DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppn and ADAMTS6

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_922932.2	Gene:	ADAMTS6 / 11174	HGNCID:	222	Length:	1117	Species:	Homo sapiens

Alignment Length:	666	Identity:	222/666 - (33%)
Similarity:	309/666 - (46%)	Gaps:	149/666 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 WTPWSSPSDCSRTCGGGVSYQTREC-LRRDDRGEAVCSGGSRRYFSCNTQDCPEEESDFRAQQCS 123
            |.|||...:||||||||||...|.| ......|...|.|..:||.||||..||....|||.:||:
Human   561 WGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCA 625

  Fly   124 RFDRQQFDGVFYEWVPYT-NAPNPCELNCMPKGERFYYRQREKVVDGTRCNDKDLDVCVNGECMP 187
            .||...|.|.:|.|.||| ....||.|||:.:|..||..:...|:|||:||...||:|:||||..
Human   626 DFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKH 690

  Fly   188 VGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLLLLPEGATNIRIEETVPSSN 252
            ||||.:|||||:||:||.||||||||..|...........||.:::.:|.|:.:|.:.|...|.|
Human   691 VGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKN 755

  Fly   253 YLACRNHSGHYYLNGDWRIDFPRPMFFANSWWNYQRKPMGFAAPDQLTCSGPISESLFIVMLVQE 317
            |:|.::....||:||.|.||:||....|.:.::|:|..   ..|:.|...||.||:|.:::|:||
Human   756 YIALKSEGDDYYINGAWTIDWPRKFDVAGTAFHYKRPT---DEPESLEALGPTSENLIVMVLLQE 817

  Fly   318 KNISLDYEYSIPESLSHSQQDT--HTWTHHQFNACSASCGGGSQSRKVTCNNRITLAEVNPSLCD 380
            :|:.:.|::::|.:.:.|..:.  .||.|..::.|||:|.||.|.::|.|......:.|..:.||
Human   818 QNLGIRYKFNVPITRTGSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCD 882

  Fly   381 QKSKPVEEQ-ACGTEPCAPHWVEGEWSKCSKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKE 444
            ..|||.|.| ||.||||.|.|..|:|.:|||.|  ||
Human   883 PDSKPPENQRACNTEPCPPEWFIGDWLECSKTC--DG---------------------------- 917

  Fly   445 VGNKPATKQECNRDVKNCPKYHLGPWTPCDKLCGDGKQTRKVTCFIEENGHKRVLPEEDCVEEKP 509
                                               |.:||.|.|.      :::.|.|:
Human   918 -----------------------------------GMRTRAVLCI------RKIGPSEE------ 935

  Fly   510 ETEKSCLLTPCEGVDWIISQWSGCNACGQNTETRTAICGNKEGKVYPEEFCEPEVPTLSRPCKSP 574
                       |.:|     :|||..                           ..|....||.:.
Human   936 -----------ETLD-----YSGCLT---------------------------HRPVEKEPCNNQ 957

  Fly   575 KCEAQWFSSEWSKCSAPCGKGVKSRIVICGEFDGKTVTPADDDSKCNKETKPESEQDCE-GEEKV 638
            .|..||.:.:||:|:..||.|.|.|||:|...|.....||   ::|.:|:||.....|. |.
Human   958 SCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPA---AQCPEESKPPVRIRCSLGR--- 1016

  Fly   639 C-PGEWFTGPWGKCSKPCGGGERVREVLCLS-NGTKSVNCDEEKVEPLSEKCNSEACTEDEILPL 701
            | |..|.||.||:||..||.|:::|.|.||| .|..|.:|.|....|..::|.|:.    :..|:
Human  1017 CPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKC----DSTPI 1077

  Fly   702 TSTDKPIEDDEEDCDE 717
            ::|        |:|.:
Human  1078 SNT--------EECKD 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	25/51 (49%)
		ADAM_spacer1	214..329	CDD:283607	35/114 (31%)
		TSP1	468..521	CDD:214559	7/52 (13%)
		TSP_1	645..693	CDD:278517	21/48 (44%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
ADAMTS6	NP_922932.2	Pep_M12B_propep	69..190	CDD:279848
		Reprolysin	250..468	CDD:279729
		ZnMc_ADAMTS_like	250..465	CDD:239801
		TSP1	561..613	CDD:214559	25/51 (49%)
		Spacer	717..843		37/128 (29%)
		ADAM_spacer1	719..829	CDD:283607	35/112 (31%)
		TSP1	848..900	CDD:214559	22/51 (43%)
		TSP1	902..960	CDD:214559	24/177 (14%)
		TSP1	1022..1069	CDD:214559	20/46 (43%)
		PLAC	1083..1115	CDD:285849	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I11597
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2734
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840