DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppn and Adamts1

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_033751.3	Gene:	Adamts1 / 11504	MGIID:	109249	Length:	968	Species:	Mus musculus

Alignment Length:	518	Identity:	161/518 - (31%)
Similarity:	229/518 - (44%)	Gaps:	115/518 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 YLPESSVTPGGEG---------NDPD----------EWTPWSSPSDCSRTCGGGVSYQTRECLRR 87
            :.|.:..|..|||         |..|          .|.||....||||||||||.|..|||
Mouse   526 HFPWADGTSCGEGKWCVSGKCVNKTDMKHFATPVHGSWGPWGPWGDCSRTCGGGVQYTMREC--- 587

  Fly    88 DD----RGEAVCSGGSRRYFSCNTQDCPEEE-SDFRAQQC---SRFDRQQF-DGVFYEWVPYTNA 143
            |:    .|...|.|...||.|||.:|||:.. ..||.:||   :.|.:..| :....||.|....
Mouse   588 DNPVPKNGGKYCEGKRVRYRSCNIEDCPDNNGKTFREEQCEAHNEFSKASFGNEPTVEWTPKYAG 652

  Fly   144 PNP---CELNCMPKGERFYYRQREKVVDGTRCNDKDLDVCVNGECMPVGCDMMLGSDAKEDKCRK 205
            .:|   |:|.|..||..:::..:.||||||.|:.....|||.|:|:..|||.::.|..|.|||..
Mouse   653 VSPKDRCKLTCEAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGV 717

  Fly   206 CGGDGSTCKTIRNTITTKDLAPGYNDLLLLPEGATNIRIEE-----TVPSSNYLACRNHSGHYYL 265
            |||:|||||.:...:|:  ..|||:|::.:|.|||||.::.     :..:.::||.|...|.|.|
Mouse   718 CGGNGSTCKKMSGIVTS--TRPGYHDIVTIPAGATNIEVKHRNQRGSRNNGSFLAIRAADGTYIL 780

  Fly   266 NGDWRID-FPRPMFFANSWWNYQRKPMGFAAPDQLTCSGPISESLFIVMLVQEKNISLDYEYSIP 329
            ||::.:. ..:.:.:..:...|....   ||.:::....|:.|.|.|.:|:
Mouse   781 NGNFTLSTLEQDLTYKGTVLRYSGSS---AALERIRSFSPLKEPLTIQVLM-------------- 828

  Fly   330 ESLSHSQQDTHTWTHHQFNACSASCGGGSQSRKVTCNNRITLAEVNPSLCDQKSKPVEEQACGTE 394
              :.|:.:....:|:.             ..:|....|.|
Mouse   829 --VGHALRPKIKFTYF-------------MKKKTESFNAI------------------------- 853

  Fly   395 PCAPHWVEGEWSKCSKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDV 459
            |....||..||.:|||.||| |:|.|.:.|..|:.   |...|   |.|||  |||:.:.| .|:
Mouse   854 PTFSEWVIEEWGECSKTCGS-GWQRRVVQCRDING---HPASE---CAKEV--KPASTRPC-ADL 908

  Fly   460 KNCPKYHLGPWTPCDKLCGDGKQTRKVTCFIEENGHKRVLPEEDCVE-EKPETE-KSCLLTPC 520
            . ||.:.:|.|:||.|.||.|.:.|.:.|...:.|   ||..|.|.. :||:.. ..|.||.|
Mouse   909 P-CPHWQVGDWSPCSKTCGKGYKKRTLKCVSHDGG---VLSNESCDPLKKPKHYIDFCTLTQC 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	27/54 (50%)
		ADAM_spacer1	214..329	CDD:283607	28/120 (23%)
		TSP1	468..521	CDD:214559	21/55 (38%)
		TSP_1	645..693	CDD:278517
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
Adamts1	NP_033751.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Pep_M12B_propep	70..194	CDD:279848
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..253
		Cysteine switch. /evidence=ECO:0000250	204..211
		Reprolysin	259..468	CDD:279729
		ZnMc_ADAMTS_like	259..464	CDD:239801
		ADAM_CR	469..549	CDD:301627	5/22 (23%)
		ADAM_CR	530..699	CDD:301627	62/171 (36%)
		TSP1	563..615	CDD:214559	27/54 (50%)
		Spacer	726..850		31/157 (20%)
		ADAM_spacer1	726..843	CDD:283607	30/150 (20%)
		TSP1	857..911	CDD:214559	26/64 (41%)
		TSP1	912..>954	CDD:214559	15/44 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810