DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppn and Adamts6

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_001074489.1	Gene:	Adamts6 / 108154	MGIID:	1347348	Length:	1117	Species:	Mus musculus

Alignment Length:	666	Identity:	217/666 - (32%)
Similarity:	310/666 - (46%)	Gaps:	149/666 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 WTPWSSPSDCSRTCGGGVSYQTREC-LRRDDRGEAVCSGGSRRYFSCNTQDCPEEESDFRAQQCS 123
            |..||...:||||||||||...|.| ......|...|.|..:||.||||..||....|||.:||:
Mouse   561 WGSWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCA 625

  Fly   124 RFDRQQFDGVFYEWVPYT-NAPNPCELNCMPKGERFYYRQREKVVDGTRCNDKDLDVCVNGECMP 187
            .||...|.|..|.|.||| ....||.|||:.:|..||..:...|:|||:||...||:|:||||..
Mouse   626 DFDSMPFRGKHYNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKH 690

  Fly   188 VGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLLLLPEGATNIRIEETVPSSN 252
            ||||.:|||||:||:||.||||||||..|...........||.:::.:|.|:.:|.:.|...|.|
Mouse   691 VGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVSMSKN 755

  Fly   253 YLACRNHSGHYYLNGDWRIDFPRPMFFANSWWNYQRKPMGFAAPDQLTCSGPISESLFIVMLVQE 317
            |:|.::....||:||.|.||:||....:.:.::|:|..   ..|:.|...||.||:|.:::|:||
Mouse   756 YIALKSEGDDYYINGAWTIDWPRKFDVSGTAFHYKRPT---DEPESLEALGPTSENLIVMVLLQE 817

  Fly   318 KNISLDYEYSIP--ESLSHSQQDTHTWTHHQFNACSASCGGGSQSRKVTCNNRITLAEVNPSLCD 380
            :|:.:.|::::|  .:.|...:....||:..:..|||:|.||.|.::|.|......:.|..:.||
Mouse   818 QNLGIRYKFNVPIVRTGSGDNEVGFMWTYQPWAECSATCAGGVQRQEVVCKRLDDNSIVQNNFCD 882

  Fly   381 QKSKPVEEQ-ACGTEPCAPHWVEGEWSKCSKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKE 444
            ..|||.|.| ||.||||.|.|..|:|.:|||.| ..|.:.|::                 :|:::
Mouse   883 PDSKPPENQRACNTEPCPPEWFIGDWLECSKTC-DGGMRTRAV-----------------LCIRK 929

  Fly   445 VGNKPATKQECNRDVKNCPKYHLGPWTPCDKLCGDGKQTRKVTCFIEENGHKRVLPEEDCVEEKP 509
            ||  |:.::                                            .|...||:..:|
Mouse   930 VG--PSEEE--------------------------------------------TLDYGDCLTHRP 948

  Fly   510 ETEKSCLLTPCEGVDWIISQWSGCNACGQNTETRTAICGNKEGKVYPEEFCEPEVPTLSRPCKSP 574
            ..::|                                                        |.:.
Mouse   949 VEKES--------------------------------------------------------CNNQ 957

  Fly   575 KCEAQWFSSEWSKCSAPCGKGVKSRIVICGEFDGKTVTPADDDSKCNKETKPESEQDCE-GEEKV 638
            .|..||.:.:||:|:..||.|.|.|||:|...|.....||   ::|.:|:||.:...|. |.
Mouse   958 SCPPQWVALDWSECTPKCGSGFKHRIVLCKSSDLSKTFPA---AQCPEESKPPARIRCSLGR--- 1016

  Fly   639 C-PGEWFTGPWGKCSKPCGGGERVREVLCLS-NGTKSVNCDEEKVEPLSEKCNSEACTEDEILPL 701
            | |..|.||.||:||..||.|:::|.|.||| .|..||:|.|....|..::|:|:.    :..||
Mouse  1017 CPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASVDCPETVRPPSMQQCDSKC----DSTPL 1077

  Fly   702 TSTDKPIEDDEEDCDE 717
            :||        |:|.:
Mouse  1078 SST--------EECKD 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	24/51 (47%)
		ADAM_spacer1	214..329	CDD:283607	34/114 (30%)
		TSP1	468..521	CDD:214559	5/52 (10%)
		TSP_1	645..693	CDD:278517	22/48 (46%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
Adamts6	NP_001074489.1	Pep_M12B_propep	43..191	CDD:366707
		ZnMc_ADAMTS_like	250..465	CDD:239801
		ADAM_CR_2	480..548	CDD:375321
		TSP1	561..613	CDD:214559	24/51 (47%)
		ADAM_spacer1	719..829	CDD:368694	34/112 (30%)
		TSP1	843..900	CDD:214559	24/56 (43%)
		TSP1	902..960	CDD:214559	19/177 (11%)
		TSP1	1022..1069	CDD:214559	21/46 (46%)
		PLAC	1083..1115	CDD:370061	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11602
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2734
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840