DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and ADAMTS7

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:XP_005254194.1 Gene:ADAMTS7 / 11173 HGNCID:223 Length:1689 Species:Homo sapiens


Alignment Length:1153 Identity:238/1153 - (20%)
Similarity:332/1153 - (28%) Gaps:537/1153 - (46%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 YLPESSVTPGGEGNDPDEWTPWSSPSDCSRTCGGGVSYQTRECLRRDDRGEA-VCSGGSRRYFSC 105
            :.||:  ..||       |:.||:.|.|||:||.||....|:|.:...:.:. .|.|..:|:..|
Human   532 FRPEA--VDGG-------WSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLC 587

  Fly   106 NTQDCPEEESDFRAQQCSRFDRQQFDGVFYEWVPYTNAPNPCELNCMPKGERFYYRQREKVVDGT 170
            |.|.||.....||..|||.||...:.|..:.|||..|..|||||:|.|..|.|..:.|:.|||||
Human   588 NLQACPAGRPSFRHVQCSHFDAMLYKGQLHTWVPVVNDVNPCELHCRPANEYFAEKLRDAVVDGT 652

  Fly   171 RCND--KDLDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLL 233
            .|..  ...|:|:||.|..||||..:.|.|.||:|..|.|:||||.|:..|....: ..||.|:.
Human   653 PCYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAE-GLGYVDVG 716

  Fly   234 LLPEGATNIRIEETVPSSNYLACRNHSGH-YYLNGDWRIDFPRPMFFANSWWNYQRKPMGFAAPD 297
            |:|.||..|||:|...::|:||.|:.... |:|||.|.|.:......|.:.:.|.|:    ...:
Human   717 LIPAGAREIRIQEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARR----GNWE 777

  Fly   298 QLTCSGPISESLFIVMLVQEKNISLDYEYSIPESLSHSQQDTH--------TWTHHQFNACSASC 354
            .||..||..|.::|.:|.||.|..:.|||:|     |.:...|        :|.:..:..|:.:|
Human   778 NLTSPGPTKEPVWIQLLFQESNPGVHYEYTI-----HREAGGHDEVPPPVFSWHYGPWTKCTVTC 837

  Fly   355 GGGSQSRKVTCNNRITLAEVNPSLCDQKSKPVEEQ-ACGTEPCAPHWVEGEWSKCSKGCGSDGFQ 418
            |.|.|.:.|.|..| ....|:...||...:|.::| .|..:||...|..|||..||..||..|..
Human   838 GRGVQRQNVYCLER-QAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLS 901

  Fly   419 NRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVKNCP-KYHLGPWTPCDKLCGDGKQ 482
            .|::.|.|.....|.:..|...|  |...:|.|:..|||.|. || .:.:|.|:.|...||:|.|
Human   902 RRAVLCIRSVGLDEQSALEPPAC--EHLPRPPTETPCNRHVP-CPATWAVGNWSQCSVTCGEGTQ 963

  Fly   483 TRKVTC----------------------------------------------------------- 488
            .|.|.|                                                           
Human   964 RRNVLCTNDTGVPCDEAQQPASEVTCSLPLCRWPLGTLGPEGSGSGSSSHELFNEADFIPHHLAP 1028

  Fly   489 ------------------------------FIEE--------NGHK------------------- 496
                                          |:::        |.|:                   
Human  1029 RPSPASSPKPGTMGNAIEEEAPELDLPGPVFVDDFYYDYNFINFHEDLSYGPSEEPDLDLAGTGD 1093

  Fly   497 ----------------------------------------------------------------- 496
                                                                             
Human  1094 RTPPPHSHPAAPSTGSPVPATEPPAAKEEGVLGPWSPSPWPSQAGRSPPPPSEQTPGNPLINFLP 1158

  Fly   497 -------------------RV-------------------------------------------- 498
                               ||                                            
Human  1159 EEDTPIGAPDLGLPSLSWPRVSTDGLQTPATPESQNDFPVGKDSQSQLPPPWRDRTNEVFKDDEE 1223

  Fly   499 ----------------------------------------------------------------- 498
                                                                             
Human  1224 PKGRGAPHLPPRPSSTLPPLSPVGSTHSSPSPDVAELWTGGTVAWEPALEGGLGPVDSELWPTVG 1288

  Fly   499 -----------LPE--------------------------------------------------- 501
                       |||                                                   
Human  1289 VASLLPPPIAPLPEMKVRDSSLEPGTPSFPTPGPGSWDLQTVAVWGTFLPTTLTGLGHMPEPALN 1353

  Fly   502 ----------------------------------------------------------------- 501
                                                                             
Human  1354 PGPKGQPESLSPEVPLSSRLLSTPAWDSPANSHRVPETQPLAPSLAEAGPPADPLVVRNAGWQAG 1418

  Fly   502 -------------------------EDCVEE-KPETEKSCLLTPCEGVDWIISQWSGCN-ACGQN 539
                                     |||... :|:..:.|.|.||  ..|....||.|: :||..
Human  1419 NWSECSTTCGLGAVWRPVRCSSGRDEDCAPAGRPQPARRCHLRPC--ATWHSGNWSKCSRSCGGG 1481

  Fly   540 TETRTAIC-GNKEGKVYPEEFCE--PEVPTLSRPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRIV 601
            :..|...| ..::.:......|:  |..|...|||.:..| ..|::|.|.:||..||.|.:.|:|
Human  1482 SSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPC-LSWYTSSWRECSEACGGGEQQRLV 1545

  Fly   602 ICGEFDGKTVTPADDDSKCNKETKPESEQDCEGEEKVCPGEWFTGPWGKCSKPCGGGERVREVLC 666
            .|.|           ...|.:..:|.:.:.|....  |. :|..||||:||.|||||.:.|.|.|
Human  1546 TCPE-----------PGLCEEALRPNTTRPCNTHP--CT-QWVVGPWGQCSGPCGGGVQRRLVKC 1596

  Fly   667 LSNGT-----KSVNCDEEKVEPLSEKCNSEACTEDEILPLTSTDKPIE 709
            ::..|     .|..|..|.....|..|.:|.|            :|:|
Human  1597 VNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC------------EPVE 1632

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559 19/51 (37%)
ADAM_spacer1 214..329 CDD:283607 39/115 (34%)
TSP1 468..521 CDD:214559 25/514 (5%)
TSP_1 645..693 CDD:278517 21/52 (40%)
Kunitz_BPTI 1611..1663 CDD:278443
Kunitz_BPTI 1670..1721 CDD:278443
Kunitz_BPTI 1729..1781 CDD:278443
Kunitz_BPTI 1789..1840 CDD:278443
Kunitz_BPTI 1848..1899 CDD:278443
KU 1920..1973 CDD:238057
Kunitz_BPTI 2001..2051 CDD:278443
KU 2071..2121 CDD:238057
Kunitz_BPTI 2127..2178 CDD:278443
KU 2192..2245 CDD:238057
KU 2251..2304 CDD:238057
KU 2316..2372 CDD:238057
WAP 2457..2497 CDD:278522
Ig 2521..2610 CDD:299845
IG_like 2530..2610 CDD:214653
IG_like 2627..2703 CDD:214653
Ig 2636..2701 CDD:143165
IG_like 2766..2841 CDD:214653
Ig 2768..2830 CDD:299845
PLAC 2851..2883 CDD:285849
ADAMTS7XP_005254194.1 Pep_M12B_propep 68..183 CDD:279848
Reprolysin 242..452 CDD:279729
ZnMc_ADAMTS_like 242..449 CDD:239801
ADAM_CR <474..530 CDD:301627
TSP1 541..593 CDD:214559 19/51 (37%)
ADAM_spacer1 699..809 CDD:283607 40/119 (34%)
TSP1 825..880 CDD:214559 16/55 (29%)
TSP1 946..994 CDD:214559 10/47 (21%)
TSP1 1466..1521 CDD:214559 14/54 (26%)
TSP1 1570..1629 CDD:214559 24/71 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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