DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and adamtsl3

DIOPT Version :10

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:XP_012814972.2 Gene:adamtsl3 / 100493011 XenbaseID:XB-GENE-923351 Length:1777 Species:Xenopus tropicalis


Alignment Length:1931 Identity:431/1931 - (22%)
Similarity:675/1931 - (34%) Gaps:556/1931 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 ALVAFIVLASIHDSQSRFPG-LRQKRQYGANMYLPESSVTPGG---------------------- 52
            ||.|.|:|.      .:||| |....|.....:|||.:::|.|                      
 Frog    19 ALWAVILLT------IKFPGNLASVDQTQGAYFLPEFALSPQGSFLEDTTGEQFLTYRYDDQTSR 77

  Fly    53 ---EGNDPDE-WTPWSSPSDCSRTCGGGVSYQTRECLRRDDRGEAVCSGGSRRYFSCNTQDCPEE 113
               ..:|.|. |..|.:.||||||||||.||..|.||    .|.: |.|.:.||.:|:..|||.:
 Frog    78 ITRSDDDKDNGWDAWGTWSDCSRTCGGGASYSLRRCL----NGRS-CEGRNIRYKTCSNNDCPSD 137

  Fly   114 ESDFRAQQCSRFDRQQFDGVFYEWVP-YTNAPNPCELNCMPKGERFYYRQREKVVDGTRCNDKDL 177
            ..||||||||..:..::.|.:|||.| |.:|..||.|.|...|:........||:||||||....
 Frog   138 VGDFRAQQCSAHNDVKYQGQYYEWQPVYNDASAPCALKCQAVGKNLVVELAPKVLDGTRCNTDSP 202

  Fly   178 DVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYND--LLLLPEGAT 240
            |:|::|.|..||||..|||:||||.|..|.||||||:.:|.. |...|:|...:  ::.:|.|:.
 Frog   203 DMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQ-TRSHLSPEKREETIIAVPHGSR 266

  Fly   241 NIRIEETVPSSNYLACRNHSGHYYLNGDWRIDFPRPMFFANSWWNYQRKPMGFAAPDQLTCSGPI 305
            ::||....|:..::..:...|.   :|:.....|......|:...:||.    :..:.|...||:
 Frog   267 SVRITVKGPAHVFIESKTLQGE---SGEHSFTSPGSYVIENTTVEFQRG----SEREILKIPGPL 324

  Fly   306 SESLFIVMLVQEKNISLDYEYSIPE----SLSHSQQDTHTWTHHQFNACSASCGGGSQSRKVTCN 366
            ... ||:.:          :|:.|:    .....|..:|.|....|..|:.:||||.|.....|.
 Frog   325 RAD-FIIKI----------KYAAPKDSIVQFYFYQPISHQWRQTDFFPCTVTCGGGYQLNSAECV 378

  Fly   367 NRITLAEVNPSLC-----DQKSKPVEEQACGTEPC-----------------APHWVEGEWSKCS 409
            :......||...|     ::|.|| :.:.|..|||                 .|.|....|:.||
 Frog   379 DIRLNRTVNDHYCHYYPENKKPKP-KLKECNMEPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACS 442

  Fly   410 KGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVKNCPKY--------- 465
            ..||. |.|.|||.|...:..||....|:..|:  ...||...|.||  :.:|||:         
 Frog   443 VSCGG-GIQRRSIVCVEETMHGEILQVEEWKCM--YAPKPTIMQTCN--LFDCPKWMAMEWSQCT 502

  Fly   466 --------------------HLG------------------------------------------ 468
                                |.|                                          
 Frog   503 VTCGRGLRYRVVLCNDHRGQHTGGCNPQLKPHIKEECVVPVPCFKPRERFPVEAKHPWLKQAQEL 567

  Fly   469 ---------------PWTPCDKLCGDGKQTRKVTC--FIEENGHKRVLPEEDCVEEKPETEKSCL 516
                           .|:||...||.|.|.|:|.|  .:.....:..||:|:|.||||:||::|.
 Frog   568 EETKTASDEPTFIPEAWSPCSVSCGRGMQVRQVKCRILLSFTQTELELPDEECEEEKPDTERACY 632

  Fly   517 LTPCEG------------------VDWIISQWSGC-NACGQNTETRTAICGNKEGK-VYPEEFCE 561
            |.||||                  .||....::.| ::|....:...|:|.|.:.| ......|:
 Frog   633 LLPCEGDPGTQTSEHLPHDIESPLYDWEYIGFTSCSSSCSGGRQEAIAVCLNMQTKQSVNNSLCD 697

  Fly   562 PEV--PTLSRPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRIVICGEFDGKTVTPADDDS--KCNK 622
            ..|  |.::|.|.:..|..:|.:..||:|||.||.|:::|.|.|     .:|:.:.::|  :|..
 Frog   698 SSVRPPAMTRACNTKLCPPRWNTGSWSRCSATCGVGIQTRDVYC-----SSVSESGNNSEQECGA 757

  Fly   623 ETKPESEQDCEGEEKVCPGEWFTGPWGKCSKPCGGGERVREVLC---LSNGTKSVNCDE--EKVE 682
            | ||.:.|.|...:  ||..|.|..|.:||:.||||.::|.|.|   |::|:.....||  :..:
 Frog   758 E-KPSAIQPCNQID--CPPAWHTEDWQQCSRTCGGGVQIRRVTCKQLLADGSFLKLGDELCQMQK 819

  Fly   683 PLSEK-CNSEAC----TEDE------------------ILPLTSTDKPIEDDEEDCDEDGIELIS 724
            |.|.| |....|    |..|                  .|.:|:....|..::..|         
 Frog   820 PGSHKPCGKADCPPQLTTGEWSKCSTKCSVGIQRRKMICLKITAKGHLIPINDSHC--------- 875

  Fly   725 DGLSDDE--KSEDVIDLEGTAKT-------ETTPEAEDLM------------------------- 755
            .||....  :|..:    |..:|       ||:||:.:::                         
 Frog   876 HGLPSPALVRSCHM----GVCQTKQHNPNRETSPESPEILSIHRVYIQTRQEKRINFTIGSRAYL 936

  Fly   756 -----------------------QSDSPTPYDEFESTGTTFEGS-GYDSESTTDSGISTEGSGDD 796
                                   :.|.|..|.  :..|.|..|| ...:....|.|:....:...
 Frog   937 LPKTSVVIKCPVRGIQKSLIKWEKDDQPLKYS--KKLGVTKSGSLKIHNLEAQDIGVYKCIANSA 999

  Fly   797 EETSEASTDLSSSTDSGSTSSDSTSSDSSSSISSDATSEAPASSVSDSSDSTDASTETTGVSDDS 861
            .||.....   ...|:....:.|...|.:.:.:..|.....:......:...:...|.:...::.
 Frog  1000 HETFVLKL---IGRDNRLLEAPSFEKDHNEANNLGAKWHKMSKMWKSWNKKNNLYLEDSQAQEEL 1061

  Fly   862 TDVSSSTEASASESTDVSGASDSTGSTNASDSTPESSTEASSSTDD-STDSSDNSSNVSESSTEA 925
              |..:.|...|.|.:|.|:.|          ..|...||:..... |.|::...:.|...|...
 Frog  1062 --VLRNLETLVSNSAEVYGSQD----------FKEKRLEAAVLQGAYSMDTAQFEALVKNMSELI 1114

  Fly   926 SSSSVSDS----------NDSS--DGSTDGVSSTTENSSDSTSDATSDSTAS-----SDSTDSTS 973
            .:..:||.          |:.|  ..:||....||||:...|.....:..||     .|:...:.
 Frog  1115 EAGEISDDFASQIISHVVNELSKPQSTTDKWKQTTENNKSDTKYINKEPYASVHFNIKDAEVESG 1179

  Fly   974 DQTTETTPES------STDST-----ESSTLDASSTTDASSTSESSSESST------DGSSTTSN 1021
            .|..:...:.      ||:.|     .:|....::|...:...|.:.:|.|      ||...|  
 Frog  1180 KQWQQIIRKQKPGQVMSTNRTLHLIIGNSAFFTNNTQRITIQCEVAGDSITKITWAKDGEPLT-- 1242

  Fly  1022 SASSETTGLSSDGSTTDATTAASD-----NTDITTDGSTDESTDGSSNASTEGSTEGASEDTTIS 1081
              |||...:.::|.....:.:|.|     ...|...||..||:  ..|.:...:.:.:.::.|..
 Frog  1243 --SSEKIAMENNGILQILSPSARDVGLYECKAINEYGSDKESS--RLNFAERPAIQSSEKNITYL 1303

  Fly  1082 TESSGSTESTDAIASDGSTT---EGSTV------------------EDLSSSTSSDVTSD----- 1120
            .:.|       .||..|.|.   .|..|                  ::.:.:.:|.:.|:     
 Frog  1304 EDGS-------IIALVGGTVMARRGVNVMVQCPVKGFPQPKLTWLKKEYALANNSFLLSNGSLLL 1361

  Fly  1121 STITDSSPSTEVSGSTDSSSSTDGSSTDASSTEASSTDVTESTDSTVSG---------GTSDTTE 1176
            :.::|.:..|....:|::.    |.:...|....|...:.:|:|....|         ..|.|..
 Frog  1362 TNVSDGNEGTYFCIATNAL----GKTVAMSVLRLSGHRIQDSSDEQSKGKGRRRIIMASASGTHV 1422

  Fly  1177 SGPTEESTTEGSTESTTEGSTD----STQSTD----------LDSTTSDIWSTSDKD-------D 1220
            .|...:....|....|:..:|.    .||..:          :.....:|:..|::.       .
 Frog  1423 EGKLGDLLRIGCPVQTSHRNTIHWFLGTQPIEGIEGFQYRVLVSGRVLEIYPLSEQSVGEYRCWT 1487

  Fly  1221 ESESSTPYSFDSEVTKSKPRKCKPKKSTCAKSEYGCCPDGKSTPKGPFDEGCPIAKTCADTKYGC 1285
            .:.|.|..::.:...:|            .:.|||......||        |....|.:.|::  
 Frog  1488 SNNSKTMSAWVNVTLQS------------YQLEYGDWTQCSST--------CGNNGTQSSTQH-- 1530

  Fly  1286 CLDGVSPAKGK--NNKGCP-------KSQCAETLFGC----CPDK-FTAADGENDEGCPETTTVP 1336
            |::    .||.  |:..|.       :||      .|    ||.: |..|..:....| .|....
 Frog  1531 CVN----VKGHRVNDSWCEHLHPLVIRSQ------ACNRKDCPARWFPGAWSDCSTSC-GTGFQQ 1584

  Fly  1337 PTTTTEETQPETTTEIEGSGQDSTTSEPDTKKSCSFSEFGCCPDAETSAKGPDFEGC---GLASP 1398
            .....::|:.:.:.::..||.......|.|:|.||..   .|.|......|.....|   |:...
 Frog  1585 RQVICQQTKLDGSIKVLPSGSCQYADRPVTQKPCSSD---ACVDWIPQPWGQCLNQCIGQGMGLQ 1646

  Fly  1399 VAKGCAESENG-CCPDGQTPASGPNGEGCSGCTRER----FGCCPDSQTPAH---GPNKEGCCLD 1455
            ..:...:..|| ..|:             :.|.|::    ...||......:   ||.:      
 Frog  1647 HRQVLCQHHNGTTLPE-------------ASCDRKKRLAARKTCPSEMCDVYWRTGPWR------ 1692

  Fly  1456 TQFGCCPDNILAARGPNNEGCECHYTPYGCCPDNKSAATGYNQEGCACE---TTQYGCCPDKITA 1517
                  |.......|..:...:|.:.     .::|:.|..|    |..:   ||...|   |.|:
 Frog  1693 ------PCTAACGNGFQSRKVDCMHK-----KNSKAVADQY----CVWKRRPTTWQHC---KATS 1739

  Fly  1518 -AKGPKHEGCPCETTQFGCCPDGLTFAKGPHHHGCHCTQTEFKCCD 1562
             .||      .|:.|...|     ||.|  |...||....:.:||:
 Frog  1740 CGKG------ECKDTTHYC-----TFVK--HLKLCHIDLYKQRCCE 1772

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559 24/50 (48%)
ADAMTS_CR_3 116..213 CDD:437068 49/97 (51%)
ADAMTS_spacer1 222..329 CDD:461796 19/108 (18%)
TSP1_ADAMTS 347..396 CDD:465950 16/53 (30%)
TSP1_ADAMTS 400..457 CDD:465950 20/56 (36%)
TSP1_ADAMTS 465..520 CDD:465950 24/142 (17%)
TSP1_ADAMTS 580..632 CDD:465950 19/53 (36%)
TSP1_ADAMTS 643..693 CDD:465950 20/55 (36%)
MSCRAMM_ClfA <1049..1262 CDD:468110 41/268 (15%)
Kunitz_papilin_lacunin-like 1612..1663 CDD:438681
Kunitz_BPTI 1670..1721 CDD:425421
Kunitz-type 1730..1780 CDD:438633
Kunitz_BPTI 1789..1840 CDD:425421
Kunitz_papilin_mig6-like 1849..1899 CDD:438679
Kunitz_papilin_mig6-like 1922..1972 CDD:438679
Kunitz_papilin_mig6-like 2001..2051 CDD:438679
Kunitz-type 2071..2121 CDD:438633
Kunitz_BPTI 2127..2178 CDD:425421
Kunitz_BPTI 2193..2245 CDD:425421
Kunitz_BPTI 2252..2303 CDD:425421
Kunitz_BPTI 2317..2372 CDD:425421
WAP 2455..2497 CDD:459672
Ig 2530..2610 CDD:472250
Ig strand B 2539..2543 CDD:409353
Ig strand C 2552..2556 CDD:409353
Ig strand E 2576..2579 CDD:409353
Ig strand F 2589..2594 CDD:409353
Ig strand G 2603..2606 CDD:409353
IG_like 2627..2703 CDD:214653
Ig strand B 2636..2640 CDD:409353
Ig strand C 2649..2653 CDD:409353
Ig strand E 2670..2674 CDD:409353
Ig strand F 2684..2689 CDD:409353
Ig strand G 2697..2700 CDD:409353
I-set 2766..2845 CDD:400151
Ig strand B 2771..2775 CDD:409353
Ig strand C 2784..2788 CDD:409353
Ig strand F 2821..2826 CDD:409353
PLAC 2851..2883 CDD:462560
adamtsl3XP_012814972.2 TSP1 89..135 CDD:214559 24/50 (48%)
ADAMTS_CR_3 140..238 CDD:437068 49/97 (51%)
ADAMTS_spacer1 257..349 CDD:461796 18/109 (17%)
TSP1_ADAMTS 354..412 CDD:465950 17/58 (29%)
TSP1_ADAMTS 433..490 CDD:465950 21/61 (34%)
TSP1_ADAMTS 493..545 CDD:465950 2/51 (4%)
TSP1_ADAMTS 584..636 CDD:465950 22/51 (43%)
TSP1_ADAMTS 718..771 CDD:465950 20/60 (33%)
TSP1_ADAMTS 775..831 CDD:465950 20/55 (36%)
TSP1_ADAMTS 837..892 CDD:465950 9/67 (13%)
Ig 943..999 CDD:472250 9/57 (16%)
Ig strand B 943..946 CDD:409353 0/2 (0%)
Ig strand C 955..959 CDD:409353 0/3 (0%)
Ig strand E 977..981 CDD:409353 2/3 (67%)
Ig strand F 991..996 CDD:409353 0/4 (0%)
Ig 1216..1285 CDD:472250 17/74 (23%)
Ig strand B 1218..1222 CDD:143259 0/3 (0%)
Ig strand C 1231..1235 CDD:143259 0/3 (0%)
Ig strand E 1253..1257 CDD:143259 1/3 (33%)
Ig strand F 1267..1272 CDD:143259 0/4 (0%)
Ig strand G 1280..1283 CDD:143259 1/2 (50%)
Ig 1318..1382 CDD:472250 7/67 (10%)
Ig strand B 1324..1328 CDD:409353 1/3 (33%)
Ig strand C 1337..1341 CDD:409353 0/3 (0%)
Ig strand E 1357..1361 CDD:409353 0/3 (0%)
Ig strand F 1371..1376 CDD:409353 1/4 (25%)
Ig_3 1416..1489 CDD:464046 10/72 (14%)
TSP1_ADAMTS 1508..1562 CDD:465950 16/73 (22%)
TSP1_ADAMTS 1566..1623 CDD:465950 12/60 (20%)
TSP1_ADAMTS 1626..1682 CDD:465950 10/68 (15%)
TSP1_ADAMTS 1686..1740 CDD:465950 14/77 (18%)
PLAC 1745..1774 CDD:462560 11/35 (31%)
Blue background indicates that the domain is not in the aligned region.

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