DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppn and hmcn2

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	XP_031747766.1	Gene:	hmcn2 / 100490941	XenbaseID:	XB-GENE-6034990	Length:	4625	Species:	Xenopus tropicalis

Alignment Length:	1015	Identity:	213/1015 - (20%)
Similarity:	311/1015 - (30%)	Gaps:	373/1015 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  2017 WNYNETEGRCQSFYYGGCGGNDNRFATEEECSARCSVNIDIRIGADPVEHDTSKCFLAFEPGNCY 2081
            |..|||. ...|..:|         ..|..|.||          |.||            ||
Frog  1523 WASNETT-EVASLLHG---------TVELRCEAR----------ASPV------------PG--- 1552

  Fly  2082 NNVTRWFYNS-----------AEG----------LCDEFVYTGCGGNANNYATEEE--------- 2116
              :| ||.:.           .||          |.|...|| |.. .||..|.|:
Frog  1553 --IT-WFKDKRPIVSSSRATYREGGRSLQLSRVLLSDVGTYT-CRA-TNNAGTAEKSYRLEVYVS 1612

  Fly  2117 --------------------CQNECNDAQTTCALPPVRGRCSD---LSRRWYFDERSGECHEFEF 2158
                                .:.||:   .|...||......|   ||.|.....:.|....:..
Frog  1613 PDIEGGGSKPLPIKAILGQALELECS---ATGHPPPTLSWLKDGLMLSERDGLQIKDGGRTLYIG 1674

  Fly  2159 TGCRGNRNNFVSQSDCLNFCI-GEPVVEPSAPTYSVCA-EPPEA--GECDNRTTAWFYDSENMAC 2219
            ....|.:..|.    |:...: ||.|:.     |:|.. .||:.  ||.....|....|..:::|
Frog  1675 IVSEGTQGTFT----CVAISLAGENVLH-----YTVTVLVPPKVVIGEGSEHVTVTANDPLDLSC 1730

  Fly  2220 TAFTY--------------TGCGG----NGNRFETRDQCE-RQCGEFKGVDVCNEPVTTGPCTDW 2265
            .|..|              :...|    ||.:..|..|.: ...|::|    |.....:|....|
Frog  1731 HATGYPTPTIQWLRNNHSLSHEDGVEVLNGGKMLTIRQIQPEHAGKYK----CKAEGDSGTAEAW 1791

  Fly  2266 QTKYYFNTASQACEPFTYGG---------------CDGTGNRFSDLFECQTVCLAGREPRVGSAK 2315
                 .....|.....|..|               ||.:|:               ..|.|...|
Frog  1792 -----VEVEVQELPSVTIAGGTTMVVNFLKRVVLECDVSGS---------------PPPSVTWWK 1836

  Fly  2316 EICLLPVATGRCNGPSVHERRWYYDDE-AGNCVSFIYAGCSGNQNNFRSFEACTNQCRPEPNKQD 2379
            :..||||     .||.:.......||| ...||:..:|| .|.|:...:...       .||.:.
Frog  1837 DGFLLPV-----QGPKLQIDSVSIDDEGVYTCVATNFAG-EGRQDVVLTVLV-------SPNIEP 1888

  Fly  2380 NEIGQNPCDTFDA--ECQELRCPY-------GVRRVAARSQPECTQCICENPCEGYSCPEGQQCA 2435
            :::.|...:...|  ||.....|.       |.:.::|  .|..|           ...||:...
Frog  1889 SDVNQTVIENLPASFECLASGSPLPLVSWYRGEQLLSA--APGIT-----------LLNEGKTLQ 1940

  Fly  2436 IDVASSDDRQFAPVCRDIYKPGECPALSANASGCARECYTDADCRGDNKCCSDGCGQLCVHPARP 2500
            |:.|.|.|            .||...:::|.:|.....|                 .|.|:.|
Frog  1941 IESAKSSD------------SGEYRCVASNTAGSTELQY-----------------NLLVNVA-- 1974

  Fly  2501 TQPPRTQAPVVSYPGDARAALEPKEAHELDVQTAIGGIAV-LRCFATGNPAPNITWSLKNLVINT 2564
                                  |:....:|..|.:....| |.|.|||.|.|.|.|....:.::|
Frog  1975 ----------------------PRIVSMMDFATFLVNEQVWLECNATGVPEPAIMWLKDQVPVST 2017

  Fly  2565 N-KGRYVLTANGDLTIVQVRQTDDGTYVCVASNGLGEPVRREVALQVTEPVSQPAYIYGDKNVTQ 2628
            . .|..::.....|::.....:|.|.|.|||.|..||. ...:||||..|.:    |.|:: :..
Frog  2018 AIAGLQIMEQGRILSLRAAHVSDSGIYSCVAVNPAGED-SHHIALQVFVPPT----IMGEE-LNS 2076

  Fly  2629 IVELNRPAVIRCPAGGFPEPHVSWWRNGQMFGLKNNLMARD--YSLVFNSIQLSDLGLYTCEVYN 2691
            .:.:|:|.::.|.:...|.|.::|.::|:....:..:...|  :.|..:..||.|.|.||||..|
Frog  2077 SIAVNQPLLLECQSTAIPPPLITWLKDGRPLLQRPGVQVIDDGHYLQIDQAQLRDAGRYTCEASN 2141

  Fly  2692 QRRPVSLRVTLKAVGPVRPLSPEEEQYMQYVLNPATRPVTQRPSYPYRPTRPAY----------- 2745
            .                  ....|:.|...:..|        ||:| .|:.|.:
Frog  2142 D------------------AGRTEKHYNVIIWVP--------PSFP-EPSAPHHSIIEGQPVSFT 2179

  Fly  2746 -----VPEPTVN---------------VHA--------VLALEPKNSY----------------- 2765
                 ||.||:.               |.|        .:.|..:.||
Frog  2180 CECTGVPPPTLTWTKNGLPLTVEDSGLVSAGGRLLQIGKVQLSDEGSYICECSNQAGSNKKEYWL 2244

  Fly  2766 -------------TP-------GSTIVMSCSVQGYPEPNVTWIKDDVPLYNNERVQITYQPHRLV 2810
                         ||       ||.:.|.|.|.|.|.|:|||:||..||.|...:....:..:|.
Frog  2245 EVYAQPMIAGSSNTPKQLMVNKGSLVTMECVVSGKPSPSVTWLKDGYPLGNGPDLFFQNKGQQLT 2309

  Fly  2811 LSDVTSADSGKYTCRASNAYTYANGEANVSIQSVVPVSPE 2850
            :.....:.||:|.|.|.|    |.|:.::..:..|.|.||
Frog  2310 ILKAQPSHSGRYVCVAVN----AAGQTDIKYEVFVQVPPE 2345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559
		ADAM_spacer1	214..329	CDD:283607
		TSP1	468..521	CDD:214559
		TSP_1	645..693	CDD:278517
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443	9/33 (27%)
		KU	2071..2121	CDD:238057	16/99 (16%)
		Kunitz_BPTI	2127..2178	CDD:278443	11/53 (21%)
		KU	2192..2245	CDD:238057	15/74 (20%)
		KU	2251..2304	CDD:238057	9/67 (13%)
		KU	2316..2372	CDD:238057	15/56 (27%)
		WAP	2457..2497	CDD:278522	7/39 (18%)
		Ig	2521..2610	CDD:299845	27/90 (30%)
		IG_like	2530..2610	CDD:214653	26/81 (32%)
		IG_like	2627..2703	CDD:214653	18/77 (23%)
		Ig	2636..2701	CDD:143165	16/66 (24%)
		IG_like	2766..2841	CDD:214653	27/81 (33%)
		Ig	2768..2830	CDD:299845	23/61 (38%)
		PLAC	2851..2883	CDD:285849	213/1015 (21%)
hmcn2	XP_031747766.1	vWFA	29..165	CDD:238119
		IG_like	434..503	CDD:214653
		Ig strand B	434..438	CDD:409353
		Ig strand C	447..451	CDD:409353
		Ig strand E	469..473	CDD:409353
		Ig strand F	483..488	CDD:409353
		Ig	514..592	CDD:416386
		Ig strand A'	515..518	CDD:409353
		Ig strand B	524..531	CDD:409353
		Ig strand C	537..542	CDD:409353
		Ig strand C'	544..546	CDD:409353
		Ig strand D	551..555	CDD:409353
		Ig strand E	558..563	CDD:409353
		Ig strand F	571..579	CDD:409353
		Ig strand G	582..592	CDD:409353
		I-set	596..681	CDD:400151
		Ig strand B	613..617	CDD:409353
		Ig strand C	626..630	CDD:409353
		Ig strand E	648..652	CDD:409353
		Ig strand F	662..667	CDD:409353
		Ig strand G	676..679	CDD:409353
		Ig	695..770	CDD:416386
		Ig strand B	703..707	CDD:409353
		Ig strand C	716..720	CDD:409353
		Ig strand E	736..740	CDD:409353
		Ig strand F	750..755	CDD:409353
		Ig strand G	763..766	CDD:409353
		Ig strand A	774..778	CDD:409353
		IG_like	780..864	CDD:214653
		Ig strand A'	781..786	CDD:409353
		Ig strand B	790..798	CDD:409353
		Ig strand C	804..809	CDD:409353
		Ig strand C'	812..815	CDD:409353
		Ig strand D	822..825	CDD:409353
		Ig strand F	843..851	CDD:409353
		I-set	870..957	CDD:400151
		Ig strand A'	878..881	CDD:409353
		Ig strand B	887..895	CDD:409353
		Ig strand C	901..906	CDD:409353
		Ig strand C'	909..911	CDD:409353
		Ig strand D	917..921	CDD:409353
		Ig strand E	923..927	CDD:409353
		Ig strand F	936..944	CDD:409353
		Ig strand G	947..957	CDD:409353
		I-set	961..1048	CDD:400151
		Ig strand A'	969..973	CDD:409353
		Ig strand B	977..984	CDD:409353
		Ig strand C	991..996	CDD:409353
		Ig strand C'	998..1001	CDD:409353
		Ig strand D	1007..1011	CDD:409353
		Ig strand E	1014..1020	CDD:409353
		Ig strand F	1027..1035	CDD:409353
		Ig strand G	1038..1048	CDD:409353
		Ig	1065..1146	CDD:416386
		Ig strand A'	1067..1070	CDD:409353
		Ig strand B	1076..1083	CDD:409353
		Ig strand C	1089..1094	CDD:409353
		Ig strand C'	1096..1098	CDD:409353
		Ig strand D	1105..1109	CDD:409353
		Ig strand E	1112..1117	CDD:409353
		Ig strand F	1125..1133	CDD:409353
		Ig strand G	1136..1146	CDD:409353
		Ig	1157..1237	CDD:416386
		Ig strand B	1167..1174	CDD:409353
Ig strand C	1180..1185	CDD:409353
Ig strand C'	1187..1189	CDD:409353
Ig strand D	1196..1200	CDD:409353
Ig strand E	1203..1208	CDD:409353
Ig strand F	1216..1224	CDD:409353
Ig strand G	1227..1237	CDD:409353
Ig	1241..1329	CDD:416386
Ig strand A	1241..1244	CDD:409353
Ig strand A'	1250..1253	CDD:409353
Ig strand B	1259..1266	CDD:409353
Ig strand C	1272..1277	CDD:409353
Ig strand C'	1280..1282	CDD:409353
Ig strand D	1289..1293	CDD:409353
Ig strand E	1295..1299	CDD:409353
Ig strand F	1308..1316	CDD:409353
Ig strand G	1319..1329	CDD:409353
I-set	1342..1420	CDD:400151
Ig strand A'	1343..1346	CDD:409353
Ig strand B	1352..1359	CDD:409353
Ig strand C	1365..1370	CDD:409353
Ig strand C'	1373..1375	CDD:409353
Ig strand D	1381..1385	CDD:409353
Ig strand E	1387..1392	CDD:409353
Ig strand F	1401..1409	CDD:409353
Ig strand G	1412..1420	CDD:409353
I-set	1434..1516	CDD:400151
Ig strand A'	1436..1439	CDD:409353
Ig strand B	1445..1452	CDD:409353
Ig strand C	1458..1463	CDD:409353
Ig strand C'	1465..1467	CDD:409353
Ig strand D	1474..1478	CDD:409353
Ig strand E	1481..1487	CDD:409353
Ig strand F	1495..1503	CDD:409353
I-set	1538..1609	CDD:400151	23/100 (23%)
Ig strand B	1539..1546	CDD:409353	2/6 (33%)
Ig strand C	1552..1557	CDD:409353	3/10 (30%)
Ig strand C'	1559..1561	CDD:409353	0/1 (0%)
Ig strand D	1567..1571	CDD:409353	0/3 (0%)
Ig strand E	1574..1580	CDD:409353	0/5 (0%)
Ig strand F	1588..1596	CDD:409353	3/9 (33%)
Ig strand G	1599..1609	CDD:409353	2/9 (22%)
Ig	1621..1703	CDD:416386	18/93 (19%)
Ig strand A'	1624..1628	CDD:409353	0/3 (0%)
Ig strand B	1632..1639	CDD:409353	2/9 (22%)
Ig strand C	1646..1651	CDD:409353	0/4 (0%)
Ig strand C'	1653..1656	CDD:409353	0/2 (0%)
Ig strand D	1661..1665	CDD:409353	0/3 (0%)
Ig strand E	1668..1675	CDD:409353	0/6 (0%)
Ig strand F	1682..1690	CDD:409353	2/11 (18%)
I-set	1717..1796	CDD:400151	15/87 (17%)
Ig strand C	1739..1743	CDD:409353	0/3 (0%)
Ig strand E	1762..1766	CDD:409353	0/3 (0%)
Ig strand F	1776..1781	CDD:409353	2/8 (25%)
Ig	1796..1880	CDD:416386	24/104 (23%)
Ig strand A'	1801..1804	CDD:409353	0/2 (0%)
Ig strand B	1818..1825	CDD:409353	2/6 (33%)
Ig strand C	1831..1836	CDD:409353	1/4 (25%)
Ig strand C'	1838..1840	CDD:409353	0/1 (0%)
Ig strand F	1859..1867	CDD:409353	2/7 (29%)
Ig strand G	1870..1880	CDD:409353	3/10 (30%)
I-set	1886..1964	CDD:400151	19/102 (19%)
Ig strand A'	1892..1895	CDD:409353	1/2 (50%)
Ig strand B	1901..1908	CDD:409353	3/6 (50%)
Ig strand C	1914..1919	CDD:409353	0/4 (0%)
Ig strand C'	1920..1922	CDD:409353	1/1 (100%)
Ig strand D	1929..1933	CDD:409353	1/14 (7%)
Ig strand E	1936..1942	CDD:409353	1/5 (20%)
Ig strand F	1950..1958	CDD:409353	2/7 (29%)
Ig	1984..2063	CDD:416386	25/79 (32%)
Ig strand B	1992..1999	CDD:409353	3/6 (50%)
Ig strand C	2005..2010	CDD:409353	2/4 (50%)
Ig strand C'	2012..2014	CDD:409353	0/1 (0%)
Ig strand D	2022..2025	CDD:409353	0/2 (0%)
Ig strand E	2029..2035	CDD:409353	1/5 (20%)
Ig strand F	2042..2049	CDD:409353	4/6 (67%)
Ig strand G	2055..2063	CDD:409353	2/8 (25%)
Ig_3	2066..2141	CDD:404760	20/79 (25%)
Ig strand B	2084..2088	CDD:409353	0/3 (0%)
Ig strand C	2097..2101	CDD:409353	0/3 (0%)
Ig strand E	2120..2124	CDD:409353	1/3 (33%)
Ig strand F	2134..2139	CDD:409353	3/4 (75%)
Ig strand A	2158..2161	CDD:409353	2/2 (100%)
Ig strand A'	2167..2170	CDD:409353	0/2 (0%)
Ig	2170..2246	CDD:416386	9/75 (12%)
Ig strand B	2176..2183	CDD:409353	0/6 (0%)
Ig strand C	2189..2194	CDD:409353	1/4 (25%)
Ig strand C'	2197..2199	CDD:409353	0/1 (0%)
Ig strand E	2204..2216	CDD:409353	2/11 (18%)
Ig strand F	2225..2233	CDD:409353	2/7 (29%)
Ig strand G	2236..2246	CDD:409353	0/9 (0%)
I-set	2259..2340	CDD:400151	26/84 (31%)
Ig strand B	2270..2274	CDD:409353	1/3 (33%)
Ig strand C	2283..2287	CDD:409353	2/3 (67%)
Ig strand E	2306..2310	CDD:409353	1/3 (33%)
Ig strand F	2320..2325	CDD:409353	2/4 (50%)
Ig_3	2343..2421	CDD:404760	2/3 (67%)
Ig strand B	2364..2368	CDD:409353
Ig strand C	2377..2381	CDD:409353
Ig strand E	2400..2404	CDD:409353
Ig strand F	2414..2419	CDD:409353
Ig strand A	2437..2440	CDD:409353
I-set	2447..2526	CDD:400151
Ig strand A'	2447..2450	CDD:409353
Ig strand B	2455..2463	CDD:409353
Ig strand C	2469..2473	CDD:409353
Ig strand C'	2476..2479	CDD:409353
Ig strand D	2484..2488	CDD:409353
Ig strand E	2492..2497	CDD:409353
Ig strand F	2505..2513	CDD:409353
Ig strand G	2516..2526	CDD:409353
I-set	2530..2622	CDD:400151
Ig strand B	2552..2556	CDD:409353
Ig strand C	2565..2569	CDD:409353
Ig strand E	2588..2592	CDD:409353
Ig strand F	2602..2607	CDD:409353
I-set	2633..2720	CDD:400151
Ig strand B	2650..2654	CDD:409353
Ig strand C	2663..2667	CDD:409353
Ig strand E	2686..2690	CDD:409353
Ig strand F	2700..2705	CDD:409353
Ig	2760..2830	CDD:416386
Ig strand B	2760..2764	CDD:409353
Ig strand C	2773..2777	CDD:409353
Ig strand E	2797..2800	CDD:409353
Ig strand F	2810..2815	CDD:409353
I-set	2839..2925	CDD:400151
Ig strand A'	2845..2850	CDD:409353
Ig strand B	2855..2863	CDD:409353
Ig strand C	2867..2873	CDD:409353
Ig strand C'	2875..2877	CDD:409353
Ig strand D	2883..2889	CDD:409353
Ig strand E	2890..2896	CDD:409353
Ig strand F	2905..2912	CDD:409353
Ig strand G	2915..2923	CDD:409353
I-set	2929..3017	CDD:400151
Ig strand A	2929..2932	CDD:409353
Ig strand A'	2936..2941	CDD:409353
Ig strand B	2947..2954	CDD:409353
Ig strand C	2960..2965	CDD:409353
Ig strand D	2976..2979	CDD:409353
Ig strand E	2983..2989	CDD:409353
Ig strand F	2996..3003	CDD:409353
Ig strand G	3009..3017	CDD:409353
Ig strand A	3020..3029	CDD:409353
I-set	3034..3111	CDD:400151
Ig strand B	3039..3049	CDD:409353
Ig strand C	3053..3059	CDD:409353
Ig strand C'	3061..3064	CDD:409353
Ig strand E	3077..3083	CDD:409353
Ig strand F	3089..3098	CDD:409353
Ig_3	3116..3189	CDD:404760
Ig strand A	3119..3122	CDD:409353
Ig strand A'	3124..3128	CDD:409353
Ig strand B	3132..3139	CDD:409353
Ig strand C	3146..3151	CDD:409353
Ig strand C'	3153..3156	CDD:409353
Ig strand D	3162..3166	CDD:409353
Ig strand E	3168..3174	CDD:409353
Ig strand F	3181..3189	CDD:409353
Ig_3	3206..3284	CDD:404760
Ig strand B	3225..3229	CDD:409353
Ig strand C	3238..3242	CDD:409353
Ig strand E	3263..3267	CDD:409353
Ig strand F	3277..3282	CDD:409353
Ig strand G	3291..3294	CDD:409353
I-set	3318..3391	CDD:400151
Ig strand B	3321..3325	CDD:409353
Ig strand C	3334..3338	CDD:409353
Ig strand E	3357..3361	CDD:409353
Ig strand F	3371..3376	CDD:409353
Ig strand A	3395..3398	CDD:409353
Ig strand A'	3403..3408	CDD:409353
I-set	3406..3484	CDD:400151
Ig strand B	3414..3421	CDD:409353
Ig strand C	3427..3432	CDD:409353
Ig strand D	3443..3446	CDD:409353
Ig strand E	3450..3456	CDD:409353
Ig strand F	3463..3470	CDD:409353
Ig strand G	3476..3484	CDD:409353
Ig_3	3487..3561	CDD:404760
Ig strand A'	3498..3501	CDD:409353
Ig strand B	3507..3514	CDD:409353
Ig strand C	3520..3525	CDD:409353
Ig strand C'	3527..3529	CDD:409353
Ig strand D	3534..3538	CDD:409353
Ig strand E	3541..3546	CDD:409353
Ig strand F	3554..3562	CDD:409353
I-set	3585..3668	CDD:400151
Ig strand A'	3589..3592	CDD:409353
Ig strand B	3598..3605	CDD:409353
Ig strand C	3611..3616	CDD:409353
Ig strand C'	3618..3620	CDD:409353
Ig strand D	3626..3630	CDD:409353
Ig strand E	3633..3639	CDD:409353
Ig strand F	3647..3655	CDD:409353
Ig strand G	3658..3668	CDD:409353
I-set	3672..3759	CDD:400151
Ig strand A	3673..3676	CDD:409353
Ig strand A'	3680..3683	CDD:409353
Ig strand B	3689..3696	CDD:409353
Ig strand C	3702..3707	CDD:409353
Ig strand C'	3709..3711	CDD:409353
Ig strand D	3718..3722	CDD:409353
Ig strand E	3725..3730	CDD:409353
Ig strand F	3738..3746	CDD:409353
TSP1	3766..3817	CDD:214559
TSP1	3822..3873	CDD:214559
nidG2	3876..4057	CDD:412205
EGF_CA	4111..4149	CDD:214542
EGF_CA	4151..4194	CDD:311536
EGF_CA	4196..4233	CDD:214542
EGF_CA	4234..4267	CDD:214542
EGF_CA	4276..4317	CDD:311536
EGF_CA	4319..4358	CDD:311536
EGF_CA	4424..4463	CDD:214542
EGF_CA	4464..4504	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910