633 --EGE-----------------------------------------------EKVCPGEWFTGPW 648
              ||.                                               .|.||..|..|.|
Mosquito  1410 DAEGRRKPNVICKRLYPKSIDNPHPLRTGRKVDPKYCANARMPTPAKLKKKCSKPCPFRWVPGNW 1474

  Fly   649 GKCSKPCGGGERVREVLCLSNGT-----------------------------------------K 672
            .:||..||.|..||.|.|.:..|                                         :
Mosquito  1475 SECSVGCGTGRTVRNVTCTNGRTIMPKACNAMLKPPNTKVCEALTHCRWRISKPNKCNCKGKQNR 1539

  Fly   673 SVNCDEEKVEPLSEKCN-------SEACTEDEILPLTSTDKPIEDDEEDCDEDGIELISDGLSDD 730
            :|.|.:||::..|.:|:       :.:|.:.........::..|....:|::...:..:||
Mosquito  1540 TVKCYDEKMKVESNRCSESTRPSKTASCQKPPGCRTALRNRHHEPVYRNCNDARRKHKTDG---- 1600

  Fly   731 EKSEDVIDLEGTAKTETTPEAEDLMQSDSPTPYDEFESTGTTFEGSGYDSESTTDSGISTEGSGD 795
               |.::.:.|| |.:.....   |.:|:||.|....: |.|...:.|.:....|:........|
Mosquito  1601 ---EYMMHVNGT-KAKIYCHG---MATDTPTEYLSLPA-GPTENYAIYINRRAADANKCENSQRD 1657

  Fly   796 --DEETSEASTDLSSSTDSGST----SSDSTSSDSSSSISSDATSEAPASSVSDSSDST 848
              |...|..:|.......:.||    ::|...::||.       .:.|..|..|...:|
Mosquito  1658 WADSSISYGATHYRKIRINVSTLQVHTNDFRFTNSSG-------KKQPFGSAGDCYSNT 1709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	24/51 (47%)
		ADAMTS_CR_3	116..213	CDD:437068	42/104 (40%)
		ADAMTS_spacer1	222..329	CDD:461796	31/126 (25%)
		TSP1_ADAMTS	347..396	CDD:465950	15/140 (11%)
		TSP1_ADAMTS	400..457	CDD:465950	19/56 (34%)
		TSP1_ADAMTS	465..520	CDD:465950	11/54 (20%)
		TSP1_ADAMTS	580..632	CDD:465950	16/51 (31%)
		TSP1_ADAMTS	643..693	CDD:465950	19/97 (20%)
		MSCRAMM_ClfA	<1049..1262	CDD:468110
		Kunitz_papilin_lacunin-like	1612..1663	CDD:438681
		Kunitz_BPTI	1670..1721	CDD:425421
		Kunitz-type	1730..1780	CDD:438633
		Kunitz_BPTI	1789..1840	CDD:425421
		Kunitz_papilin_mig6-like	1849..1899	CDD:438679
		Kunitz_papilin_mig6-like	1922..1972	CDD:438679
		Kunitz_papilin_mig6-like	2001..2051	CDD:438679
		Kunitz-type	2071..2121	CDD:438633
		Kunitz_BPTI	2127..2178	CDD:425421
		Kunitz_BPTI	2193..2245	CDD:425421
		Kunitz_BPTI	2252..2303	CDD:425421
		Kunitz_BPTI	2317..2372	CDD:425421
		WAP	2455..2497	CDD:459672
		Ig	2530..2610	CDD:472250
		Ig strand B	2539..2543	CDD:409353
		Ig strand C	2552..2556	CDD:409353
		Ig strand E	2576..2579	CDD:409353
		Ig strand F	2589..2594	CDD:409353
		Ig strand G	2603..2606	CDD:409353
		IG_like	2627..2703	CDD:214653
		Ig strand B	2636..2640	CDD:409353
		Ig strand C	2649..2653	CDD:409353
		Ig strand E	2670..2674	CDD:409353
		Ig strand F	2684..2689	CDD:409353
		Ig strand G	2697..2700	CDD:409353
		I-set	2766..2845	CDD:400151
		Ig strand B	2771..2775	CDD:409353
		Ig strand C	2784..2788	CDD:409353
		Ig strand F	2821..2826	CDD:409353
		PLAC	2851..2883	CDD:462560
AdamTS-A	XP_061498656.1	None