DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and adamtsl3

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:XP_012814972.2 Gene:adamtsl3 / 100493011 XenbaseID:XB-GENE-923351 Length:1777 Species:Xenopus tropicalis


Alignment Length:1931 Identity:431/1931 - (22%)
Similarity:675/1931 - (34%) Gaps:556/1931 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 ALVAFIVLASIHDSQSRFPG-LRQKRQYGANMYLPESSVTPGG---------------------- 52
            ||.|.|:|.      .:||| |....|.....:|||.:::|.|                      
 Frog    19 ALWAVILLT------IKFPGNLASVDQTQGAYFLPEFALSPQGSFLEDTTGEQFLTYRYDDQTSR 77

  Fly    53 ---EGNDPDE-WTPWSSPSDCSRTCGGGVSYQTRECLRRDDRGEAVCSGGSRRYFSCNTQDCPEE 113
               ..:|.|. |..|.:.||||||||||.||..|.||    .|.: |.|.:.||.:|:..|||.:
 Frog    78 ITRSDDDKDNGWDAWGTWSDCSRTCGGGASYSLRRCL----NGRS-CEGRNIRYKTCSNNDCPSD 137

  Fly   114 ESDFRAQQCSRFDRQQFDGVFYEWVP-YTNAPNPCELNCMPKGERFYYRQREKVVDGTRCNDKDL 177
            ..||||||||..:..::.|.:|||.| |.:|..||.|.|...|:........||:||||||....
 Frog   138 VGDFRAQQCSAHNDVKYQGQYYEWQPVYNDASAPCALKCQAVGKNLVVELAPKVLDGTRCNTDSP 202

  Fly   178 DVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYND--LLLLPEGAT 240
            |:|::|.|..||||..|||:||||.|..|.||||||:.:|.. |...|:|...:  ::.:|.|:.
 Frog   203 DMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQ-TRSHLSPEKREETIIAVPHGSR 266

  Fly   241 NIRIEETVPSSNYLACRNHSGHYYLNGDWRIDFPRPMFFANSWWNYQRKPMGFAAPDQLTCSGPI 305
            ::||....|:..::..:...|.   :|:.....|......|:...:||.    :..:.|...||:
 Frog   267 SVRITVKGPAHVFIESKTLQGE---SGEHSFTSPGSYVIENTTVEFQRG----SEREILKIPGPL 324

  Fly   306 SESLFIVMLVQEKNISLDYEYSIPE----SLSHSQQDTHTWTHHQFNACSASCGGGSQSRKVTCN 366
            ... ||:.:          :|:.|:    .....|..:|.|....|..|:.:||||.|.....|.
 Frog   325 RAD-FIIKI----------KYAAPKDSIVQFYFYQPISHQWRQTDFFPCTVTCGGGYQLNSAECV 378

  Fly   367 NRITLAEVNPSLC-----DQKSKPVEEQACGTEPC-----------------APHWVEGEWSKCS 409
            :......||...|     ::|.|| :.:.|..|||                 .|.|....|:.||
 Frog   379 DIRLNRTVNDHYCHYYPENKKPKP-KLKECNMEPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACS 442

  Fly   410 KGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVKNCPKY--------- 465
            ..||. |.|.|||.|...:..||....|:..|:  ...||...|.||  :.:|||:         
 Frog   443 VSCGG-GIQRRSIVCVEETMHGEILQVEEWKCM--YAPKPTIMQTCN--LFDCPKWMAMEWSQCT 502

  Fly   466 --------------------HLG------------------------------------------ 468
                                |.|                                          
 Frog   503 VTCGRGLRYRVVLCNDHRGQHTGGCNPQLKPHIKEECVVPVPCFKPRERFPVEAKHPWLKQAQEL 567

  Fly   469 ---------------PWTPCDKLCGDGKQTRKVTC--FIEENGHKRVLPEEDCVEEKPETEKSCL 516
                           .|:||...||.|.|.|:|.|  .:.....:..||:|:|.||||:||::|.
 Frog   568 EETKTASDEPTFIPEAWSPCSVSCGRGMQVRQVKCRILLSFTQTELELPDEECEEEKPDTERACY 632

  Fly   517 LTPCEG------------------VDWIISQWSGC-NACGQNTETRTAICGNKEGK-VYPEEFCE 561
            |.||||                  .||....::.| ::|....:...|:|.|.:.| ......|:
 Frog   633 LLPCEGDPGTQTSEHLPHDIESPLYDWEYIGFTSCSSSCSGGRQEAIAVCLNMQTKQSVNNSLCD 697

  Fly   562 PEV--PTLSRPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRIVICGEFDGKTVTPADDDS--KCNK 622
            ..|  |.::|.|.:..|..:|.:..||:|||.||.|:::|.|.|     .:|:.:.::|  :|..
 Frog   698 SSVRPPAMTRACNTKLCPPRWNTGSWSRCSATCGVGIQTRDVYC-----SSVSESGNNSEQECGA 757

  Fly   623 ETKPESEQDCEGEEKVCPGEWFTGPWGKCSKPCGGGERVREVLC---LSNGTKSVNCDE--EKVE 682
            | ||.:.|.|...:  ||..|.|..|.:||:.||||.::|.|.|   |::|:.....||  :..:
 Frog   758 E-KPSAIQPCNQID--CPPAWHTEDWQQCSRTCGGGVQIRRVTCKQLLADGSFLKLGDELCQMQK 819

  Fly   683 PLSEK-CNSEAC----TEDE------------------ILPLTSTDKPIEDDEEDCDEDGIELIS 724
            |.|.| |....|    |..|                  .|.:|:....|..::..|         
 Frog   820 PGSHKPCGKADCPPQLTTGEWSKCSTKCSVGIQRRKMICLKITAKGHLIPINDSHC--------- 875

  Fly   725 DGLSDDE--KSEDVIDLEGTAKT-------ETTPEAEDLM------------------------- 755
            .||....  :|..:    |..:|       ||:||:.:::                         
 Frog   876 HGLPSPALVRSCHM----GVCQTKQHNPNRETSPESPEILSIHRVYIQTRQEKRINFTIGSRAYL 936

  Fly   756 -----------------------QSDSPTPYDEFESTGTTFEGS-GYDSESTTDSGISTEGSGDD 796
                                   :.|.|..|.  :..|.|..|| ...:....|.|:....:...
 Frog   937 LPKTSVVIKCPVRGIQKSLIKWEKDDQPLKYS--KKLGVTKSGSLKIHNLEAQDIGVYKCIANSA 999

  Fly   797 EETSEASTDLSSSTDSGSTSSDSTSSDSSSSISSDATSEAPASSVSDSSDSTDASTETTGVSDDS 861
            .||.....   ...|:....:.|...|.:.:.:..|.....:......:...:...|.:...::.
 Frog  1000 HETFVLKL---IGRDNRLLEAPSFEKDHNEANNLGAKWHKMSKMWKSWNKKNNLYLEDSQAQEEL 1061

  Fly   862 TDVSSSTEASASESTDVSGASDSTGSTNASDSTPESSTEASSSTDD-STDSSDNSSNVSESSTEA 925
              |..:.|...|.|.:|.|:.|          ..|...||:..... |.|::...:.|...|...
 Frog  1062 --VLRNLETLVSNSAEVYGSQD----------FKEKRLEAAVLQGAYSMDTAQFEALVKNMSELI 1114

  Fly   926 SSSSVSDS----------NDSS--DGSTDGVSSTTENSSDSTSDATSDSTAS-----SDSTDSTS 973
            .:..:||.          |:.|  ..:||....||||:...|.....:..||     .|:...:.
 Frog  1115 EAGEISDDFASQIISHVVNELSKPQSTTDKWKQTTENNKSDTKYINKEPYASVHFNIKDAEVESG 1179

  Fly   974 DQTTETTPES------STDST-----ESSTLDASSTTDASSTSESSSESST------DGSSTTSN 1021
            .|..:...:.      ||:.|     .:|....::|...:...|.:.:|.|      ||...|  
 Frog  1180 KQWQQIIRKQKPGQVMSTNRTLHLIIGNSAFFTNNTQRITIQCEVAGDSITKITWAKDGEPLT-- 1242

  Fly  1022 SASSETTGLSSDGSTTDATTAASD-----NTDITTDGSTDESTDGSSNASTEGSTEGASEDTTIS 1081
              |||...:.::|.....:.:|.|     ...|...||..||:  ..|.:...:.:.:.::.|..
 Frog  1243 --SSEKIAMENNGILQILSPSARDVGLYECKAINEYGSDKESS--RLNFAERPAIQSSEKNITYL 1303

  Fly  1082 TESSGSTESTDAIASDGSTT---EGSTV------------------EDLSSSTSSDVTSD----- 1120
            .:.|       .||..|.|.   .|..|                  ::.:.:.:|.:.|:     
 Frog  1304 EDGS-------IIALVGGTVMARRGVNVMVQCPVKGFPQPKLTWLKKEYALANNSFLLSNGSLLL 1361

  Fly  1121 STITDSSPSTEVSGSTDSSSSTDGSSTDASSTEASSTDVTESTDSTVSG---------GTSDTTE 1176
            :.::|.:..|....:|::.    |.:...|....|...:.:|:|....|         ..|.|..
 Frog  1362 TNVSDGNEGTYFCIATNAL----GKTVAMSVLRLSGHRIQDSSDEQSKGKGRRRIIMASASGTHV 1422

  Fly  1177 SGPTEESTTEGSTESTTEGSTD----STQSTD----------LDSTTSDIWSTSDKD-------D 1220
            .|...:....|....|:..:|.    .||..:          :.....:|:..|::.       .
 Frog  1423 EGKLGDLLRIGCPVQTSHRNTIHWFLGTQPIEGIEGFQYRVLVSGRVLEIYPLSEQSVGEYRCWT 1487

  Fly  1221 ESESSTPYSFDSEVTKSKPRKCKPKKSTCAKSEYGCCPDGKSTPKGPFDEGCPIAKTCADTKYGC 1285
            .:.|.|..::.:...:|            .:.|||......||        |....|.:.|::  
 Frog  1488 SNNSKTMSAWVNVTLQS------------YQLEYGDWTQCSST--------CGNNGTQSSTQH-- 1530

  Fly  1286 CLDGVSPAKGK--NNKGCP-------KSQCAETLFGC----CPDK-FTAADGENDEGCPETTTVP 1336
            |::    .||.  |:..|.       :||      .|    ||.: |..|..:....| .|....
 Frog  1531 CVN----VKGHRVNDSWCEHLHPLVIRSQ------ACNRKDCPARWFPGAWSDCSTSC-GTGFQQ 1584

  Fly  1337 PTTTTEETQPETTTEIEGSGQDSTTSEPDTKKSCSFSEFGCCPDAETSAKGPDFEGC---GLASP 1398
            .....::|:.:.:.::..||.......|.|:|.||..   .|.|......|.....|   |:...
 Frog  1585 RQVICQQTKLDGSIKVLPSGSCQYADRPVTQKPCSSD---ACVDWIPQPWGQCLNQCIGQGMGLQ 1646

  Fly  1399 VAKGCAESENG-CCPDGQTPASGPNGEGCSGCTRER----FGCCPDSQTPAH---GPNKEGCCLD 1455
            ..:...:..|| ..|:             :.|.|::    ...||......:   ||.:      
 Frog  1647 HRQVLCQHHNGTTLPE-------------ASCDRKKRLAARKTCPSEMCDVYWRTGPWR------ 1692

  Fly  1456 TQFGCCPDNILAARGPNNEGCECHYTPYGCCPDNKSAATGYNQEGCACE---TTQYGCCPDKITA 1517
                  |.......|..:...:|.:.     .::|:.|..|    |..:   ||...|   |.|:
 Frog  1693 ------PCTAACGNGFQSRKVDCMHK-----KNSKAVADQY----CVWKRRPTTWQHC---KATS 1739

  Fly  1518 -AKGPKHEGCPCETTQFGCCPDGLTFAKGPHHHGCHCTQTEFKCCD 1562
             .||      .|:.|...|     ||.|  |...||....:.:||:
 Frog  1740 CGKG------ECKDTTHYC-----TFVK--HLKLCHIDLYKQRCCE 1772

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559 24/50 (48%)
ADAM_spacer1 214..329 CDD:283607 21/116 (18%)
TSP1 468..521 CDD:214559 24/111 (22%)
TSP_1 645..693 CDD:278517 19/53 (36%)
Kunitz_BPTI 1611..1663 CDD:278443
Kunitz_BPTI 1670..1721 CDD:278443
Kunitz_BPTI 1729..1781 CDD:278443
Kunitz_BPTI 1789..1840 CDD:278443
Kunitz_BPTI 1848..1899 CDD:278443
KU 1920..1973 CDD:238057
Kunitz_BPTI 2001..2051 CDD:278443
KU 2071..2121 CDD:238057
Kunitz_BPTI 2127..2178 CDD:278443
KU 2192..2245 CDD:238057
KU 2251..2304 CDD:238057
KU 2316..2372 CDD:238057
WAP 2457..2497 CDD:278522
Ig 2521..2610 CDD:299845
IG_like 2530..2610 CDD:214653
IG_like 2627..2703 CDD:214653
Ig 2636..2701 CDD:143165
IG_like 2766..2841 CDD:214653
Ig 2768..2830 CDD:299845
PLAC 2851..2883 CDD:285849
adamtsl3XP_012814972.2 TSP1 89..135 CDD:214559 24/50 (48%)
TSP1_ADAMTS 354..412 CDD:408800 17/58 (29%)
TSP1_ADAMTS 433..490 CDD:408800 21/61 (34%)
TSP1_ADAMTS 493..545 CDD:408800 2/51 (4%)
TSP1_ADAMTS 579..636 CDD:408800 22/56 (39%)
TSP1_ADAMTS 718..771 CDD:408800 20/60 (33%)
TSP1_ADAMTS 775..831 CDD:408800 20/55 (36%)
TSP1_ADAMTS 837..892 CDD:408800 9/67 (13%)
Ig 943..999 CDD:416386 9/57 (16%)
Ig strand C 955..960 CDD:409353 0/4 (0%)
Ig strand C' 962..965 CDD:409353 1/2 (50%)
Ig strand D 970..974 CDD:409353 1/3 (33%)
Ig strand E 977..983 CDD:409353 2/5 (40%)
Ig strand F 990..998 CDD:409353 1/7 (14%)
Ig 1216..1285 CDD:416386 17/74 (23%)
Ig strand B 1216..1225 CDD:409353 1/8 (13%)
Ig strand C 1231..1235 CDD:409353 0/3 (0%)
Ig strand C' 1238..1240 CDD:409353 1/1 (100%)
Ig strand D 1248..1252 CDD:409353 0/3 (0%)
Ig strand E 1253..1258 CDD:409353 1/4 (25%)
Ig strand F 1266..1274 CDD:409353 0/7 (0%)
Ig 1318..1382 CDD:416386 7/67 (10%)
Ig strand B 1322..1329 CDD:409353 1/6 (17%)
Ig strand C 1337..1341 CDD:409353 0/3 (0%)
Ig strand D 1353..1356 CDD:409353 0/2 (0%)
Ig strand E 1357..1362 CDD:409353 0/4 (0%)
Ig strand F 1370..1378 CDD:409353 1/7 (14%)
Ig_3 1416..1489 CDD:404760 10/72 (14%)
Ig strand C 1443..1447 CDD:409353 1/3 (33%)
Ig strand E 1468..1472 CDD:409353 0/3 (0%)
Ig strand F 1482..1487 CDD:409353 0/4 (0%)
TSP1_ADAMTS 1508..1562 CDD:408800 16/73 (22%)
TSP1_ADAMTS 1566..1623 CDD:408800 12/60 (20%)
TSP1_ADAMTS 1626..1682 CDD:408800 10/68 (15%)
TSP1_ADAMTS 1686..1740 CDD:408800 14/77 (18%)
PLAC 1745..1774 CDD:400844 11/35 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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