DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppn and adamts17

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	XP_021333385.1	Gene:	adamts17 / 101884120	ZFINID:	ZDB-GENE-121030-7	Length:	1134	Species:	Danio rerio

Alignment Length:	647	Identity:	187/647 - (28%)
Similarity:	279/647 - (43%)	Gaps:	154/647 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 SVTPGGEGNDPDEWTPWSSPSDCSRTCGGGVSYQTRECLRRDD----RGEAVCSGGSRRYFSCNT 107
            |.||..:..|.| |:|||:.|.||||||.|..::.|:|   |:    .|...|...|..:..|..
Zfish   524 SKTPIPQHVDGD-WSPWSTWSMCSRTCGTGARFRQRKC---DNPPPGPGGKYCQKASVEHKVCEG 584

  Fly   108 QDCPEEESDFRAQQCSRFDRQ-----QFDGVFYEWVPYTNAPNPCELNCMPKGERFYYRQREKVV 167
            ..|.:....||.|||...:||     |.      |....:...||.|.|.|.|........|:|:
Zfish   585 PPCTKGLPTFRDQQCQSHERQASKKSQM------WTAVIDDEKPCALYCTPVGSDSPVLVAERVL 643

  Fly   168 DGTRCNDKDLDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTIT-TKDLAPG--- 228
            |||.|...:.|:||||:|..:|||.::||.||||:|..|.|||.:|:.::.... :|.:.|.
Zfish   644 DGTPCGPYESDLCVNGKCQKIGCDGIIGSSAKEDRCGVCNGDGKSCRIVKGDFNHSKGMVPHSLC 708

  Fly   229 --------------------YNDLLLLPEGATNIRIEETVPSSNYLACRNHSGHYYLNGDWRIDF 273
                                |.:..::|.||..|::.|..||.::||.:: |....:|.||:|:.
Zfish   709 KKVSTCVMSKPRAVLKCFSCYIEAAVIPVGARRIKVVEDKPSHSFLALKD-SSKRSINNDWKIEL 772

  Fly   274 PRPMFFANSWWNYQRKPMGFAAPDQLTCSGPISESL-FIVMLVQEKNISLDYEYSIPESLSHSQQ 337
            |.....|.:...|.|:.:.    ::::..||....| .:|:|..::...:.|||::  :|:|||:
Zfish   773 PGEFELAGTTVRYVRRGLW----EKMSAKGPTKTPLHLMVLLFHDQTYGIHYEYTV--ALNHSQE 831

  Fly   338 DT----------HTWTHHQFNACSASCGGGSQSRKVTCNNRI--TLAEVNPSLCDQKSKPVEE-Q 389
            ::          :.|||..:..||..||||.:...|:|...|  |:..||.|.|..::||..: :
Zfish   832 NSSDLVKEPEHMYLWTHSSWEDCSVHCGGGERRTVVSCMRIINKTMTPVNDSSCQVENKPSPQIR 896

  Fly   390 ACGTEPCAPHWVEGEWSKCSKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQE 454
            .|...||...||.|:|::||..||. |.|.|.:.|.....:|.:....|..||   .:|||:.|.
Zfish   897 QCNIHPCQYRWVTGDWTQCSLTCGK-GLQQREVGCIYQLQNGTYIPTRDLYCL---SSKPASVQH 957

  Fly   455 CNRDVKNCPKYHLGPWTPCDKLCGDGKQTRKVTCFIEENGHKRVLPEEDCVEEKPETEKSCLLTP 519
            |                                    |..|                   ||..
Zfish   958 C------------------------------------EGRH-------------------CLTV- 966

  Fly   520 CEGVDWIISQWSGCNA-CGQNTETRTAICGNKEGKVYPEEFCEPEVPTLSRPCKSPKCE-----A 578
                 |..|:||.|:: ||..:..||..|.|      |...|:|    :|||.:...||     .
Zfish   967 -----WEASEWSQCSSECGHGSRRRTVTCTN------PHGLCDP----VSRPAEVEACEDHSKCY 1016

  Fly   579 QWFSSEWSKCSAPCGKGVKSRIVIC-GEFDGKTVTPADDDSKCNKETKPESEQDCEGEEKVC 639
            :|.:.||||||:.||:|::||:|.| ....|:      ..|.|....||.:.:.|  .:..|
Zfish  1017 EWKTGEWSKCSSSCGRGLQSRVVQCMHRVSGR------HGSDCPAVLKPATYRQC--HQSTC 1070

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	19/54 (35%)
		ADAM_spacer1	214..329	CDD:283607	29/139 (21%)
		TSP1	468..521	CDD:214559	4/52 (8%)
		TSP_1	645..693	CDD:278517
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
adamts17	XP_021333385.1	Pep_M12B_propep	33..170	CDD:307618
		ZnMc_ADAMTS_like	223..439	CDD:239801
		TSP1	536..587	CDD:214559	19/53 (36%)
		ADAM_spacer1	729..824	CDD:310520	27/99 (27%)
		TSP1	907..>931	CDD:214559	11/24 (46%)
		TSP1	966..1013	CDD:214559	19/62 (31%)
		TSP1	1018..1070	CDD:214559	20/59 (34%)
		PLAC	1099..1123	CDD:312271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810