DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and Adamts7

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_001313280.1 Gene:Adamts7 / 108153 MGIID:1347346 Length:1657 Species:Mus musculus


Alignment Length:1617 Identity:367/1617 - (22%)
Similarity:535/1617 - (33%) Gaps:550/1617 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 GANMYLPESSVTPGGEGNDPDE----WTPWSSPSDCSRTCGGGVSYQTRECLR--RDDRGEAVCS 96
            |.|.:..:....|  ||..|:.    |:.||:.|||||:||.||....|:|.:  ..:||: .|.
Mouse   502 GKNKWCLKGECVP--EGFQPEAVDGGWSGWSAWSDCSRSCGVGVRSSERQCTQPVPKNRGK-YCV 563

  Fly    97 GGSRRYFSCNTQDCPEEESDFRAQQCSRFDRQQFDGVFYEWVPYTNAPNPCELNCMPKGERFYYR 161
            |..:|...||...||.:...||..|||:||...:.|..::|||..|..|||||:|.|.......:
Mouse   564 GERKRSQLCNLPACPPDRPSFRHTQCSQFDGMLYKGKLHKWVPVPNDDNPCELHCRPSNSSNTEK 628

  Fly   162 QREKVVDGTRCNDKDL--DVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKD 224
            .|:.|||||.|....:  |:|:||.|..||||.::.|.|:||:|..|.||||||:|:..|....:
Mouse   629 LRDAVVDGTPCYQSRISRDICLNGICKNVGCDFVIDSGAEEDRCGVCRGDGSTCQTVSRTFKETE 693

  Fly   225 LAPGYNDLLLLPEGATNIRIEETVPSSNYLACRNHS-GHYYLNGDWRIDFPRPMFFANSWWNYQR 288
             ..||.|:.|:|.||..|.|||...::|:||.|:.. ..|:|||.|.|.:......|.:.:.|.|
Mouse   694 -GQGYVDIGLIPAGAREILIEEVAEAANFLALRSEDPDKYFLNGGWTIQWNGDYRVAGTTFTYAR 757

  Fly   289 KPMGFAAPDQLTCSGPISESLFIVMLVQEKNISLDYEYSIPESLSHSQQDTH--------TWTHH 345
            |    ...:.||..||.||.::|.:|.||||..:.|:|:|       |:|:|        :|.:.
Mouse   758 K----GNWENLTSPGPTSEPVWIQLLFQEKNPGVHYQYTI-------QRDSHDQVRPPEFSWHYG 811

  Fly   346 QFNACSASCGGGSQSRKVTCNNRITLAEVNPSLCDQKSKPVEEQ-ACGTEPCAPHWVEGEWSKCS 409
            .::.|:.:||.|.|.:.:.|..| ....|....|:..::|.|.| .|..|||.|.|..|||..||
Mouse   812 PWSKCTVTCGTGVQRQSLYCMER-QAGVVAEEYCNTLNRPDERQRKCSEEPCPPRWWAGEWQPCS 875

  Fly   410 KGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVKNCPK-YHLGPWTPC 473
            :.||.:|...|::.|.|.....|....|.:.|  |...:|..:..|||.| .||. :.:|.|:.|
Mouse   876 RSCGPEGLSRRAVFCIRSMGLDEQRALELSAC--EHLPRPLAETPCNRHV-ICPSTWGVGNWSQC 937

  Fly   474 DKLCGDGKQTRKVTCFIEENGHKRVLPEEDCVE-EKPETEKSCLLTPCEGVDWIISQWSGCNACG 537
            ...||.|.:.|.|.|.     :...:|   |.| |:|.||..|.|.||:...:|:.  :|.:..|
Mouse   938 SVTCGAGIRQRSVLCI-----NNTDVP---CDEAERPITETFCFLQPCQYPMYIVD--TGASGSG 992

  Fly   538 QNTETRTAICGNKEGKVYPEEFCEPE-VPTLSRPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRIV 601
            .::               ||.|.|.: :|....|..||             .|:|          
Mouse   993 SSS---------------PELFNEVDFIPNQLAPRPSP-------------ASSP---------- 1019

  Fly   602 ICGEFDGKTVTPADDDSKCNKETKPESEQDCEGEEKVCPGEWFTGPWGKCSKPCGGGERVREVLC 666
                                   ||.|                                      
Mouse  1020 -----------------------KPVS-------------------------------------- 1023

  Fly   667 LSNGTKSVNCDEEKVEPLSEKCNSEACTEDEILPLTSTDKPIEDDEEDCDEDGI---ELISDGLS 728
            :||.     .|||:::|                     ..|:..|:...|.:.|   |.:|.| |
Mouse  1024 ISNA-----IDEEELDP---------------------PGPVFVDDFYYDYNFINFHEDLSYG-S 1061

  Fly   729 DDEKSEDVIDLEG-TAKTETTPEAEDLMQSDSPTPYDEFESTGTTFEGSGYDSESTTDSGISTEG 792
            .:|...|::|..| ||.....|                              :||.:|:.:.|.|
Mouse  1062 FEEPHPDLVDNGGWTAPPHIRP------------------------------TESPSDTPVPTAG 1096

  Fly   793 SGDDEETSEASTDLSSSTDSGSTSSDSTSSDSSSSISSDATSEAPASSVSDSSDSTDASTETTGV 857
            :                  .|:.:.|...|.|.|.:.|:|:...|....:..:...:..||    
Mouse  1097 A------------------LGAEAEDIQGSWSPSPLLSEASYSPPGLEQTSINPLANFLTE---- 1139

  Fly   858 SDDSTDVSSSTEASASESTDVSGASDSTGSTNASDSTPESSTEAS--------SSTDDST----D 910
                                              :.||..:.|..        :|.||..    .
Mouse  1140 ----------------------------------EDTPMGAPELGFPSLPWPPASVDDMMTPVGP 1170

  Fly   911 SSDNSSNVSESSTEASSSSVSDSNDSSDGSTDGVSSTTENSSDSTSDATSDSTASSDSTDSTSDQ 975
            .:.:...|.|......|:..||.|..   ||||      |....||.|...|..           
Mouse  1171 GNPDELLVKEDEQSPPSTPWSDRNKL---STDG------NPLGHTSPALPQSPI----------- 1215

  Fly   976 TTETTPESSTDSTESSTLDASSTTDASSTSESSSESSTDGSSTTSNSASSETTGLSSDGSTTDAT 1040
            .|:.:|.|.                                                      :.
Mouse  1216 PTQPSPPSI------------------------------------------------------SP 1226

  Fly  1041 TAASDNTDITTDGSTDESTDGSSNASTEGSTE-GASEDTTISTESSGSTESTDAIASDGSTTEGS 1104
            |.||.:.|:                 .|.||. .|:.|..:           :|....|.....|
Mouse  1227 TQASPSPDV-----------------VEVSTGWNAAWDPVL-----------EADLKPGHGELPS 1263

  Fly  1105 TVEDLSSSTSSDVTSDSTITDSSPSTEVSGSTDSSSSTDGSSTDASSTEASSTDVTESTDSTVSG 1169
            |||         |.|...:    |...|.|.....|..:..:...||.|.||..:...|    ..
Mouse  1264 TVE---------VASPPLL----PMATVPGIWGRDSPLEPGTPTFSSPELSSQHLKTLT----MP 1311

  Fly  1170 GT------SDTTESGPTEESTTEGSTESTTEGSTDSTQSTDLDSTTSDIWSTSDKDDESESSTPY 1228
            ||      :|....||:.:..|.         :.:.|||..|..|.:           .|:.|..
Mouse  1312 GTLLLTVPTDLRSPGPSGQPQTP---------NLEGTQSPGLLPTPA-----------RETQTNS 1356

  Fly  1229 SFDSEVTKSKPRKCKPKKSTCAKSEYGCCPDGKSTPKGPFDEGCPIAKTCADTKYGCCLDGVSPA 1293
            |.|.||...:|          :..|.|             |...|:                 ||
Mouse  1357 SKDPEVQPLQP----------SLEEDG-------------DPADPL-----------------PA 1381

  Fly  1294 KGKNNKGCPKSQCAETLFGCCPDKFTAADGENDEGCPETTTVPPTTTTEETQPETTTEI------ 1352
            :..:.:....|||:.|.......:..:....|||.|         |.....||.....:      
Mouse  1382 RNASWQVGNWSQCSTTCGLGAIWRLVSCSSGNDEDC---------TLASRPQPARHCHLRPCAAW 1437

  Fly  1353 ---------EGSGQDSTTSE---PDTKKSCSFSEFGCCPDAETSAKGPDFEGCGLASPVAKGCAE 1405
                     ...|..|:|.:   .||:.......|.|.|.   ..|.|:.:.|| ..|.......
Mouse  1438 RTGNWSKCSRNCGGGSSTRDVQCVDTRDLRPLRPFHCQPG---PTKPPNRQLCG-TQPCLPWYTS 1498

  Fly  1406 SENGCCPDGQTPASGPNGEGCSGCTRERFGCCPDSQTPAHGPNKEGCCLDTQFGCCPDNILAARG 1470
            |...|            .|.|.|..::|...||:.                  |.|.:::   |.
Mouse  1499 SWREC------------SEACGGGEQQRLVTCPEP------------------GLCEESL---RP 1530

  Fly  1471 PNNEGCECH------YTPYGCCPDNKSAATGYNQEGCACETTQYGCCPDKITAAKGPKHEGCPCE 1529
            .|:..|..|      ..|:|.|  :.....|..:....|..||.|...:.....   .||..| |
Mouse  1531 NNSRPCNTHPCTQWVVGPWGQC--SAPCGGGVQRRLVRCVNTQTGLAEEDSDLC---SHEAWP-E 1589

  Fly  1530 TTQFGCCPDGLTFAKGPHHHGCHCTQTEFKCCDDEKTPAKGPNGDGCTCVESKFGCC 1586
            ::: .|..:.....:.|.   |...:..|..|:..:...:      |.....:..||
Mouse  1590 SSR-PCATEDCELVEPPR---CERDRLSFNFCETLRLLGR------CQLPTIRAQCC 1636

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559 21/52 (40%)
ADAM_spacer1 214..329 CDD:283607 41/115 (36%)
TSP1 468..521 CDD:214559 19/53 (36%)
TSP_1 645..693 CDD:278517 6/47 (13%)
Kunitz_BPTI 1611..1663 CDD:278443
Kunitz_BPTI 1670..1721 CDD:278443
Kunitz_BPTI 1729..1781 CDD:278443
Kunitz_BPTI 1789..1840 CDD:278443
Kunitz_BPTI 1848..1899 CDD:278443
KU 1920..1973 CDD:238057
Kunitz_BPTI 2001..2051 CDD:278443
KU 2071..2121 CDD:238057
Kunitz_BPTI 2127..2178 CDD:278443
KU 2192..2245 CDD:238057
KU 2251..2304 CDD:238057
KU 2316..2372 CDD:238057
WAP 2457..2497 CDD:278522
Ig 2521..2610 CDD:299845
IG_like 2530..2610 CDD:214653
IG_like 2627..2703 CDD:214653
Ig 2636..2701 CDD:143165
IG_like 2766..2841 CDD:214653
Ig 2768..2830 CDD:299845
PLAC 2851..2883 CDD:285849
Adamts7NP_001313280.1 Pep_M12B_propep 58..173 CDD:279848
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 165..221
Cysteine switch. /evidence=ECO:0000250 192..199
Reprolysin 226..437 CDD:279729
ZnMc_ADAMTS_like 226..434 CDD:239801
TSP1 526..578 CDD:214559 21/52 (40%)
ADAM_spacer1 683..794 CDD:283607 42/122 (34%)
Spacer 683..794 42/122 (34%)
TSP1 808..863 CDD:214559 16/55 (29%)
TSP1 927..977 CDD:214559 18/57 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1009..1034 13/113 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1073..1127 17/101 (17%)
MISS 1083..1334 CDD:292450 72/455 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1140..1237 28/187 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1283..1304 6/20 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1317..1384 22/126 (17%)
TSP1 1437..1492 CDD:214559 12/58 (21%)
TSP1 1541..1600 CDD:214559 13/65 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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