DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppn and thsd7bb

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	XP_009304440.1	Gene:	thsd7bb / 100333732	ZFINID:	ZDB-GENE-090708-2	Length:	1637	Species:	Danio rerio

Alignment Length:	1071	Identity:	212/1071 - (19%)
Similarity:	329/1071 - (30%)	Gaps:	423/1071 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RRLCSTALVAFIVLASIHDSQSRFPGLRQKRQYGAN------MYLPESSVTPGGEGNDPDEW--- 60
            :|||........||.......|.......|.|.|..      :.||.....|...|::.::|
Zfish   592 QRLCEMPCPGDCVLGHWGFWTSCSQSCSSKHQEGKQSRSRLVLALPGDYGKPCPPGSELEQWRSC 656

  Fly    61 ------------TPW--------SSPSDCSR--------TCGGGVSYQTRECL-RRDDRGEAVCS 96
                        :||        :..::.:|        |||.|:  |||:.: ||...|..:
Zfish   657 GAHSCTVYHWDASPWDPCMPNTITDKTERNRTVQMEDDSTCGTGL--QTRQVICRRAGNGHVL-- 717

  Fly    97 GGSRRYFSCNTQDCPEEESDFRAQQC---SRFDRQQFDGVFYEWVPYTNAPNPCELNCMPKGERF 158
                      .:.|||.......:.|   .:.|  .....|.||       :.|..:|:......
Zfish   718 ----------PKRCPESSRPDSVRSCPLPCKVD--CIVTAFSEW-------SVCPTSCLSVNATV 763

  Fly   159 YYRQREKVV------DGTRCND-----KDLD---VCVN--------GECMPVGCDMMLGSDAKED 201
            ..:.|.:::      .|..|.|     ::.|   :|..        .:|:.|           .|
Zfish   764 STQSRHRIIIQRHANGGQECPDTLYEERNCDPPPLCPTYRWQTHRWHQCVLV-----------PD 817

  Fly   202 KCRKC-GGDGSTC----KTIRNTITTKDLAPGYNDLLLLPEGATNIRIEE-TVPS---------S 251
            ..|:. ||....|    :|...|....|.||......:...|...:.:.| .||.         |
Zfish   818 SVRQAVGGPAEACGSGLETREVTCVGADDAPAEMAECVSWAGLMPVSVRECRVPCRDECSFTSWS 882

  Fly   252 NYLACRNHSGHYYLNGDWRIDFPRPMFFANSWWNYQR-------------------KPMGFAAPD 297
            .:..||.       .|.||......:..:...|..|:                   :|.|..:|.
Zfish   883 RFSQCRG-------CGSWRTRTRSLIGRSKKRWRCQQEELFPLLEKEACPCSEFHSRPQGPWSPC 940

  Fly   298 QL-----TCSGPISESLFI--VMLVQEKN-----------------ISLDY-----EYSIPESLS 333
            .|     |...|..:.:|.  ...||:..                 :.||:     |.::..|..
Zfish   941 LLSAVKSTAGRPFIQGVFHQGQKAVQDWRGLRRSSECGHGRRYRALVCLDHLRQLVEPALCSSPG 1005

  Fly   334 HSQQDTHT----------WTHHQFNACSASCGGGSQSR----------------KVTCNNRITLA 372
            :.::..|.          |:|  ::|||||||||.:.|                |:...|:..::
Zfish  1006 YEEESCHVSCSTDCKLSEWSH--WSACSASCGGGVKVRSQWLREKPFNGGRPCPKLNSKNQAQVS 1068

  Fly   373 EVNP------------------------------------------------------------- 376
            ||.|
Zfish  1069 EVLPCYSDCSQYIWEVQSWSVCIINPQNNLTNIRPNHQPVCGEGFRTSKIRCLKRGGENQDEVVD 1133

  Fly   377 -SLCDQKSKPVEEQACGTEPCAPHWVEGEWS---KCSKGCGSDG---FQNRSITCERISSSGEHT 434
             ||||.:.:|...:.| ..||..|.|..|||   :||..| :||   :::||:.         ..
Zfish  1134 NSLCDLEERPSTAETC-LLPCPAHCVTSEWSQWTRCSVDC-NDGDLSWRSRSVL---------RW 1187

  Fly   435 VEEDAVCLKEVGNKPATKQECNRDVKNCPKYHLGPWTPC----DKLCGDGKQTRKVTCFIEENGH 495
            .|||..|.:....||.|...|.:     ..|....|:.|    ..:||.|.:||.:.| :..:|
Zfish  1188 PEEDHTCPELNQTKPCTNMACLK-----YSYVYSDWSSCQLSESAVCGRGIKTRLLNC-VRSDG- 1245

  Fly   496 KRVLPEEDCVEEKPETEKSCLLTPCE---GVDWIISQWSGCNAC-----GQNTETRTAI---CGN 549
             :::....|.|..|...|  |..|||   .|:.:|::||..:.|     ||:..:|:.:   ..:
Zfish  1246 -KLVELSLCKELGPSRGK--LSAPCEVACPVNCLITEWSAWSECSHTCGGQSQRSRSRVVLQADS 1307

  Fly   550 KEGKVYPEEFCEPEVPTLSRPCKSPKCEAQWFSSEWSKC---SAPCGKGVKSRIVIC----GEFD 607
            :.|:..|.:..:      :|||....|.: |..::||.|   .|.||:||..|...|    |...
Zfish  1308 EGGRPCPSQLSQ------TRPCPIRPCYS-WTLADWSPCRVEGADCGEGVSRRERSCVLHWGSLS 1365

  Fly   608 GKTVTPADDDSKC-----NKETKPESEQDCEGEEKVCPGE-----WFTGPWGKC----------- 651
            |.......:|.||     :|.::.|..|.|   ...||||     |  .||..|
Zfish  1366 GPPQPVPVEDEKCVGHLQSKVSEIEFLQPC---TVPCPGECHLTQW--SPWSSCQLMCLDGRSFE 1425

  Fly   652 ----------------------------SKPCGGG-------------ERVREVLC-------LS 668
                                        ::||.||             ...|.|.|       ::
Zfish  1426 TWGRQARSRAVVTQVQENQESCPSQTYETRPCQGGTCLSYEWMTGEWRHNRRLVWCQRSDGVNVT 1490

  Fly   669 NGTKSVN-------CDEEKVEPLSEKCNSEACTEDEILPLTSTDKPIEDDEEDCDEDGIELI-SD 725
            .|..:||       |.....:|.|      .||::.:.              .|::...|:: |.
Zfish  1491 GGCMAVNQPSAVRQCQPPCTKPFS------FCTQNGVC--------------GCEKGFTEVMTSH 1535

  Fly   726 GLSD--------DEKSEDVIDLEGTAKTETT 748
            |..|        |.|..||....|..:.:.|
Zfish  1536 GFLDYCTRTPGLDHKKADVKSTAGRLRPDYT 1566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	14/82 (17%)
		ADAM_spacer1	214..329	CDD:283607	29/172 (17%)
		TSP1	468..521	CDD:214559	15/56 (27%)
		TSP_1	645..693	CDD:278517	16/113 (14%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
thsd7bb	XP_009304440.1	TSP1	173..217	CDD:214559
		TSP1	1022..1065	CDD:214559	14/44 (32%)
		TSP1	1278..1328	CDD:214559	11/55 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000