DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppn and adamtsl3

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	XP_003198947.4	Gene:	adamtsl3 / 100534944	ZFINID:	ZDB-GENE-121030-8	Length:	1760	Species:	Danio rerio

Alignment Length:	1926	Identity:	430/1926 - (22%)
Similarity:	635/1926 - (32%)	Gaps:	621/1926 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 QYGANMYLPESSVTPGGEGNDPDEWTPWSSPSDCSRTCGGGVSYQTRECLRRDDRGEAVCSGGSR 100
            ||....|..:||.|...:......|..|.:.||||||||||.||..|.||...:     |.|.:.
Zfish    54 QYLTYRYDDQSSRTTRSDEERDTGWDAWGTWSDCSRTCGGGASYSLRRCLNGGN-----CEGRNI 113

  Fly   101 RYFSCNTQDCPEEESDFRAQQCSRFDRQQFDGVFYEWVPYTNAP-NPCELNCMPKGERFYYRQRE 164
            ||.:|:..|||.|..||||||||..:..::.|..|||:|.|..| :||.|.|..:|:........
Zfish   114 RYRTCSNTDCPLESGDFRAQQCSAHNDIKYQGQTYEWIPVTYDPVSPCALRCQARGKGQVVELAP 178

  Fly   165 KVVDGTRCNDKDLDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRN----------- 218
            ||:|||||....||:|::|.|..||||..|||:||||.|..|.||||||:.||.
Zfish   179 KVLDGTRCKADSLDMCISGICQEVGCDRQLGSNAKEDNCGVCAGDGSTCRLIRGQALPHVSPEEP 243

  Fly   219 --------------TITTKDLAPGYNDLLLLPEGATNIRIEETVPSSNYLACRNHSGHYYLNGDW 269
                          .||.|  .|   |::::.....|.|.||...||        ||.:.| |:.
Zfish   244 IKTVIEVPMGSRGLRITAK--GP---DMIVIEAHGQNSRREEVHFSS--------SGSHSL-GNN 294

  Fly   270 RIDFPRP--------------------------------MFFANSWWNYQRKPMGFAAPDQLTCS 302
            .::|.|.                                ||:...  .||.:...| .|..:||.
Zfish   295 TVEFQRGAERQTLRCYGPLTADFTVKVKYAGPKDTVIQFMFYQPI--RYQWRETDF-FPCSVTCG 356

  Fly   303 GPISESLFIVMLVQEKNISLDYEYSIPESLSHS-------------------------------- 335
            |.       ..|.....:.:.|..|:.|.|.||
Zfish   357 GG-------YQLNSADCVDIRYNRSVAEHLCHSFPENTKPTPKLKECNMEPCPESDGFKEVMPYD 414

  Fly   336 -QQDTHTWTHHQFNACSASCGGGSQSRKVTCNNRIT---LAEVNPSLCDQKSKPVEEQACGTEPC 396
             .|....|..:.:.:||.|||||||.|.:.|.....   :.:|....|....:|:.:|.|.|..|
Zfish   415 HFQPLPRWEQNPWTSCSVSCGGGSQERSIVCVEEDVHGQIVQVEDWKCTHSPRPISKQNCNTFDC 479

  Fly   397 APHWVEGEWSKCSKGCGSDGFQNRSITCERISSSGEHT----------VEEDAV----CLKEVGN 447
             |.|:..|||:|:..|| .|.:.|.:.|  :..:|:|.          ::||.:    |.|...|
Zfish   480 -PQWMAMEWSQCTVTCG-PGLRYRVVLC--VDYNGQHAGGCNPHLKPHIKEDCLVPIACHKPREN 540

  Fly   448 KP----------ATKQECNRDVKNCPKYHLGPWTPCDKLCGDGKQTRKVTC--FIEENGHKRVLP 500
            :|          |.:.|..:.....|.:...||:.|...||.|.|.|:|.|  .:.....:..||
Zfish   541 QPVEAKLPWLKQAQELEETKVALEDPTFVPEPWSSCSVSCGLGIQRRQVKCKVLLSFTQAEVELP 605

  Fly   501 EEDCVEEKPETEKSCLLTPC--------------EG----------------------------- 522
            :|:|.||||.:::||...||              ||
Zfish   606 DEECHEEKPSSQRSCDSGPCLAAPDSSRWPLRTPEGPNQHGYAWEYIGFTACSASCAVGKQMAVV 670

  Fly   523 ----------VD-------------------------WIISQWSGCN-ACGQNTETRTAIC---- 547
                      ||                         |.:|.|:.|: :||...:||:..|
Zfish   671 RCVNTLKKEIVDDLLCNGSKAPVSLLRICNPQPCPSRWEVSVWNLCSVSCGVGLQTRSVSCVRSV 735

  Fly   548 -GNKEGKVYPEEFCEPEVPTLSRPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRIVICGE--FDGK 609
             ||:...:..:: |..:.|...:.|....|...|.:.||.:||..||:|.:.|.|.|.:  ..|.
Zfish   736 AGNRTESLSSKD-CVEKRPNELQACNQVACPPSWEAEEWQQCSHSCGRGSQWRKVYCKQRLATGS 799

  Fly   610 TVTPADDDSKCNKETKPESEQDCEGEEKVCP---GEWFTGPWGKCSKPCGGGERVREVLCLSNGT 671
            .....|:|  |: ..||:..:.|...:.:.|   |    |.|.|||..||.|.:.||.:|.....
Zfish   800 YRRLRDED--CS-GPKPDVHRICTNADCLLPRLEG----GEWSKCSVTCGKGVQRREPVCRRQTA 857

  Fly   672 KS-------VNCDEEKVEPLSEKCNSEACTEDE-------------------------------- 697
            ..       .:|.:..:.||...|....|.:.:
Zfish   858 SGQLVTLDRTSCSDLPLPPLIRSCRMSPCNKHKHSKKRCPQVIGLKRIYIQNRPEKRLSFTIGGR 922

  Fly   698 --ILPLTST--DKPIE---DDEEDCDEDGIELISDGLSDDEKSEDVIDLEGTAKTETTPEAEDL- 754
              :||.|:.  ..|:.   ..:...::||.||.|.......||       |..:.... ||||:
Zfish   923 AYLLPKTTVIIKCPVRHFPKAQIRWEKDGDELTSSKRLSITKS-------GALRIYNL-EAEDIG 979

  Fly   755 -----MQSDSPT------PYD----EFESTGTTFEGS---------GYDS----ESTTDSGISTE 791
                 ...||.|      .|:    :..|.|....|:         |:.|    |..|:...:::
Zfish   980 VYRCWANQDSDTFILKLIGYNNRLLDHPSLGKERRGNFHPYLNKEGGFVSSKCNEGFTNGNKASK 1044

  Fly   792 GS---------GDDEETSEASTDLSSSTDSGSTSSDSTSSDSSSSISSDATSEAPASSVSDSSDS 847
            .|         .||....|...|..:..:....|  ||||.:.:.:...|..|....::|..::|
Zfish  1045 SSWMQKNEFYRDDDGHPKEMLWDTLALGNYALAS--STSSHTGAFVLEPAQFEELVKNISQLAES 1107

  Fly   848 TDASTETTGVSDDSTDVSSSTEASASESTDVSGASDSTGSTNASDSTPESSTEASSSTDDSTDSS 912
            .|.:.|          ::|.......|....:|..             :...|.|::.|:..|.:
Zfish  1108 GDVTDE----------MASQLIGKLLEDLAAAGQG-------------QVPIEESTTVDNYLDRT 1149

  Fly   913 DNSSNVSESSTEASSSSVSDSNDSSDGSTDGVSSTTENSSDSTSDATSDSTASSDSTDSTSDQTT 977
            .|:|.:..:.....::.|...:..|..|..             .|.......::..|::|...|.
Zfish  1150 SNTSELFGTEVSKIAAIVRQKHHGSVMSFQ-------------RDLRIHVGRTAYLTNATHSLTL 1201

  Fly   978 ETTPESSTDSTESSTLDASSTTDASSTSESSS----ESSTDGSSTTSNSASSETTGLSSDGSTTD 1038
            ....:.|.....|.|.|.:...|.:..|..||    ..|:.|:|.......:.|..|.||..||.
Zfish  1202 LCPSKGSPKPKLSWTKDGAPLQDINRVSWDSSGGELHISSPGASDVGIYRCTSTNELGSDSETTQ 1266

  Fly  1039 ATTAASDNTDITTDGSTD-ESTD------------GSSNASTEGSTEGASE------------DT 1078
            ...|.|.....:...::| :||.            ..:|.:.|...:|...            |.
Zfish  1267 VLLAESPTIAASRRNTSDLKSTSLKVVVGGVIRVRSGANLTLECPVKGVPHPAVSWHRKEGPLDA 1331

  Fly  1079 TISTESSGSTESTDAIASDGSTTEGSTVEDLSSSTSSDVTSDSTITDSSPSTEVS-----GSTDS 1138
            ..|...|||...|:....|    ||         |.|.:.: :||..|:.|:.:|     |..|.
Zfish  1332 RASPLLSGSLLLTNLTQQD----EG---------TYSCIAA-NTIGKSAASSRISVEGAVGEPDL 1382

  Fly  1139 SSSTD-------GSSTDASSTEASSTDV-------------------TESTDSTVSGGTSDTTES 1177
            .||..       .:|...:|......|.                   ...|.:..:||.......
Zfish  1383 QSSKQMNRKRVLMASQVGTSAYVRPGDTLRIGCPVVPGHRRPIRWRFENRTLAAAAGGLYRLLVG 1447

  Fly  1178 GPTEESTTEGSTESTTEGSTDSTQSTDLDSTTSDI-------------WSTSDKDDESESSTPYS 1229
            |...|..|.  |.|.:......||:.:....|:.|             |||...          |
Zfish  1448 GRVLEINTH--TGSFSGRYQCQTQTNNQQQLTAWIHLLSQEFEWRLGDWSTCSS----------S 1500

  Fly  1230 FDSEVTKSKPRKC---KPKKSTCAKSEYGCCPDGKSTPKGPFDEGCPIAKTCADTKYGCCLDGVS 1291
            ..:..|:.|..||   :.::|:.|...|...|..::.|                     |
Zfish  1501 CGNRGTQMKKIKCVSSEGRESSHAACHYLPKPSSQTRP---------------------C----- 1539

  Fly  1292 PAKGKNNKGCPKSQCAETLFGCCPDKFTAADGENDEGCPETTTVPPTTTTEETQPETTTEIEGSG 1356
                 |...||.| ...|::..|.........|....|.:.    ..:.:.:..|  ::|.|||
Zfish  1540 -----NLLHCPPS-WVSTVWSRCSSSCGRGFRERRVSCQQV----EASGSVKVLP--SSECEGS- 1591

  Fly  1357 QDSTTSEPDTKKSCSFSEFGCCPDAETSAKGPDFEGCGLASPVAKGCAESENGCCPDGQTPASGP 1421
                 ..|:.::.||                            ::.|.|.           .|||
Zfish  1592 -----PRPEDRQECS----------------------------SQACVEW-----------ISGP 1612

  Fly  1422 NGEGCSG-CTRERFGCCPDSQTPAHGPNKEGCCL---DTQFGCCP-DNILAARGPNNEGCECHYT 1481
            .|: |:| |    .|....:||     ....|.|   .|...|.| :...|.|..::|.|:.|:.
Zfish  1613 WGK-CAGRC----LGPAMATQT-----RTVSCRLFSNSTSKTCDPKERPSAVRNCSSEMCDVHWK 1667

  Fly  1482 --PYGCCPDNKSAATGYNQEGCACETTQ-YGCCPDKITA-AKGP---KHEGCPCETTQFGC-CPD 1538
              |:..|  ..:..:|:......|...| ....||:..| .:.|   :|    |..|..|. |.|
Zfish  1668 VFPWRTC--TVACGSGFQSRRVECVHRQNKKTLPDQHCAWQRRPVTWQH----CNITSCGSECKD 1726

  Fly  1539 GLTFAKGPHHHGC----------------HCTQTEFKCCDD 1563
                    ..|.|                .|.||   |..|
Zfish  1727 --------RTHYCPAVKRLKLCSVDLYRQRCCQT---CLQD 1756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	23/50 (46%)
		ADAM_spacer1	214..329	CDD:283607	31/171 (18%)
		TSP1	468..521	CDD:214559	22/68 (32%)
		TSP_1	645..693	CDD:278517	15/54 (28%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
adamtsl3	XP_003198947.4	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810