DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppn and adamts12

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	XP_017946319.2	Gene:	adamts12 / 100380018	XenbaseID:	XB-GENE-959575	Length:	1569	Species:	Xenopus tropicalis

Alignment Length:	954	Identity:	246/954 - (25%)
Similarity:	347/954 - (36%)	Gaps:	342/954 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 TP----GGEGNDPDEWTPWSSPSDCSRTCGGGVSYQTRECLRRDDR-GEAVCSGGSRRYFSCNTQ 108
            ||    ||.|    .||||   |.||||||.|.....|:|.....: |...|:|..:||..||.|
Frog   549 TPQTINGGWG----AWTPW---SHCSRTCGAGAENAERKCNNPQPKFGGKYCTGERKRYRICNIQ 606

  Fly   109 DCPEEESDFRAQQCSRFDRQQFDGVFYEWVPYTNAPNPCELNCMPKGERFYYRQREKVVDGTRC- 172
            .||::...||..||:.|:...:....|:|:|..|..|||||:|......|..:..:.|:|||.|
Frog   607 PCPKDYPSFREMQCTEFNTVPYKNELYQWIPIYNTENPCELHCRSSSGNFANKFLDAVIDGTPCF 671

  Fly   173 -NDKDLDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLLLLP 236
             .:|..|||:||.|..||||..:.|:|.||:|..|.||||:|:||:......| ..||.|:.|:|
Frog   672 ERNKSRDVCINGICKKVGCDYEIDSNATEDRCGICLGDGSSCQTIKKVFNQTD-GFGYVDVGLIP 735

  Fly   237 EGATNIRIEETVPSSNYLACRNHS-GHYYLNGDWRIDFPRPMFFANSWWNYQRKPMGFAAPDQLT 300
            :||.:|:|||...:.|:||.|:.. |.|||||.:.|.:......|.:.::|||.    ...:.:|
Frog   736 KGARDIKIEEVEEAGNFLALRSEDPGKYYLNGAYIIQWNGEYKVAGTIFHYQRN----NDTENIT 796

  Fly   301 CSGPISESLFIVMLVQEKNISLDYEYSIPE--SLSHSQQDTHTWTHHQFNACSASCGGGSQSRKV 363
            .|||.:||::|.:|.||.|..:.|||.|.:  :|.:..:..:||.:..:..|||:||.|.|.:..
Frog   797 ASGPTNESIWIQLLFQEHNPGVRYEYVIQKDVNLENEIESVYTWRYGGWTDCSATCGTGVQHQIS 861

  Fly   364 TCNNRITLAEVNPSLCDQKSKPVEEQ-ACGTEPCAPHWVEGEWSKCSKGCGSDGFQNRSITCERI 427
            .|.|: ....|..:.|||:.:|:..| .|.|:.|.|.|..|:|.:||..||..|.:.|::.|.:.
Frog   862 RCVNK-KRGVVKNTFCDQEMQPITRQKKCNTKECPPRWWVGQWQQCSTTCGPTGEKKRTVLCLKT 925

  Fly   428 SSSGEHTV-EEDAVCLKEVGNKPATKQECNRDVKNCPK-YHLGPWTPCDKLCGDGKQTRKVTC-- 488
            |.|.|..: .||...|    .||.....||||:. ||. :.:..|:.|...||.|.:||.:||
Frog   926 SGSDEEALRSEDCHHL----TKPKVYLSCNRDIL-CPSDWTVSNWSECSVTCGGGVRTRNITCAK 985

  Fly   489 ------------------------------------------------------FIEENGHK--- 496
                                                                  |:....|:
Frog   986 NNDEPCDSSKKPNSKALCGLQQCYVQKTLPKPPIKYNYRKKIIKKKSGDPKRRIFLPNKNHRVQT 1050

  Fly   497 -----RVL--------------------------------------------------------- 499
                 ||.
Frog  1051 TTGLPRVFMSTSSTNSSSPSVKSIKEDFQINEIPNSTHFNIDYKYNFVLVENNKRKVHVNATSIS 1115

  Fly   500 ---------------------------------PEE-----DCVEEKPE---------------- 510
                                             |||     ..:.|:|:
Frog  1116 PSVSNRTKVGNMETGTESIAEKDSPPIFTTTRRPEELTSKYQLLTEQPQSQTESGNMRGSTVDPN 1180

  Fly   511 ---------------------------------------TEKSCLL--TP-----------CEG- 522
                                                   |..|.|:  ||           .||
Frog  1181 GDYDTDINFIIESRSKRHKGKTNQNQNHPGTNLNQTESPTNSSILINQTPLSTYNTVSISNTEGN 1245

  Fly   523 ----------------------------------------------------------------V 523
                                                                            |
Frog  1246 STRNNQDWRDVAPTASAQPSFLQVTTSNTPENSTWKVNNASNRYLLNYTHYENGTGLNFNVSKEV 1310

  Fly   524 DWIISQWSGCN-ACGQNTETRTAICGNKEGKVYPEEFCEPEVPTLSRPCKSPKCEAQWFSSEWSK 587
            .||:..||.|: :||.....|...|..:    :.::....:.|..:|.|....| |:|.:.:|:|
Frog  1311 YWIVGNWSECSTSCGLGAMWRPVDCSTE----FDDDCKHIKKPDPARRCHLRPC-ARWETGDWTK 1370

  Fly   588 CSAPCGKGVKSRIVICGEF-DGKTVTPADDDSKCNKETK-PESEQDCEGEEKVCPGEWFTGPWGK 650
            ||..|..|.|:|.|.|.:. :.:.:.|    ..|....| ||....|..|..:   .|...||.:
Frog  1371 CSKNCQGGFKTREVQCVDIRENRPLRP----FHCQSPGKNPEQNVSCNTEPCL---SWLAKPWSE 1428

  Fly   651 CSKPCGGGERVREVLCLSNGTKSVNCDEEKVEPLSEKCNSEACT 694
            |||.||||.|.|:|||    .|...||.:|:.|:|..||.|.||
Frog  1429 CSKTCGGGIRQRQVLC----PKEDRCDWKKIPPVSLPCNDEPCT 1468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	22/51 (43%)
		ADAM_spacer1	214..329	CDD:283607	43/115 (37%)
		TSP1	468..521	CDD:214559	23/279 (8%)
		TSP_1	645..693	CDD:278517	23/47 (49%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
adamts12	XP_017946319.2	Pep_M12B_propep	65..200	CDD:396235
		ZnMc_ADAMTS_like	258..465	CDD:239801
		ADAM_CR_2	480..544	CDD:407643
		ADAM_CR	527..688	CDD:417715	57/145 (39%)
		TSP1	557..609	CDD:214559	23/58 (40%)
		ADAM_spacer1	714..825	CDD:368694	43/115 (37%)
		TSP1_ADAMTS	840..894	CDD:408800	18/54 (33%)
		TSP1_ADAMTS	898..952	CDD:408800	19/57 (33%)
		TSP1_ADAMTS	960..1008	CDD:408800	9/47 (19%)
		TSP1_ADAMTS	1312..1360	CDD:408800	12/51 (24%)
		TSP1_ADAMTS	1363..1418	CDD:408800	18/58 (31%)
		TSP1_ADAMTS	1421..1467	CDD:408800	24/49 (49%)
		TSP1_ADAMTS	1470..1525	CDD:408800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11084
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000