DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppn and adamts10

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	XP_004911053.2	Gene:	adamts10 / 100494667	XenbaseID:	XB-GENE-961723	Length:	1139	Species:	Xenopus tropicalis

Alignment Length:	660	Identity:	210/660 - (31%)
Similarity:	297/660 - (45%)	Gaps:	140/660 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 EGNDPDEWTPWSSPSDCSRTCGGGVSYQTREC-LRRDDRGEAVCSGGSRRYFSCNTQDCPEEESD 116
            ||.| ..|..|||..:||||||||||...|.| ..|...|...|.|..:||.|||..|||....|
Frog   579 EGVD-GAWGSWSSWGECSRTCGGGVSSSVRHCDSPRPTIGGKYCLGERKRYRSCNIDDCPAGSQD 642

  Fly   117 FRAQQCSRFDRQQFDGVFYEWVPYT-NAPNPCELNCMPKGERFYYRQREKVVDGTRCNDKDLDVC 180
            ||..||:.||...|.|.:|.|..|. .....|.|||:.:|..||..:...|:|||.|.....|:|
Frog   643 FREVQCAEFDNVPFRGKYYSWKSYRGGGVKSCSLNCLAEGFNFYTERAAAVIDGTLCRQDSYDIC 707

  Fly   181 VNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLLLLPEGATNIRIE 245
            |||||..||||.:||||.||||||.||||||||:||...........||.:::.:|:|:.:|.|.
Frog   708 VNGECKHVGCDRILGSDTKEDKCRVCGGDGSTCETIEGIFNQSLPEGGYEEVVWIPKGSVHIDIR 772

  Fly   246 ETVPSSNYLACRNHSG-HYYLNGDWRIDFPRPMFFANSWWNYQRKPMGFAAPDQLTCSGPISESL 309
            :...|.:|||.:...| .||:||.:..|.|:....|.:.::| |:|.  ..|:.|...||.:.:|
Frog   773 QLNISLSYLALKAKEGSEYYINGRFPPDTPQRFDVAGTIFHY-RRPQ--EEPESLEALGPTNTTL 834

  Fly   310 FIVMLVQEKNI-SLDYEYSIPESLSHSQQDTHTWTHHQFNACSASCGGGSQSRKVTCNNRITLAE 373
            .:::.|:|:.: .:.|:::.|  ::...|:::.|....:..|||.|.||.|.::|.|......:.
Frog   835 IVMVAVREEILPGIRYKFNAP--INQVTQNSYAWYLSSWTKCSAICAGGVQLQQVLCKKFSDGST 897

  Fly   374 VNPSLCDQKSKPVEEQ-ACGTEPCAPHWVEGEWSKCSKGCGSDGFQNRSITCERISSSGEHTVEE 437
            |:..|||..|:..|:| .|.||||.|.|..|.||:||:.|.| |.:.||:.|:|..|..:
Frog   898 VSGDLCDPSSRIQEKQRPCNTEPCPPEWAIGAWSECSRSCNS-GVRTRSVICQRRVSGTD----- 956

  Fly   438 DAVCLKEVGNKPATKQECNRDVKNCPKYHLGPWTPCDKLCGDGKQTRKVTCFIEENGHKRVLPEE 502
                                                                      |:.|.:.
Frog   957 ----------------------------------------------------------KKSLDDA 963

  Fly   503 DCVEEKPETEKSCLLTPCEGVDWIISQWSGCNACGQNTETRTAICGNKEGKVYPEEFCEPEVPTL 567
            .|.:.:|.     :|.||                  ||:|                 |.||
Frog   964 SCPQPRPS-----MLEPC------------------NTDT-----------------CPPE---- 984

  Fly   568 SRPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRIVICGEFDGKTVTPADDDSKCNKETKPESEQDC 632
                        |.:.:||:|:..||.|.:.|:|:|...|..:..|   .|.|..:.||.:...|
Frog   985 ------------WVALDWSECTPSCGPGYRHRVVLCKIGDQDSTLP---HSHCQAKDKPATTMRC 1034

  Fly   633 EGEEKVCPGEWFTGPWGKCSKPCGGGERVREVLCLSN-GTKSVNCDEEKVEPLSEKCNSEACTED 696
            . .::..|..|.||.||:||..||.|::.|.|.|||: |..|:.|.|.......::|.:: |..|
Frog  1035 T-LQRCPPSRWITGEWGECSANCGLGQQRRSVQCLSHIGQPSIECTESFRPSAMQQCENK-CLAD 1097

  Fly   697 EILPLTSTDK 706
               |..|.|:
Frog  1098 ---PSDSPDE 1104

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	26/51 (51%)
		ADAM_spacer1	214..329	CDD:283607	31/116 (27%)
		TSP1	468..521	CDD:214559	6/52 (12%)
		TSP_1	645..693	CDD:278517	19/48 (40%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
adamts10	XP_004911053.2	Pep_M12B_propep	74..217	CDD:396235
		ZnMc_ADAMTS_like	276..489	CDD:239801
		ADAM_CR_2	504..572	CDD:407643
		TSP1	585..637	CDD:214559	26/51 (51%)
		ADAM_spacer1	741..855	CDD:368694	31/116 (27%)
		TSP1_ADAMTS	866..921	CDD:408800	20/54 (37%)
		TSP1_ADAMTS	925..981	CDD:408800	24/159 (15%)
		TSP1_ADAMTS	985..1039	CDD:408800	17/57 (30%)
		TSP1_ADAMTS	1044..1093	CDD:408800	20/48 (42%)
		PLAC	1105..1137	CDD:400844	210/660 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I4974
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000