Protein Alignment Ppn and SPINT2

DIOPT Version :10

• Sequence 1: NP_788752.2
• Gene: Ppn / 43872
• FlyBaseID: FBgn0003137
• Length: 2898
• Species: Drosophila melanogaster
• Sequence 2: NP_066925.1
• Gene: SPINT2 / 10653
• HGNCID: 11247
• Length: 252
• Species: Homo sapiens
• Alignment Length: 158
• Identity: 52/158 - (32%)
• Similarity: 68/158 - (43%)
• Gaps: 24/158 - (15%)

  Fly  1847 DICEIPAEVGECANYVTSWYYDTQDQACRQFYYGGCGGNENRFPTEESCLARCDRKPEPTTTTPA 1911
            |.|.:...||.|...:..|:|:..|.:|:.|.||||.||.|.:.|:|.||.:|....|..|...|
Human    36 DFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDLA 100

  Fly  1912 TR---------PQPSRQD-------------VCDEEPAPGECSTWVLKWHFDRKIGACRQFYYGN 1954
            |.         ..|.|||             .|......|.|.....:|:||.:..:|..|.||.
Human   101 TSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGG 165

  Fly  1955 CGGNGNRFETENDCQQRCLSQE--PPAP 1980
            |.||.|.:.:|..|..||..|:  ||.|
Human   166 CRGNKNSYRSEEACMLRCFRQQENPPLP 193

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559
		ADAMTS_CR_3	116..213	CDD:437068
		ADAMTS_spacer1	222..329	CDD:461796
		TSP1_ADAMTS	347..396	CDD:465950
		TSP1_ADAMTS	400..457	CDD:465950
		TSP1_ADAMTS	465..520	CDD:465950
		TSP1_ADAMTS	580..632	CDD:465950
		TSP1_ADAMTS	643..693	CDD:465950
		MSCRAMM_ClfA	<1049..1262	CDD:468110
		Kunitz_papilin_lacunin-like	1612..1663	CDD:438681
		Kunitz_BPTI	1670..1721	CDD:425421
		Kunitz-type	1730..1780	CDD:438633
		Kunitz_BPTI	1789..1840	CDD:425421
		Kunitz_papilin_mig6-like	1849..1899	CDD:438679	20/49 (41%)
		Kunitz_papilin_mig6-like	1922..1972	CDD:438679	16/49 (33%)
		Kunitz_papilin_mig6-like	2001..2051	CDD:438679
		Kunitz-type	2071..2121	CDD:438633
		Kunitz_BPTI	2127..2178	CDD:425421
		Kunitz_BPTI	2193..2245	CDD:425421
		Kunitz_BPTI	2252..2303	CDD:425421
		Kunitz_BPTI	2317..2372	CDD:425421
		WAP	2455..2497	CDD:459672
		Ig	2530..2610	CDD:472250
		Ig strand B	2539..2543	CDD:409353
		Ig strand C	2552..2556	CDD:409353
		Ig strand E	2576..2579	CDD:409353
		Ig strand F	2589..2594	CDD:409353
		Ig strand G	2603..2606	CDD:409353
		IG_like	2627..2703	CDD:214653
		Ig strand B	2636..2640	CDD:409353
		Ig strand C	2649..2653	CDD:409353
		Ig strand E	2670..2674	CDD:409353
		Ig strand F	2684..2689	CDD:409353
		Ig strand G	2697..2700	CDD:409353
		I-set	2766..2845	CDD:400151
		Ig strand B	2771..2775	CDD:409353
		Ig strand C	2784..2788	CDD:409353
		Ig strand F	2821..2826	CDD:409353
		PLAC	2851..2883	CDD:462560
SPINT2	NP_066925.1	Kunitz_HAI2_1-like	36..88	CDD:438664	21/51 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	100..122		6/21 (29%)
		Kunitz_HAI2_2-like	131..183	CDD:438665	16/51 (31%)