DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and Aplp2

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_001344627.1 Gene:Aplp2 / 11804 MGIID:88047 Length:763 Species:Mus musculus


Alignment Length:359 Identity:83/359 - (23%)
Similarity:113/359 - (31%) Gaps:115/359 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  1684 TKKWYFDVDRNRCEEFQYGGCYGTNNRFDSLEQCQGTCAASE--NLPTCEQPVESGPCAGNFERW 1746
            |.||..|....:       .|.||..  :.|:.||......:  |:....|||       |.:.|
Mouse    67 TGKWEPDPTGTK-------SCLGTKE--EVLQYCQEIYPELQITNVMEANQPV-------NIDSW 115

  Fly  1747 YYDNETDICRPFTYGGCKGNKNNYPTEHACNYNCRQPGVLKDRCALP-------KQTGDCSEKLA 1804
                            |:.:|....:.....:.|.....:.|...:|       ::..:..||..
Mouse   116 ----------------CRRDKRQCKSHIVIPFKCLVGEFVSDVLLVPDNCQFFHQERMEVCEKHQ 164

  Fly  1805 KWHFSESEKRC----VPFYYSG----CGG------------------------------------ 1825
            :||....| .|    :..|..|    ||.                                    
Mouse   165 RWHTLVKE-ACLTEGLTLYSYGMLLPCGVDQFHGTEYVCCPQTKTVDSDSTMSKEEEEEEEDEED 228

  Fly  1826 -------NKNNFPTLESCEDHCPRQVAKDICEIPAEVGECANYVTSWYYDTQDQACRQFYYGGCG 1883
                   :|:.|||....||.  .:.|.|..|...|.||.......:|||.         :.|..
Mouse   229 EEEDYDLDKSEFPTEADLEDF--TEAAADEEEEDEEEGEEVVEDRDYYYDP---------FKGDD 282

  Fly  1884 GNENRFPTEESCLARCDRKPEPTTTTPATRPQPSRQDVCDEEPAPGECSTWVLKWHFDRKIGACR 1948
            .||.. |||.|.......| |......|         ||.:|...|.|...:.:|:||...|.|.
Mouse   283 YNEEN-PTEPSSEGTISDK-EIVHDVKA---------VCSQEAMTGPCRAVMPRWYFDLSKGKCV 336

  Fly  1949 QFYYGNCGGNGNRFETENDCQQRCLSQEPPAPTP 1982
            :|.||.||||.|.||:|:.|...|.:..||.|.|
Mouse   337 RFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPLP 370

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559
ADAM_spacer1 214..329 CDD:283607
TSP1 468..521 CDD:214559
TSP_1 645..693 CDD:278517
Kunitz_BPTI 1611..1663 CDD:278443
Kunitz_BPTI 1670..1721 CDD:278443 10/36 (28%)
Kunitz_BPTI 1729..1781 CDD:278443 7/51 (14%)
Kunitz_BPTI 1789..1840 CDD:278443 17/108 (16%)
Kunitz_BPTI 1848..1899 CDD:278443 14/50 (28%)
KU 1920..1973 CDD:238057 22/52 (42%)
Kunitz_BPTI 2001..2051 CDD:278443
KU 2071..2121 CDD:238057
Kunitz_BPTI 2127..2178 CDD:278443
KU 2192..2245 CDD:238057
KU 2251..2304 CDD:238057
KU 2316..2372 CDD:238057
WAP 2457..2497 CDD:278522
Ig 2521..2610 CDD:299845
IG_like 2530..2610 CDD:214653
IG_like 2627..2703 CDD:214653
Ig 2636..2701 CDD:143165
IG_like 2766..2841 CDD:214653
Ig 2768..2830 CDD:299845
PLAC 2851..2883 CDD:285849
Aplp2NP_001344627.1 A4_EXTRA 42..204 CDD:128326 31/169 (18%)
Kunitz_BPTI 309..361 CDD:278443 22/51 (43%)
APP_E2 365..547 CDD:315580 4/6 (67%)
APP_amyloid 709..759 CDD:313694
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4295
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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