DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppn and WFIKKN1

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_444514.1	Gene:	WFIKKN1 / 117166	HGNCID:	30912	Length:	548	Species:	Homo sapiens

Alignment Length:	568	Identity:	119/568 - (20%)
Similarity:	160/568 - (28%)	Gaps:	196/568 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1821 SGCGGNKNNFPTLESCEDHCPRQVAKDICEIPAEVGECANYVTSWYYDTQDQACRQFYYGGCGGN 1885
            ||.|    ..|.|.|....||.|::.::                 :.|.|....|:     |..:
Human    18 SGAG----LLPGLGSHPGVCPNQLSPNL-----------------WVDAQSTCERE-----CSRD 56

  Fly  1886 ENRFPTEESCLARCDRKPEPTTTTPATRPQPSRQDVCDEEPAP---GECSTWVLKWHFDRKIGAC 1947
            ::....|:.|:..|..........|.:...|:....|:....|   .:|..|     ..:.:..|
Human    57 QDCAAAEKCCINVCGLHSCVAARFPGSPAAPTTAASCEGFVCPQQGSDCDIW-----DGQPVCRC 116

  Fly  1948 RQ---------------FYYGNCGGNGNRFETENDCQ----------QRCLSQEPPAPTPPRAPA 1987
            |.               .||..|      :.....|.          :..||..|.:|.||...|
Human   117 RDRCEKEPSFTCASDGLTYYNRC------YMDAEACLRGLHLHIVPCKHVLSWPPSSPGPPETTA 175

  Fly  1988 -PTRQPDPAPTVAQCSQPADPGQCDKWALHWNYNETEGRCQSFYYGGCGGNDNRFATEEECSARC 2051
             ||....|.|. |..|.|:.                    |:...||            ..|..|
Human   176 RPTPGAAPVPP-ALYSSPSP--------------------QAVQVGG------------TASLHC 207

  Fly  2052 SVNIDIRIGADP-------VEHDTSKCFLAFEPGNCYNNVTRWFYNSAEGLCDEFVYTGCGGNAN 2109
            .|:     |..|       ..|....  |...|...|.||               |.|..|....
Human   208 DVS-----GRPPPAVTWEKQSHQREN--LIMRPDQMYGNV---------------VVTSIGQLVL 250

  Fly  2110 NYATEEECQNECNDAQTTCALPPVRGRCSDLSRRWYFDERSGECHEFEFTGCRGNRNNFVSQSDC 2174
            ..|..|:.      ...||......|..                           |.:|.
Human   251 YNARPEDA------GLYTCTARNAAGLL---------------------------RADFP----- 277

  Fly  2175 LNFCIGEPV--VEPSAPTYSVCAEPPEAGECDNRTT----AWFYDSENMACTAFTYTGCGGNGNR 2233
            |:....||.  ..||.|..:.|.  |:...|...|:    .|.||.:...|..|...||.|....
Human   278 LSVVQREPARDAAPSIPAPAECL--PDVQACTGPTSPHLVLWHYDPQRGGCMTFPARGCDGAARG 340

  Fly  2234 FETRDQCERQCGEFKGVDVCNEPVTTGPCTDWQTKYYFNTASQACEPFTYGGCDGTGNRFSDLFE 2298
            |||.:.|::.|....| |.|..|...|||..|:.::.::...|.|.||.||||:|.||.|.....
Human   341 FETYEACQQACARGPG-DACVLPAVQGPCRGWEPRWAYSPLLQQCHPFVYGGCEGNGNNFHSRES 404

  Fly  2299 CQTVCLAGREPR---------------------VGSAKEICLLPVATG 2325
            |:..|...|.|.                     ||...|:...|.|.|
Human   405 CEDACPVPRTPPCRACRLRSKLALSLCRSDFAIVGRLTEVLEEPEAAG 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559
		ADAM_spacer1	214..329	CDD:283607
		TSP1	468..521	CDD:214559
		TSP_1	645..693	CDD:278517
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443	6/18 (33%)
		Kunitz_BPTI	1848..1899	CDD:278443	6/50 (12%)
		KU	1920..1973	CDD:238057	10/80 (13%)
		Kunitz_BPTI	2001..2051	CDD:278443	6/49 (12%)
		KU	2071..2121	CDD:238057	10/49 (20%)
		Kunitz_BPTI	2127..2178	CDD:278443	6/50 (12%)
		KU	2192..2245	CDD:238057	16/56 (29%)
		KU	2251..2304	CDD:238057	20/52 (38%)
		KU	2316..2372	CDD:238057	4/10 (40%)
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
WFIKKN1	NP_444514.1	WAP	29..76	CDD:306578	10/68 (15%)
		KAZAL_FS	120..155	CDD:238052	4/40 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	164..184		7/19 (37%)
		Ig_3	200..280	CDD:143242	24/151 (16%)
		KU	307..351	CDD:294074	13/43 (30%)
		Kunitz_BPTI	358..409	CDD:278443	19/50 (38%)
		NTR_WFIKKN	427..537	CDD:239630	6/26 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810