DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and ADAMTS5

DIOPT Version :10

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_008969.2 Gene:ADAMTS5 / 11096 HGNCID:221 Length:930 Species:Homo sapiens


Alignment Length:534 Identity:138/534 - (25%)
Similarity:196/534 - (36%) Gaps:169/534 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 LRQKRQYGANMYLPESSVTPGGEG-------------------NDPDEWTPWSSPSDCSRTCGGG 76
            :||.:.......||....||.|:|                   :....|..|.|...|||:||||
Human   522 VRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGG 586

  Fly    77 VSYQTRECLRRDDRGEA-VCSGGSRRYFSCNTQDCPEEESDFRAQQCSRFDRQQFD--GV--FYE 136
            |.:..|.|.....|... .|:|....|.||:...||.....||.:||...:..|.|  ||  |.|
Human   587 VQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVE 651

  Fly   137 WVPYTNAPNP---CELNCMPKGERFYYRQREKVVDGTRCNDKDLDVCVNGECMPVGCDMMLGSDA 198
            |||......|   |:|.|..||..:|.....||.|||.|......|||.|:|:..|||.::||..
Human   652 WVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKL 716

  Fly   199 KEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLLLLPEGATNIRI-----EETVPSSNYLACRN 258
            :.|||..||||.|:|..|..|...|  :.||.|::.:|||||:|::     ::....:.|||.:.
Human   717 QYDKCGVCGGDNSSCTKIVGTFNKK--SKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKK 779

  Fly   259 HSGHYYLNGDWRIDFPRPMFFAN------SWWNYQ---RKPMGFAAPDQLTCSGPISESLFIVML 314
            .:|.|.:||.:.|.....:...|      |.|:::   ...||::|         ..|.|.:.:|
Human   780 KNGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSA---------TKEILIVQIL 835

  Fly   315 VQEKNISLDYEYS--IPESLSHSQQDTHTWTHHQFNACSASCGGGSQSRKVTCNNRITLAEVNPS 377
            ..:....||..||  :|:.   |....::.|.|           ||        |::        
Human   836 ATDPTKPLDVRYSFFVPKK---STPKVNSVTSH-----------GS--------NKV-------- 870

  Fly   378 LCDQKSKPVEEQACGTEPCAPHWVEGEWSKCSKGCGSDGFQNRSITCERISSSGEHTVEEDAVCL 442
                          |:....|.||.|.|..||:.|.: |:..|::.|                  
Human   871 --------------GSHTSQPQWVTGPWLACSRTCDT-GWHTRTVQC------------------ 902

  Fly   443 KEVGNKPATKQECNRDV-KNCPKYHLGPWTPCDKLCGDGKQTRKVTCFIEENGHKRVLPEEDCVE 506
                      |:.||.: |.||                                         :.
Human   903 ----------QDGNRKLAKGCP-----------------------------------------LS 916

  Fly   507 EKPETEKSCLLTPC 520
            ::|...|.|||..|
Human   917 QRPSAFKQCLLKKC 930

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559 19/51 (37%)
ADAMTS_CR_3 116..213 CDD:437068 44/103 (43%)
ADAMTS_spacer1 222..329 CDD:461796 31/122 (25%)
TSP1_ADAMTS 347..396 CDD:465950 4/48 (8%)
TSP1_ADAMTS 400..457 CDD:465950 11/56 (20%)
TSP1_ADAMTS 465..520 CDD:465950 5/54 (9%)
TSP1_ADAMTS 580..632 CDD:465950
TSP1_ADAMTS 643..693 CDD:465950
MSCRAMM_ClfA <1049..1262 CDD:468110
Kunitz_papilin_lacunin-like 1612..1663 CDD:438681
Kunitz_BPTI 1670..1721 CDD:425421
Kunitz-type 1730..1780 CDD:438633
Kunitz_BPTI 1789..1840 CDD:425421
Kunitz_papilin_mig6-like 1849..1899 CDD:438679
Kunitz_papilin_mig6-like 1922..1972 CDD:438679
Kunitz_papilin_mig6-like 2001..2051 CDD:438679
Kunitz-type 2071..2121 CDD:438633
Kunitz_BPTI 2127..2178 CDD:425421
Kunitz_BPTI 2193..2245 CDD:425421
Kunitz_BPTI 2252..2303 CDD:425421
Kunitz_BPTI 2317..2372 CDD:425421
WAP 2455..2497 CDD:459672
Ig 2530..2610 CDD:472250
Ig strand B 2539..2543 CDD:409353
Ig strand C 2552..2556 CDD:409353
Ig strand E 2576..2579 CDD:409353
Ig strand F 2589..2594 CDD:409353
Ig strand G 2603..2606 CDD:409353
IG_like 2627..2703 CDD:214653
Ig strand B 2636..2640 CDD:409353
Ig strand C 2649..2653 CDD:409353
Ig strand E 2670..2674 CDD:409353
Ig strand F 2684..2689 CDD:409353
Ig strand G 2697..2700 CDD:409353
I-set 2766..2845 CDD:400151
Ig strand B 2771..2775 CDD:409353
Ig strand C 2784..2788 CDD:409353
Ig strand F 2821..2826 CDD:409353
PLAC 2851..2883 CDD:462560
ADAMTS5NP_008969.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..69
Pep_M12B_propep 66..178 CDD:460254
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 206..231
Cysteine switch. /evidence=ECO:0000250 207..214
ZnMc_ADAMTS_like 269..473 CDD:239801
ADAMTS_CR_2 487..554 CDD:465496 8/31 (26%)
TSP1 570..622 CDD:214559 19/51 (37%)
ADAMTS_CR_3 628..731 CDD:437068 44/102 (43%)
Spacer 732..874 41/196 (21%)
ADAMTS_spacer1 733..852 CDD:461796 33/129 (26%)
TSP1_ADAMTS 879..930 CDD:465950 21/120 (18%)
Blue background indicates that the domain is not in the aligned region.

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