DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppn and ADAMTS13

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_620594.1	Gene:	ADAMTS13 / 11093	HGNCID:	1366	Length:	1427	Species:	Homo sapiens

Alignment Length:	735	Identity:	200/735 - (27%)
Similarity:	286/735 - (38%)	Gaps:	148/735 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 WTPWSSPSDCSRTCGGGVSYQTRECLR-RDDRGEAVCSGGSRRYFSCNTQDCPEEESDFRAQQCS 123
            |:.|...|.|||:|||||..:.|:|.. |...|...|.|...:...||||.|.:.:.:|.:|||:
Human   387 WSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCA 451

  Fly   124 RFDRQQF-----DGVFYEW---VPYTNAPNPCELNCMPKGERFYYRQREKVVDGTRC------ND 174
            |.|.|..     ...||.|   ||::.....|...|...||.|..::.:..:|||||      .|
Human   452 RTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPRED 516

  Fly   175 KDLDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLLLLPEGA 239
            ..|.:||:|.|...|||..:.|....|:|:.||||.|||...:.:.|. ..|..|...|.:....
Human   517 GTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTA-GRAREYVTFLTVTPNL 580

  Fly   240 TNIRIEETVPSSNYLACRNHSGHYYLNGDWRIDFPR---PMFFANSWWNYQ------RKPMGFAA 295
            |::.|....|...:||.| ..|.|.:.|...|. |.   |....:....|:      |.|    .
Human   581 TSVYIANHRPLFTHLAVR-IGGRYVVAGKMSIS-PNTTYPSLLEDGRVEYRVALTEDRLP----R 639

  Fly   296 PDQLTCSGPISESLFIVMLVQEKNISLDYEYSIPESLSHSQQDTHTWTHHQ------------FN 348
            .:::...||:.|         :.:|.:...|.  |...:..:...|:|:.|            ..
Human   640 LEEIRIWGPLQE---------DADIQVYRRYG--EEYGNLTRPDITFTYFQPKPRQAWVWAAVRG 693

  Fly   349 ACSASCGGGSQSRKVTCNNRITLAEVNPSLCD-QKSKPVEEQACGTEPCAPHWVEGEWSKCSKGC 412
            .||.|||.|.:....:|.::.....|....|. .:..|...:||..|||.|:|..|::..||..|
Human   694 PCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASC 758

  Fly   413 GSDGFQNRSITCERISSSGEHTVEEDAVCLKEV--------GNKPATKQE-CNRDVKNCP-KYHL 467
            |. |.:.|.:.|          ||.....||.:        ..:||...| ||  .:.|| ::.:
Human   759 GG-GLRERPVRC----------VEAQGSLLKTLPPARCRAGAQQPAVALETCN--PQPCPARWEV 810

  Fly   468 GPWTPCDKLCGDGKQTRKVTCFIEENGHKRVLPE-EDCVEEK-PETEKSCLLTPCEGVD----W- 525
            ...:.|....|.|......||....:|.:..:.| ...|:|| |..|      ||.|:.    |
Human   811 SEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPE------PCVGMSCPPGWG 869

  Fly   526 ----------IISQW-----------------SGCN-ACGQNTETRTAICGNKEGKV-YPEEFCE 561
                      ..|.|                 ..|: :||:.......:|.:...:| ..||.|
Human   870 HLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELC- 933

  Fly   562 PEVPTLSRP------CKSPKCEAQWFSSEWSKCSAPCGKGVKSRIVIC----GEFDGKTVTPADD 616
               ...|:|      |::..|.|:| ..:.:.||..||:||..||:.|    ||.||:.:..
Human   934 ---GLASKPGSRREVCQAVPCPARW-QYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILL--- 991

  Fly   617 DSKCNKETKPESEQDCEGEEKVCPGEWFTGPWGKCSKPCGGGERVREVLC--LSNGTKSVNCDEE 679
            |::|....:||.::.|..|.  ||..|.....|.||..||.|...|.|.|  |..| :.|..||.
Human   992 DTQCQGLPRPEPQEACSLEP--CPPRWKVMSLGPCSASCGLGTARRSVACVQLDQG-QDVEVDEA 1053

  Fly   680 KVEPL-----SEKCNSEACT 694
            ....|     |..|....||
Human  1054 ACAALVRPEASVPCLIADCT 1073

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	21/51 (41%)
		ADAM_spacer1	214..329	CDD:283607	24/123 (20%)
		TSP1	468..521	CDD:214559	13/54 (24%)
		TSP_1	645..693	CDD:278517	17/54 (31%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
ADAMTS13	NP_620594.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..70
		ZnMc_ADAMTS_like	80..283	CDD:239801
		TSP1	387..439	CDD:214559	21/51 (41%)
		Cysteine-rich	440..556		40/115 (35%)
		Cell attachment site. /evidence=ECO:0000255	498..500		0/1 (0%)
		Spacer	556..685		28/146 (19%)
		ADAM_spacer1	559..680	CDD:283607	27/138 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810