DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppn and adamtsl4

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	XP_002935503.2	Gene:	adamtsl4 / 100488255	XenbaseID:	XB-GENE-986796	Length:	1427	Species:	Xenopus tropicalis

Alignment Length:	792	Identity:	239/792 - (30%)
Similarity:	361/792 - (45%)	Gaps:	153/792 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SIH-DSQS-------RFPGLRQKRQYGANMYLPESSVTPGGEGNDPDEWTPWSSPSDCSRTCGGG 76
            |:| .:||       |.|.:..:|:......|.::|..|        :|..::..|:
Frog   658 SVHRPAQSDPWPAFGRSPTVAHEREQDVGSSLHQNSELP--------QWNLYNPASE-------- 706

  Fly    77 VSYQTRECLRRDDRGEAVCSGGSRRYFSCNTQDCPEEESDFRAQQCSRFDRQQFDGVFYEWVPYT 141
                           |..|.|..::|.|||.:.||..:.|.||:.|:.|:.|:|.|..|:|..:|
Frog   707 ---------------EFHCEGEQKQYKSCNQEACPSGQPDARAKHCATFNSQEFMGRLYQWEAFT 756

  Fly   142 --NAPNPCELNCMPKGERFYYRQREKVVDGTRCNDKDLDVCVNGECMPVGCDMMLGSDAKEDKCR 204
              :....|.|||.|.|.|||.|..|||.|||.|....|||||:|:|:..|||.:|||::..|.|.
Frog   757 EVSGNQRCALNCRPIGYRFYVRHTEKVQDGTPCEAGSLDVCVDGQCLSPGCDGILGSNSTLDTCG 821

  Fly   205 KCGGDGSTCKTIRNTITTKDLAPGYNDLLLLPEGATNIRIEETVPSSNYLACRNHSGHYYLNGDW 269
            .|||||||||.|..|....::..||:.:|.:|:|||.|::.|...|.||||.|:.:|..::||:|
Frog   822 VCGGDGSTCKFITGTFKETNVPIGYHKILEIPKGATQIKVRELTWSPNYLALRSRTGKSFINGNW 886

  Fly   270 RIDFPRPMFFA-NSWWNYQRKPMGFAAPDQLTCSGPISESLFIVMLVQEKNISLDYEYSI----- 328
            .:| |...:.| .:.:.|.:........:..|.:||.||:|.:.|:.|:.|..:.:::.|
Frog   887 AVD-PAGRYEAGGTVFIYTQPGREEQEGETFTAAGPTSEALDVYMIFQQDNPGISFQFFISSPTA 950

  Fly   329 PESLSH----SQQD--------------------------------------------------- 338
            .::..|    |||:
Frog   951 ADASGHQSNPSQQEYGALRSMSASETLANTGSRTQPPDDRPLVPPPQSRQRPVSTLQRNIRVPPL 1015

  Fly   339 ----THTWTHH-QF-------NACSASCGGGSQSRKVTCNNRITLAEVNPSLCDQKSKPV-EEQA 390
                .|.|... ||       .|||.|||.|.......|.:|.:|.||:...||..:||. :|:|
Frog  1016 QSPPVHYWPEQPQFFWKRVGSTACSVSCGKGFWYPVYQCVSRNSLEEVSEEECDLSNKPFPQEEA 1080

  Fly   391 CGTEPCAPHWVEGEWSKCSKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQEC 455
            |.|:||...|..|.||.||:.|| :|.|:|.:.|.::.:: ..|:.....|...|  ||...|.|
Frog  1081 CNTQPCPAFWDVGNWSVCSRTCG-NGIQHRQVLCRQMYAN-RTTMVHPQRCSHLV--KPNVTQTC 1141

  Fly   456 NRDVKNCPKYHL-GPWTPCDKLCGDGKQTRKVTCFIEENGHKRVLPEEDCVEE-KPETEKSCLLT 518
              .::.|..:.: ..|:.|..:||.|::||.|.| :...|.:  :.:.:|... :|.|.::|.:.
Frog  1142 --QLRICSHWEIQSNWSTCSVMCGLGQRTRHVRC-VSNQGDE--VGDGECSNRLRPRTNEACDMG 1201

  Fly   519 PCEGVDWIISQWSG-CNA-CGQNTETRTAICGNKEGKVYPEEFCEPEVPTLSRPCKSPKCE--AQ 579
            ||.. .|..::||. |:. ||...:.|:..|.:.......:|.|....|:..|.|.|..||  .:
Frog  1202 PCVR-SWFHNEWSPICSTECGTGIQRRSVFCLSSSPTDESQESCGGSKPSDMRVCNSGPCERTVK 1265

  Fly   580 WFSSEWSKCSAPCGKGVKSRIVIC-----GEFDGKTVTPADDDSKCNKETKPESEQDCEGEEKVC 639
            |::..|::|||.||.|.:.|.|||     .||:   ||   |.|:|:...||...|.|....  |
Frog  1266 WYTGPWTQCSADCGDGSQKRDVICVSKLGAEFN---VT---DPSECSHLEKPLPLQSCNAGP--C 1322

  Fly   640 PGEWFTGPWGKCSKPCGGGERVREVLCL-SNGTKSVNCDEEKVEPLSEKCNSEACTEDEILPLTS 703
            ...|||.||..||:.|.||.::|||.|| |:.:.|..||::........||::.|:       .:
Frog  1323 GPSWFTTPWSACSQSCLGGLQMREVRCLASDKSFSQQCDQDTKPEDKRVCNTQPCS-------AA 1380

  Fly   704 TDKPIEDDEEDC 715
            .|:...|...:|
Frog  1381 LDENCRDRYHNC 1392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	9/50 (18%)
		ADAM_spacer1	214..329	CDD:283607	36/120 (30%)
		TSP1	468..521	CDD:214559	15/53 (28%)
		TSP_1	645..693	CDD:278517	19/48 (40%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
adamtsl4	XP_002935503.2	TSP1	45..>77	CDD:214559
		ADAM_spacer1	831..945	CDD:368694	35/114 (31%)
		TSP1_ADAMTS	1037..1086	CDD:408800	20/48 (42%)
		TSP1_ADAMTS	1090..1146	CDD:408800	19/61 (31%)
		TSP1_ADAMTS	1149..1203	CDD:408800	14/56 (25%)
		TSP1_ADAMTS	1207..1260	CDD:408800	14/52 (27%)
		TSP1_ADAMTS	1266..1322	CDD:408800	23/63 (37%)
		TSP1_ADAMTS	1326..1377	CDD:408800	21/50 (42%)
		PLAC	1385..1414	CDD:400844	2/8 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910