DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppn and adamtsl4

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	XP_021322467.1	Gene:	adamtsl4 / 100333903	ZFINID:	ZDB-GENE-070815-2	Length:	1089	Species:	Danio rerio

Alignment Length:	777	Identity:	236/777 - (30%)
Similarity:	328/777 - (42%)	Gaps:	149/777 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 YLPESSVTPGGEGNDPDEWTPWSSPSDCSRTCGGGVSYQTRECLRRDDRGEAVCSGGSRRYFSCN 106
            |.|::...|     :|:.|.|..:|.:             .:..|....|...|||..|.|..|:
Zfish   324 YGPQTPSNP-----NPEPWAPVQTPGN-------------EQDWRPPVAGNYRCSGRDREYRRCS 370

  Fly   107 TQDCPEEESDFRAQQCSRFDRQQFDGVFYEWVPYTNA--PNPCELNCMPKGERFYYRQREKVVDG 169
            .|.||....:.||.|||.|:.|:|.|..|:|.|:|..  ...|||.|.|.|.|||.||.|:|.||
Zfish   371 LQACPGAAVNSRADQCSAFNAQEFMGRVYDWEPFTEVGLEQQCELTCRPVGYRFYVRQAERVRDG 435

  Fly   170 TRC-NDKDLDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLL 233
            |.| |:...||||.|.|:..|||.:|||....|:|..|||:..||:.:..:.....:..||:.:|
Zfish   436 TPCANNTPTDVCVGGRCLSEGCDGVLGSGLVRDRCGVCGGEDGTCERVSGSFMNTSVPLGYHKIL 500

  Fly   234 LLPEGATNIRIEETVPSSNYLACRNHSGHYYLNGDWRIDFPRPMFFANSWWNYQR---KPM--GF 293
            .:|.|||.|.|.|...|.||||.|:.:|...:||.|.:|.|.......:.:.|.|   :|.  |.
Zfish   501 DIPPGATAINITERRASPNYLALRSGTGQSVVNGRWAVDPPGEYQAGGAAFLYTRPKAEPQEPGE 565

  Fly   294 AAPDQLTCSGPISESLFIVMLVQEKNISLDYEYSIP----------------------------- 329
            ...:.||.:||.:..|.:.::...:|..:||||.||
Zfish   566 DRGETLTAAGPTTALLQLYIIFHRQNPGIDYEYYIPVDKRRDGEREVLRERERGRSALRETTGVS 630

  Fly   330 -------------------ESLSHSQQD--------------------------------THTWT 343
                               .|.|.|..|                                ...|.
Zfish   631 MAVENPVAPPPVSSSFPSSSSSSSSSSDRWPPERPRPQGLGPNRNARIPPRTDLPLDNLPVFVWR 695

  Fly   344 HHQFNACSASCGGGSQSRKVTCNNRITLAEVNPSLCDQKSKPV-EEQACGTEPCAPHWVEGEWSK 407
            ......|:|:||.|||.|::.|.||.|..||:...||..:||. ||:.|...||.|.|..|.||:
Zfish   696 RGALTECTATCGKGSQYREIVCVNRHTEQEVHERRCDSATKPTPEEEPCNVHPCPPFWDMGAWSE 760

  Fly   408 CSKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKEVG-NKPATKQECNRDVKNCPKYHLGP-W 470
            ||..||. |.|.|.|.| |.|.....|:.....|   .| ::|...|.|:..|  |..:.:.. |
Zfish   761 CSVSCGW-GVQQRQIQC-RQSFGNRSTMVHPQRC---AGLSRPNATQPCHPRV--CSHWEISTNW 818

  Fly   471 TPCDKLCGDGKQTRKVTCFIEENGHKRVLPEEDCVEE-KPETEKSCLLTPCEGVDWIISQWS-GC 533
            :.|...||.||:||.|.|.   :.|...:.:.:|.:. :|:..:.|.:.||. .:|..:.|: .|
Zfish   819 STCSVDCGMGKRTRNVRCV---SNHGNTVNDRECNDRLRPQHSEDCHMGPCV-TNWYFTDWTHTC 879

  Fly   534 NA-CGQNTETRTAIC----GNKEGKVYPEEFCEPEVPTLSRPCKSPKCEAQ--WFSSEWSKCSAP 591
            :| ||...:.|..:|    |.:||....|  |..:.|...:.|....|.|.  |::..|..|:|.
Zfish   880 SAECGPGVQRREVVCVSAGGRREGDGGLE--CVGDKPADMKACNGGPCTATYLWYTGPWGYCNAV 942

  Fly   592 CGKGVKSRIVICGEFDGKTVTPADDDSKCNKETKPESEQDCEGEEKVCPGEWFTGPWGKCSKPCG 656
            ||.|.:.|.|||....|...| ....|.|:...||...|.||.:.  |..:|||..|..||:.||
Zfish   943 CGNGTQRRDVICVRKSGSEFT-VSSSSDCSHLEKPSPVQPCELQP--CTPQWFTTDWSTCSRSCG 1004

  Fly   657 GGERVREVLCLS-NGTKSVNCDEEKVEPLSEKCNSEACTEDEILPLTSTDKPIEDDEEDCDE 717
            .|.:.|||.||: :...|..|..:......:.||:..|:            |.||  |:|.:
Zfish  1005 EGLQTREVRCLTPDKQHSATCHPDARPAHQQPCNTIPCS------------PFED--ENCKD 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	12/50 (24%)
		ADAM_spacer1	214..329	CDD:283607	36/119 (30%)
		TSP1	468..521	CDD:214559	15/54 (28%)
		TSP_1	645..693	CDD:278517	16/48 (33%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
adamtsl4	XP_021322467.1	TSP1	49..>81	CDD:214559
		ADAM_spacer1	481..601	CDD:310520	36/119 (30%)
		TSP1	700..750	CDD:214559	22/49 (45%)
		TSP1	753..810	CDD:214559	22/63 (35%)
		TSP1	809..866	CDD:214559	15/59 (25%)
		TSP1	872..925	CDD:214559	14/54 (26%)
		TSP1	991..1043	CDD:214559	18/51 (35%)
		PLAC	1050..1080	CDD:312271	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11507
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810