DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppn and adamts13

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	XP_031747422.1	Gene:	adamts13 / 100485801	XenbaseID:	XB-GENE-6038835	Length:	1593	Species:	Xenopus tropicalis

Alignment Length:	781	Identity:	196/781 - (25%)
Similarity:	302/781 - (38%)	Gaps:	168/781 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 SVTPGGEGNDPDEWTPWSSPSDCSRTCGGGVSYQTRECLR-RDDRGEAVCSGGSRRYFSCNTQDC 110
            ||..||       |:.|.|.|.|||:|||||..:.|:|.. |...|...|.|.:.:...||||.|
Frog   494 SVVHGG-------WSSWGSFSSCSRSCGGGVVMRKRQCNNPRPAFGGRACEGSNLQAEMCNTQVC 551

  Fly   111 PEEESDFRAQQCSRFDRQQF---DGV--FYEW---VPYTNAPNPCELNCMPKGERFYYRQREKVV 167
            ...:..|..:|||..|.:..   .|:  ||:|   |.:.:....|:..|..:|:.|...:.:..:
Frog   552 SSTQIGFMNEQCSDTDTKPLYLSPGIPSFYKWTSAVGFVDGKALCQYMCRAQGKSFIVARGKSFL 616

  Fly   168 DGTRCN-----DKDLDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAP 227
            |||||.     :..|.:||.|.|...|||.::||...:|:|..||||.|||..|..:. ::..|.
Frog   617 DGTRCETNKEANAKLGLCVAGSCRVFGCDGVMGSGMVKDQCGVCGGDNSTCNRIHGSF-SEGKAG 680

  Fly   228 GYNDLLLLPEGATNIRIEETVPSSNYLACRNHSGHYYL---NGDWRIDFPRPMFFANSWWNYQRK 289
            .|...|.||.|:|::::....|...:|..:.:.  .||   .|...::...|....:....|:..
Frog   681 EYVSFLTLPPGSTSLKVTNQKPVFTHLGIKVND--EYLVAGKGSISLNVTYPSVLEDQTIEYRLF 743

  Fly   290 PMGFAAP--DQLTCSGPISESLFIVM---LVQE----KNISLDYEYSIPESLSHSQQDTHTWTHH 345
            ......|  :|:...||.::.|.|.:   ..||    .|..:.|.|.||:     :...:.|
Frog   744 LNADKLPHLEQIHIEGPTTKELEIQVYRKYGQEYGDATNPDIIYSYHIPK-----KDIEYKW--- 800

  Fly   346 QF---NACSASCGGGSQSRKVTCNNRITLAEVNPSLCDQKSKPVE-EQACGTEPCAPHWVEGEWS 406
             |   ..|||||.||.......|:.......|..|||:..::|.. .:.||.:||.|.|...|.|
Frog   801 -FPVPGPCSASCDGGFHLVSYECSEHDLNQLVQSSLCNDSARPSSFHEPCGIDPCPPRWDVKESS 864

  Fly   407 KCSKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVKNCP-KYHLGPW 470
            .|:..||. |...|::.|.:: ..|..|:..||.|  :...:|.....|.  ::.|| ::.....
Frog   865 PCTVSCGG-GVVLRTLHCVQM-QQGIETILFDAYC--DHSTRPEAFVACG--LEPCPARWEASEA 923

  Fly   471 TPCDKLCGDGKQTRKVTCFIEENGHKRVLPEEDCV-EEKPETEKSCLLTPCEGVDWIISQ----- 529
            ..|..:||.|...|.|:|.....|.:..:.|.:|: :|||.|:..|:::.|. |.|.:..
Frog   924 GLCPVVCGSGLALRNVSCVQSHAGLEVAVEESNCLGQEKPTTQVECVVSVCP-VGWDMQMDSSLR 987

  Fly   530 -------------------WS---------------------------------GCN-------- 534
                               ||                                 .||
Frog   988 LSERSSREETAEKHTEVYVWSPRVGPCSVSCGTGISELSYICVDFYTKTETAEENCNQTLKPEPR 1052

  Fly   535 -----------------------ACGQNTETRTAICGNKEGKV---YPEEFCE--PEVPTLSRPC 571
                                   .||..|.....||..::|.:   .|...|.  |. |..|:||
Frog  1053 PNVCNLGTCPPLWEVKELGPCPVTCGGATIPLAVICVRRDGNISYSLPHSKCSRIPR-PRASKPC 1116

  Fly   572 KSPKCEAQWFSSEWSKCSAPCGKGVKSRIVICGEF--DGKTVTPADDDSKCNKETKPESEQDCEG 634
            ....|..:| ..:...||..||.|:..|::.|..:  .|::......|.:|.....||.::.|
Frog  1117 GMEPCPVRW-RYKTGSCSVSCGGGILQRVLYCSRYPQKGESEEQIVSDLECQHLPHPEGQEPC-- 1178

  Fly   635 EEKVCPGEWFTGPWGKCSKPCGGGERVREVLCLSNGTKSVNCDEEKVEPLSEKCNSEACTEDEIL 699
            .:::||..|.......||..||.|...:.|:|:           :.||...::.:.::|...|..
Frog  1179 NQQLCPPRWKVAEATPCSAACGYGISKQRVVCV-----------QTVEGAEKEMDLDSCVLQEKP 1232

  Fly   700 P 700
            |
Frog  1233 P 1233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	22/51 (43%)
		ADAM_spacer1	214..329	CDD:283607	26/126 (21%)
		TSP1	468..521	CDD:214559	15/53 (28%)
		TSP_1	645..693	CDD:278517	9/47 (19%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
adamts13	XP_031747422.1	Pep_M12B_propep	<99..167	CDD:396235
		ZnMc_ADAMTS_like	198..400	CDD:239801
		ADAM_CR_2	414..484	CDD:407643
		TSP1	<511..552	CDD:214559	16/40 (40%)
		ADAM_spacer1	670..792	CDD:368694	26/124 (21%)
		TSP1_ADAMTS	800..854	CDD:408800	17/57 (30%)
		TSP1_ADAMTS	858..914	CDD:408800	16/61 (26%)
		TSP1_ADAMTS	918..974	CDD:408800	15/55 (27%)
		TSP1_ADAMTS	1012..1061	CDD:408800	2/48 (4%)
		TSP1_ADAMTS	1065..1121	CDD:408800	13/56 (23%)
		TSP1_ADAMTS	1125..1183	CDD:408800	14/60 (23%)
		TSP1_ADAMTS	1187..1243	CDD:408800	13/58 (22%)
		TSP1_ADAMTS	1247..1301	CDD:408800
		CUB	1471..1579	CDD:412131
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910