DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and ADAMTS7

DIOPT Version :10

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:XP_047288078.1 Gene:ADAMTS7 / 11173 HGNCID:223 Length:1689 Species:Homo sapiens


Alignment Length:1153 Identity:238/1153 - (20%)
Similarity:332/1153 - (28%) Gaps:537/1153 - (46%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 YLPESSVTPGGEGNDPDEWTPWSSPSDCSRTCGGGVSYQTRECLRRDDRGEA-VCSGGSRRYFSC 105
            :.||:  ..||       |:.||:.|.|||:||.||....|:|.:...:.:. .|.|..:|:..|
Human   532 FRPEA--VDGG-------WSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLC 587

  Fly   106 NTQDCPEEESDFRAQQCSRFDRQQFDGVFYEWVPYTNAPNPCELNCMPKGERFYYRQREKVVDGT 170
            |.|.||.....||..|||.||...:.|..:.|||..|..|||||:|.|..|.|..:.|:.|||||
Human   588 NLQACPAGRPSFRHVQCSHFDAMLYKGQLHTWVPVVNDVNPCELHCRPANEYFAEKLRDAVVDGT 652

  Fly   171 RCND--KDLDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLL 233
            .|..  ...|:|:||.|..||||..:.|.|.||:|..|.|:||||.|:..|....: ..||.|:.
Human   653 PCYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAE-GLGYVDVG 716

  Fly   234 LLPEGATNIRIEETVPSSNYLACRNHSGH-YYLNGDWRIDFPRPMFFANSWWNYQRKPMGFAAPD 297
            |:|.||..|||:|...::|:||.|:.... |:|||.|.|.:......|.:.:.|.|:    ...:
Human   717 LIPAGAREIRIQEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARR----GNWE 777

  Fly   298 QLTCSGPISESLFIVMLVQEKNISLDYEYSIPESLSHSQQDTH--------TWTHHQFNACSASC 354
            .||..||..|.::|.:|.||.|..:.|||:|     |.:...|        :|.:..:..|:.:|
Human   778 NLTSPGPTKEPVWIQLLFQESNPGVHYEYTI-----HREAGGHDEVPPPVFSWHYGPWTKCTVTC 837

  Fly   355 GGGSQSRKVTCNNRITLAEVNPSLCDQKSKPVEEQ-ACGTEPCAPHWVEGEWSKCSKGCGSDGFQ 418
            |.|.|.:.|.|..| ....|:...||...:|.::| .|..:||...|..|||..||..||..|..
Human   838 GRGVQRQNVYCLER-QAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLS 901

  Fly   419 NRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVKNCP-KYHLGPWTPCDKLCGDGKQ 482
            .|::.|.|.....|.:..|...|  |...:|.|:..|||.|. || .:.:|.|:.|...||:|.|
Human   902 RRAVLCIRSVGLDEQSALEPPAC--EHLPRPPTETPCNRHVP-CPATWAVGNWSQCSVTCGEGTQ 963

  Fly   483 TRKVTC----------------------------------------------------------- 488
            .|.|.|                                                           
Human   964 RRNVLCTNDTGVPCDEAQQPASEVTCSLPLCRWPLGTLGPEGSGSGSSSHELFNEADFIPHHLAP 1028

  Fly   489 ------------------------------FIEE--------NGHK------------------- 496
                                          |:::        |.|:                   
Human  1029 RPSPASSPKPGTMGNAIEEEAPELDLPGPVFVDDFYYDYNFINFHEDLSYGPSEEPDLDLAGTGD 1093

  Fly   497 ----------------------------------------------------------------- 496
                                                                             
Human  1094 RTPPPHSHPAAPSTGSPVPATEPPAAKEEGVLGPWSPSPWPSQAGRSPPPPSEQTPGNPLINFLP 1158

  Fly   497 -------------------RV-------------------------------------------- 498
                               ||                                            
Human  1159 EEDTPIGAPDLGLPSLSWPRVSTDGLQTPATPESQNDFPVGKDSQSQLPPPWRDRTNEVFKDDEE 1223

  Fly   499 ----------------------------------------------------------------- 498
                                                                             
Human  1224 PKGRGAPHLPPRPSSTLPPLSPVGSTHSSPSPDVAELWTGGTVAWEPALEGGLGPVDSELWPTVG 1288

  Fly   499 -----------LPE--------------------------------------------------- 501
                       |||                                                   
Human  1289 VASLLPPPIAPLPEMKVRDSSLEPGTPSFPTPGPGSWDLQTVAVWGTFLPTTLTGLGHMPEPALN 1353

  Fly   502 ----------------------------------------------------------------- 501
                                                                             
Human  1354 PGPKGQPESLSPEVPLSSRLLSTPAWDSPANSHRVPETQPLAPSLAEAGPPADPLVVRNAGWQAG 1418

  Fly   502 -------------------------EDCVEE-KPETEKSCLLTPCEGVDWIISQWSGCN-ACGQN 539
                                     |||... :|:..:.|.|.||  ..|....||.|: :||..
Human  1419 NWSECSTTCGLGAVWRPVRCSSGRDEDCAPAGRPQPARRCHLRPC--ATWHSGNWSKCSRSCGGG 1481

  Fly   540 TETRTAIC-GNKEGKVYPEEFCE--PEVPTLSRPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRIV 601
            :..|...| ..::.:......|:  |..|...|||.:..| ..|::|.|.:||..||.|.:.|:|
Human  1482 SSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPC-LSWYTSSWRECSEACGGGEQQRLV 1545

  Fly   602 ICGEFDGKTVTPADDDSKCNKETKPESEQDCEGEEKVCPGEWFTGPWGKCSKPCGGGERVREVLC 666
            .|.|           ...|.:..:|.:.:.|....  |. :|..||||:||.|||||.:.|.|.|
Human  1546 TCPE-----------PGLCEEALRPNTTRPCNTHP--CT-QWVVGPWGQCSGPCGGGVQRRLVKC 1596

  Fly   667 LSNGT-----KSVNCDEEKVEPLSEKCNSEACTEDEILPLTSTDKPIE 709
            ::..|     .|..|..|.....|..|.:|.|            :|:|
Human  1597 VNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC------------EPVE 1632

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559 19/51 (37%)
ADAMTS_CR_3 116..213 CDD:437068 46/98 (47%)
ADAMTS_spacer1 222..329 CDD:461796 37/107 (35%)
TSP1_ADAMTS 347..396 CDD:465950 14/49 (29%)
TSP1_ADAMTS 400..457 CDD:465950 19/56 (34%)
TSP1_ADAMTS 465..520 CDD:465950 24/516 (5%)
TSP1_ADAMTS 580..632 CDD:465950 14/51 (27%)
TSP1_ADAMTS 643..693 CDD:465950 22/54 (41%)
MSCRAMM_ClfA <1049..1262 CDD:468110
Kunitz_papilin_lacunin-like 1612..1663 CDD:438681
Kunitz_BPTI 1670..1721 CDD:425421
Kunitz-type 1730..1780 CDD:438633
Kunitz_BPTI 1789..1840 CDD:425421
Kunitz_papilin_mig6-like 1849..1899 CDD:438679
Kunitz_papilin_mig6-like 1922..1972 CDD:438679
Kunitz_papilin_mig6-like 2001..2051 CDD:438679
Kunitz-type 2071..2121 CDD:438633
Kunitz_BPTI 2127..2178 CDD:425421
Kunitz_BPTI 2193..2245 CDD:425421
Kunitz_BPTI 2252..2303 CDD:425421
Kunitz_BPTI 2317..2372 CDD:425421
WAP 2455..2497 CDD:459672
Ig 2530..2610 CDD:472250
Ig strand B 2539..2543 CDD:409353
Ig strand C 2552..2556 CDD:409353
Ig strand E 2576..2579 CDD:409353
Ig strand F 2589..2594 CDD:409353
Ig strand G 2603..2606 CDD:409353
IG_like 2627..2703 CDD:214653
Ig strand B 2636..2640 CDD:409353
Ig strand C 2649..2653 CDD:409353
Ig strand E 2670..2674 CDD:409353
Ig strand F 2684..2689 CDD:409353
Ig strand G 2697..2700 CDD:409353
I-set 2766..2845 CDD:400151
Ig strand B 2771..2775 CDD:409353
Ig strand C 2784..2788 CDD:409353
Ig strand F 2821..2826 CDD:409353
PLAC 2851..2883 CDD:462560
ADAMTS7XP_047288078.1 Pep_M12B_propep 44..184 CDD:460254
ZnMc_ADAMTS_like 242..449 CDD:239801
ADAMTS_CR_2 464..528 CDD:465496
TSP1 541..593 CDD:214559 19/51 (37%)
ADAMTS_CR_3 <629..697 CDD:437068 32/67 (48%)
ADAMTS_spacer1 699..809 CDD:461796 40/119 (34%)
TSP1_ADAMTS 825..879 CDD:465950 15/54 (28%)
TSP1_ADAMTS 883..942 CDD:465950 22/61 (36%)
TSP1_ADAMTS 946..994 CDD:465950 10/47 (21%)
PHA03247 <1027..1468 CDD:223021 17/442 (4%)
TSP1_ADAMTS 1415..1463 CDD:465950 6/47 (13%)
TSP1_ADAMTS 1466..1521 CDD:465950 14/54 (26%)
TSP1_ADAMTS 1524..1570 CDD:465950 15/58 (26%)
TSP1_ADAMTS 1573..1628 CDD:465950 22/54 (41%)
Blue background indicates that the domain is not in the aligned region.

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